AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
HLA AntigensHLA-B AntigensHLA-DR AntigensHLA-A AntigensHistocompatibility TestingHLA-DRB1 ChainsHLA-DQ beta-ChainsHLA-DQ AntigensAntigensHistocompatibility Antigens Class IAllelesHLA-C AntigensHLA-G AntigensLeukocytesAntigens, NeoplasmHaplotypesAntigens, SurfaceHLA-DP beta-ChainsHLA-B52 AntigenGenes, MHC Class IAntigens, BacterialHistocompatibilityHLA-A2 AntigenHLA-B44 AntigenHLA-D AntigensHLA-DR Serological SubtypesGenes, MHC Class IIMolecular Sequence DataHLA-DP AntigensHistocompatibility Antigens Class IIGene FrequencyAntigens, ViralGenetic Predisposition to DiseaseAmino Acid SequenceEpitopesT-Lymphocytes, CytotoxicT-LymphocytesLeukocyte RollingHLA-B27 AntigenHLA-A24 AntigenMajor Histocompatibility ComplexGenotypeHLA-B8 AntigenHLA-B18 AntigenAntigens, CDPolymorphism, GeneticHLA-DP alpha-ChainsIsoantibodiesHLA-B51 AntigenHLA-DR3 AntigenHLA-DR2 AntigenReceptors, KIRHistocompatibility AntigensKiller Cells, NaturalTransplantation, HomologousHLA-A1 AntigenHLA-B35 AntigenBase SequenceAntibodies, MonoclonalHLA-DQ alpha-ChainsHLA-DR4 AntigenEpitopes, T-LymphocyteGraft RejectionTissue DonorsChromosomes, Human, Pair 6Graft vs Host DiseaseFlow CytometryHLA-B7 AntigenCase-Control StudiesGraft SurvivalHLA-A3 AntigenLeukocyte Countbeta 2-MicroglobulinCD8-Positive T-LymphocytesPeptidesCell LineReceptors, Antigen, T-CellLymphocyte ActivationChromosome MappingReceptors, ImmunologicReceptors, Natural Killer CellLeukocyte ElastasePolymerase Chain ReactionPhenotypeH-2 AntigensCytotoxicity, ImmunologicAntigens, ProtozoanMultigene FamilyCord Blood Stem Cell TransplantationInterferon-gammaLinkage DisequilibriumHLA-DR beta-ChainsAntigens, Polyomavirus TransformingReceptors, KIR3DL1Hematopoietic Stem Cell TransplantationNarcolepsyGenesChemotaxis, LeukocyteMelanomaHLA-DR5 Antigen
Immune systemChromosomeHLAsPolymorphismsProfessional antigen-preseHistocompatibilityHighly polymorphicVariantsAntibodiesLociMoleculesProteinsSusceptibilityGeneticAllelesGeneticsLinkageMajorTransplantImmunologyMutationsEpitopesGenotypingGenomePolymorphismPeripheralDiseaseResearch integrates issuesSeveral genesInnateMarkersMolecularPopulationsToxinMoleculePeptidesTransplantationReceptorRegulationEncodesMicrobialRoleMacrophagesSNVsIsotypeIntegratesProteinAbstractAdaptiveLymphocyteStronglyCellFamilyFragmentsCloselyGroupPerson'sStudyLocusDevelopment
Immune system17
  • Individuals inherit two different HLA haplotypes, one from each parent, each containing more than 200 genes relevant to helping the immune system recognize foreign invaders. (wikipedia.org)
  • MHC Class II molecules-HLA-DR, and HLA-DQ and HLA-DP-are only present on antigen presenting cells and are responsible for presenting molecules from invading organisms to cells of the immune system. (wikipedia.org)
  • The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
  • This genetic complex helps the immune system distinguish between the body's own proteins and those made by viruses and bacteria. (medicalnewstoday.com)
  • The HLA genotype affects the presentability of tumour antigens to the immune system. (fondationuniversitaire.be)
  • These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbiota. (biomedcentral.com)
  • The immune system genes that protected north coast First Nations from possibly dangerous local pathogens thousands of years ago likely increased their vulnerability to European diseases in the nineteenth century, resulting in the disastrous population crash, a new genetic study has discovered. (nwcoastenergynews.com)
  • The most well-studied of these genes is HLA-DQB1 , which provides instructions for making part of a protein that plays an important role in the immune system. (encyclopedia.pub)
  • The HLA-DQB1 gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. (encyclopedia.pub)
  • By staying informed about emerging discoveries and their potential clinical implications, we can work together to translate these insights into improved patient outcomes and a better understanding of the human immune system. (thesequencingcenter.com)
  • Proteins called Major Histocompatibility Complex (MHC) are involved in the functioning of the immune system. (scienceabc.com)
  • The HLA complex is an important part of the immune system, helping distinguish between harmless proteins (from self, diet or environment) and harmful foreign proteins from viruses and bacteria. (dnaaccesslab.com)
  • The protein encoded by the HLA-DQA1 and HLA-DQB1 genes form a complex together to display foreign proteins to the immune system in order to trigger a response against the foreign invader. (dnaaccesslab.com)
