• Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. (nih.gov)
  • Mutations in the CTNNB1 gene can cause a type of aggressive but noncancerous (benign) growth called a desmoid tumor. (medlineplus.gov)
  • CTNNB1 gene mutations are found in about 85 percent of all noninherited (sporadic) desmoid tumors. (medlineplus.gov)
  • The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
  • The CTNNB1 gene mutations that cause desmoid tumors usually occur in a region of the gene called exon 3. (medlineplus.gov)
  • These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (medlineplus.gov)
  • Somatic mutations in the CTNNB1 gene are found in almost all pilomatricomas, a type of benign skin tumor associated with hair follicles. (medlineplus.gov)
  • The CTNNB1 gene mutations found in pilomatricomas are described as gain-of-function mutations. (medlineplus.gov)
  • Like pilomatricomas, pilomatrix carcinomas have somatic mutations in the CTNNB1 gene. (medlineplus.gov)
  • Mutations in the CTNNB1 gene have been found in Wilms tumor, a rare form of kidney cancer that occurs almost exclusively in children. (medlineplus.gov)
  • CTNNB1 gene mutations in Wilms tumor result in an overly active protein. (medlineplus.gov)
  • Among the clinical populations of Gram-negative microorganisms, bla TEM-1 is the most frequently detected antimicrobial resistance gene and, although its expression results in penicillin resistance, diverse point mutations in the bla TEM-1 gene have contributed to the emergence of TEM-type extended-spectrum β-lactamases (ESBLs), resulting in simultaneous resistance to penicillins and broad-spectrum cephalosporins (8). (scielo.br)
  • GDF5 is a susceptibility gene for osteoarthritis (OA) and mutations in GDF5 are associated with a wide variety of skeletal malformations ranging from complex syndromes such as acromesomelic chondrodysplasias to isolated forms of brachydactylies or multiple synostoses syndrome 2 (SYNS2). (uni-wuerzburg.de)
  • Functional studies, including chondrogenesis assays with primary mesenchymal cells, luciferase reporter gene assays and Surface Plasmon Resonance analysis, of the GDF5 W-414R variant in comparison to other GDF5 mutations associated with isolated BDA1 (p.R399C) or SYNS2 (p.E491K) revealed a dual pathomechanism characterized by a gain-and loss-of-function at the same time. (uni-wuerzburg.de)
  • Mutations in this gene have been associated with adult i blood group phenotype. (nih.gov)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • in 2016, a tenth type was defined based on mutations in the AP3D1 gene. (medscape.com)
  • Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
  • Type 2 results from mutations in the glucose diphosphate (GDP)-fucose transporter gene. (msdmanuals.com)
  • Type 3 is caused by mutations in the FERMT3 gene (11q13.1), which encodes kindlin-3 in hematopoietic cells. (msdmanuals.com)
  • Mutation analysis of the TBCE gene of this syndrome was shown to be due to Polymerase chain reaction/single-strand mutations in the TBCE gene in chromosom- conformation polymorphism analysis and al area 1q42-q43 [ 4,5 ]. (who.int)
  • Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
  • Currently, manufacturers are focusing on and targeting assays to mutations in the S gene. (who.int)
  • Additional splice variants may exist for this gene, but they have not been fully described. (wikipedia.org)
  • Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (ucsc.edu)
  • The presence or absence of one exon by alternative splicing of the gamma-1 gene resulted in two transcript variants which code for predicted proteins containing 298 amino acids (4 cystathionine beta-synthase domains, CBSD) or 276 amino acids (3 CBSD). (usda.gov)
  • For the gamma-2 gene, use of an alternate initiation site and promoter and/or alternative splicing resulted in four different transcript variants which code for predicted proteins containing 567 (4 CBSD), 452 (4 CBSD), 328 (3 CBSD) and 158 (2 CBSD) amino acids. (usda.gov)
  • Alternative splicing of exon 3 in the gamma-3 gene resulted in a shift of the open reading frame and the production of 'long' and 'short' transcript variants that code for predicted proteins of 383 and 363 amino acids, both with 4 CBSD. (usda.gov)
  • With regard to glucose homeostasis, genetic variants in the IGF2R gene have been shown to be associated with both type 1 [ 5 ] and type 2 diabetes (T2DM) [ 6 ]. (hindawi.com)
  • However, whether circulating IGF2R is determined by IGF2R gene variants and how soluble IGR2R is related to diabetes in adults are currently unknown. (hindawi.com)
