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  • sequence
  • To identify the hDINB1 gene, we searched the database of expressed sequence tags (Dbest) for human cDNAs that share homology with the yeast RAD30 gene. (pnas.org)
  • Using degenerate primers based on the N-terminal sequence and the conserved C-terminal sequence of several flagellins, the gene encoding the flagellum subunit (fliC) was isolated and sequenced from two virulent strains. (nih.gov)
  • Enhanced overproduction of greater than 1000-fold was achieved by replacing the natural Shine-Dalgarno sequence with that of the phage T7 phi 10 gene and placing this priA under the control of the T7 phage promoter and RNA polymerase. (nih.gov)
  • See reference mRNA sequence for the Prkcd gene (NM_133307.1). (nih.gov)
  • Nucleotide sequence data are available in the DDBJ/EMBL/GenBank databases under accession numbers EU595730 for mecA gene and EU595731 for mecB gene. (springer.com)
  • To distinguish the past action of evolutionary forces in introns known to have regulatory information, we examined nucleotide sequence variation at 991 sites in a random sample of 16 Drosophila melanogaster alleles of the gene encoding the myosin alkali light chain (Mlc1). (genetics.org)
  • Three Conserved Domains Revealed by Sequence Alignment between RGA, Other Cloned Genes, and ESTs. (plantcell.org)
  • homolog
  • It should be noted that plasmids with the NAP gene homolog also carried the relaxase gene involved in the conjugative transfer of plasmids more frequently than did those without the NAP gene homolog, implying that plasmid-encoded NAP homologs positively contribute to transmissible plasmids. (hindawi.com)
  • phage
  • The E. coli dinB gene, also a member of this superfamily, is required for untargeted mutagenesis in unirradiated λ phage ( 6 ), and it encodes Pol IV ( 7 ). (pnas.org)
  • yeast
  • In the yeast Saccharomyces cerevisiae , the REV1, REV3, and REV7 genes are required for DNA damage-induced mutagenesis. (pnas.org)
  • The human counterpart of yeast RAD30 , hRAD30A , encodes the human Pol η, which can also bypass a cis-syn T-T dimer ( 14 , 15 ). (pnas.org)
  • However, the close proximity between yeast genes can complicate the interpretation of yeast genetic data, particularly high-throughput data. (springer.com)
  • Together, our results outline complex interactions, in cis and in trans , between genes encoding PAF1 and ESCRT-II complex components that affect telomere function and cell viability in yeast. (springer.com)
  • 2016 ). Such a high density of genes in yeast often leads to adjacent gene effects where deletion of one gene affects the function of the adjacent gene, for example by interfering with 5′ UTR (untranslated regions) or 3′ UTRs sequences (Ben-Shitrit et al. (springer.com)
  • In yeast, CDC73 , encoding a component of the PAF1 complex, is adjacent to VPS36 , encoding a component of the ESCRT machinery and the two genes have been suggested to show an adjacent gene effect (Ben-Shitrit et al. (springer.com)
  • TAFI
  • Taken together, this thesis provides further evidence supporting the hypothesis that platelet-derived TAFI is originated from CPB2 gene expression in megakaryocytes. (queensu.ca)
  • sequences
  • The two gene sequences exhibited 91% inter-strain identity. (nih.gov)
  • The sequences analyzed included the ORFs of all identified genes in or near the interval ( Fig. 1 A ). In this comparison, we detected only a 1-nt difference between mutant and parent strains, a C-to-T transition in the ORF of the CG15720 ( 11 ) predicted gene. (pnas.org)
  • Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. (osti.gov)
  • Further provided are methods of at least partially degrading xylotriose, xylobiose, and/or arabinofuranose-substituted xylan using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof. (osti.gov)
  • deletion
  • Genetic recombination and deletion mapping of the memory defect placed the gene in a 140-kb stretch in region 11D of the X chromosome ( 4 ). (pnas.org)
  • Gene disruption resulting from a deletion/substitution demonstrates that ERG3 is not essential for cell viability or the sparking function. (nih.gov)
  • Deletion of both endogenous copies of the CaPKC1 gene in diploid C. albicans cells resulted in an osmotically remedial cell lysis defect of both the budding and the hyphal growth form and morphologically aberrant cells of the budding form. (nih.gov)
