SubunitProteinsVariantsReceptorsMutations in the geneSubunitsTranscriptDifferentially expressed genesProtein encoded by this geneChromosomeEnzymeIsoformsAnnotationEnzymatic activitiesEnzymesPolymeraseNuclear encodedPutativePhenotypesCaused by mutationsSequenceMolecularMicroarrayMitochondrialUpstreamOperonAdrenergic receptorRegulationPolymorphismsMetabolic genesGenomeLigandMRNAGeneticVariations in the expressionImmunoglobulinNucleusSubtypesGenomicSubtypeGammaRegulatePathwaysPromoterPolypeptideInteractionGlycoproteinDifferent geneDeficiencyMotif
Subunit17
- This gene encodes the alpha subunit. (wikipedia.org)
- This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). (thermofisher.com)
- The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. (thermofisher.com)
- Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
- Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
- This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
- At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. (antikoerper-online.de)
- Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. (wikipedia.org)
- The alpha subunit and beta subunit. (wikipedia.org)
- I. alpha subunit. (wikipedia.org)
- Molecular cloning of the human thyrotropin-beta subunit gene. (wikipedia.org)
- Linear amino acid sequence of the alpha subunit. (wikipedia.org)
- Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). (wikipedia.org)
- This gene encodes the delta subunit. (avivasysbio.com)
- The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. (novusbio.com)
- In the hypokalemic form, 70% of affected people have a mutation in the alpha-subunit of the voltage-sensitive muscle calcium channel gene on chromosome 1q (HypoPP type I). In some families, the mutation is in the alpha-subunit of the sodium channel gene on chromosome 17 (HypoPP type II). (msdmanuals.com)
- The hyperkalemic form is due to mutations in the gene that encodes the alpha-subunit of the skeletal muscle sodium channel ( SCN4A ). (msdmanuals.com)
Proteins13
- The genes encoding the red- and green-color-detecting proteins of the human eye are located next to one another on the X chromosome and probably evolved from a common ancestral pigment gene. (quizlet.com)
- There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (nih.gov)
- Focusing on the S10 -spc-alpha operon, for which about half the ribosomal proteins are coded, enables genetic information to be associated with molecular weight information from MALDI-TOF MS, even for non-genome sequenced bacterial species. (shimadzu.com)
- Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)
- This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (ucsc.edu)
- The presence or absence of one exon by alternative splicing of the gamma-1 gene resulted in two transcript variants which code for predicted proteins containing 298 amino acids (4 cystathionine beta-synthase domains, CBSD) or 276 amino acids (3 CBSD). (usda.gov)
- For the gamma-2 gene, use of an alternate initiation site and promoter and/or alternative splicing resulted in four different transcript variants which code for predicted proteins containing 567 (4 CBSD), 452 (4 CBSD), 328 (3 CBSD) and 158 (2 CBSD) amino acids. (usda.gov)
- Alternative splicing of exon 3 in the gamma-3 gene resulted in a shift of the open reading frame and the production of 'long' and 'short' transcript variants that code for predicted proteins of 383 and 363 amino acids, both with 4 CBSD. (usda.gov)
- We identified the specific amino acids (the basic building blocks of proteins) encoded by this gene which determine BSMV pathogenicity to oat. (usda.gov)
- All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. (rndsystems.com)
- To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
- RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)
- Genes for proteins interacting with other hormones may have a greater effect. (cdc.gov)
Variants8
- Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. (nih.gov)
- Multiple transcript variants encoding different isoforms have been found for this gene. (thermofisher.com)
- Further analyses identified shared genetic variants found in metabolism of alpha-linolenic pathway for type 2 diabetes. (plos.org)
- Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (ucsc.edu)
- Alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
- Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. (novusbio.com)
- Two transcript variants encoding different isoforms have been found for this gene. (prosci-inc.com)
- Alpha, Beta, Gamma and Delta variants. (who.int)
Receptors11
- To define the domain(s) responsible for this unusual binding property, we constructed a series of M alpha 2-10H/human alpha 2-C10 chimeric receptors. (aspetjournals.org)
- Analysis of these receptors identified a conservative Cys201 to Ser201 change in the fifth transmembrane domain of M alpha 2-10H as being responsible for the low affinity of the mouse receptor for yohimbine. (aspetjournals.org)
- Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. (nih.gov)