  • These complexes recognize the gliadin fraction from gluten and display this foreign protein to the immune system, initiating an immune response. (dnaaccesslab.com)
  • The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
  • Substantial scientific evidence suggests that a group of related genes that make up part of our immune system or Human Leukocyte Antigen (HLA) Complex can be predictive of physical attraction and long-term relationship satisfaction. (dnamatch.love)
Chromosome10
HLAs4
Polymorphisms9
  • After adjusting for potential confounders, single nucleotide polymorphisms (SNPs) mapping to HLA-E, HLA-B, HLA-DOA, HLA-DQA2, and HLA-DPB1 genes showed associations with altered risk of developing DA. (cdc.gov)
  • This was done by a large number of techniques that make use of DNA fragments (restriction fragment-length polymorphisms) so as to permit linkage mapping and gene sequencing. (medscape.com)
  • Other polymorphisms, besides the 14 bp polymorphism (rs66554220), in the 3′-untranslated region (3′-UTR) (exon 8) of the HLA-G gene might be associated with severe pre-eclampsia, especially in primiparas. (ruc.dk)
  • To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)
  • This gene exhibits few polymorphisms. (nih.gov)
  • 2 - 9 The underlying pathogenic mechanisms of the co-occurrence between AITD and RA are not well understood, but polymorphisms in genes involved in the regulation of T-cell response may play a key role. (bmj.com)
  • To investigate the possible role of IFNA gene polymorphisms in the pathogenesis of narcolepsy, we have genotyped two single nucleotide polymorphisms in IFNA genes as well as a neighbouring microsatellite. (uni-luebeck.de)
  • They looked at many points on the human genome called single-nucleotide polymorphisms (SNPs), with each SNP representing a difference in a single DNA building block, called a nucleotide. (nih.gov)
  • Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
Professional antigen-prese1
Histocompatibility16
Highly polymorphic2
  • The MHC genes are highly polymorphic, with thousands of versions of the MHC receptors in the population, though any one individual can have no more than two versions for any one locus. (wikipedia.org)
  • Given their immunological importance, HLA genes are highly polymorphic, with HLA-A being one of the most diverse. (thesequencingcenter.com)
Variants14
  • Variants in the HLA-B gene, particularly a version called HLA-B27 , significantly increase the risk of developing ankylosing spondylitis. (medlineplus.gov)
  • MHC class I and class II gene variants are associated with diisocyanate -induced asthma. (cdc.gov)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • We interrogated 850,000 CpG sites of the human genome for DNA methylation variants. (cdc.gov)
  • In the new study, the team found that variants of an immune-related gene that were beneficial to many of those living in the region before European contact proved disadvantageous once the Europeans arrived. (nwcoastenergynews.com)
  • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. (research.com)
  • In this blog post, we will discuss common allele variants of HLA-A and their associated disease states, as well as ongoing research that seeks to improve our understanding of HLA-A's role in human health. (thesequencingcenter.com)
  • The HLA-A gene is a fascinating and complex subject of study, with its diverse allele variants playing crucial roles in human immunity and disease. (thesequencingcenter.com)
  • Namely, a significant portion of the inherited susceptibility to common diseases may be due to summation of the effects of a series of low-frequency dominantly and independently acting variants of a variety of different genes. (nature.com)
  • 6 Regarding RA, deep exon sequencing of 25 biological candidate genes which were identified by genome-wide association studies revealed that the aggregated contribution of low-frequency and common coding variants to the risk of RA using 10 609 RA cases and 35 605 controls. (nature.com)
  • NIH researchers identify new gene variants associated with risk for complex inflammatory syndrome. (nih.gov)
  • She noted that not all of the 800,000 gene variants analyzed were directly genotyped. (nih.gov)
  • Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci. (elifesciences.org)
  • In order to expand our understanding of how recombination might influence virus variation during the course of adaptation, we focused on large DNA viruses, in which rapidly evolving populations can simultaneously harbor both adaptive gene copy number variation and beneficial single nucleotide variants (SNVs) at the same locus. (elifesciences.org)
