Gene antigens cd5. Medical search. Frequent questions

CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction. (thermofisher.com)
The results suggest that the novel protein is a macrophage-specific membrane receptor with a role in host defense, as it shows postnatal expression in macrophages, which are considered responsible for the binding of bacterial antigens and phagocytosis. (embl.de)
The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). (exbio.cz)
CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. (exbio.cz)
Current projects include the analysis of transgenic and conditional deletion mutants of the T cell antigen receptor (TCR) signaling subunits at specific stages of T cell development. (nih.gov)
however, the main focus of his lab is the role and importance of signals transduced by the T cell antigen receptor (TCR) for T cell maturation. (nih.gov)
The first area of research, representing a long-term project in the lab, involves characterization of the role of T cell antigen receptor (TCR) signals, and in particular, individual TCR signal transducing subunits and signal transducing motifs in T cell development. (nih.gov)
3. Stimulation of CD5 Enhances Signal Transduction by the T cell Antigen Receptor. (nordicmubio.com)
CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72. (biolegend.com)
These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. (omicsdi.org)
In addition, T cell receptor β gene rearrangement was detected by polymerase chain reaction analysis. (springeropen.com)
The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
The team adapted mRNA delivery technology seen in current COVID-19 vaccines and applied it to basic Chimeric Antigen Receptor design. (medika.life)
Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. (arigobio.cn)
According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstream of the T cell receptor. (nature.com)
Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)

The following product was used in this experiment: CD5 Monoclonal Antibody (53-7.3), NovaFluor™ Red 725, eBioscience™ from Thermo Fisher Scientific, catalog # M026T03R05, RRID AB_2926168. (thermofisher.com)
C57BL/6 mouse splenocytes were unstained (left) or stained with 0.2 µg of CD5 Monoclonal Antibody, NovaFluor Red 725 (Product # M026T03R05) (right). (thermofisher.com)
Description: The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. (thermofisher.com)
The mouse monoclonal antibody CRIS1 reacts with an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). (exbio.cz)
Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-CD5 monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. (exbio.cz)
The CD5 antibody, clone L17F12, is derived from the hybridization of NS-1/Ag4 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with human T-acute lymphoblastic leukemia (ALL) cells. (bdbiosciences.com)
The CD5 antibody is composed of mouse IgG2a heavy chains and kappa light chains. (bdbiosciences.com)
Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. (bdbiosciences.com)
1. Anti-DNA Antibody Production by CD5+ and CD5- B Cells of Patients with Systemic Lupus Erythematosus. (nordicmubio.com)
4. Surface Immunoglobulin Ligands and Cytokines Differentially Affect Proliferation and Antibody Production by Human CD5+ and CD5- B Lymphocytes. (nordicmubio.com)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Purified Anti-Mouse CD5 antibody for use in flow cytometry assays. (southernbiotech.com)
Western blot: 10 µg of Jurkat cell lysate stained with ARG66751 anti-CD5 antibody [SQab20184] at 1:1000 dilution. (arigobio.cn)
The tissue section was stained with ARG66751 anti-CD5 antibody [SQab20184] at 18°C - 25°C for 30 minutes. (arigobio.cn)

Western blotting analysis of human CD5 using mouse monoclonal antibodies MEM-32, CRIS1, and L17F12 on laurylmaltoside lysates of Jurkat cells and of K562 cells (negative control) under non-reducing conditions. (exbio.cz)
Human T-cell antigens deﬁned by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. (bdbiosciences.com)
Warnke RA, Levy R. Detection of T and B cell antigens with hybridoma monoclonal antibodies: a biotinavidin-horseradish peroxidase method. (bdbiosciences.com)

CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. (thermofisher.com)
CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. (biolegend.com)
CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. (southernbiotech.com)

Induction of C-Myc Gene Expression via Two Distinct Signal Transduction Pathways. (nordicmubio.com)
It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. (southernbiotech.com)

