Gene ccaat enhancer binding protein alpha. Medical search. Frequent questions

Analysis of mRNA for three isoforms of the CCAAT/enhancer binding protein (C/EBP) revealed that TCDD (5 nM) selectively inhibited the induction of C/EBP alpha mRNA but did not block the induction of C/EBP beta and C/EBP delta in response to differentiation inducers. (aspetjournals.org)
These isoforms have proteins with 215 and 216 amino acids, respectively. (wikipedia.org)
No isoforms for the human PANO1 protein could be identified. (wikipedia.org)
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)

In addition, we found that TBS enhanced the expression of the adenosine monophosphate-activated protein kinase (AMPK) and inhibited the expression of transcription factors, such as CCAAT/enhancer-binding proteins (C/EBPs), sterol regulatory element-binding protein 1 (SREBP1), and peroxisome proliferator-activated receptor γ (PPARγ) in the liver and epididymal WAT as measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (biomedcentral.com)
The adenosine monophosphate-activated protein kinase (AMPK) is a principal energy sensor, defined as a protein kinase activated by an increase in the AMP/ATP energy ratio [ 14 ]. (biomedcentral.com)
PANO1 contains 2 cAMP phosphorylation sites, 6 N-myristoylation sites, 4 protein kinase C phosphorylation sites, 3 bipartite nuclear localization signals as well as arginine-rich and proline-rich regions. (wikipedia.org)
As mentioned previously, 6 N-myristoylation sites, 2 cAMP phosphorylation sites, and 4 protein kinase C phosphorylation sites are also present. (wikipedia.org)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
This gene is a member of the protein-tyrosine kinase oncogene family. (cancerindex.org)
The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)
Previous studies have demonstrated that DNA damage-inducible transcript 4 (DDIT4), Trib3 (tribbles pseudo kinase 3), alpha-synuclein (α-syn) are involved in METH-induced dopaminergic neurotoxicity. (cancerindex.org)
OMIM:615812]) is a rare autosomal dominant disorder caused by pathogenic variants in the dual-specificity tyrosine phosphorylation-regulated kinase 1B gene ( DYRK1B ) located on chromosome 19q13.2 [ 1 ]. (biomedcentral.com)

One category of mutations prevent CCAAT/enhancer-binding protein alpha DNA binding by altering its COOH-terminal basic leucine zipper domain. (wikipedia.org)
The other category of mutations disrupt the translation of the CCAAT/enhancer-binding protein alpha NH2 terminus. (wikipedia.org)
CEBPA mutations, which result in diminished CCAAT/enhancer-binding protein alpha activity, contribute to the transformation of myeloid antecedents. (wikipedia.org)
The mutations in the genes encoding the antibiotic target protein are significant risk factors for resistance. (pubfacts.com)
Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. (qxmd.com)
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPA(dm)) versus single mutations (CEBPA(sm)) in 1182 cytogenetically normal acute myeloid leukemia (AML) patients (16-60 years of age). (qxmd.com)
Germline mutations in the gene AML1 ( RUNX1, CBFA2 ) occur in the familial platelet disorder with predisposition for AML, an autosomal dominant disorder characterized by moderate thrombocytopenia, a defect in platelet function, and propensity to develop AML. (medscape.com)
Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). (ox.ac.uk)
The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. (wikipedia.org)
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and gene enhancers. (wikipedia.org)
CCAAT/enhancer-binding protein alpha, the transcription factor that is encoded by CEBPA, is very important in the differentiation of immature granulocytes. (wikipedia.org)
Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
To highlight some of relevance and importance to PANO1: Wilms tumor suppressor, spermatogenic zip 1 transcription factor, signal transducer and activator of transcription, pleomorphic adenoma gene, general transcription factor IIIA, stimulating protein 1, CCAAT/enhancer binding protein, GC box elements and HMG box-containing protein 1. (wikipedia.org)
The C/EBP-α (CCAAT/enhancer-binding protein, alpha), is a family of transcription factor and recognizes the CGCAAT motif in the promoters of target genes. (gentarget.com)
It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. (antibodypedia.com)
VDR belongs to the superfamily of nuclear receptors for steroid hormones and regulates gene expression by acting as a ligand-activated transcription factor [ 3 ]. (biomedcentral.com)

CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. (wikipedia.org)
It has been shown that suppression of CEBPA expression and blocking of CCAAT/enhancer-binding protein alpha stops the differentiation of myeloid progenitors. (wikipedia.org)
Mutation of the CEBPA gene has been shown to play a crucial role in leukemogenesis and prognosis in acute myeloid leukemia patients. (wikipedia.org)
Unsupervised and supervised GEP analyses showed that CEBPA(dm) AML (n = 42), but not CEBPA(sm) AML (n = 18), expressed a unique gene signature. (qxmd.com)
During the rest period of the day, they found a circadian protein called CCAAT enhancer binding protein alpha (CEBPA) causes a rapid increase in the production of PPARG. (bariatricnews.net)

Fucoidan treatment of HCT-116 colon cancer cells resulted in downregulation of the ER protein 29 (ERp29), and triggered the phosphorylation of eukaryotic initiation element 2 alpha (p-eIF2a)/CCAAT/enhancer binding protein homologous protein (CHOP) pro-apoptotic cascade [14]. (irjs.info)

Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
Adipogenesis is a well-organized process regulated by adipogenic transcription factors, such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), sterol regulatory element binding protein (SREBP) family, and CCAAT-enhancer binding protein (C/EBP) family," the authors write in their introduction. (med-chemist.com)

Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Estrogen signaling in bone occurs mainly through two estrogen receptors, estrogen receptor alpha (ER-α) and ER-β. (molcells.org)

We also found that ER-α interacts with Dlx3 and increases its transcriptional activity and DNA binding affinity. (molcells.org)
nuclear protein 1, transcriptional regula. (gsea-msigdb.org)
Piperine was also shown to repress LXR-alpha, another transcriptional factor that is involved in the induction of adipogenesis as well as the synthesis of cholesterol and fatty acids. (med-chemist.com)
Taken together, our findings suggest that piperine, a major component of black pepper, inhibits fat cell differentiation by down-regulating the transcriptional activity of PPAR-gamma (and LXR-alpha) and suppressing the expression of PPAR-gamma (and LXR-alpha), thus leading to its potential use in the treatment of obesity-related diseases," the authors conclude. (med-chemist.com)

Hematopoietic transcription factors (= gene regulatory proteins) concertedly control cell proliferation, lineage commitment, and cell differentiation. (mdc-berlin.de)

The encoded protein is a key regulator of adipogenesis (the process of forming new fat cells) and the accumulation of lipids in those cells, as well as in the metabolism of glucose and lipids in the liver. (wikipedia.org)
An expression of genes involved in adipogenesis was also assessed. (biomedcentral.com)
Accordingly, it is likely that the expression of the AMPK is a latent gene target for the suppression of adipogenesis. (biomedcentral.com)
Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of duck adipogenesis. (biomedcentral.com)
The expression of Lcn2 is induced during 3T3-L1 adipogenesis in a CCAAT/enhancer-binding protein-dependent manner. (evanrosenlab.com)

Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. (cdc.gov)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. (antibodypedia.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
DYRK1B inhibits the Sonic Hedgehog and WNT pathways, increasing the expression of master adipogenic transcription factors CCAAT/enhancer binding protein (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma (PPAR-gamma) [ 2 ]. (biomedcentral.com)
an infection model, a fucoidan remove elevated the immunity from the web host organism and downregulated quorum sensing genes in the bacterial pathogen, Rabbit polyclonal to c Fos which implies that fucoidans likewise have the to influence gene appearance and mobile signaling pathways [6]. (irjs.info)
One recommended mode of actions consists of fucoidan-induced endoplasmic reticulum (ER) tension that induces apoptotic cancers cell loss of life via the activation of unfolded protein response (UPR) pathways [14,16,17]. (irjs.info)
By evaluating the overall development (population thickness) from the gene deletion strains in the lack and existence of fucoidan we could actually unearth genes, and therefore potential hereditary/useful pathways influenced by fucoidan. (irjs.info)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
In this second study, Teruel and her colleagues attached a red fluorescent protein to protein that controls the expression of important circadian clock genes and a yellow fluorescent protein to peroxisome proliferator activated receptor gamma (PPARG), a protein that regulates fat cell production. (bariatricnews.net)
The expression levels of LPL (lipoprotein lipase), HSL (Hormone-sensitive lipase), FAS (fatty acid synthase), and PPARα/PPARγ (peroxisome proliferator-activated receptor alpha/gamma) were significantly changed in the sheep preadipocytes during differentiation for 7 days. (academic-accelerator.com)

The lab currently focuses on functions of transcription factors of the CCAAT Enhancer Binding Protein family (C/EBPs). (mdc-berlin.de)

