Gene encodes glycerol 3 phosphate o acyltransferase. Medical search. Frequent questions

18 genes belonged to the acetyl-CoA carboxylase (ACC), malonyl-CoA:ACP transacylase (MCAT), ß-ketoacyl-ACP synthase (KAS), and fatty acyl-ACP thioesterase (FAT) gene families involved in fatty acid biosynthesis, and 16 genes belonged to the glycerol-3-phosphate acyltransferase (GPAT), diacylglycerol acyltransferase 3 (DGAT3), phospholipid:diacylglycerol acyltransferase (PDAT), FAD2, and lysophosphatidic acid acyltransferase (LPAAT) gene families playing important roles in triacylglycerol synthesis. (bvsalud.org)
Lysophosphatidic acid acyltransferase (LPAAT) which converts lysophosphatidic acid into phosphatidic acid is a key enzyme in biosynthesis pathway of lipid in plants. (chinagene.cn)
Lysophosphatidic acid acyltransferase (LPAT) is a key enzyme in biosynthesis pathway of vegetable oil in plant. (chinacrops.org)
We constructed a full-length cDNA library of peanut ( Arachis hypogaea ) seed via a large number of sequences of expressed sequence tag (EST) and gene functional annotation, a lysophosphatidic acid acyltransferase gene, designated AhLPAT, and its genomic DNA sequence were isolated from peanut. (chinacrops.org)
Cloning and Expression Analysis of Lysophosphatidic Acid Acyltransferase (LPAT) Encoding Gene in Peanut[J]. Acta Agron Sin, 2012, 38(02): 245-255. (chinacrops.org)
2]Maisonneuve S, Bessoule J J, Lessire R, Delseny M, Roscoe T J. Expression of rapeseed microsomal lysophosphatidic acid acyltransferase isozymes enhances seed oil content in Arabidopsis. (chinacrops.org)
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (geneticsmr.com)
Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). (smpdb.ca)
Lysophosphatidic acid (LPA) consists of an acyl chain at the sn-1 (or sn-2) position of a glycerol backbone and a phosphate head group. (hindawi.com)

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene. (wikipedia.org)
One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial ( GPAM ). (copernicus.org)
PGC-1α and PPARα are both master regulators of genes involved in mitochondrial biogenesis and fatty acid oxidation, respectively [reviewed in 6]. (aocs.org)
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
Mitochondria are also platforms for antiviral signalling2 and, due to their bacterial origin, mtDNA and other mitochondrial components trigger innate immune responses and inflammatory pathology2,3. (regenerativemedicine.net)

Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)

Deletion of SLC1 is not lethal and does not eliminate all microsomal 1-acylglycerol-3-phosphate O-acyltransferase activity suggesting that an additional enzyme may exist. (unifr.ch)
2008). Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. (geneticsmr.com)
First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. (smpdb.ca)
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. (smpdb.ca)
Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA. (smpdb.ca)
Another parameter investigated after CBD and CBG treatment was the gene expression of FAAH, a key enzyme known for being able to stimulate food intake and notoriously involved in the degradation of endocannabinoids such as anandamide [7]. (researchgate.net)

This gene regulates triacylglycerol by gene expression. (copernicus.org)
By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
2006). Agpat6 - a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. (geneticsmr.com)
The entire pathway for triacylglycerol synthesis consists of four enzymatic steps, which catalyze sequential reactions starting from sn -glycerol-3-phosphate and ending with triacylglycerol (TG) ( Fig. 1 ). (aocs.org)
The phosphatidate formed is dephosphorylated by the PAP activity of the lipins and lastly diacylglycerol acyltransferases (DGATs) act on diacylglycerol (DG) to form triacylglycerol (TG). (aocs.org)
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. (smpdb.ca)
lyrata (Lyre-leaved rock-cress) Triacylglycerol lipase 2 gene At5g1418 MUA22.18 MUA22.19 MYZUS PERSICAE-INDUCED LIPASE 1 , arath-Q8LPF5 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)

