Loading...
  • polymorphism
  • The point mutations in exon IV of bovine β-Lactoglobulin gene determine two allelic variants A and B. These variants were distinguished by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) analysis in two indigenous Bos indicus breeds viz. (biomedcentral.com)
  • T polymorphism in the MBL2 gene. (bioscirep.org)
  • Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence? (hindawi.com)
  • Polymorphism in the length of the polyA tract in different genes has been associated with different diseases [ 17 , 18 ]. (hindawi.com)
  • Studies show that polymorphism in the length of the polyA tract of FOXE1 gene (rs71369530) is associated with thyroid disorders [ 19 - 21 ]. (hindawi.com)
  • Calpastatin Gene Polymorphism in Raini and Tali Goat in the Kerman Province', Iranian Journal of Applied Animal Science , 7(3), pp. 461-464. (ac.ir)
  • PCR-RFLP genotyping was used to detect the polymorphism in the region between exons 6 and 7 of the calpastatin gene. (ac.ir)
  • Conclusions: We conclude that MTHFR gene C677T polymorphism has no role in predisposition to the migraine in our population and cannot serve as a predictive factor for the risk of migraine. (scirp.org)
  • Allelic and genotypic frequencies and HWE of identified polymorphism in 3' UTR of SPP1 gene. (thefreedictionary.com)
  • Moreover, CYP19 gene polymorphism did not affect birth weight (BW), weaning weight (WW), 6, 9 and 12 months (YW) body weights, age at first lambing (AFL) and lambing interval (LI). (ac.ir)
  • In the routine practice, in addition of classic parameters, it will be useful to measure the concentration of apo E and that of Homocysteine and if possible to determine the APO E gene polymorphism. (beds.ac.uk)
  • APO E gene, the most extensively studied polymorphism among apolipoproteins, has three common alleles designated E2, E3 and E4 coding for three protein isoforms (apo E2, apo E3 and apo E4, respectively) [ 9 ] that serve as a ligand for members of the low-density lipoprotein receptor (LDLR) family. (beds.ac.uk)
  • An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. (ijbs.com)
  • The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). (ijbs.com)
  • However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. (ijbs.com)
  • In-vitro studies showed , I/D polymorphism of ADRA2B gene to affect an impaired agonist-induced desensitization of the receptor [ 8 ]. (ijbs.com)
  • D variant of I/D polymorphism of ADRA2B gene influence the sympathetic nervous system activity and meant of to develop EHT. (ijbs.com)
  • In addition, a cross-sectional clinical study in the Brazilian population suggested that 12Glu9 deletion polymorphism of ADRA2B gene might result in reduced autonomic responsiveness by altering cardiac sympathetic and vagal function during sustained handgrip exercise in normotensive obese women [ 11 ]. (ijbs.com)
  • Since this pathogen has been implicated in the pathogenesis of human IBDs, the goal of this study was to assess whether single nucleotide polymorphism (SNPs) in several well-known candidate genes for human IBD are associated with susceptibility to MAP infection in dairy cattle. (pubmedcentralcanada.ca)
  • Therefore, A6G polymorphism of the AGT gene could be a potential genetic marker for increased susceptibility to essential hypertension with or without T2DMin Malaysian subjects. (nih.gov)
  • lane 1 represents homozygous CC genotypes, lane 2 and 5 represents heterozygous AC genotypes and lane 3, 4, 6, and 7 represents homozygous AA genotypes of A20C polymorphism of AGT gene. (nih.gov)
  • For example, reduced expression of the circadian gene PER2 has been detected in lymphoma cell lines and in samples drawn from patients with acute myeloid leukemia ( 4 ), and a recent genetic association study showed that a nonsynonymous polymorphism in the core circadian gene NPAS2 is associated with decreased risk of NHL, especially B-cell lymphoma ( 5 ). (aacrjournals.org)
  • A SNP at position -155 among these three polymorphism sites (-440, -155, +501) was found to exert a marked influence on the transcription of the porcine APOE gene. (biomedcentral.com)
  • The aim of our research was to clarify study whether IL-28B gene polymorphism (rs8099917) is associated with HTLV-1/HCV co-infection. (biomedcentral.com)
  • target genes
  • Among TD-related genes, FOXE1 gene plays an important role in the migration of precursor cells from thyroid follicles, in addition to being a factor that regulates the transcription of target genes such as thyroglobulin and thyroperoxidase [ 14 ]. (hindawi.com)
  • major genes
  • Molecular genetics allows for the study the genetic make-up of individuals at the DNA level and may provide the tools to make those opportunities a reality, either by direct selection on genes that affect traits of interest major genes or quantitative trait loci (QTL) - or through selection on genetic markers linked to QTL. (intechopen.com)
  • Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws. (biomedcentral.com)
  • A hierarchical model was derived for detecting major genes affecting a quantitative trait based on progeny tests of outcrossing species. (biomedcentral.com)
  • exon
  • Exon 12 of the HIF1A gene was amplified by PCR, and the genotypes of HIF1A were determined by DNA sequencing. (biomedcentral.com)
  • FOXE1 gene (also called TTF-2 or FKHL15 ) is located on chromosome 9q22.33 and contains a single exon distributed along 3,461 bp. (hindawi.com)
  • Polymerase chain reaction was carried out to amplify 824 bp fragment of exon 2 of MTNR1A and 140 bp fragment of the exon 3 of the ovine CYP19 genes. (ac.ir)
  • variant