  • Alternatively spliced transcript variants encoding different isoforms have been described. (nih.gov)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (thermofisher.com)
  • Genome-wide association studies have identified common genetic effects on handedness or brain asymmetry, which mostly involve variants outside protein-coding regions and may affect gene expression. (mpi.nl)
  • This study revealed a role for rare, protein-altering variants in left-handedness, providing further evidence for the involvement of microtubules and disorder-relevant genes. (mpi.nl)
  • Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. (genetex.com)
  • Interestingly, the researchers identified a number of very rare variants in the COL25A1 gene of 10 individuals who were part of the Wellderly study. (medicalnewstoday.com)
  • Those gene variants might offer a pathway for the development of new treatments for Alzheimer's," notes Torkamani. (medicalnewstoday.com)
  • Two transcript variants encoding different isoforms have been found for this gene. (prosci-inc.com)
  • Alpha, Beta, Gamma and Delta variants. (who.int)
  • In order to address these knowledge gaps, this scoping literature review was established focusing on the detection of two important and readily mobile ARGs, namely, extended spectrum beta-lactamase (ESBL) and carbapenemase genes. (nuigalway.ie)
  • ESBL genes were reported in 29/41 (70.7%) studies, while carbapenemase genes were reported in 13/41 (31.7%), including joint reporting in 9 studies. (nuigalway.ie)
  • CRPA isolates for carbapenemase genes and implementation of occupied room X while receiving mechanical ventilation for sink hygiene interventions, was critical in the identification of 4 weeks. (cdc.gov)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • Autosomal recessive retinitis pigmentosa (ARRP) is a degenerative disease of photoreceptors in which defects in the rhodopsin and phosphodiesterase beta-subunit (PDEB) loci have been reported. (nih.gov)
  • Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 is a protein that in humans is encoded by the GNB3 gene. (wikipedia.org)
  • Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. (wikipedia.org)
  • This gene encodes a beta subunit. (wikipedia.org)
  • Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
  • Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
  • Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
  • EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. (thermofisher.com)
  • The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. (thermofisher.com)
  • This gene encodes the delta subunit. (avivasysbio.com)
  • HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( AP3BA ), which assists in the vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
  • Because the expression of the beta-3A subunit is normally ubiquitous, deficiency of the beta-3A subunit leads to a precise phenotype in cells with a large number of intracellular granules (eg, neutrophils, natural killer cells, cytotoxic T lymphocytes, platelets, melanocytes). (medscape.com)
  • hCG is a dimer consisting of a 145 amino acid beta-subunit that is unique to hCG and a 92 amino acid alpha-subunit. (medscape.com)
  • the beta-subunit contains 2 N-linked oligosaccharides, as well as 4 O-linked oligosaccharides on the C-terminal extension. (medscape.com)
  • This gene encodes one of the connexin proteins. (nih.gov)
  • Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
  • Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
  • Four main classes of zein proteins are: alpha, beta, gamma and delta zein. (intechopen.com)
  • This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (ucsc.edu)
  • This gene encodes a member of the galectin family of carbohydrate binding proteins. (origene.com)
  • Implicated genes include several that encode tubulins (microtubule components) or microtubule-associated proteins. (mpi.nl)
  • Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • The findings of this scoping review expose the presence of clinically significant ARGs in the natural aquatic environment and highlights the potential ability of environmental isolates to disseminate these genes among different bacterial species. (nuigalway.ie)
  • Both isolates had active-on-imipenem metallo-beta-lactamase emase genes. (cdc.gov)
  • Sixty-seven of the 110 isolates (60.9%) were resistant to carbapenems, 80.60% (54/67) of which carried the bla OXA-23 gene. (frontiersin.org)
