AntibodyCD18Specialized antigen-preseCD11aGlycoproteinCD45IntegrinDIFFERENTIATION ANTIGENSDendritic CellsExpressionSubsetsCD54CD11cCloneCD103InnateMyeloid cellsAntibodiesReceptorImmuneEncodesMultiple genesAdhesion moleculeCD32CellsMacrophagesSurfaceTumorInteractionsPathwaysActivationTranscriptionProteinExpressMiceProvide
Antibody4
- Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
- The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. (cytekbio.com)
- The M gene of influenza A encodes 2 proteins, both specific antibody responses and protected against highly conserved: M1, the capsid protein, and M2, an ion challenge with lethal influenza. (cdc.gov)
- 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
CD185
- CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). (exbio.cz)
- CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
- CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. (biolegend.com)
- It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. (nih.gov)
- Generation of recombinant fragments of CD11b expressing the functional β-glucan-binding lectin site of CR3 (CD11b/CD18). (southernbiotech.com)
Specialized antigen-prese2
- Conventional dendritic cells (cDCs) are specialized antigen-presenting cells of the immune system. (life-science-alliance.org)
- Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
CD11a1
- In particular, CD11 is composed of CD11a, CD11b and CD11c. (thermofisher.com)
Glycoprotein3
- Furthermore, closed head injury was associated with a delayed increase in the expression of the immune cell surface glycoprotein Mac-1 (CD11B antigen) at the injury site that was decreased in NAP-treated mice. (nih.gov)
- CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. (biolegend.com)
- From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. (nih.gov)
CD452
- Polarization states of microglia, defined as CD11b + CD45 low cells, were determined by the expression of M1 surface markers, major histocompatibility complex (MHC) II, CD32, and CD86, and M2 surface marker, CD206 (mannose receptor). (uky.edu)
- EtOH rats showed the most dramatic increases in microglia activation markers CD11b and CD45, and M1 (MHC-II) and M2 (CD206) markers at T2, when additional M1 markers CD86 and CD32 were also increased. (uky.edu)
Integrin2
- CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. (biolegend.com)
- Term] id: PR:000001012 name: integrin alpha-M def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. (proconsortium.org)
DIFFERENTIATION ANTIGENS1
- Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)
Dendritic Cells2
- Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). (life-science-alliance.org)
- Absence of ILC2s leads to utero-placental abnormalities, including poor vascular remodelling, increased Il1b and decreased Il4, Il5 , and Il13 gene expression, and reduced alternative activation of dendritic cells (DCs) and macrophages. (elifesciences.org)
Expression18
- This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. (hindawi.com)
- In spite of tissue origin, many other elements such as culture method and further modulations also influence the heterogeneity of MSCs, leading to differential gene expression profiles, growth phenotype, and differentiation potentials [15-17]. (researchsquare.com)
- Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
- Instead, using microarray analysis we have elucidated that ERα-mediated estrogen signaling in osteoclast progenitors decreases "oxidative phosphorylation" and the expression of mitochondria complex I genes. (bvsalud.org)
- We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. (life-science-alliance.org)
- Cytokine gene expression was measured by reverse transcriptase polymerase chain reaction. (uky.edu)
- Surprisingly, proinflammatory gene expression of CCL2, IL-1β, IL-6, and TNF-α generally was decreased at all time points in EtOH rats except for IL-6 which was increased at T0 and TNF-α which was not changed at T0 in either region. (uky.edu)
- Simultaneously, BDNF expression was increased at T2 and T7, while IGF1 and TGF-β gene expression was decreased. (uky.edu)
- TotalSeq™-A antibodies are compatible with 10x Genomics Single Cell Gene Expression Solutions . (biolegend.com)
- Placentas exhibit signs of adaptation to stress, including larger maternal blood spaces and increased expression of nutrient transporter genes. (elifesciences.org)
- To clarify the biologic role of retinoic acid compounds (all-trans,- 9-cis-, and 13-cis-retinoic acid) in hematopoietic cells, we studied their effects on clonal growth, differentiation, and expression of RAR-α and RXR-α genes in HL-60 cells. (elsevierpure.com)
- Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. (southernbiotech.com)
- DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
- This study provides a differential gene expression profile between TMJ fibrous and bony ankylosis. (medscimonit.com)
- In addition to its role in cellular processes and interactions, LOC100240734 has also been shown to be involved in the regulation of gene expression. (silexon.ai)
- It is a type-I transmembrane protein that is involved in the regulation of gene expression by intracellular signaling pathways, including the TCR signaling pathway. (silexon.ai)
- In conclusion, LOC100240734 is a protein that is expressed in various tissues of the body and is involved in various cellular processes, including the regulation of cell adhesion and interactions, the regulation of inflammation and immune responses, and the regulation of gene expression. (silexon.ai)
