Loading...
  • heterozygous
  • 3. Despite a halved functional gene dosage, heterozygous muscles display an average G(Cl), which is not significantly different from that of homozygous wild-type animals. (uni-bielefeld.de)
  • XCI was calculated for informative heterozygous individuals as the ratio of the peak area of two alleles of the highly polymorphic CAG repeat of the androgen receptor (AR) gene (Xq11-12). (scirp.org)
  • In contrast, an extremely skewed XCI can be observed in heterozygous females carrying gene mutations involved in X-linked conditions, such as X-linked intellectual disability, Barth syndrome and X-linked sideroblastic anemia [12- (scirp.org)
  • novel
  • Guided by strong preliminary data, we propose the following novel mechanism for identifying genes for coordinate regulation: CLAMP and the MSL complex associate inter-dependently, thereby generating a positive feedback amplification system that creates X- specificity from a two-fold X-enrichment of MRE sequences. (grantome.com)
  • We describe a comparative sequence analysis algorithm for detecting novel structural RNA genes. (biomedcentral.com)
  • It further allows assessing the validity of microarray-based inference on dosage compensation with a novel technology. (biomedcentral.com)
  • sequence
  • the RNase MRP gene was only detected in the completely sequenced CHH critical region because the RNase MRP sequence was already in the databases. (biomedcentral.com)
  • protein
  • First, we found that copy numbers correlated to maintain stoichiometric balance in protein complexes and biochemical pathways, consistent with the gene balance hypothesis. (biomedcentral.com)
  • The X-linked Larval serum protein one α ( Lsp1 α) gene has long been known to be not dosage compensated. (biomedcentral.com)
  • a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant, Genes Dev. (semanticscholar.org)
  • Noncoding RNA gene sequences do not have strong statistical signals, unlike protein coding genes. (biomedcentral.com)
  • Gene discovery methods (whether experimental or computational) typically assume that the target is a protein coding gene that produces a messenger RNA. (biomedcentral.com)
  • Need-based upregulation of protein levels in response to deletion of their duplicate genes. (springerlab.org)
  • Genomic
  • Genomic compensation observed in the mother probably occurred as a consequence of interchromosomal postzygotic nonallelic homologous recombination. (beds.ac.uk)
  • Unlike
  • Unlike control X-linked genes, Lsp1 α was not enriched for H4K16ac in the third instar larval fat body, the tissue in which the gene is actively expressed. (biomedcentral.com)
  • findings
  • These findings suggest that the contribution of X-linked genes to the etiology of ASD is still likely but it is not supported by X-inactivation patterns on peripheral blood cells. (scirp.org)
  • active
  • The most likely explanation for why Lsp1 α is not dosage compensated is that the gene has not evolved a mechanism to independently recruit the MSL complex, possibly because of its recent evolutionary origin, and because there appears to be a low level of bound MSL complex in a nearby gene that is active in the same tissue. (biomedcentral.com)
  • study
  • This study is to identify the preferred vaccine dosage (of antigen and adjuvant) and schedule (one or two administrations) of the cell-derived H1N1sw monovalent vaccine in healthy adults b. (bioportfolio.com)
  • describe
  • Our proposed research is significant because we expect to describe for the first time the previously unknown mechanism that allows MSL complex to identify its high affinity sites, thereby defining the critical first step in establishing coordinate gene regulation. (grantome.com)
  • studies
  • Further dosage and haplotype familial studies revealed that both the maternal grandfather and uncle had also the same 16p duplication as the proband. (beds.ac.uk)
  • Microarray studies as well as quantitative PCR (qPCR) based studies suggest values somewhere in between 1 (full compensation) and 2 (absence of compensation). (biomedcentral.com)
  • complex
  • The rationale for this work is that determining how the MSL complex specifically targets the X-chromosome will yield key insight into how genes are identified for coordinately regulation within sub-nuclear domains. (grantome.com)