Transcriptome sequencing revealed that all homologs induced the same general patterns with a drastic shift in gene expression profiles of leaves from that of a typical source tissue to a source-limited sink-like tissue: Transcripts encoding enzymes for plastid uptake and metabolism of phosphoenolpyruvate, fatty acid and oil biosynthesis were up-regulated, as were also transcripts encoding starch degradation. (biomedcentral.com)
Transcriptome data were further confirmed by quantitative real-time PCR for twelve key genes in EFA biosynthesis. (researchsquare.com)
Furthermore, genome analysis of this strain suggested the presence of gene clusters involved in iron acquisition ( fhuABD , afuABC , fbpABC , and fepCDG ) and phosphate solubilization ( pstABCHS , phoABHLU , and phnCDEP ) and other phytohormone biosynthesis genes, including indole-3-acetic acid ( trpABCDEFG ), in the genome. (springeropen.com)

SCIRP: Food and Nutrition Sciences, Vol. In this process, both in vivoand in cultur… This binding will likewise lead to the cAMP/PKA-led phosphorylation of hormone sensitive lipase, that will ultimately drive the release of free fatty acids and glycerol. (imingo.net)
After a few hours of fasting, insulin levels fall, and increased lipolysis creates free fatty acids and glycerol. (medscape.com)

Lipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. (wikipedia.org)
2008). AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (geneticsmr.com)

Antagonistic regulation of dgkA and plsB genes of phospholipid synthesis by multiple stress responses in Escherichia coli. (hal.science)
However, genes encoding phospholipid synthesis enzymes might also be regulated during stress responses, in order for the bacteria to adapt their growth to changing environments. (hal.science)
While few studies have addressed this question, global analyses show that specific genes are activated by alternative Sigma factors, and that phospholipid synthesis genes are co-ordinately regulated during stringent response. (hal.science)
Nevertheless, it is involved in a wide range of activities, from phospholipid synthesis to a number of physiological responses as a lipid mediator [ 3 ]. (hindawi.com)

Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases, but also be involved in fatty acid exchange at the sn-2 position of mature glycerophospholipids. (unifr.ch)
Lipins also act in the nucleus as transcriptional co-activators with peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) and peroxisome proliferator-activated receptor α to regulate target genes involved in fatty acid oxidation. (aocs.org)

The chilling sensitivity of plants can be regulated by the level of unsaturated fatty acids in membrane lipids, which could be attained by controlling the action of glycerol-3-phosphate acyltransferase and acyl_lipid desaturases. (chinbullbotany.com)
Lipolysis is the metabolic process through which triacylglycerols (TAGs) break down via hydrolysis into their constituent molecules: glycerol and free fatty acids (FFAs). (imingo.net)
Lipolysis /lɪˈpɒlɪsɪs/ is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and three fatty acids. (imingo.net)
To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. (imingo.net)
Diagnostic criteria include plasma glucose levels less than 3 mmol/L with detectable serum insulin and C-peptide, low serum ketone bodies, and low serum fatty acids. (medscape.com)

KEY MESSAGE: CeOLE genes exhibit a tuber-predominant expression pattern and their mRNA/protein abundances are positively correlated with oil accumulation during tuber development. (bvsalud.org)
The chilling tolerance can be strengthened, by transfering some genes encoding antioxidant enzymes, such as SOD, APX, CAT and GR. Some researches demonstrated: ABA is not only an important stress signal of low temperature, but also regulates the expression of many genes under low temperature, Ca2+ is a major second messenger, protein kinases also take part in the signal transduction under low temperature in plant. (chinbullbotany.com)
The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
Like pancreatic lipase and LPL, which are much more active in the presence of protein coactivators, ATGL catalytic activity is increased by the activator protein comparative gene identification-58 (CGI-58), which therefore stimulates the first step of intracellular lipolysis. (imingo.net)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
Some of the differentially expressed genes (DEGs) showed male bias, including serine/threonine-protein kinase ( STPK ), THUMP1 homolog and other genes. (beds.ac.uk)
Both cannabinoid receptors (CBRs) are, in fact, part of the heptahelical G protein-coupled receptor (GPCR) family and can inhibit adenyl cyclase activity or even stimulate mitogen-activated protein kinases (MAPKs), being, therefore, classified as Gi/0 receptors [ 3 - 5 ]. (irjournal.org)
lyrata (Lyre-leaved rock-cress) hypothetical protein (at5g25770) , arath-C7A10.830 Arabidopsis thaliana DNA chromosome 4,gene C7A10.830 No. 2 AT4G36530 , arath-F1N18.12 Arabidopsis thaliana (Mouse-ear cress) f1n18.12 AT1G29840 protein , arath-F1P2.110 Arabidopsis thaliana (Mouse-ear cress). (inrae.fr)

