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  • coronary
  • Diabetic coronary arteries showed significant reduction in ACh-mediated maximal relaxation compared to controls.Diabetic vessels showed also significant increases in lipid-peroxides, nitrotyrosine, and active RhoA and 50% reduction in eNOS mRNA expression.Treatment of diabetic animals with FeTTPS blocked these effects. (nih.gov)
  • Diabetic coronary arteries showed significant reduction in ACh-mediated maximal relaxation compared to controls. (nih.gov)
  • Methods and Results- En face immunohistochemistry demonstrated a significant increase of PKC βΙΙ and decrease of PKCδ expression in coronary arterial endothelium of Zucker diabetic rats. (ahajournals.org)
  • 2-4 ⇓ ⇓ We and others have shown elevated PKC activity 5,6 ⇓ and expression 7 in the heart of diabetic rats and pigs, concomitant with coronary venular hyperpermeability. (ahajournals.org)
  • Rosano GM, Vitale C, Sposato B et al (2003) Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study. (springer.com)
  • Metabolism
  • Our previous reports identify several significant associations between the genotypes of cytokine genes and T2DM and/or the clinical lipid parameters, which strongly suggest the participation of immune-regulatory molecules in lipid metabolism. (medsci.org)
  • etiology
  • Our data broadens the relevance of PGC-1α in the etiology of diabetic angiopathy, now with a potential to therapeutically restore EPCs vasculogenicity, and may provide an opportunity to improve the efficacy of autologous adoptive EPC therapy for limb and myocardial ischemia in DM. (ahajournals.org)
  • Genetic and environmental factors are the study focus of T2DM etiology, and linkage studies have localized some of the genes that influence the development of this disorder. (medsci.org)
  • Therapy
  • The objectives of this investigation were: 1) to evaluate the distribution of APOE polymorphisms in a large diabetic case-control sample from South Asia, 2) to examine the impact of APOE polymorphisms on quantitative risk factors of T2D and CAD, and 3) to explore the contribution of APOE genotypes in the response to anti-diabetic therapy. (nih.gov)
  • Mice
  • Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that the overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function. (diabetesjournals.org)
  • METHODS Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic male RAGE/apolipoprotein E double knockout (RAGE/apoE DKO) mice were treated with quinapril (30 mg/kg/day) for 20 weeks. (semanticscholar.org)
  • Polymorphisms
  • Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis. (clinicaltrials.gov)
  • Multiple Sclerosis Risk Conferred by Single Nucleotide Polymorphisms (SNPs) of Interleukins, Glypican, and Human Leukocyte Antigen Genes. (clinicaltrials.gov)
  • To estimate the prevalence and the relationship of three polymorphisms (43, 63 and 2037) and insertion-deletion 19 of the CAPN10 gene in a cohort of Irish patients with T2DM. (rcsi.ie)
  • mRNA
  • b) Microarray data was confirmed by real-time RT-PCR showing that protected individuals have low levels of PAI-1 mRNA compared to diabetic individuals. (nih.gov)
  • Diabetic vessels showed also significant increases in lipid-peroxides, nitrotyrosine, and active RhoA and 50% reduction in eNOS mRNA expression. (nih.gov)
  • Expression
  • This study is designed to investigate the regulation of EN-RAGE gene expression in human macrophages. (nii.ac.jp)
  • Importantly, T2DM induction by high-fat diet feeding also caused reduction in the EPCs abundance and EC gene expression of PB-MNCs, which was rescued by PGC-1α ablation in KO. (ahajournals.org)
  • a) Ingenuity pathway map shows the gene expression profile. (nih.gov)
  • FeTPPs restored nitric oxide production and eNOS expression in diabetic rat vessels. (nih.gov)
  • Inhibition
  • In this report, we examine the effect of transient inhibition of plasminogen activator inhibitor-1 (PAI-1), a major gene target of TGF-β1 activation. (nih.gov)
  • T2DM
  • The aim of this study is to determine the distribution of gene encoding cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a T-cell negative regulator, in T2DM patients and health subjects. (medsci.org)
  • In Taiwan, more than 98% of diabetic patients are characterized as T2DM [ 3 ], affecting more than 1 million individuals. (medsci.org)
  • CAPN10 gene study suggests associations between genetic variability in this gene and T2DM in the Irish population and further exploration of this and other genes may lead to earlier identification of subjects for interventions to reduce the risk of development of the disease. (rcsi.ie)
  • Diseases
  • Dragon Database for Methylated Genes and Diseases (DDMGD) can provide associations between methylated genes and diseases. (edu.sa)
  • The associations were extracted automatically from PubMed abstracts and PubMed Central full text articles using Dragon Extractor of Methylated Genes in Diseases (DEMGD) tool. (edu.sa)
  • You can search using the gene, diseases and/or species. (edu.sa)
  • DDMGD: the database of text-mined associations between genes methylated in diseases from different species. (edu.sa)
  • angiogenesis
  • Several proteins have been effective in targeting angiogenesis of the penis in diabetic or hypercholesterolemic animal models of ED, including VE growth factor, angiopoietin (Ang)-1, and Ang4 ( 7 - 14 ). (diabetesjournals.org)
  • Disease
  • Evaluation of the role of RANK and OPG genes in Paget's disease of bone," Bone , vol. 28, no. 1, pp. 104-107, 2001. (hindawi.com)
  • important gene associated
  • An important gene associated with Ocular Toxoplasmosis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling . (malacards.org)
  • An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall . (malacards.org)
  • atherosclerotic
  • Findings by us and others demonstrate that increased flux via AR in diabetics perpetuates increased injury after myocardial infarction, accelerates atherosclerotic lesion formation, and promotes restenosis via multiple mechanisms. (springer.com)
  • enzymes
  • In support, our results indicate that in the diabetic state, tetrahydrobiopterin salvage enzymes are impaired leading to the accumulation of pterin oxidation products and subsequent eNOS uncoupling. (ufl.edu)