Antibodies3
Loci6
  • Increased T1D disease risk from IL-2 pathway loci in the TwinsUK cohort of human subjects resulted in some similar microbiota changes to those observed in the NOD mouse. (biomedcentral.com)
  • The DNA methylation content of 33 CpG loci was linked with the presence of MIS-C. Of these sites, 18 (54.5%) were located in described genes. (cdc.gov)
  • In a recent meta-analysis using greater than 100 000 subjects, the 100 RA risk loci outside the human leukocyte antigen region explained only 5.5% and 4.7% of heritability in Europeans and Asians, respectively. (nature.com)
  • The current study represents an important advance because it dramatically broadens the spectrum of genetic loci associated with Behcet's disease," said Dan Kastner, M.D., Ph.D., scientific director of the Intramural Research Program at the National Human Genome Research Institute and senior author of the study. (nih.gov)
  • The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
  • Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
Molecules6
  • MHC Class I molecules-HLA-A, HLA-B, and HLA-C-are present on all nucleated cells and are responsible for signaling to an immune cell that an antigen is inside the cell. (wikipedia.org)
  • for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
  • MHC molecules display a molecular fraction called an epitope and mediate interactions of leukocytes with other leukocytes or body cells. (projekthouse.eu)
  • Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
  • Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
  • Therefore, the lymphocytes are distinguished by their function and response to antigen, their cell membrane molecules and receptors, their types of secreted proteins, and their tissue location. (pediagenosis.com)
Proteins5
  • These genes include MHC class I and class II cell-surface proteins. (wikipedia.org)
  • MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. (medlineplus.gov)
  • The HLA-B gene has many possible variations, that result in the production of proteins that differ by changes in at least one protein building block (amino acid). (medlineplus.gov)
  • The 17- and 45-kDa proteins, which are also present in greater amounts with the T. pallidum inner membrane protoplasmic cylinder complex, had been previously characterized lipoproteins and are, therefore, not membrane-spanning but rather membrane-anchored by their lipid moiety. (cdc.gov)
  • The proteins encoded by genes in Human Leukocyte Antigen (HLA) complex regulate the innate and adaptive arms of human immune responsiveness through antigen recognition, and presentation, inflammation regulation, and the complement system, and the impact of this region is well documented in solid organ and hematopoietic stem cell transplantation, and in various immune-mediated conditions. (frontiersin.org)
Susceptibility4
  • Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
  • Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
  • Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
  • Genetic factors are thought to play a role in susceptibility to Behcet's disease, with the human leukocyte antigen (HLA) B-51 gene region of the genome, accounting for about 20 percent of genetic risk for the disease. (nih.gov)
Genetic11
  • In the 1930s and 1940s, George Snell and Peter Gorer individually isolated the genetic factors that when similar allowed transplantation between mouse strains, naming them H and antigen II respectively. (wikipedia.org)
  • The present results are consistent with the hypothesis that an immunological mechanism is involved in DA and that genetic variations within HLA genes play a role in DA risk. (cdc.gov)
  • As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
  • The DRom 1.0 algorithm developed by DNA Romance utilizes 100 SNP markers in candidate genes associated with attraction and relationships to predict romantic chemistry between individuals in online dating, offering a more efficient and transparent matchmaking process by considering genetic compatibility in addition to other factors such as personality and interests. (dnaromance.com)
  • Natural selection meant that those ancient people with genetic resistance to those local diseases had an advantage that resulted in the genes becoming part of the population. (nwcoastenergynews.com)
  • Her biological study deals with issues like HLA Complex, which deal with fields such as Genetic predisposition. (research.com)