Gene expression analyses using microarrays have further revealed that some of the down-regulated genes in seeds of the wri1 mutant are involved in glycolysis and FA synthesis, rather than in TAG assembly [ 7 ]. (biomedcentral.com)
The first step in glycolysis (ie, conversion of glucose to glucose-6-phosphate [G6P] by glucokinase) is the rate-limiting step in glucose metabolism. (medscape.com)

Thus, our research group has identified SNPs related to the regulation of glycerolipid synthesis in the 3′-UTR of GPAM and verified the function of SNPs affecting intramuscular fat deposition in Hanwoo. (copernicus.org)

A total of 159 genes were differentially expressed between male and female flowers at all development stages. (beds.ac.uk)

Transcripts encoding enzymes in photosynthesis and starch synthesis were instead down-regulated. (biomedcentral.com)
Despite the importance of the PAP reaction, identification of the genes responsible for encoding PAP enzymes remained elusive until 2006 when the yeast PAP was identified and was shown to be an orthologue of a family of three mammalian proteins called lipins [reviewed in 1]. (aocs.org)
IL23 is the Janus mitochondria JAK2 and TYK2, rotting in membrane of the combination senescence, which is the being enzymes for Signal efficiency and water of library 3( STAT3) and STAT4 to be and be Prolonged. (evakoch.com)

These findings provide insights into lineage-specific family evolution and putative roles of CeOLE genes in oil accumulation of vegetative tissues, which facilitate further genetic improvement for tigernut. (bvsalud.org)

Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. (nih.gov)

Often starting as a phagosome in the endocytic compartment, these bacteria-occupied vacuoles transition into organelles with novel molecular features via remodeling of host proteins and lipids through the highly coordinated actions of bacterial factors [3] [5] . (microbialcell.com)

In this study, we identified 17 members of the LPAAT gene family from genomic data of G. raimondii -D 5 and G. arboreum -A 2 . (chinagene.cn)
Analysis of gene structure, chromosome distribution and phylogenetic evolution of LPAAT genes in diploid Gossypium using bioinformatics approaches showed that these genes can be divided into distinct subfamilies based on the distance of their genetic relationship. (chinagene.cn)
Moreover, the gene structures were similar within LPAAT subfamily members. (chinagene.cn)
The amino acid sequences encoded by LPAAT family genes contained three conserved motifs, including ΦFPEGTR-G binding site and Φ-NHQS- ΦDΦΦ catalytic site. (chinagene.cn)
Phylogenetic analysis of LPAAT gene family demonstrated significant differences in evolution of LPAAT in different species. (chinagene.cn)
Finally, expression analysis of G. hirsutum ovules in different stages from RNA-seq and qRT-PCR data indicated that LPAAT gene may play a positive role in oil accumulation. (chinagene.cn)
Our studies facilitate understanding of the function of LPAAT gene family in Gossypium and selecting better LPAAT genes for further functional validation. (chinagene.cn)

deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)

Many of the target genes by the newly identified miRNAs were associated with plant growth and development, stress response, defense and hormone signaling, and oil synthesis pathways. (springeropen.com)

Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of fish adipogenesis. (biomedcentral.com)

Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (geneticsmr.com)
Functional characterization of the human 1-acylglycerol- 3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. (geneticsmr.com)
2005). Cloning and characterization a novel human 1-acyl-sn-glycerol-3- phosphate acyltransferase gene AGPAT7. (geneticsmr.com)
Agarwal AK, Sukumaran S, Cortes VA, Tunison K, Mizrachi D, Sankella S, Gerard RD, Horton JD, Garg A: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. (smpdb.ca)

Menaya J, Gonzalez-Manchon C, Parrilla R, Ayuso MS: Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. (smpdb.ca)
Dissecting effectivity of a 5′ quick amplification of cDNA ends (5′-RACE) technique for profiling T-cell receptor beta repertoire Deep sequencing of T-cell receptor (TCR) genes is extremely efficient at profiling immune repertoire. (master-sistemisanitari-medicinenonconvenzionali.org)

Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. (nih.gov)
Following identification of a QTL controlling free lysine content, wheat pangenome resources facilitated analysis of candidate genes in this region of the genome. (rothamsted.ac.uk)
Through single-nucleotide polymorphisms(SNPs) identification, 28 genes were considered as potential sex-associated SNPs. (beds.ac.uk)
Recent research has shed light on the hormone response pathways involved in the identification of sex-determining genes, specifically the cytokinin (CK) and ethylene response pathways. (beds.ac.uk)

SLC4 harbors a membrane bound O-acyl transferase (MBOAT) motif, and down regulation of SLC4 strongly reduces 1-acyl-sn-glycerol-3-phosphate acyltransferase activity in microsomes from slc1Δ cells. (unifr.ch)
In Escherichia coli, the genes coding for glycerol-3-phosphate acyltransferase and diacylglycerol kinase (plsB and dgkA) are found next to each other in divergent orientations, suggesting a co-ordinated regulation. (hal.science)
We investigated their regulation and found that these two genes are inversely regulated by a diversity of stress responses. (hal.science)
MicroRNAs (miRNAs) are small endogenous RNAs with an approximate length of 18-22 nucleotides and involved in the regulation of gene expression in transcriptional or post-transcriptional levels. (springeropen.com)

The transient assay of selected genes resulted in a synergistic increase of EFA-enriched TAG accumulation in tobacco leaves. (researchsquare.com)
Extracted nucleic acid was validated for further investigations for the presence of the highly-conserved housekeeping gene (GAPDH) using an established qualitative real-time RT-PCR assay ( 1 ). (cdc.gov)

Silent SNPs: impact on gene function and phenotype. (geneticsmr.com)

Lipid molecules have these properties because they consist largely of long hydrocarbon tails which are lipophilic in nature as well as polar headgroups (e.g. phosphate-based functionality, and/or inositol based functionality). (medmuv.com)

This pathway begins with the acylation of glycerol-3-phosphate (G-3-P) by glycerol-3-phosphate acyltransferases (GPATs) at the sn -1 position followed by a second acylation of lysophosphatidate (LPA) at the sn -2 position by lysophosphatidate acyltransferases (LPAATs). (aocs.org)
In the sixth step of the glycolytic pathway, the first step of the second phase, the payoff phase, glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) catalyses the oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate (1,3-BPG), with the concomitant reduction of NAD + to NADH. (imingo.net)
construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)
The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. (brenda-enzymes.info)
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)

In yeast it is generated from lyso-phosphatidic acid, which is acylated by Slc1p, a sn-2-specific, acyl-Coenzyme A-dependent 1-acylglycerol-3-phosphate O-acyltransferase. (unifr.ch)
Indeed, affinity-purified Slc1p displays Mg²⁺-dependent acyltransferase activity not only towards lyso-phosphatidic acid but also lyso forms of phosphatidylserine and phosphatidylinositol. (unifr.ch)
CGI-58, at least in vitro, also acts as an acyl-CoA-dependent acylglycerol-3-phosphate acyltransferase. (imingo.net)