  • Presence and phenotypic expression of blaTEM, blaSHV, and blaCTX-M ESBL-encoding genes were investigated in environmental water isolates of Aeromonas hydrophila and Aeromonas jandaei. (scielo.br)
  • Presence of blaSHV and blaCTX-M genes was not observed, and blaTEM gene was verified in 91% of the isolates. (scielo.br)
  • Presence of bla SHV and bla CTX-M genes was not observed, and bla TEM gene was verified in 91% of the isolates. (scielo.br)
  • Although, almost all previous studies and efforts to control the dissemination of these genes have been based on isolates from clinical samples, antibiotic resistance genes can also occur in nonpathogenic bacteria, which can then be transferred via lateral gene transfer (6). (scielo.br)
  • The aim of this study was to investigate the presence and phenotypic expression of bla TEM , bla SHV, and bla CTX-M ESBL- encoding genes in 87 environmental water isolates of Aeromonas hydrophila (n=41) and Aeromonas jandaei (n=46). (scielo.br)
  • Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
  • We report 8 patients from 7 Jordanian families, 6 of whom underwent genetic testing and were found to have a 12 bp (155-166 del) deletion within the tubulin-specific chaperone E (TBCE gene) in exon 3 at 1q42-43. (who.int)
  • In general, resistance can either occur through a spontaneous mutation (which is transmitted only vertically through proliferation) or through acquisition of extrachromosomal genetic elements containing the genes responsible for the resistance (which can be transmitted via horizontal gene transfer). (vin.com)
  • Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
  • Genetic homogeneity among beta-lactamases is remarkable. (lu.se)
  • We will utilize multiple different approaches to discover and evaluate novel noninvasive diagnostic and prognostic biomarkers, including measurements of four kallikrein markers and microseminoprotein- beta (MSP) in blood adjusted with the interaction from GWAS-based genetic variation in certain biomarker-encoding gene loci to further improve the specificity in our previously reported detection of lethal PCa-forms at very early, curable stages. (lu.se)
  • Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. (wikidoc.org)
  • 3 cows were pooled, and the gene lists subjected to David functional annotation cluster analysis. (biomedcentral.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • The objective of this study was to characterize chicken AMPK gamma gene expression. (usda.gov)
  • SecinH3-treated mice show increased expression of gluconeogenic genes, reduced expression of glycolytic, fatty acid and ketone body metabolism genes in the liver, reduced liver glycogen stores, and a compensatory increase in plasma insulin. (nature.com)
  • Inactivating Gene Expression with Antisense Modified Oligonucleotides. (yale.edu)
  • PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. (genetex.com)
  • Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
  • 3 cows with MP 2-3 as background using DESeq2 followed by weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)
  • If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)
  • Optimized expression of a synthetic gene encoding a beta-glucosidase in E. coli using molecular chaperones. (lu.se)
  • tures and gene expression patterns. (lu.se)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • the gene expression profile during B lymphoid differentiation. (lu.se)
  • The natural aquatic environment is a significant contributor to the development and circulation of clinically significant antibiotic resistance genes (ARGs). (nuigalway.ie)
  • The rapid emergence of antibiotic resistance among bacteria is, to a great extent, due to the dissemination of antibiotic resistance genes by horizontal transfer mediated by plasmids, transposons and integrons (5). (scielo.br)
  • The authors demonstrated that ceftriaxone, a beta-lactam antibiotic, turns on a gene that encodes for the glutamate transporter GLT-1. (webwire.com)
  • Overall, these studies document a new property of a very common antibiotic and demonstrate that beta-lactams can activate the gene for a neurotransmitter transporter, the researchers write in Nature. (webwire.com)
  • It is linked to the TBCE gene on chromosome 1q42-43 which encodes for the tubulin-specific chaperone E protein [2-4]. (who.int)
  • This mecA gene is contained in a staphylococcal cassette chromosome mec (SCCmec), a genomic island that in some genotypes (types I-III) also contains additional resistance genes. (vin.com)
