• In a targeted screen for V. cholerae virulence factors in a D. melanogaster model of oral infection, we discovered that, when delivered in LB broth, V. cholerae mutants defective in synthesis of the biofilm exopolysaccharide VPS killed flies significantly more slowly than WT V. cholerae ( Fig. 1 A ). We hypothesized that VPS might be required for colonization of the fly intestine. (pnas.org)
  • Since the dve -expressing anterior-most midgut constitutes the outer layer of the proventriculus, this dve phenotype suggests that dve activity is required for the functional development of outer layer cells and the consequent retention of the internal portion of the proventriculus. (sdbonline.org)
  • Similar phenotypes were observed in heads with defective proventriculus (dve) mutant clones. (sdbonline.org)
  • Temperature-sensitive molecules like dTrpA1 and shi(ts) induce temperature-dependent behavioral changes, and the temperature at which the changes are induced were lowered in the dopamine transporter-defective mutant, fumin. (jove.com)
  • The first signaling process is triggered at around the second larval instar (48 hr after egg laying, AEL) by the selector gene apterous ( ap ), which is expressed exclusively in dorsal cells ( D iaz -B enjumea and C ohen 1995 ) ( Figure 1a ). (genetics.org)
  • These results clearly indicate that not only the activation of effector genes to execute developmental program but also the repression of inappropriate program is crucial for establishment of the organ identity. (sdbonline.org)
  • Nucleotide sequencing and genetic complementation analysis revealed a 6.7-kb region of the genome with seven adjacent genes ( tadABCDEFG ) required for tight adherence. (asm.org)
  • There are seven CUT-class homeobox genes in the human genome and three pseudogenes (Holland et al. (ox.ac.uk)
  • Here we used the protozoan Trypanosoma brucei as a model to investigate efficiency and specificity of RNAi generated by expression of long dsRNA of PFRA and PFRC genes, which code for flagellar proteins required for cell motility. (jove.com)
  • In this study, we systematically evaluated the roles of the polymerase-associated (NP, P and L) protein genes in genotype VII NDV virulence after confirming the envelope-associated (F and HN) proteins contributed greatly to NDV virulence. (frontiersin.org)
  • Among their goals, the researchers sought to address how genes interact in distinct ways in different cells. (phys.org)
  • de Haan CA, Masters PS, Shen X, Weiss S, Rottier PJ (2002) The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host. (springer.com)
  • Both loss-of-function and overexpression studies have demonstrated an important role for dMyc, which is encoded by the diminutive ( dm ) gene, in regulating cellular growth. (biologists.org)
  • Yersinia pestis , the causative agent of plague, is transmitted to rodents and humans by the bites of fleas whose proventriculi are blocked by a dense mass of the bacteria ( 13 ). (asm.org)
  • Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). (princeton.edu)
  • Our results show that the tad genes are required for tight adherence of A. actinomycetemcomitans to surfaces and are therefore likely to be essential for colonization and pathogenesis. (asm.org)
  • A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
  • Database of human genes associated with cellular senescence. (senescence.info)
  • Remarkably, complete and highly conserved tad gene clusters are present in the genomes of the bubonic plague bacillus Yersinia pestis and the human and animal pathogen Pasteurella multocida . (asm.org)
  • The occurrence of similar genes in a wide array of microorganisms indicates that they have important functions. (asm.org)
  • We propose that tad -like genes have a significant role in microbial colonization. (asm.org)
  • We suggest that the tad genes are involved in secretion of factors required for tight adherence of A. actinomycetemcomitans . (asm.org)