- Putative receptors that are responsible for rhLAMAN uptake into the brain across the Blood Brain Barrier were investigated and we were able to study the outcome of long-term ERT on the neuropathology and associated behavioural deficits observed in immune-tolerant alpha-Mannosidosis mice. (europa.eu)
- Our finding of alpha-2A receptors is quite interesting because the focus has always been on alpha-2C receptors," said Pietzner. (medscape.com)
- Five distinct genes encode closely related FGF receptors, FGFR1 through 5. (rndsystems.com)
- This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
- Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. (rndsystems.com)
- A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. (rndsystems.com)
- CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. (novusbio.com)
- Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively. (bvsalud.org)
Mutations in the gene2
- Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. (medlineplus.gov)
- Alpha-Mannosidosis is caused by an enzyme defect due to mutations in the gene for lysosomal alpha-Mannosidase (LAMAN) affecting the lysosomal and cellular glycoprotein catabolism with severe consequences for the organism. (europa.eu)
Subunits6
- The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. (wikipedia.org)
- Forms heteromultimeric complex with alpha subunits. (ucsc.edu)
- The AMPK enzyme complex consists of one catalytic (alpha) and two regulatory (beta and gamma) subunits. (usda.gov)
- Previously, we found that chickens expressed three gamma subunits (gamma 1-3), each encoded by a different gene. (usda.gov)
- The primary structure of the alpha and beta subunits. (wikipedia.org)
- The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. (avivasysbio.com)
Transcript3
- The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
- Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)
- Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)
Differentially expressed genes2
- Differentially expressed genes (DEGs) were identified by comparing the gene expression of NIDCM patients with or without VA in the gene expression profile of GSE135055. (hindawi.com)
- In order to reveal the inherent molecular mechanism, NIDCM patients were divided into sinus rhythm (SR) group and VA group and differentially expressed genes (DEGs) were identified via bioinformatic methods. (hindawi.com)
Protein encoded by this gene3
- The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. (thermofisher.com)
- The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
- The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. (prosci-inc.com)
Chromosome6
- In mice, the Sry gene is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. (quizlet.com)
- The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. (sigmaaldrich.com)
- Seven genetic loci (USH1A-G) have been implicated in this disease to date, and four of the corresponding genes have been identified: USH1B, C, D and F. We carried out fine mapping of USH1G (chromosome 17q24-25), restricting the location of this gene to an interval of 2.6 Mb and then screened genes present within this interval for mutations. (nih.gov)
- The AMACR gene is found on chromosome 5 . (medlineplus.gov)
- In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
- disorder usually caused by mutations to the KCNJ2 gene located on chromosome 17q24.3 or, rarely, to the KCNJ5 gene. (msdmanuals.com)
Enzyme11
- The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
- This gene provides instructions for making an enzyme called alpha-methylacyl-CoA racemase (AMACR). (medlineplus.gov)
- Most individuals with AMACR deficiency have an AMACR gene mutation that results in a lack (deficiency) of functional enzyme. (medlineplus.gov)
- Most individuals with AMACR deficiency have an AMACR gene mutation that replaces a protein building block (amino acid) called serine with an amino acid called proline at position 52 in the enzyme sequence, written as Ser52Pro or S52P. (medlineplus.gov)
- AMACR gene mutations that result in a lack of functional AMACR enzyme have also been identified in infants with a life-threatening disorder called congenital bile acid synthesis defect type 4. (medlineplus.gov)
- Final Report Summary - ALPHA-MAN (Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme. (europa.eu)
- Today, the most promising therapy for lysosomal storage disorders including alpha-Mannosidosis is Enzyme Replacement Therapy (ERT) where the respective enzyme lacking in the patient is produced by recombinant approaches and then introduced into the blood stream, from where it is internalized by the cells and reaches the lysosomes replacing the missing endogenous enzyme. (europa.eu)
- Since pharmaceutical interest in this disease is low, two EU-supported projects (EURAMAN and HUE-MAN) within the 5th and 6th framework program, respectively have worked towards developing the recombinant human enzyme (rhLAMAN) as a therapeutic agent for patients suffering from alpha-Mannosidosis. (europa.eu)
- This gene encodes an enzyme responsible for this post-translational modification. (antikoerper-online.de)
- Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population," Alcohol. (wpunj.edu)