These genes increase oxygen availability by inducing erythropoiesis and angiogenesis, and also reduce its demand via regulation of energy metabolism by reducing oxidative phosphorylation and inducing non-oxygen-demanding glycolysis [ 5 , 6 , 7 ]. (springer.com)
CEBPα protein was an unstable hydrophilic protein with a transmembrane structure and phosphorylation/dephosphorylation. (hbnxb.net)

For this reason, CCAAT/enhancer-binding protein alpha's role during granulocyte differentiation and CEBPA's role as a tumor suppressor gene is critically important in the prognosis of acute myeloid leukemia. (wikipedia.org)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
PANO1 is an apoptosis inducing protein that is able to regulate the function of tumor suppressor. (wikipedia.org)
OBJECTIVE: We identified lipocalin 2 (Lcn2) as a gene induced by dexamethasone and tumor necrosis factor-alpha in cultured adipocytes. (evanrosenlab.com)

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. (gsea-msigdb.org)

PANO1 is a protein which in humans is encoded by the PANO1 gene. (wikipedia.org)

It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma, as well as distinct transcription factors such as c-Jun. (wikipedia.org)
Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
Yak was used as the experimental object to clone the yak CCAAT/Enhancer binding protein alpha( CEBPα ) gene, predicted its protein structure and function, isolated yak adipocyte, and detected the expression of CEBPα in different tissues of yak and yak fat expression during cell induction and differentiation. (hbnxb.net)
The results of qRT-PCR showed that the CEBPα gene was most highly expressed in the lower adipose tissue of the yak, and lowly expressed in the kidney, spleen and visceral adipose tissue. (hbnxb.net)
In this experiment, we cloned and obtained the CDS region sequence of CEBPα , determined its expression in various tissues of yak and clarified the expression pattern of this gene in the process of induced differentiation of yak adipocytes. (hbnxb.net)
Provide basic data to reveal the function of CEBPα gene in yak adipose tissue and adipocyte. (hbnxb.net)
Cloning of Yak CEBPα Gene and Its Expression Pattern in Yak Adipocytes[J]. ACTA AGRICULTURAE BOREALI-SINICA , 2021, 36(6): 228-234. (hbnxb.net)

Alteration by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells. (aspetjournals.org)
Brain and muscle Arnt-like protein-1 ( BMAL1 ) knockout mice exhibit accelerated aging, abnormal glucose metabolism, and impaired adipocyte differentiation, among other phenotypes, which are effects associated with the BMAL1 gene. (go.jp)
For this purpose, chondrogenic differentiation characteristics and specific marker gene expression were analyzed using cell lines showing different characteristics of spontaneous adipocyte formation. (e-jarb.org)

2012. Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism. . (oregonstate.edu)
2014. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. . (oregonstate.edu)
Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)
These data indicate that suppression of differentiation in the 3T3-L1 preadipocyte cell line by TCDD occurs at a short but defined period, during the differentiation program, and involves altered regulation of C/EBP, including the inhibition of C/EBP alpha. (aspetjournals.org)
It functions in homodimers and also heterodimers with C/EBP-β (beta) and C/EBP-γ (gamma), regulate the expression of genes that involves in different cellular responses, such as mitotic growth arrest and differentiation, cell cycle regulation, metabolism, osteoporosis, and in immunity, as well as in body weight homeostasis. (gentarget.com)
Furthermore, we demonstrated that the regulation of Dlx3 activity by ER-α is independent of the ligand (estradiol) binding domain. (molcells.org)
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells. (cornell.edu)

Genes related to lipid metabolism and proteolysis were found among those upregulated in IB. (biomedcentral.com)

Exposure of isolated human adipocytes to insulin enhanced SREBP1 gene expression and promoted its proteolytic cleavage to the active form. (diabetesjournals.org)

In this study, we employed a high-density single nucleotide polymorphism (SNP) chip to genotype 386 Nellore steers, a Bos indicus breed and, a Bayesian approach to identify genomic regions and putative candidate genes that could be involved with deposition and composition of IMF. (biomedcentral.com)

Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing cultured cells to stop dividing. (wikipedia.org)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
Immunoblot analysis with specific antibodies to each C/EBP isoform demonstrated that the levels of C/EBP delta and C/EBP beta protein were rapidly induced (by day 1) and then abrogated by day 4 and 8, respectively, in solvent-treated (control) cells. (aspetjournals.org)
In TCDD-treated cells, however, the levels of C/EBP beta and C/EBP delta protein persisted at these time points. (aspetjournals.org)
Gel shift analysis of nuclear extract binding to an oligonucleotide containing a C/EBP DNA recognition sequence revealed no difference between extracts from control and TCDD-treated cells in the binding pattern at day 2 of differentiation. (aspetjournals.org)
We also measured the levels of phosphorylated tuberous sclerosis complex 2 (TSC2) protein and Parkin protein level in SH-SY5Y cells. (cancerindex.org)
Key gene regulatory proteins control cell multiplication and instruct cells to adopt distinct cell fates. (mdc-berlin.de)
To acquire an unbiased watch from the multiple, conflicting sometimes, biological actions and signaling systems that are influenced by fucoidans in proliferating cells, this research initially examined the consequences of the well-defined fucoidan remove in the edible macroalga by testing a gene deletion collection. (irjs.info)
Forskolin stimulation and C/EBP beta overexpression in 3T3-L1 cells increased C/EBP beta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1 alpha proximal CRE. (elsevierpure.com)
Overexpression of ATF-2 and CHOP10 in 3T3-L1 cells decreased Pgc-1 alpha transcription. (elsevierpure.com)
Knockdown of Chop10 in 3T3-L1 cells using siRNA increased Pgc-1 alpha transcription, whereas siRNA against C/ebp beta in HIB-1B cells decreased Pgc-1 alpha and Ucp1 expression. (elsevierpure.com)

Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
Piglets (14 from each genetic type) were slaughtered at weaning (28 days) and longissimus dorsi was sampled for composition and gene expression studies. (biomedcentral.com)
Correlation among the expression of these RF and DE genes show relevant differences between genetic types. (biomedcentral.com)
The mechanism of this arrest is under study, but in many cases, it involves the activation of abnormal genes through chromosomal translocations and other genetic abnormalities. (medscape.com)
The genes present in these regions were identified and some can help explain the genetic basis of deposition and composition of fat in cattle. (biomedcentral.com)
The genomic regions and genes identified contribute to a better understanding of the genetic control of fatty acid deposition and can lead to DNA-based selection strategies to improve meat quality for human consumption. (biomedcentral.com)
Changes in DNAm can regulate gene function by modulating gene expression in response to a wide range of environmental factors or genetic determinants [ 10 ]. (biomedcentral.com)

Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)

Candidate genes with known effects on muscle growth were found among the DE genes upregulated in DU×IB. (biomedcentral.com)

Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
Cold stress in rodents increases the expression of UCP1 and PGC-1 alpha in brown and white adipose tissue. (elsevierpure.com)

2014. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. . (oregonstate.edu)
Previous studies from our laboratory indicated that C/EBPβ is implicated in inflammatory process and brain injury, since mice lacking this gene were less susceptible to kainic acid-induced injury. (biomedcentral.com)
Among the genes displaying significant changes in expression was complement component 3 ( C3 ), which showed a dramatic decrease in mRNA content in the hippocampus of C/EBPβ −/− mice. (biomedcentral.com)
More recently we have demonstrated that C/EBPβ regulates the expression of several genes involved in inflammatory processes and brain injury [ 14 ] and mice lacking C/EBPβ showed a reduced inflammatory response after kainic acid injection and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus [ 15 ]. (biomedcentral.com)
INTERPRETATION: These results demonstrated that an RBD-Fc protein subunit/MF59® adjuvanted vaccine can induce high levels of broadly reactive nAbs, including when used as a booster following prior immunisation of mice with whole ancestral-strain spike vaccines. (bvsalud.org)
Meanwhile, triglyceride (TG) content was decreased and lipolysis genes expressions, such as adipose triglyceride lipase (ATGL), hormone sensitive lipase (HSL) and lysosomal acid lipase (LAL) were elevated in the jejunum and ileum of inulin and propionate treated mice. (academic-accelerator.com)
Here we show that in mice exposed to a cold environment for 24 h, Pgc-1 alpha, Ucp1, and C/ebp beta but not C/ebp alpha or C/ebp delta expression were increased in BAT. (elsevierpure.com)
Reacclimatization of cold-exposed mice to a warm environment for 24 h completely reversed these changes in gene expression. (elsevierpure.com)

METHODS: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. (bvsalud.org)

Specific growth-related genes up-regulated by NK3-4 are involved in biological processes, including responses to auxin, hormone biosynthesis, cellular component biogenesis, root system development, and other functions. (bvsalud.org)
Vitamin D is a steroid hormone that exerts most of its biological activities by binding to a specific high-affinity receptor, the vitamin D receptor (VDR). (biomedcentral.com)

Examination of the expression of several early marker genes of preadipocyte differentiation through Northern blot analysis and of differentiation-dependent mitosis showed that TCDD did not interfere with the earliest known responses of preadipocytes to inducers of differentiation. (aspetjournals.org)
In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1 alpha, Ucp1, and C/ebp beta early in differentiation and inhibited Chop10 expression. (elsevierpure.com)