  • Although a strong link has been established of complex interactions between genetic background and environmental factors. (physio-pedia.com)
  • [14] Studies have shown factors such as genetic background gene called ( HLA-B27), microbial infection, endocrinal abnormalities and immune reaction related to the occurrence of AS. (physio-pedia.com)
  • Named for the Turkish physician who described it in 1937, Behcet's (pronounced BET'-chets) disease is triggered by complex genetic and environmental factors, and causes inflammation of blood vessels in various parts of the body. (nih.gov)
  • This study reveals a new mechanism for the fluid gain of beneficial mutations in genetic regions undergoing active recombination in viruses and illustrates the value of long read sequencing technologies for investigating complex genome dynamics in diverse biological systems. (elifesciences.org)
  • Gene duplication is long recognized as a potential source of genetic innovation ( Ohno, 1970 ). (elifesciences.org)
Alleles6
  • Most HLA-B gene alleles are rare, while others do not affect protein function or change the structure of the protein. (medlineplus.gov)
  • Hundreds of versions (alleles) of the HLA-B gene are known, each of which is given a particular number (such as HLA-B27 ). (medlineplus.gov)
  • Sequence determination of the MICA gene identifies 5 alleles with 4, 5, 6, and 9 repetitions of GCT or 5 repetitions of GCT with 1 additional insertion (GGCT), and the alleles are referred to as A4, A5, A5.1, A6, and A9. (nih.gov)
  • The HLA classifier uses machine learning to provide a positive or negative call for 145 HLA genes and alleles. (adaptivebiotech.com)
  • HLA genes vary significantly between individuals and several hundred different versions (or alleles) of the HLA-DQA1 and HLA-DQB1 genes have been identified. (dnaaccesslab.com)
  • Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
Genetics4
  • Her primary areas of investigation include Immunology, Genetics, Human leukocyte antigen, Genome-wide association study and Single-nucleotide polymorphism. (research.com)
  • Benedicte A. Lie mainly focuses on Genetics, Immunology, Human leukocyte antigen, Allele and Single-nucleotide polymorphism. (research.com)
  • Benedicte A. Lie works mostly in the field of Genome-wide association study, limiting it down to concerns involving Arthritis and, occasionally, Genetics and Candidate gene. (research.com)
  • One of the purposes of this website is to allow the possibility to explore the often overlooked component of genetics as it may relate to personality and human love relationships. (dnamatch.love)
Linkage1
Major1
  • In the next step, four SNVs from three genes related to the mitochondrial respiratory chain were selected, which is a major source of ROS, and conducted a case-control study. (nature.com)
Transplant1
  • HLA traveled a long distance from initially being regarded as a transplant antigen to becoming a molecule of interest in the 21st century for the development of novel diagnostics and therapeutics in the treatment of human diseases, vaccine design, pharmacogenetics, and genomics. (frontiersin.org)
Immunology1
  • The scientist's investigation covers issues in Internal medicine, Human leukocyte antigen, microRNA, Chronic fatigue syndrome and Immunology. (research.com)
Mutations5
  • By the mid 1980s, techniques largely had switched from those of the biochemistry of intermediates and enzymes to the identification of mutations in genes. (medscape.com)
  • Data from the Human Genome Project surely will be useful in identifying mutations in the thousands of genes that must underlie inherited diseases of the central and peripheral nervous system. (medscape.com)
  • Until the genes and their mutations that underlie neurological disease are characterized, inherited disorders have to be defined the way clinicians have been classifying disease over the last 2 centuries. (medscape.com)
  • However, many simulations revealed that mutations in certain genes such as human leukocyte antigen (HLA) complex may trigger the risk of developing Juvenile Idiopathic Arthritis. (delveinsight.com)
  • Canine narcolepsy is caused by mutations in the orexin receptor 2 gene, and narcoleptic patients show specifically decreased cerebrospinal fluid orexin levels. (uni-luebeck.de)
Epitopes1
Genotyping2
  • However, NGS SNP calling or genotyping is no small feat. The obtained sequences often contain subtle yet complex errors involving uncertainties, biases, and pesky false positive results. (bitesizebio.com)