  • The impaired function of specific organelles indicates that the causative genes encode protein complexes that regulate vesicle trafficking in the endolysosomal system including AP-3, BLOC-1, BLOC-2, and BLOC-3. (medscape.com)
  • Reverse sequence analysis showed that the MLLT1 gene was fused to the 16p11.2 region. (cancerindex.org)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (ucsc.edu)
  • Chicken gamma genes displayed similar structures and high sequence homology compared to corresponding mammalian gamma gene homologues. (usda.gov)
  • The sequence of the beta-lactamase gene was also determined. (lu.se)
  • Two nucleotides were different between the E. coli (Tn3) and H. ducreyi (pCb) genes that affected the amino-acid sequence. (lu.se)
  • Intersubunit surfaces in G protein alpha beta gamma heterotrimers. (wikipedia.org)
  • The AMPK enzyme complex consists of one catalytic (alpha) and two regulatory (beta and gamma) subunits. (usda.gov)
  • Previously, we found that chickens expressed three gamma subunits (gamma 1-3), each encoded by a different gene. (usda.gov)
  • The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. (avivasysbio.com)
  • Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. (genetex.com)
  • C8 is composed of three polypeptide chains (alfa, beta, and gamma), each encoded by distinct genes. (lu.se)
  • C8 beta deficiency is more common in Caucasians and C8 alfa-gamma deficiency is more common in African-Americans. (lu.se)
  • Molecular characterization of the gene in that family (a consanguineous pedigree) revealed a homozygous 71-bp tandem duplication in exon 1 of the affected member, the parents being heterozygous. (nih.gov)
  • Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)
  • Recently, the gene causing CED has been assigned to the chromosomal region 19q13 (refs 1-3). (vub.be)
  • possess different chromosomal β-lactamase genes. (scielo.br)
  • are among the few microorganisms harboring different chromosomal β-lactamase genes, including cphA (also named imiH ), cepH and ampH , encoding class B, C and D β-lactamases, respectively (1). (scielo.br)
  • Another cluster included genes encoding enzymes in the mitochondrial beta-oxidation pathway. (biomedcentral.com)
  • In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. (nih.gov)
  • We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
  • GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
  • Functional Polymorphism in the ADRB3 Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder. (urotoday.com)
  • There are reports suggesting an association between the rs4994 polymorphism in the ADRB3 gene encoding the beta-3 adrenergic receptor and OAB risk in females. (urotoday.com)
  • A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. (wikipedia.org)
  • In conclusion, IGF2R gene polymorphism and circulating IGF2R are associated with T2DM. (hindawi.com)
  • In this variant, a 16-base pair frame shift duplication occurs at exon 15 of the HPS1 gene. (medscape.com)
  • All affected persons had homozygous deletion of 12 bp (155-166del) in exon 3 of the TBCE gene. (who.int)
  • Exons 2 (first coding exon), 3 (second cod- and Kuwait: the incidence in Saudi Ara- ing exon) and 12 of the TBCE gene were bia varies from 1:40 000 to 1:100 000 live chosen for the initial screening as they were births [ 6 ]. (who.int)
  • This gene encodes the CD8 alpha chain isoforms. (wikidoc.org)
  • Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. (wikidoc.org)
  • The ability of environmental bacteria to successfully transfer resistance genes via conjugation was also examined in 11 of the included studies. (nuigalway.ie)
  • Both of those have developed a resistance to beta-lactam antibiotics (penicillins and cephalosporins). (vin.com)
  • The gene responsible for the methicillin resistance is the mecA gene that encodes the penicillin-binding protein 2a. (vin.com)
  • In contrast, type IV and V are smaller, lack other resistance genes and are associated with community-acquired MRSA that occurred later and infected healthy people not in contact with healthcare facilities. (vin.com)
  • It confirmed that the enzyme belonged to a class A beta-lactamase which had 99% identity to the ampicillin resistance transposon Tn3 of pBR322. (lu.se)
  • Amino acid sequencing of some beta-lactamases has shown that substitution of only a few amino acids in the bla gene leads to high-level resistance against specific cephalosporins. (lu.se)
  • The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
  • Pancreatic beta cells were engineered with a gene that encodes a photoactivatable adenylate cyclase (PAC) enzyme. (newswise.com)