- RNA-Seq analysis of primary oligodendrocytes and microglia cells uncovers gene expression signatures associated with activated stress responses and increased post mitotic cellular senescence (PoMiCS) which was confirmed by elevated senescence-associated β-galactosidase activity and SASP gene expression profile. (biomedcentral.com)
Subsets1
- Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. (cytekbio.com)
CD541
- The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. (exbio.cz)
CD11c1
- BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry. (cytekbio.com)
Clone1
- C57BL/6 mouse bone marrow cells were stained with Ly-6G/Ly-6c (GR-1) Pacific Blue™ and CD11b (clone M1/70) Brilliant Violet 750™ (left) or Ly-6G/Ly-6C (Gr-1) Pacific Blue™ only (right). (biolegend.com)
CD1033
- Also, XCR1+ DCs are related to CD103+CD11b- DCs. (wikipedia.org)
- Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
- However, gut CD103 + DCs are now subdivided into CD103 + CD11b + cDC2 and CD103 + CD11b − cDC1. (life-science-alliance.org)
Innate2
- Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
- We investigated for the first time whether F. hepatica soluble antigens ( Fh Ag) can also trigger NETosis and innate immune reactions in exposed ovine PMN. (biomedcentral.com)
Myeloid cells2
- Whole genome transcriptome analysis was performed to assess the antitumor immunomodulatory effect of STING (stimulator of interferon genes) agonists on myeloid cells in the TME of PARPi-resistant ovarian tumors. (bmj.com)
- VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
Antibodies1
- The antigen is extracted from the cell in an appropriate lysis buffer, and antibodies are added to the lysate to allow formation of the immune complex. (neuromantics.net)
Receptor2
- The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. (wikipedia.org)
- Biotinylated anti-CD3ε, anti-T-cell receptor (TCR)αβ, anti-Thy-1.2, and anti-Mac-1 (CD11b) were detected by streptavidin-Cy5 (Jackso. (neuromantics.net)
Immune1
- Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Encodes1
- Isolated from a strain of E. coli that carries a plasmid which encodes the β-Agarase I gene. (neuromantics.net)
Multiple genes2
- To do so, MYC controls transcription of multiple genes involved in cell growth and metabolism, vasculogenesis, cell adhesion, and genomic stability. (ashpublications.org)
- Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. (novusbio.com)
Adhesion molecule1
- LC0072 is also known as CD11b, which is a cell adhesion molecule that is expressed in various tissues of the body, including the brain. (silexon.ai)
CD321
- The CD64 proteins are high affinity receptors (~10 -8 ‑10 -9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10 -6 ‑10 -7 M) only recognizing IgG aggregates surrounding multivalent antigens (1, 4). (novusbio.com)
Cells5
- XCR1+ and CD8+cells work together to cross-present antigen and communicate CD8+ activation. (wikipedia.org)
- Naive CD8+ T cells are prepared when tumors form by cross-presentation via XCR1+ DCs and as a result will require a lower threshold to respond to antigen. (wikipedia.org)
- In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
- These concentrations of the retinoids had no capacity to induce differentiation of leukemic cells as measured by ability either to reduce nitroblue tetrazolium and to express CD11b antigens, suggesting that retinoids at very low concentrations may stimulate proliferation of leukemic cells rather than induce their differentiation. (elsevierpure.com)
- Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
Macrophages1
- 95% pure) of microglia/macrophages according to CD11b immunoreactivity. (uky.edu)
Surface2
- Microglia were isolated from the entorhinal cortex and hippocampus by Percoll gradient centrifugation, labeled with surface antigens for activation, and analyzed by flow cytometry. (uky.edu)
- LC0072 is a cell-surface antigen that is expressed in various tissues of the body, including the brain, spleen, and Peyer's patches. (silexon.ai)
Tumor1
- However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Interactions1
- Its unique gene structure and involvement in cellular interactions and communications make it an attractive drug target or biomarker for future research. (silexon.ai)
Pathways3
- Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
- A total of 7,928 SDE genes and 46 canonical pathways derived from it were identified. (frontiersin.org)
- Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
Activation1
- MYC/MAX heterodimers bind to specific DNA elements, designated as E-boxes, located in the promoter regions of target genes mediating either activation or repression of transcription. (ashpublications.org)
Transcription1
- The development transcription factor Batf3 helps develop the differences between XCR1+ DCs and CD103+ CD11b- DCs. (wikipedia.org)
Protein3
- Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
- The NAP sequence was identified by peptide structure/function scanning of activity-dependent neuroprotective protein (ADNP), a gene product essential for brain formation. (nih.gov)
- This means that it is a single-exon protein that is encoded from the same gene as another protein called ORF21. (silexon.ai)
Express1
Mice1
- RNA-seq was performed in blood Ly6C high and Ly6C low MC sorted by flow cytometry from control and HHcy cystathionine β-synthase gene-deficient ( Cbs -/- ) mice. (frontiersin.org)
Provide2
- Further study of these key genes may provide new ideas for future treatment of TMJ bony ankylosis. (medscimonit.com)
- Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)