Gene d utp. Medical search. Frequent questions

A Rossman fold motif participates in binding of the UTP nucleotide and a sugar-binding domain (residues T286-G293) coordinates with the glucose ring. (wikipedia.org)
Serogroup-specific capsule biosynthesis genes located in region A have been published for serogroup X, and nucleotide sequences for serogroups E, L, and Z have been submitted to GenBank (accession nos. (cdc.gov)
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. (nih.gov)
1996). „Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (wikipedia.org)
1996). „Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. (wikipedia.org)

UTP-glucose-1-phosphate uridylyltransferase also known as glucose-1-phosphate uridylyltransferase (or UDP-glucose pyrophosphorylase) is an enzyme involved in carbohydrate metabolism. (wikipedia.org)
i.e., glucose-1-phosphate + UTP ⇌ {\displaystyle \rightleftharpoons } UDP-glucose + pyrophosphate UTP-glucose-1-phosphate uridylyltransferase is an enzyme found in all three domains (bacteria, eukarya, and archaea) as it is a key player in glycogenesis and cell wall synthesis. (wikipedia.org)
Recently, human UTP-glucose-1-phosphate uridylyltransferase has been studied and crystallized, revealing a different type of regulation than other organisms previously studied. (wikipedia.org)
The structure of UTP-glucose-1-phosphate uridylyltransferase is significantly different between prokaryotes and eukaryotes, but within eukaryotes, the primary, secondary, and tertiary structures of the enzyme are quite conserved. (wikipedia.org)
In many species, UTP-glucose-1-phosphate uridylyltransferase is found as a homopolymer consisting of identical subunits in a symmetrical quaternary structure. (wikipedia.org)
Crystal structure of UTP-glucose-1-phosphate uridylyltransferase from Burkholderia xenovorans Human UTP-glucose-1-phosphate uridylyltransferase isoform 1 subunit with UDP-glucose bound Human genes encoding proteins with UTP-glucose-1-phosphate uridylyltransferase activity include two isoforms with molecular weights of 56.9 and 55.7 kDa, respectively. (wikipedia.org)
UTP-glucose-1-phosphate uridylyltransferase is ubiquitous in nature due to its important role in the generation of UDP-glucose, a central compound in carbohydrate metabolism. (wikipedia.org)
In plant leaves, UTP-glucose-1-phosphate uridylyltransferase is a key part of the sucrose biosynthesis pathway, supplying Uridine diphosphate glucose to Sucrose-phosphate synthase which converts UDP-glucose and D-fructose 6-phosphate into sucrose-6-phosphate. (wikipedia.org)
An exception is the brain, which has high levels of glycogen but low specific activity of UTP-glucose-1-phosphate uridylyltransferase. (wikipedia.org)
In animal cells, UTP-glucose-1-phosphate uridylyltransferase is found predominantly in the cytoplasm. (wikipedia.org)
UTP-glucose-1-phosphate uridylyltransferase is also required for galactose metabolism in animals and microorganisms. (wikipedia.org)
Bacteria with defective UTP-glucose-1-phosphate uridylyltransferase are unable to incorporate galactose into their cell walls. (wikipedia.org)
UTP-glucose-1-phosphate uridylyltransferase uses an ordered sequential Bi Bi mechanism for both the forward and reverse reactions. (wikipedia.org)
Similar to other sugar nucleotidyltransferases, UTP-glucose-1-phosphate uridylyltransferase activity requires two divalent cations to stabilize the binding of negatively charged phosphate groups. (wikipedia.org)

This product GTTS-WK0216MR is a type of mRNA having 120 nt poly(A) tail and modified with Cap 0 & Pseudo-UTP. (creative-biolabs.com)
There are currently no Customer reviews or questions for IVTScrip™ mRNA-Human CRABP1, (Cap 0, Pseudo-UTP, 120 nt-poly(A)) (GTTS-WK0216MR). (creative-biolabs.com)
It may be combined with a modified UTP, such as N 1 -Methyl-Pseudo-UTP. (roche.com)
Obtain all natural NTPs and N1-Methyl-Pseudo-UTP from a single source. (roche.com)

Gene Ontology analysis showed that genes involved in embryonic development and growth are significantly over-represented in regenerating early hindlimb buds and that successful regeneration in the Xenopus hindlimb correlates with the induction of stress response pathways. (biomedcentral.com)

Language": "en", "Country": "XG", "Code": "CB - Order Information" }, { "Name": "Positioning", "Value": "NTPs are the critical starting materials of in vitro mRNA synthesis for therapeutics or vaccines. (roche.com)
Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis. (expasy.org)
The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. (cdc.gov)
Language": "en", "Country": "XG", "Code": "Applications" }, { "Name": "Product Description", "Value": "UTP is produced enzymatically, a virus filtration concludes the synthesis, a TSE/BSE statement is available. (roche.com)
The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. (sagepub.com)
HS had nega- * Correspondence: [email protected] tive effects on oocyte maturation via down-regulation of Equal contributors the gene expression in steroid hormone synthesis or their National Engineering Laboratory for Animal Breeding, Key Laboratory of receptors. (sagepub.com)