  • Deletion analysis of the CPB2 promoter indicated cell-type specific regulation of CPB2 gene expression. (queensu.ca)
  • Inhibition
  • Phenotypic characterization of uvsB mutants shows that they possess defects in additional aspects of the DNA damage response besides checkpoint control, including inhibition of septum formation, regulation of gene expression, and induced mutagenesis. (genetics.org)
  • cerevisiae
  • The S. cerevisiae RAD30 gene is involved in error-free bypass of UV-induced DNA damage, because mutations in it result in increased UV mutability ( 11 , 12 ). (pnas.org)
  • amino acid
  • On the basis of the mode of mecA and mecB regulation by homocysteine, these genes may be classified in a group of genes upregulated directly or indirectly by this amino acid. (springer.com)
  • The rs6971 polymorphism in the TSPO gene causes an amino acid substitution (Ala147Thr) within the transmembrane domain where the cholesterol-binding pocket is located, and has been shown to affect the steroidogenic pathway. (nih.gov)
  • species
  • In this study, we analyzed the function of four putative endo-beta-1,4-xylanase-encoding genes (ppxyn1-ppxyn4) from Phytophthora parasitica , an oomycete plant pathogen known to cause severe disease in a wide variety of plant species. (springer.com)
  • adjacent
  • The gene maps to 88.7 minutes on the chromosome adjacent to the cytR locus. (nih.gov)
  • We document a complex set of genetic interactions, which include an adjacent gene effect between CDC73 and VPS36 and synthetic sickness between vps36Δ and cdc73Δ, paf1Δ , or ctr9Δ . (springer.com)
  • 2016 ). Adjacent gene effects can confound interpretation of genetic data, especially in large-scale studies. (springer.com)
  • studies
  • Further studies of the rare AAED1 gene variant on brain development that are already carried out by our joint team with German researchers, may help better understand pathological mechanisms that lead to the occurrence of this disease,' concludes Evgeniy Svirin. (news-medical.net)
  • These studies suggested that the rplA gene is expressed in all stages of differentiation as a 1400-nucleotides transcript. (mendeley.com)
  • FISH studies localized the gene to 4q32.2. (uniprot.org)
  • cDNA
  • It has a 2329 bp cDNA, a 1278 bp open-reading frame, and is predicted to encode 425 amino acids with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site. (uniprot.org)
  • functional
  • The scientists focused on studying the rare functional variants in whole set of genes in several generations of families with running ADHD. (news-medical.net)
  • The functional gene has been localized on a 2.5-kb HindIII-BamHI fragment containing an open reading frame comprising 365 amino acids. (nih.gov)
  • imply
  • Taken together, these results imply that the RB gene product may function in regulating other genes within the cell. (uniprot.org)
  • cell
  • Recent observations suggest that these genes are likely to control cell cycle checkpoint responses to DNA damage and incomplete replication. (genetics.org)
  • high
  • The NGFI-A gene is expressed at relatively high levels in the brain, lung, and superior cervical ganglion of the adult rat. (sciencemag.org)
  • Both genes have a similar interrupted structure and an exon that encodes closely related tandem repeats of very high histidine and alanine content. (pnas.org)
  • several
  • The ATF1 gene encodes an alcohol acetyl transferase (AATase), that catalyses the synthesis of acetate esters from acetyl CoA and several kinds of alcohols. (nih.gov)
  • growth
  • Homocysteine induced transcription of both genes when added to the growth medium or overproduced in a regulatory mutant. (springer.com)
  • However
  • However, the putative rpoZ-dependent promoter, P(ren25), was located divergently in the coding region of the rplA gene and was inactive in S. aureofaciens. (mendeley.com)
  • thus
  • As a 'cancer suppressor' gene, RB thus functions in a manner opposite to that of most other oncogenes. (uniprot.org)
  • shown
  • Finally, genetic screens have shown that Cdc73, Leo1, and Rtf1 are important for the fitness of telomere defective cells (carrying a cdc13-1 temperature-sensitive allele of the telomere capping gene CDC13 ) (Addinall et al. (springer.com)