All six members of this family exhibit a high sequence similarity in their C-terminal DNA binding domain and a more diverge regulatory N-terminus [ 1 , 2 ]. (biomedcentral.com)
We disclose molecular and functional interactions between regulatory proteins and determine how they orchestrate the complex process of proper gene expression and thereby reveal novel therapeutic targets. (mdc-berlin.de)

The protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. (wikipedia.org)

The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. (cdc.gov)
Alternatively spliced transcript variants have been found for this gene. (antibodypedia.com)
Furthermore, when used as a heterologous third dose booster, the RBD-Fc vaccines combined with MF59® increased titres of nAb against other variants including alpha, delta, delta+, gamma, lambda, mu, and omicron BA.1, BA.2 and BA.5. (bvsalud.org)
In silico analysis revealed impairment of the DYRK1B protein function by both variants. (biomedcentral.com)
The identification of carriers of pathogenic variants in genes such as DYRK1B could be useful for establishing early diagnostic strategies and medical interventions in a reasonable number of affected individuals even before symptoms or complications appear. (biomedcentral.com)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

Expression of the genes for PPAR-gamma, SREBP-1c and C/EBP-beta were all found to be decreased, as was the binding of PPAR-gamma to a coactivator known as CREB-binding protein following the administration of either treatment. (med-chemist.com)

A functional analysis of these types of genes revealed that they often have tissue-specific expression in tissues such as the nervous system and testis. (wikipedia.org)
The NK3-4 treatment induced the differential transcription of genes in 1794 GO functional groups, with 1531 functional groups containing up-regulated genes. (bvsalud.org)

Its protein contains 1 exon and 215 amino acids. (wikipedia.org)
A possible cleavage site was identified between amino acids 33 and 34 as depicted in the PANO1 protein model. (wikipedia.org)
PANO1 was compared to two other genes, fibrinogen alpha chain as well as cytochrome C. The date of divergence as well as amino acid changes were tracked over many different species types to generate a divergence date vs. number of amino acids changes as seen to the right. (wikipedia.org)
Beef has high nutritional value from children to seniors, is a rich source of protein (essential amino acids), iron, zinc, B vitamins and essential polyunsaturated fatty acids such as linoleic and linolenic acid [ 2 ]. (biomedcentral.com)

RNA data sourced from Human Protein Atlas . (antibodypedia.com)

Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)

After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)

The same analysis indicated that the protein does not contain any hydrophobic or transmembrane regions. (wikipedia.org)

Transcript differences were validated for a subset of DE genes by qPCR. (biomedcentral.com)

This study identified SNPs mapping to the HERC2, CDH17, and ODZ3 genes as potential susceptibility loci for DA. (cdc.gov)

lipopolysaccharide binding protein [Sourc. (gsea-msigdb.org)

Search results: The pahtway p1352 has 309 genes in the original annotation. (uth.edu)

Adusumilli PS, Chan MK, Hezel M, Yu Z, Stiles BM, Chou TC, Rusch VW, Fong Y. Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. (famri.org)
From these, 136 genes (77%) were associated with well explained cellular processes and 41 genes (23%) were of unknown function. (irjs.info)

Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)

Accordingly, we review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D-related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ . (biomedcentral.com)

Furthermore, 3 h of in vivo hyperinsulinemia also significantly increased SREBP1 gene expression in human skeletal muscle. (diabetesjournals.org)

Anatomy20

Organisms4

Diseases4

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes32

Disciplines and Occupations1

Information Science3

Isoforms4

Kinase9

Mutations10

Transcription factor8

CEBPA5

Homologous protein1

Sterol3

Receptors2

Transcriptional4

Cell Proliferation1

Adipogenesis5

Pathways9

Peroxisome3

EBPs1

Phosphorylation2

Tumor4

Acute1

Humans1

CEBP7

Adipocyte3

Regulation7

Metabolism1

Adipocytes1

Putative1

Cells11

Genetic7

Myeloid1

Candidate genes1

Adipose tissue2

Mice8

Immunoglobulin1

Biological2

Differentiation2

Regulatory2

Modulate1

Variants5

Cytokines1

SREBP1

Functional2

Amino acids4

Human Protein Atlas1

Actin1

Antigen1

Transmembrane1

QPCR1

Susceptibility1

Lipopolysaccharide1

Annotation1

Cellular2

Antibodies1

Lesions1

Vivo1