Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate). (wikipedia.org)
It oxidizes cysteine to the corresponding sulfinic acid by activation of dioxygen, although the exact mechanism of the reaction is still unclear. (wikipedia.org)
CDO oxidizes to cysteine sulfinic acid (which exists predominantly in the anionic sulfinate form in vivo). (wikipedia.org)
Annotation2
Search results: The pahtway p3258 has 419 genes in the original annotation. (uth.edu)
The corresponding genes for the DFS-SEs were significantly enriched in mitochondria and their associated pathways according to Gene Ontology annotation and in the pathways of fatty acid metabolism, oxidative phosphorylation and Huntington's disease according to a Kyoto Encyclopedia of Genes and Genomes pathway analysis. (spandidos-publications.com)
Metabolism2
CDO is responsible for the first major step in metabolism of cysteine. (wikipedia.org)
Furthermore, crystal structures show the amino nitrogen and thiolate sulfur of cysteine coordinated to the iron in addition to a single water molecule (see figure). (wikipedia.org)
Cysteine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. (cannabisdatabase.ca)
The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. (mcw.edu)
Proteins1
Genes encoding proteins involved in processing of drugs and other xenobiotics. (gsea-msigdb.org)
Sulfur1
One proposed mechanism, supported by computational and spectroscopic studies, involves O2 binding cis to a thiolate to form reactive iron (III)-superoxo species (A), which then attacks the bound sulfur of cysteine to form a four-membered ring structure (B). Heterolytic O-O bond cleavage then affords a high-valent iron (IV) oxo intermediate (C), which transfers the second oxygen to sulfur. (wikipedia.org)
Enzyme3
Overall, the reaction involves addition of O2 to cysteine, which occurs spontaneously without enzyme catalysis. (wikipedia.org)
In addition, L-cysteine can be converted into hydrogen sulfide and pyruvic acid through the action of the enzyme cystathionine gamma-lyase. (cannabisdatabase.ca)
Pathway1
Currently, there are 273 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
Species1
L-Cysteine exists in all living species, ranging from bacteria to humans. (cannabisdatabase.ca)
Compound3
L-Cysteine is a very strong basic compound (based on its pKa). (cannabisdatabase.ca)
Outside of the human body, L-Cysteine is found, on average, in the highest concentration within a few different foods, such as sunflowers, soy beans, and watermelons and in a lower concentration in common wheats, dates, and beers. (cannabisdatabase.ca)
The role of CDO may vary between cell types as it can either be used primarily for taurine or sulfate production or for degradation of cysteine. (wikipedia.org)
CDO is tightly regulated in the cell to maintain cysteine homeostasis. (wikipedia.org)
Class1
L-Cysteine, also known as C or e 920, belongs to the class of organic compounds known as cysteine and derivatives. (cannabisdatabase.ca)
Levels of cysteine3
CDO plays an important role in cysteine catabolism, regulating intracellular levels of cysteine and responding changes in cysteine availability. (wikipedia.org)
Crosslinking increases efficiency of CDO ten-fold and is regulated by levels of cysteine, an unusual example of protein cofactor formation mediated by substrate (feedforward activation). (wikipedia.org)
Additionally, after treatment of TE 671 cells with 0.005-0.5 μM 4- n -octylphenol, bis(2-ethylhexyl)phthalate, and diisodecyl phthalate, real-time RT-PCR showed dose-dependent decreases in the steady-state mRNA levels of cysteine dioxygenase type I, sulfite oxidase, and 3′-phosphate 5′-phosphosulfate synthase I. (nih.gov)
Hypermethylation2
5. Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer. (nih.gov)
16. Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN). (nih.gov)
Promoter DNA5
Using pharmacological unmasking microarray, we identified promoter DNA methylation of cysteine dioxygenase 1 (CDO1) gene in human cancer. (nih.gov)
Promoter DNA of the CDO1 gene was hypermethylated in 6 BC cell lines except SK-BR3, and CDO1 gene expression was all silenced at mRNA level in the 7 BC cell lines. (nih.gov)
6. Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer. (nih.gov)
10. Promoter DNA methylation of CDO1 gene and its clinical significance in esophageal squamous cell carcinoma. (nih.gov)
13. Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma. (nih.gov)
Intracellular1
Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. (nih.gov)
Ontology1
Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)
Chemotherapy3
In this study, we assessed the clinicopathological significance of CDO1 methylation in primary breast cancer (BC) with no prior chemotherapy. (nih.gov)
The CDO1 DNA methylation was quantified by TaqMan methylation specific PCR (Q-MSP) in 7 BC cell lines and 172 primary BC patients with no prior chemotherapy. (nih.gov)
12. Prediction of Efficacy of Postoperative Chemotherapy by DNA Methylation of CDO1 in Gastric Cancer. (nih.gov)
Protein4
In particular, CDO responds to changes in dietary cysteine availability and protein intake, maintaining decreased activity with low cysteine levels and increased activity at high levels to prevent cytotoxicity. (wikipedia.org)
These sequences represent the protein coding region of the Cdo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.52 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Hypotaurine1
CDO is also regulated in adipose tissue, where high cysteine levels cause increased hypotaurine/taurine production. (wikipedia.org)
Approved gene symbol with link to HUGO Gene Nomenclature Committee. (nih.gov)
Significance1
1. Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer. (nih.gov)
Sulfate1
The role of CDO may vary between cell types as it can either be used primarily for taurine or sulfate production or for degradation of cysteine. (wikipedia.org)
Cancers2
CDO has been implicated in various neurodegenerative diseases and cancers, which is likely related to cysteine toxicity. (wikipedia.org)
7. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. (nih.gov)
Reaction3
It oxidizes cysteine to the corresponding sulfinic acid by activation of dioxygen, although the exact mechanism of the reaction is still unclear. (wikipedia.org)
Overall, the reaction involves addition of O2 to cysteine, which occurs spontaneously without enzyme catalysis. (wikipedia.org)
Presented here are the results of O2-dependent 2-mercaptoaniline reaction using two different thiol dioxygenase enzymes mouse CDO and 3-mercaptopropionic acid dioxygenase isolated from Azotobacter vinelandii. (genscript.com)
Mechanism1
One proposed mechanism, supported by computational and spectroscopic studies, involves O2 binding cis to a thiolate to form reactive iron (III)-superoxo species (A), which then attacks the bound sulfur of cysteine to form a four-membered ring structure (B). Heterolytic O-O bond cleavage then affords a high-valent iron (IV) oxo intermediate (C), which transfers the second oxygen to sulfur. (wikipedia.org)
Expression2
We investigated the ontogeny of Cdo1 mRNA expression in mouse fetal and placental tissues, which showed increasing levels from embryonic day 10.5 and was localised to the decidua and several fetal tissues including nasal cavities and brain. (genscript.com)
14. Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome. (nih.gov)
15. CDO1 promoter methylation is associated with gene silencing and is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients. (nih.gov)
Summary1
Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
Articles1
Jensen Lab generated fractional counting score for the prevalence of this gene in Pubmed articles. (nih.gov)