  • The Human leukocyte antigen study combines topics in areas such as Haplotype, Genotyping, Allele frequency and Asymptomatic. (research.com)
Genome5
  • The human genome at one time was estimated to have 70,000-100,000 genes. (medscape.com)
  • New data from the Human Genome Project suggest this number may be closer to 30,000. (medscape.com)
  • Here are ten ways scent, our sense of smell and the human genome interacts to influence our relationships. (dnaromance.com)
  • Researchers have identified four new regions on the human genome associated with Behcet's disease, a painful and potentially dangerous condition found predominantly in people with ancestors along the Silk Road. (nih.gov)
  • Critical to sub-classify SRBCTs, Khan et al .6 used to measure genome-wide gene expres- .com decisions in cancer therapeutics are to microarrays to monitor the expression sion for a variety of biological samples. (lu.se)
Polymorphism2
  • A 14 bp insertion/deletion polymorphism exists in exon 8 of the HLA-G gene. (ruc.dk)
  • Her Single-nucleotide polymorphism research is multidisciplinary, relying on both IRF5, Locus and Candidate gene. (research.com)
Peripheral4
  • Multiparameter flow cytometric analysis of HLA-DR expression on Human peripheral blood leucocyte populations. (bdbiosciences.com)
  • All experiments performed on human Peripheral blood mononuclear cells in the presence of human SeroBlock ( BUF070A ). (bio-rad-antibodies.com)
  • Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells. (research.com)
  • HuT 78, HT, CEMx174) and in primary human and nonhuman primate peripheral blood leukocyte cultures (13). (cdc.gov)
Disease11
  • Several versions of the HLA-B gene, particularly HLA-B51 , are associated with an increased risk of developing Behçet disease, a chronic inflammatory condition that affects many parts of the body. (medlineplus.gov)
  • Although many people with Behçet disease have the HLA-B51 variation, most people with this version of the HLA-B gene never develop the condition. (medlineplus.gov)
  • The genes most likely linked with autoimmune Addison's disease belong to the human leukocyte antigen complex. (medicalnewstoday.com)
  • It is an autoimmune, polygenic disease, associated with several genes on different chromosomes. (nih.gov)
  • The genes, the human leukocyte antigen gene family, known as HLA, helps the body recognize and respond to pathogens, or disease causing bacteria and viruses. (nwcoastenergynews.com)
  • Narcolepsy is a neuropsychiatric disease caused by complex disturbance of sleep regulation. (uni-luebeck.de)
  • Find out whether you carry any genes associated with celiac disease. (dnaaccesslab.com)
  • For nearly 2,000 years, traders used this 4,000-mile network linking the Far East with Europe to exchange goods, culture and, in the case of the Silk Road disease, genes. (nih.gov)
  • An important association between Behcet's disease and a gene called ERAP1. (nih.gov)
  • Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)
  • Her primary tasks involve coordinating human disease surveillance activities for tickborne and mosquito-borne diseases in Minnesota as well as working on a variety of studies and special projects regarding the ecology and epidemiology of vector borne diseases in the upper Midwest. (cdc.gov)
Research integrates issues1
  • His research integrates issues of Molecular biology, Human leukocyte antigen and Regeneration in his study of Induced pluripotent stem cell. (research.com)
Several genes1
Innate1
  • Leukocytes involved in the innate immune response, such as macrophages and DCs, also play a key role in adaptive immunity because they function as APCs. (pediagenosis.com)
Markers2
  • Since few DNA testing companies offer exactly the same DNA test, making a comparison between tests can be confusing, here we outline the number of DNA markers provided by some of the notable DNA testing companies including 23andMe, Ancestry DNA, Family Tree DNA, GPS Origins, My Heritage and Genes For Good. (dnaromance.com)
  • This is because human leukocyte antigen (HLA) markers used in matching donors are inherited. (health-e.org.za)
Molecular2
  • Hiroshi Kawamoto interconnects Cell, Gene rearrangement, Gene and Transplantation in the investigation of issues within Molecular biology. (research.com)
  • His work in Molecular biology addresses issues such as Induced pluripotent stem cell, which are connected to fields such as Human leukocyte antigen, CTL*, T cell and T-Cell Receptor Gene. (research.com)
Populations2