- A SNP-induced amino acid change in COMT (V158M) influences enzyme activity of the gene product, which deactivates potentially genotoxic catechol estrogens. (cdc.gov)
Isoforms2
- This gene encodes the CD8 alpha chain isoforms. (wikidoc.org)
- Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. (wikidoc.org)
Annotation1
Enzymatic activities2
- The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. (alzforum.org)
- Individual's susceptibility to cancer may be partly explained by variability in enzymatic activities of metabolic genes. (bvsalud.org)
Enzymes4
- The other 2 genes encoded phase 2 enzymes [NAD(P)H-quinone oxidoreductase1and aldehyde dehydrogenase family 3, subfamily A1]. (thieme-connect.com)
- Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
- Various products of these genes are enzymes involved in the activation or degradation of carcinogens/pro-carcinogens. (bvsalud.org)
- Future analyses will include polymorphisms in additional genes encoding enzymes important in carcinogen metabolism, DNA repair, cell cycle control, and immune function, and additional occupational exposures. (cdc.gov)
Polymerase1
- a plastid-encoded bacterial-type RNA polymerase (PEP) and a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters. (frontiersin.org)
Nuclear encoded3
- Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
- Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
- Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)
Putative1
Phenotypes2
- Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
- Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes. (yeastgenome.org)
Caused by mutations1
- AMACR deficiency is caused by mutations in the AMACR gene. (medlineplus.gov)
Sequence6
- Sequence homology and ligand binding data allow the assignment of one clone (M alpha 2-4H) as the mouse homolog of the human alpha 2-C4 subtype. (aspetjournals.org)
- The other clone (M alpha 2-10H) closely resembles the human alpha 2-C10 subtype in sequence but binds with significantly lower affinity to yohimbine and rauwolscine, members of a distinct class of bulky alpha 2-selective antagonists commonly used to evaluate alpha 2-AR function in vivo. (aspetjournals.org)
- Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. (wikipedia.org)
- Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (ucsc.edu)
- Chicken gamma genes displayed similar structures and high sequence homology compared to corresponding mammalian gamma gene homologues. (usda.gov)
- PCR was used for detection of pcaA gene and its nucleotide sequence was also determined. (scielo.br)
Molecular5
- Molecular cloning and ligand binding studies have shown the alpha 2 class of adrenergic receptor (alpha 2-AR) to be a family of at least three related subtypes in humans. (aspetjournals.org)
- A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)
- HM038439), was 731 nucleotides long and encoded a partial protein of 124 amino acids with predicted molecular weight of 13.65 kDa and calculated 10.01 isoelectric point. (scialert.net)
- GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
- The molecular interactions of genes and gene products underlie fundamental questions of biology. (lu.se)
Microarray1
- We download the microarray expression dataset (GSE135055) from the Gene Expression Omnibus (GEO) database [ 9 ]. (hindawi.com)
Mitochondrial5
- This gene encodes the L protein of the mitochondrial glycine cleavage system. (thermofisher.com)
- We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
- While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
- Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
- in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
Upstream1
- Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. (antikoerper-online.de)
Operon3
- Certainly, STAS domain-encoding SulP genes have already been found as the different parts of antibiotic operons, like the BLM bleomycin biosynthesis operon of (Du et al. (exposed-skin-care.net)
- Import of these sugars occurs through the previously characterized raffinose ATP-binding cassette (ABC) transport system, encoded by the raf operon, that lacks the necessary ATP-binding protein. (lu.se)
- Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
Adrenergic receptor3
- Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (aspetjournals.org)
- This gene encodes alpha-1A-adrenergic receptor. (nih.gov)
- The first, ADRA2A , encodes for the alpha-2A adrenergic receptor that can cause vasoconstriction of small blood vessels in response to stress hormones. (medscape.com)
Regulation3
- This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
- 14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
- The regulation and organization of thyroid stimulating hormone genes. (wikipedia.org)
Polymorphisms5
- Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. (wikipedia.org)
- Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)
- Polymorphisms in the estrogen metabolism genes CYP17, CYP1B1, CYP1A2, COMT and ER alpha and susceptibility to primary intracranial brain gliomas in women. (cdc.gov)
- We evaluated the associations of polymorphisms in genes important in estrogen metabolism with the risk of glioma in women. (cdc.gov)