  • In 1996, Poort et al 5 described a variant of the prothrombin gene (ie, a G to A substitution at position 20210 in the 3′-untranslated region) that was associated with higher prothrombin levels and with an increased risk of venous thrombosis. (ahajournals.org)
  • In that way, recent studies suggested that, a common variant (12Glu9) of the human α 2B -adrenergic gene (ADRA2B) encodes a receptor protein leading to the insertion/deletion (I/D) of three consecutive glutamate residues at amino acid positions 301 to 303 has been associated with EHT [ 5 , 6 ], acute coronary events [ 7 ]. (ijbs.com)
  • There was significant association found only in A6G variant of AGT gene in Malaysian EHT with or without T2DM subjects. (nih.gov)
  • A mutation in the promoter region of the porcine APOE gene is an important functional variant. (biomedcentral.com)
  • The most studied gene is the collagen, type I, α 1 ( COL1A1 ) gene, especially its variant G2046T. (biomedcentral.com)
  • methods
  • Using a combination of analytical and computer simulation methods, we explicitly show that, although gene conversion has little impact on the probability that duplicates become fixed within a population, conversion can be effective at maintaining the functionality of Y-linked duplicates that have already become fixed. (genetics.org)
  • Apolipoprotein
  • C in the regulatory region of human apolipoprotein E gene ( APOE ) change the promoter activity and are associated with a wide variety of disorders including Alzheimer disease (AD). (biomedcentral.com)
  • receptor
  • Digestion products of the 836 bp fragment in the 5'UTR region of growth hormone receptor gene with enzyme AluI, loaded on 8% acrilamid gel. (intechopen.com)
  • The candidate lithogenic-genes found in humans are: ABC transporters for phosphatidylcholine (ABCB-4) and bile salts (ABCB-11), hepatocanalicular cholesterol transporter (ABCG5/G8), cholesterol-7α-hydroxylase (CYP7A1), cholecystokinine type-A receptor (CCK1R), cholesteryl ester transfer protein (CETP), and apolipoproteins (Apo) A-I, B and E[ 4 , 5 , 15 - 18 ]. (pubmedcentralcanada.ca)
  • Other genes studied in the FA family include the genes insulin-like growth factor I ( IGF-I ), integrin β-chain β 3 ( ITGB3 ), α-actinin-3 ( ACTN3 ), COL1A2 and type 1 insulin-like growth factor receptor ( IGF-IR ). (biomedcentral.com)
  • signaling pathway
  • Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. (wiley.com)
  • quantitative
  • In this situation, quantitative genetic theory can lay a sufficient foundation for gene detection and, thus, the properties of a detected gene can be adequately described by its effect and genomic location. (biomedcentral.com)
  • The quantitative trait loci (QTL) near their common glycoprotein alpha(A) subunit gene ( CGA ) have been reported inconsistently. (scielo.org.za)
  • chromosome
  • Thus, patterns of gene duplication and retention, for at least a subset of Y-linked genes, may be a general rule of Y chromosome evolution. (genetics.org)
  • Comparative analysis between humans and chimpanzees suggests ongoing recombination between the gene duplicate pairs that reside on the same Y chromosome. (genetics.org)
  • Considering both gene conversion and crossing over on the Y, recombination can be viewed as a factor that either constrains (via gene conversion) or promotes (via crossing over) Y chromosome degeneration. (genetics.org)
  • The genes coding for these apolipoproteins are close to the APO E gene on the long arm of chromosome 19 (19 q 13,2 ). (beds.ac.uk)
  • Results
  • The results may also be applicable to the recently observed pattern of tetraploidy and gene conversion in asexual, bdelloid rotifers. (genetics.org)
  • In summary, our results suggest that GNMT alteration may be an early event in HCC development and that GNMT could be a new tumor susceptibility gene for HCC. (aacrjournals.org)
  • The aim of this study was to dissect potential genetic factors for these unstable results and validate the association or linkage relationship of CGA gene with growth and carcass traits. (scielo.org.za)
  • The results suggest that NOS3 gene SNP rs2070744 was significantly associated with HIE susceptibility and symptom expression in Chinese Han population. (hindawi.com)
  • evolutionary
  • Management of economically important species can also utilize different definitions of population connectivity-in particular the degree to which gene flow affects evolutionary processes (e.g. the evolution of insecticide resistance [ 9 ])-but such genetic connectivity will not be considered here. (royalsocietypublishing.org)
  • However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially counteract forces of evolutionary decay that accompany asexual reproduction. (genetics.org)
  • Variation
  • Genetic variation in calpastatin gene and the effect on meat quality traits both in cattle and sheep has been reported by many researchers ( Zhou and Hickford, 2008 ). (ac.ir)
  • polyA
  • The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. (hindawi.com)
  • PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease. (hindawi.com)
  • A high frequency of deletion in the 3' UTR polyA sequence of EGFR has been reported in MSI-H colon cancers. (thefreedictionary.com)
  • transcriptional
  • The current study examined Cryptochrome 2 ( CRY2 ), a core circadian gene and transcriptional repressor, as a potential circadian biomarker for NHL. (aacrjournals.org)
  • chromosomes
  • Crossovers between Y-linked genes can generate acentric and dicentric Y chromosomes, resulting in infertility and disruption of the sex determination pathway ( e.g . (genetics.org)