  • The bivariate pseudocolor density plot showing the correlated expression of HLA-DR (or Ig Isotype control staining) versus side-light scatter (SSC-A) signals was derived from gated events with the side and forward light-scatter characteristics of intact leucocyte populations. (bdbiosciences.com)
  • We performed experimental evolution with vaccinia virus populations harboring a SNV in a gene actively undergoing copy number amplification. (elifesciences.org)
Toxin2
  • When an antigen (germ or toxin) enters a cell, it is broken down by intracellular enzymes into little pieces called peptide fragments. (scienceabc.com)
  • The regulatory cells assist in orchestrating and controlling the immune response, while effector cells carry out the elimination of the antigen (microbial, non microbial, or toxin). (pediagenosis.com)
Molecule1
  • Once the first encounter occurs, these cells can exactly recognize a particular microorganism or foreign molecule because each lymphocyte is capable of targeting a specific antigen and differentiating the invader from self or from other substances that may be similar to it. (pediagenosis.com)
Peptides2
  • A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
  • If we identify with the help of NGS data which tumor-specific genes express mutant peptides that are able to activate T cells, then we can design vaccines to boost the natural immune response to the tumor, this mutant peptides are also called neoantigens. (sixthresearcher.com)
Transplantation1
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Receptor4
  • This unique tool is based on T-cell receptor sequencing data generated from Adaptive's partnership with Microsoft and our Antigen Map project from ~4,000 HLA typed samples. (adaptivebiotech.com)
  • In his study, which falls under the umbrella issue of T cell, T-cell receptor, Cancer research and Antigen is strongly linked to Cytotoxic T cell. (research.com)
  • [14] [15] The exact role of this antigen is unknown but is believed to act as a receptor for an inciting antigen leading to AS. (physio-pedia.com)
  • We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
Regulation4
  • However, once the sequence was identified, the rate of accumulation of knowledge concerning the biology of this hormone was extraordinarily rapid, resulting in information about the structure of its gene complex, the mechanisms of GRH action, the regulation of its secretion, and its potential use in treating both humans and animals. (deepdyve.com)
  • His study looks at the intersection of Cellular differentiation and topics like Transcription factor with Promoter and Regulation of gene expression. (research.com)
  • His Cell biology study combines topics from a wide range of disciplines, such as Cellular differentiation, Enhancer, Transcription factor, Cell fate determination and Regulation of gene expression. (research.com)
  • Each of the four newly identified gene regions is already known to play a role in immune regulation. (nih.gov)
Encodes1
Microbial1
  • T and B lymphocytes are unique in that they are the only cells in the body capable of recognizing specific antigens present on the surfaces of microbial agents and other pathogens. (pediagenosis.com)
Role1
  • Åke Lernmark's research is focused on the role of human leukocyte antigens (HLA) and non-HLA genes in the etiology and development of type 1 diabetes, with a particular emphasis on uncovering the importance of diabetes-related autoantibodies. (lu.se)
Macrophages2
  • Cytotoxic T lymphocytes, macrophages, and other leukocytes function as effector cells in different immune responses. (pediagenosis.com)
  • SIV antigen has been demonstrated by immunohistochemical methods in lymph node sinus histiocytes, macrophages, and giant cells (14) as well as in macrophage-derived cells in brain tissue from diseased monkeys (8). (cdc.gov)
SNVs1
  • Using long sequencing reads from the Oxford Nanopore Technologies platform, we phased SNVs within large gene copy arrays for the first time. (elifesciences.org)
Isotype3
  • Human whole blood was stained with either BD Horizon™ RB780 Mouse IgG2a, κ Isotype Control (Cat. (bdbiosciences.com)
  • Figure A. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse IgG2a isotype control ( MCA929AMO ). (bio-rad-antibodies.com)
  • Figure A. RPE conjugated Mouse anti Human CD11c ( MCA2087PE ) and FITC conjugated Mouse IgG2a isotype control ( MCA929F ). (bio-rad-antibodies.com)
Integrates1
  • a pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (pVAC-Seq) that integrates tumor mutation and expression data (DNA- and RNA-Seq) ( original article ). (sixthresearcher.com)