We have begun to characterize the genes that are important for the generation and maintenance of HSCs and for their differentiation into specific hematopoietic lineages. (nih.gov)
Human Leu T-cell differentiation antigens: quantitative expression on normal lymphoid cells and cell lines. (bdbiosciences.com)
Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
Cluster of differentiation 5 (CD5) is expressed in high levels on the surface of T cells, while controversy surrounds the expression levels and role of CD5 in B cells. (abeomics.com)
The occurrence of switching without the accumulation of V gene mutations indicates that the processes of differentiation and diversification are not linked. (omicsdi.org)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. (omicsdi.org)
The lymphocytic clusters in SM contained nearly equal numbers of mature T and B cells, the latter with no coexpression of aberrant antigens, such as CD5 or CD23. (bmj.com)

CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. (exbio.cz)
The team then decorated the lipid nanoparticle surface with CD5 targeting antibodies to direct lipid uptake. (medika.life)

This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR against the cognate tumor antigen and an NK self-recognizing inhibitory CAR that transferred a 'don't kill me' signal to NK cells upon engagement with their TROG + siblings. (nature.com)
This system prevented trogocytic antigen-mediated fratricide, while sparing activating CAR signaling against the tumor antigen, and resulted in enhanced CAR-NK cell activity. (nature.com)

Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)

CD5 antigen-like is a protein that in humans is encoded by the CD5L gene. (wikipedia.org)
May bind bacterial antigens in the protein MARCO. (embl.de)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
What does this gene/protein do? (cancer-genetics.org)
What pathways are this gene/protein implicaed in? (cancer-genetics.org)
Recombinant full length protein of Human CD5 (extracellular). (arigobio.cn)
Here, we used time-resolved high-throughput proteomic analyses to identify and quantify the phosphorylation events and protein-protein interactions encoding T cell ligand discrimination in antigen-experienced T cells. (nature.com)
Genetic variation in C-reactive protein (CRP) gene is associated with retinopathy and hypertension in adolescents with type 1 diabetes - SŁOMIŃSKI BARTOSZ, JANKOWIAK MARTYNA, MACIEJEWSKA AGATA, Studziński Maciej, Mączyńska Aleksandra, SKRZYPKOWSKA MARIA, Gabig-Ciminska Magdalena, MYŚLIWIEC MAŁGORZATA. (edu.pl)

The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. (thermofisher.com)
Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. (exbio.cz)
Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. (exbio.cz)
Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone). (exbio.cz)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
We are also using gene profiling as well as RNA-seq and ChIP-seq to identify and characterize molecules that are important for thymocyte selection, a process that promotes the survival and development of functional T cells and the death of auto-reactive T cells that could cause autoimmune disease. (nih.gov)
Phenotypic and functional characterization of human Leu-1 (CD5) B cells. (bdbiosciences.com)
CD5 is intended for in vitro diagnostic use in the identification of cells expressing CD5 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
As a part of a diagnostic panel, its utility lies predominantly as a marker for T cells, with over 70% of T cell neoplasms expressing CD5. (abeomics.com)
Identification of human helper/inducer T cells expressing the 67,000 M.W. surface antigen, 85% peripheral blood lyymphocytes that form rosettes with sheep red blood cells (E+), and a small subset of B cells. (nordicmubio.com)
6. In Vivo and In Vitro Expression of Myeloid Antigens on B-lineage Acute Lymphoblastic Leukemia Cells. (nordicmubio.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
The cDNA VH-D-JH gene sequence was joined with that of the C alpha gene in the B cells of the three IgA CLLs, and with that of the C gamma gene in the IgG CLL B cells. (omicsdi.org)
In the IgA/IgG-coexpressing CLL B cells, identical VH-D-JH cDNA sequences were spliced to either C alpha or C gamma genes. (omicsdi.org)
In all five CLLs, the pattern of C mu DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the C mu exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. (omicsdi.org)
These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. (omicsdi.org)
They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. (omicsdi.org)
Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)
In this review, we examine the manufacturing and gene engineering of NK cells generated from iPSCs (iPS-NK) for ACT. (molcells.org)
The frequency of CD5 + B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5 + B cells suggest that they may represent a distinct lineage, known as B-1 cells. (southernbiotech.com)
Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
Synthetic mRNA is inserted into the cell with a retrovirus, a virus commonly used in gene therapy to permanently change other cells' genomes. (medika.life)
These T cells target either CD19 or BCMA, two antigens found on malignant B cells. (medika.life)
Antigen-specific CD4+ and CD8+ T cell responses were asynchronous, with the peak CD4+ T cell responses occurring 1 week post the second vaccination (boost), whereas CD8+ T cells peaked 2 weeks later. (stanford.edu)
T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens. (nature.com)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
We suggest that the affected gene plays a role in an undetermined damage response mechanism that results in elevated spontaneous apoptosis in lymphoid cells and radiosensitivity in fibroblasts . (lookfordiagnosis.com)

CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. (exbio.cz)
Human peripheral blood lymphocytes were stained with purified CD5 (UCHT2) (solid line) or purified mouse IgG1, κ (dashed line), followed by anti-mouse IgG PE. (biolegend.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
The stimulation of lymphocytes with antigen and mitogen was normal. (lookfordiagnosis.com)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)

Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc. (exbio.cz)

It has been identified as the major ligand of the B-cell antigen CD72. (southernbiotech.com)

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)

The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. (exbio.cz)

Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)

Human CD5L genome location and CD5L gene details page in the UCSC Genome Browser. (wikipedia.org)
The human gene database GeneCard (genecards.org) was used to design the CAR constructs such as KIR2DL1 ( GC19P067381 ), LIR-1 ( GC19P067376 ), LAIR-1 ( GC19M054351 ), NKG2A ( GC12M021112 ) and CD300A ( GC17P074466 ). (nature.com)
5. Evidence for Differential Responsiveness of Human CD5+ and CD5- B cell Subsets to T cell Independent Mitogens. (nordicmubio.com)

Fig. 4: A lower level of CAR-mediated TROG-antigen expression was associated with improved clinical response to CAR-NK cell-based immunotherapy. (nature.com)

ILC identified as CD45 + Thy1.2 + Lineage markers neg (CD3/CD4/CD5/CD8/CD11b/DX5/Gr-1/TCRδ/TCRβ/Ter-119 neg ). (elifesciences.org)
The patient was homozygous for polymorphic markers around the myosin-Va gene on chromosome 15q21, which co-localize to the Griscelli disease locus. (lookfordiagnosis.com)

Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)

Variations in dozens of genes have been studied as risk factors for rheumatoid arthritis. (medlineplus.gov)

Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). (silverchair.com)

All bacterial and many viral genes are italicized. (cdc.gov)

BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD5-UNLB (SB Cat. (southernbiotech.com)

The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development. (nih.gov)

Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)

In certain circumstances, when a lymph node is not easily accessible for excisional or incisional biopsy, a combination of core biopsy and FNA biopsies in conjunction with appropriate ancillary techniques for the differential diagnosis (immunohistochemistry, flow cytometry, PCR for IGHV and TCR gene rearrangements, karyotype, and fluorescence in situ hybridization [FISH] for major translocations) may be sufficient for diagnosis. (medscape.com)

Second, we have begun to identify and characterize the function of other signal transducing molecules that play an important role in T cell development (CCR9, CD5, TLAP). (nih.gov)

T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
Within B-lineage ALL, distinct signatures were associated with ALL1/AF4 and E2A/PBX1 gene rearrangements. (aacrjournals.org)

Although BRCA mutations have been associated with HGSCs with SET features, little is known about the role of non-BRCA homologous recombination repair (HRR) genes and the HRR status in these tumors. (qxmd.com)

Transcriptome data used in the generation of Extended Data Fig. 7g are available through the Gene Expression Omnibus ( https://www.ncbi.nlm.nih.gov/geo/ ) under accession GSE190976 . (nature.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancer-genetics.org)

RNA-seq was performed in blood Ly6C high and Ly6C low MC sorted by flow cytometry from control and HHcy cystathionine β-synthase gene-deficient ( Cbs -/- ) mice. (frontiersin.org)

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