Gene annexin a2. Medical search. Frequent questions

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
Annexin A1 (ANXA1), also known as lipocortin I, belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. (creativebiomart.net)
After extensive crescent formation at week 9 of disease, cDNA microarray analysis was performed and highly expressed genes were evaluated as molecular markers by real-time reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoassay of urine proteins. (tmu.edu.tw)
The expression of proteins encoded by these genes was predominant in the glomerular crescent. (tmu.edu.tw)
Transcriptomics of ZNF148-deficient SC-β cells identifies increased expression of annexin and S100 genes whose proteins form tetrameric complexes involved in regulation of insulin vesicle trafficking and exocytosis. (jci.org)
In the past decade, yeast have been frequently employed to study the molecular mechanisms of human neurodegenerative diseases, generally by means of heterologous expression of genes encoding the relevant hallmark proteins. (microbialcell.com)
In this respect, although obviously lacking a brain with a multicellular neuronal network, simple unicellular yeast are of great value to investigate the effects of overexpression and single point-mutations in genes encoding key proteins on cell physiology and on the function of conserved signaling cascades. (microbialcell.com)
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. (thermofisher.com)
They interact with specific intracellular receptor proteins in the target tissues and alter the expression of genes to corticosteroids. (bvsalud.org)
Among these proteins, annexin is known to inhibit phospholipase A2 and thus block the production of mediators and arachidonic acid metabolites such as the COX-2 enzyme, leukotrienes and prostaglandins, cytokines, interleukins, adhesion molecules and enzymes such as collagenase 24,25 . (bvsalud.org)
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity? (cdc.gov)
Here, in order to discover those membrane proteins that may be involved in JEV attachment to or entry into virus permissive BHK-21 cells, a chemically mutated cell line (designated 3A10-3F) that became less susceptible to JEV infection was preliminarily established and selected by repeated low moi JEV challenges and RT-PCR detection for viral RNA E gene fragment. (biomedcentral.com)
The noted discrepancy of membrane proteins included calcium binding proteins (annexin A1, annexin A2), and voltage-dependent anion channels proteins (VDAC 1, VDAC 2), suggesting that these molecules may affect JEV attachment to and/or entry into BHK-21 cells and worthy of further investigation. (biomedcentral.com)
The incorporation of cytosolic phospholipase A(2) into the membrane fraction of thrombin-activated platelets parallels that of annexin V, which suggests an interaction between the two proteins. (ox.ac.uk)
Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. (assaygenie.com)
Annexin A5(ANXA5), is a member of the structurally related family of?annexin?proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. (bioactiva.com)
185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. (wikipedia.org)
Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. (wikipedia.org)
Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body. (wikipedia.org)
This protein is a member of the annexin family. (wikipedia.org)
Annexin A2 has been shown to interact with Prohibitin, CEACAM1, S100A10, PCNA, complement Factor H, and a number of viral factors including the HPV16 minor capsid protein L2. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
Annexin A1 protein has an apparent relative molecular mass of 40kDa with phospholipase A2 inhibitory activity. (creativebiomart.net)
Furthermore, the protein level of Annexin A1, A2, A5 and A10 was increased from the early stages. (bvsalud.org)
Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)
Six genes, secreted acidic cysteine-rich glycoprotein (Sparc), thymosin beta 10 (Tmsb10), S100 calcium-binding protein A6 (S100a6), annexin A2 (Anxa2), osteopontin (OPN) and lipocalin 2 (Lcn2), were quantified by real-time RT-PCR in laser microdissected glomeruli in a time course manner. (tmu.edu.tw)
Oncogenic RAS expression increased S100A10 gene expression which resulted in an increase in S100A10 protein levels. (oncotarget.com)
These were: phosphorylated elF2 alpha, Activating transcription factor-4 (ATF4), DNA-damage-inducible transcript 3 (also known as C/EBP homology protein, termed CHOP), X-box binding protein-1 (XBP1), Activating transcription factor-6 (ATF6), GRP78 (glucose-regulated protein, 78kDa) and heme responsive genes heme oxygenase-1 and ferritin. (unideb.hu)
Consequently, there is up-regulation of target genes increasing both mRNA and protein levels of CHOP and GRP78. (unideb.hu)
Annexin V is a Ca(2+)-dependent, phospholipid-binding protein, which is proposed to regulate inflammation by inhibiting cytosolic phospholipase A(2). (ox.ac.uk)
Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. (bioactiva.com)
Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. (bioactiva.com)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)

Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. (thermofisher.com)

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)
These findings point to ZNF148 as a regulator of annexin-S100 complexes in human β cells and suggest that suppression of ZNF148 may provide a novel therapeutic strategy to enhance insulin secretion. (jci.org)

The Bert Vogelstein Laboratory seeks to develop new approaches to the prevention or treatment o ... f cancers through a better understanding of the genes and pathways underlying their pathogenesis. (hopkinsmedicine.org)
Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications. (cdc.gov)

Long-term efficacy and downstream mechanism of anti-annexinA2 monoclonal antibody (anti-ANX A2 mAb) in a pre-clinical model of aggressive human breast cancer. (gzsys.org.cn)
A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors (2022). (edu.in)

After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for antibody expression. (cellsignal.com)
Expression varies depending on the nature of the gene. (origene.com)
Clinicopathologic analysis showed that Annexin A2 expression was significantly correlated with clinical stage, and lymph node metastasis. (jcancer.org)
Kaplan-Meier analysis revealed that patients with high Annexin A2 expression had poorer overall survival rates than those with low Annexin A2 expression. (jcancer.org)
Mechanistically, our studies showed that knockdown of Annexin A2 increased the expression of p53, which in turn, induced cell cycle G2 arrest and inhibited epithelial-to-mesenchymal transition (EMT). (jcancer.org)
Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. (avivasysbio.com)
We have listed RNA Seq and gene expression data in the "Target Info" tab. (avivasysbio.com)
The expression of the following genes was salient: (a) Cd163, an anti-inflammatory stroke-associated gene, was the most differentially expressed gene by NPD1+RvD1, displaying more than a 123-fold upregulation in the ipsilesional penumbra (Lisi et al. (springer.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. (cancerindex.org)
Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. (cancerindex.org)
The new molecular targets for cancer therapy are first located by large scale gene expression analysis, whole-genome scans for altered gene copy number and high throughput sequence analysis of cancer genomes. (hopkinsmedicine.org)
Transcriptional regulation involves the binding of transcription factors to specific regions of the ANXA1 gene promoter, which can either promote or inhibit its expression. (creativebiomart.net)
To identify specific markers of CRT response, we compared pretreatment biopsies from LACC patients with pathological complete response (sensitive) with those from patients showing macroscopic residual tumor (resistant) after neoadjuvant CRT, using a proteomic approach integrated with gene expression profiling. (biomedcentral.com)
Characteristics of Structure and Expression Pattern of ADSF/resistin Gene in Korean Native Cattle Korea. (animbiosci.org)
Expression of annexin II in gastric carcinoma and its role in gastric cancer metastasis. (gzsys.org.cn)
Combined expression of S100A4 and Annexin A2 predicts disease progression and overall survival in patients with urothelial carcinoma. (gzsys.org.cn)
MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. (gzsys.org.cn)
Annexin A2: its molecular regulation and cellular expression in cancer development. (gzsys.org.cn)
Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients. (gzsys.org.cn)
Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. (gzsys.org.cn)
Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA. (gzsys.org.cn)
Clinical significance of annexin II expression in human non-small cell lung cancer. (gzsys.org.cn)
Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer. (gzsys.org.cn)
We examined the alterations in gene expression associated with the development of crescentic glomerulonephritis in murine chronic graft-versus-host disease, a model for human systemic lupus erythematosus. (tmu.edu.tw)
Analysis with the RAS effector-loop mutants that interact specifically with Raf, Ral GDS pathways highlighted the importance of the RalGDS pathways in the regulation of S100A10 gene expression. (oncotarget.com)
ZNF148 in SC-β cells prevents translocation of annexin A2 from the nucleus to its functional place at the cell membrane via direct repression of S100A16 expression. (jci.org)
Induction of apoptosis by cross-linking antibodies certain to human B-lymphoma cells: expression of Annexin V binding websites on the antibody cap. (ncbcs.org)
This poses the important question, which of these posttranslational modifications are naturally occurring in the yeast model or can be reconstituted by heterologous gene expression. (microbialcell.com)
Her contributions include, among others, a Bayesian model-based clustering procedure of temporal expression profiles (CAGED), a robust Bayesian approach to analyze differential gene expression using model averaging (BADGE), and novel methods for analysis of genetic data. (bu.edu)

Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)