Protein2
  • A unique physical feature of Treponema pallidum , the venereally transmitted agent of human syphilis, is that its outer membrane contains 100-fold less membrane-spanning protein than the outer membranes of typical gram-negative bacteria, a property that has been related to the chronicity of syphilitic infection. (cdc.gov)
  • or the transmembrane protein gene cassettes of some pathogenic bacteria ( Santoyo and Romero, 2005 ), gene conversion can also generate sequence diversity. (elifesciences.org)
Abstract1
  • abstract = "Abnormal human leukocyte antigen G (HLA-G) expression may be involved in pre-eclampsia. (ruc.dk)
Adaptive2
  • The "positive selection" genes found in the remains of ancient members of the Coast Tsimshian people, has been replaced by another gene among the modern descendants that "has been associated with a variety of colonization-era infectious diseases, including measles and tuberculosis, and with the adaptive immune response to the vaccinia virus, which is an attenuated form of smallpox," the authors wrote. (nwcoastenergynews.com)
  • Our analysis uncovered a mechanism of adaptive SNV homogenization reminiscent of gene conversion, which is actively driven by selection. (elifesciences.org)
Lymphocyte3
  • Each T lymphocyte develops specificity against a specific antigen. (pediagenosis.com)
  • Strains of SIV have been successfully cultured in human lymphocyte cell lines (e.g. (cdc.gov)
  • SIV appears to be primarily tropic for CD4 (T4)-positive leukocytes and has not been successfully propagated in B-lymphocyte cell lines (e.g. (cdc.gov)
Strongly1
  • A variation of the HLA-DQB1 gene called HLA-DQB1*06:02 has been strongly associated with narcolepsy, particularly in people who also have cataplexy and a loss of hypocretins. (encyclopedia.pub)
Cell4
  • His work deals with themes such as T cell, Leukemia, Cell culture and Antigen, which intersect with Cytotoxic T cell. (research.com)
  • Cell-mediated and humoral immunity is capable of responding to millions of antigens each day because there is an enormous variety of lymphocytes that have been programmed and selected during cellular development. (pediagenosis.com)
  • The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
  • Also, SIV is distinct from simian T-cell lymphotropic virus type I (STLY-I) which shares extensive genomic sequences with human T-lymphotropic virus type I and is associated with T-cell lymphomas in nonhuman primates (12). (cdc.gov)
Family4
  • Due to the inherited nature of HLA genes, family members are more likely to be histocompatible. (wikipedia.org)
  • HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The genes HLA-DQA1, HLA-DQB1 and HLA-DRB1 belong to a family of genes called the Human Leukocyte Antigen Complex (HLA). (sanat.io)
  • Simian immunodeficiency virus (SIV) belongs to the family Retroviridae (subfamily Lentivirinae) and is closely related to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), the etiologic agents of acquired immunodeficiency syndrome (AIDS). (cdc.gov)
Fragments2
  • This may cause nonspecific staining of target cells, such as leukocytes, which have bound the resulting erythroid fragments. (bdbiosciences.com)
  • Different MHC receptors will display different antigen peptide fragments, so having a larger repertoire of MHC receptors will result in immunity against a greater range of pathogens. (scienceabc.com)
Closely1
  • Most people with narcolepsy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes. (encyclopedia.pub)
Group1
  • Therefore, a working group was established by CDC and the National Institutes of Health (NIH) to formulate specific guidelines intended to minimize the risk of SIV transmission to humans. (cdc.gov)
Person's1
Study2
  • This study adds another layer of scientific data linking the actual ancestral human remains to their modern descendants through their DNA over a span of 6,000 years," said Barbara Petzelt, a co-author of the study and a liaison to the Metlakatla community. (nwcoastenergynews.com)
  • The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels. (who.int)
Locus1
  • Variation in the HLA-F gene locus with functional impact is associated with pregnancy success and time-to-pregnancy after fertility treatment. (nih.gov)
Development2
  • It appears likely that other factors, such as viral or bacterial infections and changes in other genes, also influence the development of this complex disorder. (medlineplus.gov)
  • It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)