The alterations, at the level of these tumor suppressor genes, that is their non-expression or a malfunction, allow the neoplastic cells to multiply in an uncontrolled way. (wikipedia.org)
In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. (aacrjournals.org)
Ovarian cancer1
In this study, we aim to leverage these metabolic changes as potential biomarkers for assessing ovarian cancer.A functional module-based approach was utilized to identify key gene expression pathways that distinguish different stages of ovarian cancer (OC) within a tissue biopsy cohort. (stanford.edu)
Pathways2
Random set analysis was used to identify biological pathways enriched for genes differentially regulated in tumors (compared with 59 samples of normal mucosa). (biomedcentral.com)
This allowed us to distinguish between pathways whose dysregulation is probably necessary throughout tumorigenesis and those whose involvement specifically drives progression from one stage to the next. (biomedcentral.com)
Tumors3
He has discovered some key factors in the regulation of the cell cycle and of mechanisms linked to the onset of tumors. (wikipedia.org)
In particular, he distinguished himself for having isolated the tumor suppressor gene, the RB2/p130, subsequently demonstrating how the same gene, introduced through a retrovirus in some animal models, is able to reduce the growth of tumors. (wikipedia.org)
One protein in particular (Isoform NSP5a3a) is highly expressed in the cell lines of some tumors and could be a very useful tumor marker. (wikipedia.org)
Vivo1
The absolute novelty consists in the first example of setting up a gene therapy model that is tested in vivo on the guinea pig animal (mouse) in which a lung tumor was induced. (wikipedia.org)
Expression2
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
Family2
Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
In 1993, Antonio Giordano identified and cloned a new tumor suppressor gene, RB2 / p130, which has a primary function in the cell cycle by controlling correct DNA replication and essentially preventing the onset of cancer. (wikipedia.org)
During his years there, he discovered the direct link between cell cycle regulation and the development of cancer. (wikipedia.org)
Potential role1
In 2004 Giordano discovered NSPs (Novel Structure Proteins), a new protein structure with a potential role in the dynamics of the nucleus during cell division. (wikipedia.org)
Human1
The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Pocket proteins1
3. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. (nih.gov)
P1306
9. A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes. (nih.gov)
14. Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins. (nih.gov)
19. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. (nih.gov)
In particular, he distinguished himself for having isolated the tumor suppressor gene, the RB2/p130, subsequently demonstrating how the same gene, introduced through a retrovirus in some animal models, is able to reduce the growth of tumors. (wikipedia.org)
In 1993, Antonio Giordano identified and cloned a new tumor suppressor gene, RB2 / p130, which has a primary function in the cell cycle by controlling correct DNA replication and essentially preventing the onset of cancer. (wikipedia.org)
Using the functionally active RB2 / p130 gene, as a vector, a retrovirus, and tumor growth has been shown to be drastically reduced after a single injection of RB2 / p130. (wikipedia.org)
Cyclin11
A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. (everypatent.com)
Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma. (everypatent.com)
Cyclin: A Nuclear Protein Whose Level Correlates Directly with the Proliferative State of Normal As Well as Transformed Cells", Leukemia Res. (everypatent.com)
Gene Expression of PCNA/Cyclin in Adult Tissues and the R3230AC Mammary Tumor of Rat", Biochem. (everypatent.com)
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner", Genes & Develop. (everypatent.com)
Human Cyclin E, a New Cyclin That Interacts with Two Members of teh CDC2 Gene Family", Cell, 66:1217-1228, (1991). (everypatent.com)
Association of Human Cyclin E with a Periodic G.sub.1 -S Phase Protein Kinase", Science 257:1958-1961 (1992). (everypatent.com)
Cyclin-Dependent Regulation of G.sub.1 in Mammalian Fibroblasts", Science, 259:1908-1912 (1993). (everypatent.com)
Redundant cyclin overexpression and gene amplification in breast cancer cells", Proc. (everypatent.com)
Expression and amplification of cyclin genes in human breast cancer", Oncogene, 8(8):2127-2133 (1993). (everypatent.com)
Induces2
4. The p107 tumor suppressor induces stable E2F DNA binding to repress target promoters. (nih.gov)
expression of these proteins is maintained in carcinoma cells lines [6], and expression of these two proteins induces immortalization and transformation in a variety of rodent and human cell types [54]. (nih.gov)
Transcription factor2
15. E2F-4, a new member of the E2F transcription factor family, interacts with p107. (nih.gov)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Regulates1
7. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. (nih.gov)
Interacts1
10. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. (nih.gov)
Tumor4
12. The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair. (nih.gov)
The alterations, at the level of these tumor suppressor genes, that is their non-expression or a malfunction, allow the neoplastic cells to multiply in an uncontrolled way. (wikipedia.org)
The absolute novelty consists in the first example of setting up a gene therapy model that is tested in vivo on the guinea pig animal (mouse) in which a lung tumor was induced. (wikipedia.org)
One protein in particular (Isoform NSP5a3a) is highly expressed in the cell lines of some tumors and could be a very useful tumor marker. (wikipedia.org)
Cellular2
1. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. (nih.gov)
In 2004 Giordano discovered NSPs (Novel Structure Proteins), a new protein structure with a potential role in the dynamics of the nucleus during cell division. (wikipedia.org)
Distinct1
Here we establish that E2F4 associates with two distinct components of the centriole replication machinery, Deup1 and SAS6, targeting nonhomologous domains in these proteins. (molbiolcell.org)
We observe that BPDCN skin tumours first develop at sun-exposed anatomical sites and are distinguished by clonally expanded mutations induced by ultraviolet (UV) radiation. (bvsalud.org)
Cervical3
Here, anonymized leftovers of fresh cervical epithelium scrapings from twice (LSIL/ASCUS and HR-HPV DNA)-positive and twice (Pap smear- and HR-HPV DNA)-negative (control) patients in a proteome-preserving solution served to assess the biomarker worth of three cervical carcinoma-related proteins, i.e. (frontiersin.org)
Logistic Regression coupled with Likelihood-Ratio Tests confirmed that a highly significant relation links increasing TKTL1/CIP-2a/B-MYB protein levels in twice-positive cervical scrapings to the risk of HR-HPV-driven oncoprogression. (frontiersin.org)
HPV-16 in particular is found in roughly half of cervical cancers [10], and HPV-16 proteins have been extensively studied. (nih.gov)
Cancer1
During his years there, he discovered the direct link between cell cycle regulation and the development of cancer. (wikipedia.org)
Mechanisms1
He has discovered some key factors in the regulation of the cell cycle and of mechanisms linked to the onset of tumors. (wikipedia.org)
Role1
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Structure1
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Elements2
16. Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product. (nih.gov)
Point mutations and deletions have been used to map the contribution of particular elements of the protein sequence to a given function. (nih.gov)
Domain2
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Levels2
Descriptive statistics showed that the three proteins levels significantly increased in the twice-positive vs. twice-negative scrapings. (frontiersin.org)
Therefore, TKTL1/CIP-2a/B-MYB protein levels could objectively predict oncoprogression risk in twice (HR-HPV- and Pap smear)-positive women. (frontiersin.org)
Formation1
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)