Gene cyclin d1. Medical search. Frequent questions

Cyclins are a group of proteins that play a key role in the control and regulation of the cell cycle. (iiarjournals.org)
Cyclin D1-CDK4 also enables the activation of cyclin E-CDK2 complex by sequestering Cip/Kip family CDK inhibitory proteins p21 and p27, allowing entry into the S phase. (wikipedia.org)
The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)
Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
What you actually find in the genome are coding genes that produce proteins, coupled to regulatory elements that switch the coding genes off and on using a kind of sophisticated boolean logic. (scienceblogs.com)
The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis. (sciencedaily.com)
And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
RNA-seq identifies a novel set of TEAD4 target genes encoding muscle structural and regulatory proteins and those required for the unfolded protein response. (nih.gov)
GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
Genetic alterations were used to propose a new molecular classification for cutaneous melanomas, based upon differentially expressed proteins and genes such as B-RAF, K-RAS, cyclin D1 e CDKN2A. (fapesp.br)
General objective: To evaluate the cell-cycle proteins, the supressor genes and oncogenes in acral lentiginous melanomas. (fapesp.br)
Tumours from 557 incident cases of CRC, assembled in tissue microarrays, were evaluated for expression of cyclin D1, mismatch repair proteins, beta-catenin and epidermal growth factor receptor (EGFR) by immunohistochemistry, and further, EGFR gene copy number (GCN) alterations by brightfield double-in situ hybridization. (lu.se)

Background/Aim: Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. (iiarjournals.org)
Cyclin D1, a 45-kDa protein encoded by the cyclin D1 gene ( CCND1 ) on 11q13, is one such molecule. (iiarjournals.org)
Expression of cyclin D1 has been reported to be a strong predictor for the clinical outcome of OSCC ( 4 ), and amplification of CCND1 was found significantly more frequently in patients with OSCC than in healthy controls ( 5 ), suggesting the predictive and prognostic value of this molecule and its potential as a therapeutic target. (iiarjournals.org)
Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. (wikipedia.org)
The CCND1 gene encodes the cyclin D1 protein. (wikipedia.org)
The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). (wikipedia.org)
Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
It was shown that amplification of CCND1, a gene encoding cyclin D1, was more prevalent in parathyroid carcinomas than in adenomas (71 vs. 21 %, p = 0.056). (nih.gov)
another is mutation of T286 in cyclin D1 (CCND1) causing the loss of phosphorylation of T286 is involved in nuclear accumulation of cyclin D1 in esophageal cancer [ 14 ]. (hindawi.com)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)

Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4. (nature.com)
We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)

Additionally, the mRNA and protein expression of cyclin D1, cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (pRb), was further down-regulated under exposure to lovastatin in condition of BRCA1 overexpression, but the expression of p21WAF1/CIP1, a cyclin-dependent kinase inhibitor (CDKI), was further up-regulated, both in vitro and in vivo detected with quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis. (nih.gov)
Further, the overexpression of HER3 enhanced cyclin D1 mRNA expression, while HER3 deleted of its identified TADs was hindered at doing so. (plos.org)
Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)
In addition, it was found that icariin-induced effect on neural stem cells is associated with increased mRNA and protein expression of cell cycle genes cyclin D1 and p21. (biomedcentral.com)
Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)
5. Correlate immunohistochemical expression, mRNA e gene amplification or deletion of genes p16, CCDN1 e PTEN. (fapesp.br)
7. Correlate the immunohistochemical, FISH and mRNA expression of cyclin D1, p16, CCDN1e PTEN, K-RAS and B-RAF mutations with histopathology and clinical behaviour. (fapesp.br)

However, compared to normal ovarian tissues, overexpression of cyclin D1 and c-Myc was observed in 42.6% (20/47) and 65.9% (31/47) of tumors examined, respectively. (bmj.com)
There was no significant difference of overexpression of cyclin D1 or c-Myc gene products between these four histologic subtypes of ovarian adenocarcinomas. (bmj.com)