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. (vectorbiolabs.com)

these effects are thought to involve alterations in gene expression. (jneurosci.org)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
these gene expression changes may be responsible for the alterations in striatal physiology. (jneurosci.org)
One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
Background: Expression analysis of estrogen response genes (ERGs) may help to predict the effectiveness of endocrine therapies in breast cancer patients. (iiarjournals.org)
Many investigators consider the expression of estrogen-responsive genes (ERGs) to be evidence of an activated, functional ER ( 6 , 7 ). (iiarjournals.org)
This system has already been used successfully in several studies for gene expression and mutation analysis ( 8 , 9 ). (iiarjournals.org)
Beyond this time, no differences in global gene expression in infected and control animals were detectable by microarray analysis. (biomedcentral.com)
Whereas in the acute phase of the disease immunoregulatory processes prevail in the hippocampus and the cortex, we observed a strong activation of neurogenic processes in the hippocampal dentate gyrus, both by gene expression and immunohistology starting as early as 3 days after infection. (biomedcentral.com)
For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain damage, i.e. the cortex and the hippocampus, at four different stages of the disease in an infant rat model. (biomedcentral.com)
Furthermore, the expression of the majority of these genes during protostome ontogeny suggests a likely role in development. (biomedcentral.com)
Gene expression studies typically analyze samples containing tumor cells and stroma. (biomedcentral.com)
Because gene expression patterns are thus derived from both tumor cells and tumor stroma, it is important to consider the degree to which inclusion of stromal cells influences the outcome of tumor profiling studies. (biomedcentral.com)
In the current study, we have taken advantage of the N1 transgenic line to directly compare morphology and gene expression in same stage regenerating vs. BMP signalling deficient non-regenerating hindlimb buds. (biomedcentral.com)
Comparison of gene expression in stage matched N1 vs. wild type hindlimb buds has revealed several new targets for regeneration research. (biomedcentral.com)
Gene over-expression analyses in Xenopus limb and tail regeneration have indicated that successful regeneration requires the re-activation of developmental FGF or BMP signalling pathways [ 8 - 12 ]. (biomedcentral.com)
A point of note is that probe selection for the Affymetrix gene expression assay is biased towards the 3' end of transcripts. (xenbase.org)
For the eukaryotic gene expression assay, labeled antisense cRNA target is hybridized to the complementary 25mer probes. (xenbase.org)
Silencing STAT2 gene expression in Saos2 and A375S Furthermore. (researchensemble.com)
Gene expression analysis was carried out on a subset of 66 clones with real time quantitative PCR and 40 clones were positive. (silverchair.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
The data presented is normalized to the expression of Rpl32 , a housekeeping gene. (cdc.gov)

Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps . (cdc.gov)
Genes within this locus are divided into 6 regions: A-D, D′, and E ( 16 ). (cdc.gov)

In this enzyme's primary reaction, the phosphate group on glucose-1-phosphate replaces the phosphoanhydride bond on UTP. (wikipedia.org)
In glycogenesis, free glucose 1-phosphate can also react with UTP to form UDP-glucose, by using the enzyme UDP-glucose pyrophosphorylase. (ecmdb.ca)
Periplasmic acid glucose-1-phosphatase (G-1-Pase) encoded by gene Agp is necessary for the growth of Escherichia coli in a minimal medium containing glucose-1-phosphate (G-1-P) as the sole source of carbon. (ecmdb.ca)

Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. (nih.gov)

Compared to primary tumors that have not formed metastases, primary HNSCC tumors that have metastasized are characterized by predominant down-regulation of tumor cell specific genes and exclusive up-regulation of stromal cell specific genes. (biomedcentral.com)
New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a macroarray cDNA library. (silverchair.com)

Mutations in the CLN8 gene, encoding an endoplasmic reticulum (ER) transmembrane protein of unknown function, underlie NCL phenotypes in humans and mice. (biomedcentral.com)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)

The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. (nih.gov)
Score represents the degree of relatedness of a KO to the query gene based on the clustering in the phylogenetic tree of protein sequences ( see below for the tree ). (umassmed.edu)
Score represents the degree of relatedness of a KO to the query gene based on the Smith-Waterman alignment of protein sequence with most similar sequences from all organisms in the KEGG database. (umassmed.edu)
Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)

Click Gene ID to show a list of GSM assays in which the gene are specifically expressed. (or.jp)
Using whole mount in situ hybridization, it was shown that these genes are specifically expressed in pigment cells. (silverchair.com)

Genes in region A encode enzymes for biosynthesis of the capsular polysaccharide, and genes in regions B and C are implicated in the translocation of the high molecular weight polysaccharides to the cell surface. (cdc.gov)

In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)
Model reactions that follow from the KEGG reactions associated with this gene, but that exclude this gene due to differences in reaction specificity or localization compared to the predictions for this gene. (umassmed.edu)

transcription using T7 or SP6 RNA polymerase (GIBCO-BRL) and [α-32P]-UTP (ICN Costa Mesa CA) (29). (researchensemble.com)
The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)