Serum annexin A2 levels in patients with colon cancer in comparison to healthy controls and in relation to tumor pathology. (gzsys.org.cn)
Scientific significance of serum anti- annexin V antibodies in Egyptian sufferers with scleroderma. (ncbcs.org)
In conclusion, measurement of serum anti-annexin V IgG antibodies in scleroderma sufferers could also be necessary for early prognosis of vascular and pulmonary issues. (ncbcs.org)

Annexin A2 has been involved in cancer cell adhesion, invasion and metastasis. (jcancer.org)
Extensive researches demonstrate that Annexin A2 plays important roles in tumor proliferation, invasion and metastasis [ 12 - 14 ]. (jcancer.org)

Maternal deficiency of the ANXA2 gene contributes to shallow decidual invasion by placental cytotrophoblast cells. (wikipedia.org)
As a result, Annexin A2 normally contributes to clearance of fibrin formation on the blood vessel surface in the case of minor vascular injury [ 8 ]. (jcancer.org)
Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells. (gzsys.org.cn)

HIF target genes are involved in a complex regulatory network, e.g. adjusting energy metabolism to available oxygen levels, regulation of pH, inhibiting apoptosis, and activation of angiogenesis. (charite.de)

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (gzsys.org.cn)
One of the most convincing methods to verify a putative virus receptor is to transfer the receptor gene into a cell line that cannot bind virus and later demonstrate that the receptor-negative cell acquires the ability to bind virus and permit virus to replicate within it after the receptor gene is regained [ 13 ]. (biomedcentral.com)

This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. (hopkinsmedicine.org)
The focus of this article is Tumor Suppressor Genes. (assaygenie.com)

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (gzsys.org.cn)

ANXA2 is part of the annexin family and is involved in the regulation of cellular growth and in signal transduction pathways. (assaygenie.com)

These molecular changes are evaluated for their potential as therapeutic targets and are often mutated genes, or genes that are over-expressed during the development of a brain cancer. (hopkinsmedicine.org)

Annexin A2 (also called ANXA2) is mainly expressed in endothelial cells. (jcancer.org)

Finally, we show that cytosolic phospholipase A(2) can be specifically purified from platelet membranes by affinity chromatography on GST-annexin V and that immunoprecipitation using antibodies against cytosolic phospholipase A(2) copurify annexin V and cytosolic phospholipase A(2) from activated platelets. (ox.ac.uk)

In this study, we showed that Annexin A2 was evidently overexpressed in human NSCLCs cell lines and NSCLCs tissues. (jcancer.org)

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects. (gzsys.org.cn)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation. (gzsys.org.cn)

Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant reactions. (wikipedia.org)

Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. (gzsys.org.cn)
We have demonstrated that RNA nanoparticles built with the 3WJ scaffold and harboring different functional modules retained their folding and independent functionalities for specific cell binding, cell entry, gene silencing, catalytic function and cancer targeting, both in vitro and in animal trials. (uky.edu)

Approved gene symbol with link to HUGO Gene Nomenclature Committee. (nih.gov)

Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. (hopkinsmedicine.org)
Although causative gene mutations have been well characterized for LGMD, no specific treatment is available for any of the LGMD syndromes yet. (medscape.com)
For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
Overlap exists with Congenital Muscular Dystrophy (CMD) as several gene mutations can cause both a LGMD and CMD phenotype. (medscape.com)
These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)

Association of a characteristic membrane pattern of annexin A2 with high invasiveness and nodal status in colon adenocarcinoma. (gzsys.org.cn)
In a time-dependent manner, an exact correlation was found between the membrane association of cytosolic phospholipase A(2) and annexin V. Calcium from the intracellular stores was sufficient for the relocation of intracellular annexin V and cytosolic phospholipase A(2) to platelet membranes. (ox.ac.uk)

Using cell-SELEX, we have identified thioaptamers, which target Annexin A2, and specifically bind to the human ovarian cancer cells. (uky.edu)

However, the exact function and mechanism of Annexin A2 in tumor progression of NSCLCs have not been elucidated. (jcancer.org)
Taken together, these data suggest that Annexin A2 plays an important role in NSCLCs progression, which could serve as a potential prognosis marker and a novel therapeutic target for NSCLCs. (jcancer.org)
However, the exact function and mechanism of Annexin A2 in tumor progression of NSCLCs need to be further determined. (jcancer.org)
Knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells, and the biological effect of Annexin A2 on proliferation and invasion was mediated by the inhibition of p53, which in turn, promoted cell cycle progression and EMT. (jcancer.org)
A2 inhibition suppresses ovarian cancer progression via regulating β-catenin/EMT. (gzsys.org.cn)