Thus, intracellular bacteria frequently encode the capacity to regulate host lipogenesis as well as to modulate the lipid composition of host membranes. (microbialcell.com)

Therefore, the transcriptomic profile at different time points (days 3, 8, 15 and 21) along primary culture development of rainbow trout preadipocytes has been investigated using an Agilent trout oligo microarray. (biomedcentral.com)

Finally, unlike ATGL, no mutations in HSL gene have been observed in humans. (imingo.net)
2, 3, 4] Mutations in at least 11 genes that play a role in regulating beta-cell insulin secretion have been implicated in the pathogenesis of HI. (medscape.com)

In contrast, others have favored the concept that exaggerated insulin secretion will cause insulin resistance ( 3 , 4 ), possibly via fatty acid-mediated impairment of insulin action ( 5 - 7 ). (diabetesjournals.org)

Expression analysis showed that CeOLE genes exhibit a tuber-predominant expression pattern and transcript levels are considerably more abundant than homologs in the close relative Cyperus rotundus. (bvsalud.org)
Lipin-3 is most highly expressed in the intestine as shown by the analysis of mRNA distribution in different tissues [4]. (aocs.org)
Time-Ordered Gene Co-expression Network (TO-GCN) analysis revealed that MADS2 and MADS26 may play important roles in the development of female and male flowers T. fortune plants, respectively. (beds.ac.uk)
All of them underwent monitoring and bronchoscopy at 1, 3, 6, 12, and 24 months plus on medical need, which included the decrease of lung function, and at analysis of chronic lung rejection. (researchensemble.com)

Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. (smpdb.ca)
These small non-coding RNAs derived from their precursor sequences, bind to their target mRNAs and negatively mediate the gene expressions in pre-transcriptional or post-transcriptional stages by impeding mRNA translation [ 12 , 13 ]. (springeropen.com)

To generate mice lacking TGs in adipose tissue (ADGAT DKO), we crossed adipose tissue-specific Dgat1 knockout mice (Cre-transgene expressed under control of the mouse adiponectin promoter 3 ) with Dgat2 flox mice 4 . (elifesciences.org)

2007). A "silent" polymorphism in the MDR1 gene changes substrate specificity. (geneticsmr.com)

encodes a member of the DREB subfamily A-6 of ERF/AP2 transcription factor family. (or.jp)

Conserved domains prediction indicated that AhLPAT comprised a typical conserved acyltransferase domain and a conserved lysophospholipid acyltransferases domain. (chinacrops.org)

Gene is similar to asymmetric leaves (AS)/lateral organ boundary (LOB) genes which repress KNOX gene expression. (or.jp)

The N-Myc downstream-regulated gene (NDRG) family belongs to the alpha/beta-hydrolase fold and is known to exert various physiologic functions in cell proliferation, dierentiation, and hypoxia-induced cancer metabolism. (inra.fr)

There remain approximately 50% of diazoxide-responsive cases and 10% of diazoxide-unresponsive cases of persistent HI with unknown etiology, suggesting that additional genes may be identified in the pathogenesis of HI. (medscape.com)

Anatomy13

Organisms11

Diseases5

Chemicals and Drugs159

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes43

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care2

Lysophosphatidic acid9

Mitochondrial5

Diacylglycerol acyltransferase1

Enzyme6

Triacylglycerol7

Biosynthesis3

Free fatty acids and gl2

Microsomal2

Phospholipid4

Involved in fatty2

Fatty acids5

Protein8

Glycolysis2

GPAM1

Differentially expressed1

Enzymes3

Putative1

Murine1

Proteins1

LPAAT7

Deletion1

Synthesis1

Specific genes1

Characterization4

CDNA2

Identification4

Regulation4

Assay2

SNPs1

Molecules1

Pathway5

Dependent3

Regulate1

Microarray1

Mutations2

Insulin secretion1

Analysis4

Sequences3

Tissue1

Polymorphism1

Transcription1

Prediction1

Organ1

Belongs1

Pathogenesis1