This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (wikipedia.org)
Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). (wikipedia.org)
Cyclin D1-CDK4 inhibits pRb through phosphorylation, allowing E2F transcription factors to transcribe genes required for entry into the S phase. (wikipedia.org)
Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. (wikipedia.org)
We found that p27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1 (CDK4-CycD1). (rcsb.org)
Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation. (nih.gov)
Cyclin-dependent kinase 4/6 (CDK4/6) inhibition, a treatment used with some breast cancers, might also prove effective against tumor suppressor SMARCA4 ( BRG1 ) mutation-harboring lung cancers and a rare, aggressive form of SMARCA4 mutation-driven ovarian cancer, suggest preclinical findings reported in a pair of papers in Nature Communications . (cancernetwork.com)
Working with Huang and others, he also showed that SMARCA4 loss in SCCOHT causes cyclin D1 deficiency, and hence, susceptibility to CDK4/6 inhibitors. (cancernetwork.com)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (wikipedia.org)
We investigated FLT3 -ITD mutations, bone marrow blast cell count, CD34, cyclin D1, Bcl-xL and hENT1 expression in bone marrow aspirates from 22 de novo AML patients in a cross sectional study. (iranpath.org)
In patients with FLT3 -ITD mutations, CD34 and cyclin D1 expressions were higher (MFI 328.80 vs 25.78, p =0.003 and MFI 74.51 vs 57.15 p =0.005) than the patients without mutations. (iranpath.org)
A significant association was found between FLT3 -ITD gene mutations in AML patients with bone marrow blast cell count, CD34, cyclin D1 and hENT1 expressions, however no association was obtained with Bcl-xL expression. (iranpath.org)
Importance of detecting FLT3 and NPM1 gene mutations in acute myeloid leukemia - World Health Organization classification 2008. (iranpath.org)
ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
Mutations of the gene encoding CDC73 ( HRPT2 , 1q31.2) cause hyperparathyroidism-jaw tumor syndrome, and a high proportion (15%-37.5%) of these patients develop parathyroid cancer. (medscape.com)
[ 6 ] HRPT2 mutations can also be seen in benign parathyroid adenomas, but carcinomas more frequently exhibit alterations in gene copy number and have large-scale chromosomal deletions. (medscape.com)
Mutations of the MEN1 gene can occasionally be seen in parathyroid carcinomas. (medscape.com)
Either at genomic or at proteomic level, mutations have significant impact on normal gene or protein function, and human diseases could be associated with mutations like nonsynonymous single-nucleotide variations (nsSNVs) on amino acids. (hindawi.com)
Yet how gene mutations affect protein activities through posttranslational modification sites have not been widely studied. (hindawi.com)
Although data of both gene mutations and PTMs are increasing fast, the proteome-wide analysis on the relationship between damaged PTMs and human diseases is not well studied. (hindawi.com)
Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
Foulkes previously discovered that loss-of-function mutations in the chromatin remodeling gene SMARCA4 is ubiquitous in SCCOHT in the course of investigating the genetic roots of rare familial ovarian tumors. (cancernetwork.com)

In certain circumstances, when a lymph node is not easily accessible for excisional or incisional biopsy, a combination of core biopsy and FNA biopsies in conjunction with appropriate ancillary techniques for the differential diagnosis (immunohistochemistry, flow cytometry, PCR for IGHV and TCR gene rearrangements, karyotype, and fluorescence in situ hybridization [FISH] for major translocations) may be sufficient for diagnosis. (medscape.com)

They are able to build complexes with cyclin-dependent kinases (CDKs) and regulate their activity ( 2 ). (iiarjournals.org)
The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). (rcsb.org)
Two new studies found that targeting the cyclin-dependent kinases 4/6 exposed a vulnerability in SMARCA4-deficient cancers. (cancernetwork.com)
Cyclins function as regulators of CDK kinases. (genetex.com)

Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. (wikipedia.org)

Cyclin D1 was originally cloned as a breakpoint rearrangement in parathyroid adenoma and was shown to be required for progression through the G1 phase of the cell cycle to induce cell migration, angiogenesis and to induce the Warburg effect. (wikipedia.org)
Cyclin D1 is a protein required for progression through the G1 phase of the cell cycle. (wikipedia.org)
Cyclin D1 overexpression has been shown to correlate with early cancer onset and tumor progression and it can lead to oncogenesis by increasing anchorage-independent growth and angiogenesis via VEGF production. (wikipedia.org)
Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
This study evidently demonstrates the potentiating effect of ICA on neural stem cell growth and proliferation, which might be mediated through regulation of cell cycle gene and protein expression promoting cell cycle progression. (biomedcentral.com)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis. (positivehealth.com)
The above studies shows how Vitamin E succinate interacts in different ways with the complex array of genes involved in the development and progression of prostate cancer - genes involved in proliferation, apoptosis, angiogenesia and metastasis. (positivehealth.com)

Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2-dependent transcription. (biomedcentral.com)
Next, we identified full-length nuclear HER3 association and regulation of a 122 bp region of the cyclin D1 promoter. (plos.org)
Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. (nature.com)

Cyclin D1 has been found to be overexpressed in breast carcinoma. (wikipedia.org)
A multiplex ligation-dependent probe amplification method was used to compare differences in copy number in 39 common tumor-associated genes among 7 patients with parathyroid carcinoma and 14 age- and sex-matched subjects with parathyroid adenoma. (nih.gov)
Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma. (nih.gov)
Cyclin D1 overexpression has been associated with parathyroid carcinoma. (medscape.com)

Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. (plos.org)
To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
SIP1 represses cyclin D1 transcriptional activity via direct interaction with Z-boxes 1-3 in the cyclin D1 promoter. (wikiversity.org)

Cyclins function as regulators of CDKs (cyclin-dependent kinase). (wikipedia.org)

it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)

Independent of CDK, cyclin D1 binds to nuclear receptors (including estrogen receptor α, thyroid hormone receptor, PPARγ and AR ) to regulate cell proliferation, growth, and differentiation. (wikipedia.org)
Cyclin D1 also binds to histone acetylases and histone deacetylases to regulate cell proliferation and cell differentiation genes in the early to mid-G1 phase. (wikipedia.org)
In this study we aimed to investigate the association of FLT3 -ITD gene mutation with bone marrow blast cell count, CD34 expression as malignant cell burden, cyclin D1 and Bcl-xL expressions as indexes of cell proliferation and anti-apoptosis and human equilibrative nucleoside transporter 1 (hENT1) expression as cytarabine transporter during AML treatment. (iranpath.org)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
Further, the mechanism of ICA-induced cell proliferation of neural stem cells was investigated by analyzing the gene and protein expression of cell cycle related genes cyclin D1 and p21. (biomedcentral.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Researchers said the EMC suppressed EATC proliferation by regulating the protein expression of cyclin D1 and p21 genes. (integrativepractitioner.com)
ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)

Cyclin D1 overexpression can also down-regulate Fas expression, leading to increased chemotherapeutic resistance and protection from apoptosis. (wikipedia.org)
[ 7 ] Parafibromin can negatively regulate cyclin D1 and may be responsible at least in part for this. (medscape.com)
methylation at certain residues of histones can regulate gene expression [ 4 ], and glycosylation is responsible for targeting substrates and changing protein half-life [ 2 ]. (hindawi.com)

β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)
The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
The TEAD (1-4) transcription factors comprise the conserved TEA/ATTS DNA binding domain recognising the MCAT element in the promoters of muscle-specific genes. (nih.gov)

In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. (sciencedaily.com)

In contrast, the Runx2 gene (also known as Cbfa1) is essential for differentiation of osteoblasts, but also promotes hypertrophic chondrocyte differentiation [ 5 , 7 ]. (biomedcentral.com)
In contrast, TEAD4 represses expression of the growth factor CTGF and Cyclin D1 to promote differentiation. (nih.gov)
Together these results show that TEAD factor activity is essential for normal C2C12 cell differentiation and define a novel and non-redundant role for TEAD4 in regulating expression of the unfolded protein response genes. (nih.gov)

HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)

Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis and deserve further study. (bmj.com)
Gene copy number variations (CNVs) play an important role in tumorigenesis. (nih.gov)
Because the cyclin D1 gene has been implicated in a variety of other human cancers these findings may have broad implications for processing of non coding RNA in human tumorigenesis. (sciencedaily.com)

Repression of cyclin A transcription by ATF3 required the CRE in the cyclin A promoter. (biomedcentral.com)
Figure 6: The role of NRIP1 in mediating gene repression. (nature.com)

Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)

Hyperparathyroidism-jaw tumor (HPT-JT) is a rare autosomal dominant familial cancer syndrome caused by inactivating germline mutation of the Cell Division Cycle 73 ( CDC73 ) gene. (medscape.com)
With the development of high-throughput sequencing technology, gene mutation detection has become another important resource to investigate regulatory mechanisms and cellular processes. (hindawi.com)
6. Identify the mutation status of genes Kras and BRAF in laser microdissected parafin embedded melanomas and epidermal melanocytes adjacent to the lesion. (fapesp.br)

29% of triple-negative BC had PIP5K1A gene amplification. (lu.se)
3. Evaluate the genes p16INK4A, CCDN1 e PTEN for amplification or deletion, through FISH. (fapesp.br)

This truncated variant, cyclin D1b, does not have the part which is required for export from the nucleus into other cell localizations and therefore has higher transforming activity ( 8 ). (iiarjournals.org)
These Ras-mediated pathways lead to the increase in transcription of cyclin D1, and inhibit its proteolysis and export from the nucleus. (wikipedia.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)

Cyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. (bmj.com)
Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)
Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)
Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)
In this type of melanoma, few molecular studies are found, though it has been found that genomic amplifications of chromosome 11q13, 22q11-13 e 5p15, inactivation of the p16 signaling pathway, as well as different expressions of pRb, cyclin D1 e p16. (fapesp.br)