Activation in the presence of arginyl-glycyl-aspartyl-serine (RGDS), which inhibits binding of fibrinogen to its adhesive ligand, does not alter the amount of cytosolic phospholipase A(2) or annexin V that binds to membranes. (ox.ac.uk)

Immunofluorescence and subcellular fractionation revealed Annexin A1, A2, and A5 in the cytoplasm and nuclei of tumor cells. (bvsalud.org)
Sera of 40 scleroderma sufferers and 15 wholesome controls have been examined for IgG and IgM anti-annexin V antibodies by ELISA and anticentromere antibodies by oblique immunofluorescence. (ncbcs.org)

The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. (hopkinsmedicine.org)

Anti-annexin V IgG antibodies correlated positively with VOC kind and negatively with HbF and age of VOC onset, whereas anti-annexin V IgM correlated positively with VOC kind, length, frequency, web site, ache severity, hospitalization, and medicine, and negatively with age of VOC onset and HbS ranges. (ncbcs.org)

Our laboratory uses large-scale genomic approaches to locate and analyze the genes that are mutated during brain cancer development. (hopkinsmedicine.org)
Our results define a predictive gene signature that can help in cervical cancer patient stratification, thus providing a useful tool towards more personalized treatment modalities. (biomedcentral.com)
Relationship Between Circulating Tumor Cells and Annexin A2 in Early Breast Cancer Patients. (gzsys.org.cn)

Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. (thermofisher.com)

Monovariate logistic regression evaluation demonstrated a optimistic dose-effect relationship for anti-annexin V IgM with VOC, with elevated VOC danger seen with elevated antibody titers. (ncbcs.org)

Moreover, we found that knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells. (jcancer.org)
Notably, increased plasma levels of Annexin A5 significantly (r2 = 0.8203) correlated with Annexin A5 levels in liver tissue from week 12 and gradually increased until week 22. (bvsalud.org)

We identified annexin A2 (ANXA2), N-myc downstream regulated gene 1 (NDRG1) and signal transducer and activator of transcription 1 (STAT1) as biomarkers of LACC patients' responsiveness to CRT. (biomedcentral.com)

Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)

We found that Anxa5 was the earliest upregulated gene at week 12 after HCC initiation, while Anxa1 and Anxa2 were upregulated in advanced HCC stages (weeks 18 and 22). (bvsalud.org)

Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors. (wikipedia.org)

The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. (nih.gov)
Investigation of the relocation of cytosolic phospholipase A2 and annexin V in activated platelets. (ox.ac.uk)
Here, we have studied the association of cytosolic phospholipase A(2) and annexin V with platelet membranes after thrombin stimulation. (ox.ac.uk)
When activation-induced actin polymerisation was prevented by cytochalasin E, the recovery of both annexin V and cytosolic phospholipase A(2) remained unchanged. (ox.ac.uk)
However, complete depolymerisation of the cytoskeleton with DNase I almost abolished the association of cytosolic phospholipase A(2) with the membranes, and it completely abolished the relocation of annexin V to platelet membranes. (ox.ac.uk)
These findings suggest that following platelet activation with thrombin, both cytosolic phospholipase A(2) and annexin V, relocate to platelet membranes where they interact. (ox.ac.uk)
An intact cytoskeleton seems to be a prerequisite for the interaction of cytosolic phospholipase A(2) and annexin V with platelet membranes. (ox.ac.uk)

The dataset collected through qPCR on these genes was used as training dataset to implement a Random Forest algorithm able to predict the response of new patients to this treatment. (biomedcentral.com)

Anatomy5

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes5

Information Science2

Proteins17

Protein17

Phospholipase A2 inhibitory1

S1002

Pathogenesis2

Monoclonal antibody2

Expression31

S100A102

Serum3

Invasion and metastasis2

Contributes3

Target genes1

Receptor2

Tumor suppr2

S100A61

Signal transduction1

Targets1

Endothelial1

Affinity chromatography1

Tissues1

Molecular2

PMID1

Metastasis1

Anticoagulant1

Vitro2

Symbol1

Mutations5

Membrane2

Ovarian cancer cells1

Progression5

Binds1

Immunofluorescence2

Angiogenesis1

Positively1

Cancer3

Mediators1

Antibody1

Significantly2

Downstream1

Annotations1

Anxa51

Regulation1

Cytosolic7

Dataset1