- However, polymorphisms in estrogen metabolism genes do not appear to have a strong association with glioma risk in women. (cdc.gov)
Metabolic genes1
- We attempted to identify carbon metabolic genes that modulate autophagy using VIGS screening of 45 glycolysis- and Calvin-Benson cycle-related genes in Arabidopsis (Arabidopsis thaliana). (bvsalud.org)
Genome6
- The m alpha La gene occurs in a single copy per haploid genome and is specifically expressed in the mammary gland where it is induced during late pregnancy. (eurekamag.com)
- The gradual conversion from endosymbiont to organelle during the course of evolution has clearly been accompanied by a dramatic reduction in genome size as the chloroplasts lost most of their genes to the nucleus. (frontiersin.org)
- Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
- The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)
- A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)
- Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
Ligand1
- The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
MRNA2
- The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
- Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. (wikidoc.org)
Genetic3
- The lysosomal storage disorder (LSD) alpha-Mannosidosis is a rare genetic disease and according to the EU regulations, designated as an "orphan" disease. (europa.eu)
- Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
- Autosomal Dominant Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
Variations in the expression1
- We examined variations in the expression of eight candidate reference genes in the leaf and root tissues of sweet potatoes (eight nonvirus-infected or eight virus-infected samples). (bvsalud.org)
Immunoglobulin1
- Both alpha and beta chains share significant homology to immunoglobulin variable light chains. (wikidoc.org)
Nucleus1
- NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import.The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)
Subtypes1
- To begin this process, we have isolated two mouse genomic clones encoding alpha 2-AR subtypes and expressed these genes in COS-7 cells for binding studies. (aspetjournals.org)
Genomic1
- Two of these methods, signature-tagged mutagenesis and in vivo expression technology, do not directly measure gene expression and do not allow true genomic-scale analysis, but they have been devised to identify genes necessary for pathogens during real infections. (cdc.gov)
Subtype1
- It should be possible to extend the analysis of alpha 2-AR subtype function to the animal level through the use of experimental mammalian embryology in mice. (aspetjournals.org)
Gamma1
- The objective of this study was to characterize chicken AMPK gamma gene expression. (usda.gov)
Regulate3
- Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
- Because the environment encountered within a living host will be quite different from the external environment, pathogens must be able to regulate the necessary genes in coordination as they move from the environment to the host and from one host niche to another. (cdc.gov)
- The main gene finding, ADRA2A , "points to a receptor on the cells that regulate the tone of these blood vessels," she continued. (medscape.com)
Pathways2
- 80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
Promoter2
- Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese. (nih.gov)
- Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. (antibodies-online.com)
Polypeptide2
- Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. (wikipedia.org)
- Desk 1 The SLC26 Multifunctional Anion Exchanger /Anion Route gene Family includes a one SulP polypeptide, YchM. (exposed-skin-care.net)
Interaction3
- However, we now have a number of methods that allow identification of genes critical for survival in a host as well as methods that allow direct measurement of gene expression during interaction with a host. (cdc.gov)
- This non systematic review summarizes current data available on the role of environment gene interaction in form of GSTM1 null polymorphism and oral carcinogenesis. (bvsalud.org)
- Relationship between GSTM1 null polymorphism in oral cancer needs to be established to confirm the role of environment gene interaction in oral carcinogenesis. (bvsalud.org)
Glycoprotein1
- Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. (wikipedia.org)
Different gene1
- Each form of familial periodic paralysis involves a different gene and electrolyte channel. (msdmanuals.com)
Deficiency2
- Alpha-methylacyl-CoA racemase (AMACR) deficiency is a disorder that causes a variety of neurological problems that begin in adulthood and slowly get worse. (medlineplus.gov)
- Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. (thermofisher.com)
Motif2
- flanking region indicated the presence of a consensus motif that occurs in all milk-protein-encoding genes, except the kappa-casein-encoding gene. (eurekamag.com)
- The SANS protein contains three ankyrin domains and a sterile alpha motif, and its C-terminal tripeptide presents a class I PDZ-binding motif. (nih.gov)