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  • Chromosome
  • The PCSK9 gene resides on chromosome 1 at the band 1p32.3 and includes 13 exons. (wikipedia.org)
  • The NR0B1 gene is located on the short (p) arm of the X chromosome between positions 21.3 and 21.2, from base pair 30,082,120 to base pair 30,087,136. (wikipedia.org)
  • Duplication of genetic material on the X chromosome in the region that contains the NR0B1 gene can cause a condition called dosage-sensitive sex reversal. (wikipedia.org)
  • In some cases, genetic material is deleted from the X chromosome in a region that contains several genes, including NR0B1. (wikipedia.org)
  • CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. (wikipedia.org)
  • domain proteins
  • Thousands of proteins containing at least one START domain have been determined in invertebrates, bacteria and plants to form a larger superfamily, variously known as START, Bet v1-like or SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) domain proteins, all of which bind hydrophobic ligands. (wikipedia.org)
  • mitochondrial
  • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. (wikipedia.org)
  • Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. (nih.gov)
  • The encoded protein catalyzes the last step of the mitochondrial fatty acid beta oxidation spiral. (wikipedia.org)
  • Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. (wikipedia.org)
  • distinct
  • The distinct pattern of cell division and differential gene expression are the first indications of histological differentiation. (iastate.edu)
  • Without the advantage of modern immunocytochemical or fluorescence microscopy techniques, Roth and Porter were able to visualize yolk protein clustered at the oocyte cell surface in invaginations that are marked on their cytoplasmic side by a distinct electron dense coat material ( 5 ). (pnas.org)
  • Prokaryotes and plants have multi-subunit ACCs composed of several polypeptides encoded by distinct genes. (wikipedia.org)
  • domains
  • Ligand binding by the START domain in multidomain proteins can also regulate the activities of the other domains, such as the RhoGAP domain, the homeodomain and the thioesterase domain. (wikipedia.org)
  • Other proteins also exist in the human with domains that are members of the START-based superfamily such as PITP, but are not part of the START domain itself. (wikipedia.org)
  • Humans and most eukaryotes have evolved an ACC with CT and BC catalytic domains and biotin carboxyl carrier domains on a single polypeptide. (wikipedia.org)
  • hepatoma
  • Here, we treated the liver hepatoma cell line HepG2 with AMP-DNM, resulting in a 70% reduction of glycosphingolipids, and we analyzed the effect on gene expression. (aspetjournals.org)
  • We monitored the effect of AMP-DNM on total gene expression in human hepatoma HepG2 cells using genome wide microarray analysis. (aspetjournals.org)
  • 2002
  • 2002) used cDNA microarrays to compare gene expression during Arabidopsis seed development between wild-type and a mutant wrinkled1 ( wri1 ) seeds that have an 80 % reduction in oil. (biomedcentral.com)
  • tissues
  • DAX1 controls the activity of certain genes in the cells that form these tissues during embryonic development. (wikipedia.org)
  • The extra copy of the NR0B1 gene prevents the formation of male reproductive tissues. (wikipedia.org)
  • Genomics
  • Comparative genomics demonstrate conservation of glycine-aromatic residue pairings through evolution as a previously unrecognized feature of all autotransporter proteins. (jove.com)
  • regulates
  • AT-1 regulates the acetylation of BACE1, LDLR, APP and other ER-based protein substrates, and is upregulated in the brain of late-onset (sporadic) AD patients. (biologists.org)
  • This protein regulates the movement of citrate across the inner membranes of the mitochondria. (nih.gov)
  • consists
  • Category V consists of 2 genes and both genes showed a medium expression at 14 DAF, the lowest expression at 28 or 42 DAF, and the highest expression at 56 DAF. (biomedcentral.com)
  • Later and quite independently, Barbara Pearse discovered that the coat consists of a structural protein, clathrin, which has the unusual property of forming a regular lattice cage polyhedron ( 6 ). (pnas.org)
  • vertebrates
  • Following the discovery of StAR, 15 START-domain-containing proteins (termed STARD1 through STARD15) were subsequently identified in vertebrates as well as other that are related. (wikipedia.org)
  • membrane protein
  • Contribution of omega-3 fatty acids to the thermodynamics of membrane protein solvation. (biomedsearch.com)
  • Increased trafficking of the LCV (Legionella-containing vacuole) to a LAMP-1 (lysosome-associated membrane protein-1)-positive compartment was observed for both the lpg1905 and lpg0971 mutants carrying pMIP. (jove.com)