The purpose of this study was to investigate whether breast cancer susceptibility gene 1 (BRCA1) overexpression sensitizes mammary cancer cells to statins. (nih.gov)

The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)

Using in situ hybridization the d1- and d3-cyclin gene expression has been shown in pea ( Pisum sativum L.) root meristem cells under slow horizontal clinorotation and in the stationary conditions. (cytgen.com)

A diagram showing the major cancer genes for some cancers. (cancerquest.org)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (wikipedia.org)

The more aggressive basal-like subtype of breast cancers, however, exhibited lower levels of cyclin D1 and Dicer, which would in turn globally reduce the level of mature miRNA. (sciencedaily.com)

Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted. (sciencedaily.com)

Increasing cyclin D1 levels during the G1 phase is induced by mitogenic growth factors primarily through Ras-mediated pathways, and hormones. (wikipedia.org)
[ 5 ] Parafibromin is thought to act as a tumor suppressor gene but may have several other effects, including histone modification and activation of signaling pathways. (medscape.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
Numerous genes have been identified as proto-oncogenes. (cancerquest.org)

How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Using antisense RNA, Dr. Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo. (sciencedaily.com)

Taken together, our results demonstrate that the exposure of cells to cadmium chloride resulted in cytotoxicity and cell death due to the enhanced ubiquitination and proteolysis and the consequent inhibition of eIF4E gene expression leading to diminished cellular level of critical genes such as cyclin D1. (cdc.gov)

Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)

Many sporadic parathyroid carcinomas also exhibit defects in this gene. (medscape.com)

We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. (biomedcentral.com)

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)

SMARCA4 is a key subunit of SWI/SNF chromatin remodeling complexes regulating gene expression," explained coauthor Sidong Huang, PhD, assistant professor of biochemistry and member of Goodman Cancer Research Centre at McGill University. (cancernetwork.com)

WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
IHC-P analysis of human tonsil tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
There are currently no references for Cyclin D1 antibody [RM241] (GTX33611) . (genetex.com)

In vivo SIP1, or Zinc finger E-box-binding homeobox 2 (ZEB2), binds "to potential SIP1-binding sites (Z-boxes) located in the vicinity of the cyclin D1 transcription start site. (wikiversity.org)

Cyclin D1 overexpression is correlated with shorter cancer patient survival and increased metastasis. (wikipedia.org)
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. (nature.com)
Study helps to shed some light on the genes that mediate breast cancer metastasis to the lung but not other organs. (hum-molgen.org)

The results reaffirm cyclin D1 as a candidate target for molecular therapeutic control of breast tumor development. (hum-molgen.org)
Molecular analysis of cyclin D1 modulators PRKN and FBX4 as candidate tumor suppressors in sporadic parathyroid adenomas. (cdc.gov)

They found that patients with the luminal A subtype of breast cancer had increased levels of expression of both cyclin D1 and Dicer. (sciencedaily.com)
Gene expression profiling predicts clinical outcome of breast cancer. (nature.com)
A gene-expression signature as a predictor of survival in breast cancer. (nature.com)
Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network vat recente ontwikkelingen samen en beschrijft hoe het Preagnant netwerk een professionele infrastructuur creeërt voor patiënten en professionals, artsen en onderzoekers. (kanker-actueel.nl)

Epstein-Barr virus latent membrane protein expression and cyclin DI cell cyase protein expression in malignant and normal oesophageal tissues to see whether any variation in their expression in these tissues could be of diagnostic or prognostic value. (bvsalud.org)

The genes in the second group are called tumor suppressors. (cancerquest.org)

Anatomy1

Chemicals and Drugs33

Phenomena and Processes8

Proteins12

CCND110

Target genes5

MRNA7

Overexpression of cyclin2

CDK49

Mutations14

Immunohistochemistry1

Kinases4

Mantle cell lym1

Progression9

Regulation3

Carcinoma4

Transcriptional3

CDKs1

Inhibits1

Proliferation8

Regulate3

Transcription factors3

Induces1

Differentiation3

Epidermal growth f1

Tumorigenesis3

Repression2

Tumour cells1

Mutation3

Amplification2

Nucleus3

Pathway5

Susceptibility1

PRAD11

Situ hybridization1

Cancer genes1

Highly conserved1

Cancers1

Induce1

Pathways4

Proto-oncogenes2

Immunohistochemical1

Mammary1

Proteolysis1

Expression of ge1

Parathyroid carcinomas1

Cell cycle1

Protein encoded by this gene1

Subunit1

Antibody3

Binds1

Metastasis3

Molecular2

Breast cancer4

Malignant1

Tumor suppressors1