A detailed understanding of the molecular and cellular mechanisms underlying pigment cell specification in sea urchin embryos will first require isolation of the genes responsible for this developmental process. (silverchair.com)

This invention relates to a method for selectively separating live cells which have expressed a specific gene. (justia.com)
In the case that the translation products of a gene are cell surface molecules, a method for selectively separating cells which have expressed the specific gene, while being viable, is to make fluorescence labeled antibodies bind to the surface molecules for labeling the cells fluorescently, to identify fluorescing cells by flow cytometry, and to separate the identified cells with a cell sorter (Fluorescence Activated Cell Sorter, FACS). (justia.com)
In the case that the translation products of a gene are not cell surface molecules but localize in the cells (in the cytoplasm or in organella), the method described above cannot be adopted. (justia.com)
In this case, it is theoretically possible to fluorescently label the gene-expressing cells by introduction of fluorescence-labeled antibodies that are specific to the molecules localized in the cells into the cells, through microinjection and to separate the objective gene-expressing cells with the cell sorter described above based on the difference in fluorescence intensity of the cells with irradiation of laser beam or the like. (justia.com)
In the case that the translation products of the gene are not cell surface molecules, but molecules that are liberated into the extracellular fluid and that do not remain in the cell or near the cell membrane, it is very difficult to selectively trap the molecules to separate the cells expressing the specific gene, from other molecules with the approaches described above. (justia.com)
Prime editors (PEs) are precision gene editing agents that can perform virtually any substitution, small deletion and small insertion at target DNA sites in living cells 2 . (nature.com)
The functionality of the IL-12 or CD gene products expressed from these vectors was validated by splenic interferon (IFN)-γ production or viability assays in cultured cells. (biomedcentral.com)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
The results suggest that S. purpuratus pks, fmo and sult could belong to a differentiation gene battery of pigment cells. (silverchair.com)

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)

The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)
Two basic types of probe sets are created: 1) those that represent gene sequences uniquely, 2) those that represent multiple closely related gene sequences. (xenbase.org)

Combined transfer of genes with different mechanisms of action may potentate the therapeutic outcome. (biomedcentral.com)

However, the therapeutic outcome appears not to be high as expected, presumably because the in vivo gene delivery efficiency is low. (biomedcentral.com)

Association scores for KOs best matching to the query gene according to each annotation predictor, and for the accepted KO if there is any (rightmost columns). (umassmed.edu)
See above for the final decision on the annotation of this gene. (umassmed.edu)

Pathway maps where this gene is represented are listed here. (umassmed.edu)

Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli. (ecmdb.ca)

Some genes are expressed at near-maximal levels within 30 min, whereas others show no substantial induction until 2 hr or more after stimulation. (jneurosci.org)

Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. (nih.gov)

Therapeutic gene transfer affords a clinically feasible and safe approach to cancer treatment but a more effective modality is needed to improve clinical outcomes. (biomedcentral.com)
Combined transfer of therapeutic genes with different modes of actions may be a means to this end. (biomedcentral.com)
Therapeutic gene transfer using viral or nonviral vectors has been shown to be clinically feasible and safe. (biomedcentral.com)

Three transcript variants encoding different isoforms have been found for this gene. (nih.gov)

This polymorphism was identified by Reichardt and Woo [Proc Natl Acad Sci U S A 88: 2633 (1991)], who pointed out that the galactosemia mutations tend to occur in regions of the gene that are highly conserved throughout evolution while the polymorphisms change variable residues. (coriell.org)

The enzyme/prodrug strategy using cytosine deaminase (CD) and 5-fluorocytosine (5-FC) has been used for cancer gene therapy. (biomedcentral.com)

Activated ER binds to estrogen-responsive elements (EREs), which are located in the promoter regions of various target genes. (iiarjournals.org)

This gene has 1 transcript ( splice variant ), 105 orthologues and 1 paralogue . (ensembl.org)

cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. (systemsbiology.net)

A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
We have evaluated the antitumor effect of combining IL-12 with CD gene transfer in mice bearing renal cell carcinoma (Renca) tumors. (biomedcentral.com)
The combined gene transfer increased splenic NK cell activity and IFN-γ production by splenocytes. (biomedcentral.com)

2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." . (wikipedia.org)

Although TLRs are widespread in animals, detailed phylogenetic studies of this gene family are lacking. (biomedcentral.com)

Anatomy6

Organisms4

Chemicals and Drugs89

Phenomena and Processes16

Information Science3

Nucleotide5

Uridylyltransferase14

Pseudo-UTP4

Ontology1

MRNA2

Synthesis5

Proteins1

Expression23

Locus2

Glucose-1-phospha3

Pyrophosphate1

Specific genes2

Phenotypes2

Protein4

Specifically expressed2

Biosynthesis1

Specificity2

Transcription2

Molecular1

Cells10

UniProt1

Sequences3

Mechanisms1

Vivo gene1

Annotation2

Pathway1

Glycogen1

Induction1

Isolation1

Therapeutic3

Isoforms1

Mutations1

Enzyme1

Promoter1

Transcript1

Motif1

Cell3

CDNA1

Phylogenetic1