  • This gene encodes the enzyme responsible for formation of the blood group I antigen. (nih.gov)
  • The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. (nih.gov)
  • Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
  • Find Integrin beta 2 ELISA Kits for a variety of species such as anti-Human Integrin beta 2, anti-Cow Integrin beta 2, anti-Mouse Integrin beta 2. (antibodies-online.com)
  • Find Integrin beta 2 ELISA Kits with a specific Detection Method. (antibodies-online.com)
  • Find Integrin beta 2 ELISA Kits with a specific Sample. (antibodies-online.com)
  • Newswise - MEDFORD/SOMERVILLE, Mass. (November 1, 2019) -Tufts University researchers have transplanted engineered pancreatic beta cells into diabetic mice, then caused the cells to produce more than two to three times the typical level of insulin by exposing them to light. (newswise.com)
  • Current treatments include the administration of drugs that enhance the production of insulin by pancreatic beta cells, or direct injection of insulin to supplement the naturally produced supply. (newswise.com)
  • Researchers found that transplanting the engineered pancreatic beta cells under the skin of diabetic mice led to improved tolerance and regulation of glucose, reduced hyperglycemia, and higher levels of plasma insulin when subjected to illumination with blue light. (newswise.com)
  • Both alpha and beta chains share significant homology to immunoglobulin variable light chains. (wikidoc.org)
  • These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • 1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
  • This gene encodes a receptor protein, which receive signals from a protein called TGF beta. (thenakedscientists.com)
  • This gene encodes a member of the tumor necrosis factor receptor superfamily. (antibodies-online.com)
  • Svi ti glikoproteini sadrže identičnu alfa podjedinicu i hormon specifičnu beta podjedinicu. (wikipedia.org)
  • Los receptores de la hormona tiroidea son codificados por dos genes (GENES ERBA): erbA-alfa y erbA-beta para los receptores de la hormona tiroidea alfa y beta, respectivamente. (bvsalud.org)
  • les analyses génétiques réalisées sur six d'entre eux ont révélé une délétion de 12 bp (155-166 del) dans l'exon 3 localisé en 1q42-43 dans le gène TBCE codant la protéine chaperon E spécifique de la tubuline. (who.int)
  • Pseudogenes of this gene are found on chromosomes 5, 6, and 14. (prosci-inc.com)
  • This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. (genetex.com)
  • NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import.The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)
  • The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. (prosci-inc.com)
  • Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)
  • The following product was used in this experiment: eIF2 beta Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-96470, RRID AB_2808272. (thermofisher.com)
  • Western blot analysis of eIF2 beta in extracts of various cell lines. (thermofisher.com)
  • Samples were incubated with eIF2 beta Polyclonal antibody (Product # PA5-96470) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. (thermofisher.com)
  • In the presence of ferrous iron, the DtxR-iron complex attaches to the tox gene operon, inhibiting transcription. (medscape.com)
  • Binding of ferrous iron to the DtxR molecule forms a complex that binds to the tox gene operator and inhibits transcription. (medscape.com)
  • The top three clusters from modules more highly expressed in the PP cows all involved regulation of gene transcription, particularly zinc fingers. (biomedcentral.com)
  • The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. (wikidoc.org)
  • After synthesis, the alpha and beta-subunits are bonded with a noncovalent bond before being released into the circulation. (medscape.com)
  • A pCb plasmid encoding a beta-lactamase from Haemophilus ducreyi was transferred to Escherichia coli, purified, and characterized. (lu.se)
  • Among genes previously implicated in autism or schizophrenia by exome screening, DSCAM and FOXP1 showed evidence for rare coding variant association with left-handedness. (mpi.nl)
  • In the Swiss variant, a frame shift occurs at codon 322 of the HPS1 gene. (medscape.com)
  • Genes and pathways associated with lactation number in cows were identified for the first time to date, and we found that many were comparable to those known to be associated with ageing in humans and model organisms. (biomedcentral.com)
  • The CTNNB1 gene provides instructions for making a protein called beta-catenin. (medlineplus.gov)