Gene adenylate kinase. Medical search. Frequent questions

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. (lu.se)
The expressions of adenylate kinase (Ak1), creatine kinase sarcomeric mitochondrial (Ckmt2), and calcium-and integrin-binding protein 2 (Cib2) are decreased. (biomedcentral.com)

Also displays broad nucleoside diphosphate kinase activity. (enquirebio.com)
Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)

The expression of creatine kinase muscle type (Ckb) and Cdc42 binding protein kinase beta (Cdc42bpb), on the other hand, although at a low level are increased in both sfx and wild type mice. (biomedcentral.com)

This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. (wikipedia.org)
This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. (antikoerper-online.de)
This gene encodes a member of the adenylate kinase family of enzymes. (origene.com)
Human species and guinea pigs have to obtain vitamin C (VC) from food because they are unable to synthesize ascorbic acid due to the absence of the gene that encodes L-gulonolactone oxidase (Gulo). (biomedcentral.com)

Three proteins involved in the purine biosynthetic pathway and nucleotide conversion, adenylate kinase (Adk), GMP synthase (GuaA), and IMP dehydrogenase (GuaB), accumulated differentially in response to changes in C(i) levels. (cnrs.fr)

Differences in expression profiles, substrate specificities, kinetic properties and subcellular localization among the AK (adenylate kinase) isoenzymes have been shown to be important for maintaining a proper adenine nucleotide composition for many different cell functions. (rhea-db.org)

A landscape of gene regulation in the parasitic amoebozoa Entamoeba spp. (openwetware.org)
Up- or down-regulation of miR-199a-3p and/or the AK4 gene was done to detect their roles in OS multi-drug resistance using drug resistance profiling assays. (biomedcentral.com)
MiRNAs (miRNAs) are small non-coding RNAs which are recognized as vital and evolutionarily ancient components of gene regulation [ 1 ]. (biomedcentral.com)
It has been demonstrated that the adenyl moiety of ATP plays a direct role in the regulation of ATP binding and/or phosphoryl transfer within a range of kinase and synthetase enzymes. (biomedcentral.com)
In synthetic biology, the strength of promoter elements is the basis for precise regulation of target gene transcription levels, which in turn increases the yield of the target product. (biomedcentral.com)
Hsp26, Hsp78, Hsp82) decreased the production of ethyl acetate, suggesting that the Hsp family was also involved in the regulation of ATF1 gene transcription. (biomedcentral.com)
Lactobacillus plantarum response to inorganic carbon concentrations: PyrR2-dependent and -independent transcription regulation of genes involved in arginine and nucleotide metabolism. (cnrs.fr)

Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. (origene.com)

Unless JohnL or anyone else is prepared to discuss and debate things like the details of how lithium affects the cascade of postsynaptic second-messenger events through adenylate-cyclase regulated protein-kinase, including c-FOS directed gene transcription, its measurement by assaying mRNA and the resulting changes in membrane-bound g-proteins, I don't feel any obligation to at this point justify why Jensen's simple "circuit" models are ludicrous. (dr-bob.org)
There are many possible applications for these genes: you could try to recreate essential gene pathways in-vitro, or purify the proteins for functional studies, or create a synthetic MoClo-compatible Bacillus subtilis genome using these genes and the sgRNAs available from the Bacillus Genetic Stock Center. (freegenes.org)
The codon table used was the FreqB table from " Design Parameters to Control Synthetic Gene Expression in Escherichia coli ", which was used because it was shown to express proteins well and was recommended to us by JCVI. (freegenes.org)

A pseudogene for this gene has been located on chromosome 17. (origene.com)
Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. (origene.com)

AQA was originally developed to inhibit human transforming growth factor receptor 1 (TGFBR1), a host kinase that is predicted to have host-adverse effects during Mtb infection. (bvsalud.org)
Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)

Ingenuity upstream analyses were used to identify potential transcription factors that regulate the AK4 metabolic gene signature. (ellynaturals.pl)
In order to identify the genes that regulate muscle development through Vitamin C (VC) pathway, we analyzed the gene expression profile in mouse muscle from femur. (biomedcentral.com)
In this study, promoters PGK1p and TDH3p with different strengths were used to regulate the transcription level of alcohol acetyl transferase encoding gene ATF1 . (biomedcentral.com)
It is beneficial to improve the protein expression and product yield by controlling the promoter strength to fine regulate the transcription level of the target gene and maximize the transcription efficiency. (biomedcentral.com)

However, PyrR(2) was not essential for the C(i)-regulated transcription of argH and guaB, demonstrating that PyrR(2) modulates only a subset of C(i)-regulated genes. (cnrs.fr)

Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. (wikipedia.org)
Individuals with a past diagnosis of severe combined immune deficiency (including many cases of 'leaky SCID', Omenn syndrome, and reticular dysgenesis) who have undergone blood and marrow transplant, gene therapy, or enzyme replacement in the past may be eligible for this study. (stanfordhealthcare.org)
The role of the C8-H of ATP in the binding and/or phosphoryl transfer on the enzyme activity of a number of kinase and synthetase enzymes has been elucidated. (biomedcentral.com)
The intrinsic catalysis rate mediated by each kinase enzyme is complex, yielding apparent K M values ranging from less than 0.4 μM to more than 1 mM for ATP in the various kinases. (biomedcentral.com)
We have demonstrated the mechanism by which the enzyme activities of Group 2 kinases, shikimate kinase (SK) and adenylate kinase 1 (AK1), are controlled by the C8-H of ATP. (biomedcentral.com)
The lability of the C8-H mediated by active site residues co-ordinated to the purine ring of ATP therefore plays a significant role in explaining the broad K M range associated with kinase steady state enzyme activities. (biomedcentral.com)
A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: a predictive and experimental study. (rhea-db.org)
The adk gene from Mycobacterium tuberculosis codes for an enzyme of 181 amino acids. (rhea-db.org)
A sequence comparison with 52 different forms of adenylate kinases (AK) suggests that the enzyme from M. tuberculosis belongs to a new subfamily of 'short' bacterial AKs. (rhea-db.org)

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. (lu.se)

Expression varies depending on the nature of the gene. (origene.com)
Identification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form. (nih.gov)
Construction and Analysis of Gene Co-Expression Network in the Pathogenic Fungus Ustilago maydis. (openwetware.org)
All the essential genes have been recorded for expression in Escherichia coli and have been made MoClo compatible. (freegenes.org)
RNA-seq analysis of their testis revealed differential gene expression of components of the axoneme and sperm flagellum as well as steroid metabolic processes. (ul.ie)
Gene expression profiles in the hippocampus and cerebellum of 6-month-old APP Sw mice were compared with age-matched controls. (jneurosci.org)
The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
Therefore, we were interested in early gene expression changes that might mediate neuroprotection in these mice. (jneurosci.org)
Thus the present study was designed to determine gene expression profiles in the hippocampus and cerebellum of 6-month-old APP Sw mice compared with age-matched controls and to identify potential mechanisms responsible for protecting neurons from Aβ toxicity. (jneurosci.org)
Because muscle forces are a strong determinant of bone structure, particularly during the process of growth and development, we examined the gene expression of muscle in sfx mice. (biomedcentral.com)
Our results indicated that 1) The expression of Myogenic factor 6 (Myf6) gene in sfx mice is increased in both female and male mice, while the increase in male mice is much higher than that in female mice. (biomedcentral.com)
Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
mRNA expression data of energy-related genes were extracted from our whole retinal Affymetrix microarray data. (molvis.org)
The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)
The combined results indicate that glycolysis is regulated by the compartmental expression of hexokinase 2, pyruvate kinase M1, and pyruvate kinase M2 in photoreceptors, whereas the inner retinal neurons exhibit a lower capacity for glycolysis and aerobic glycolysis. (molvis.org)
Expression of the Icr protein-encoding genes argH and guaB was regulated at the transcription level or by RNA stability in response to C(i) availability, as previously demonstrated for the pyr genes. (cnrs.fr)

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Using a combination of ATP deuterated at the C8 position (C8D-ATP) as a molecular probe with site directed mutagenesis (SDM) of conserved amino acid residues in shikimate kinase and adenylate kinase active sites, we have elucidated a mechanism by which the ATP C8-H is induced to be labile in the broader kinase family. (biomedcentral.com)

gene symbol (e.g. (genscript.com)

PPS1 transcript abundance is coregulated with that of the divergently transcribed DPB3 gene, which codes for a subunit of DNA polymerase II, with both transcripts showing peak abundance in S phase. (embl.de)

Phylogenetic tree showing the relationship of the three E. anophelis strains HKU36-38 to closely related bacterial species using 16S rRNA gene sequence analysis. (cdc.gov)

In 2016, a paper was published using a CRISPR-based method for knocking down essential genes in Bacillus subtilis . (freegenes.org)
We took the list of essential genes from that 2016 paper and synthesized 261 of the 289 genes through Twist Biosciences. (freegenes.org)
261 of the 289 essential genes from 2016 essential gene list are included in this distribution. (freegenes.org)

Five isozymes of adenylate kinase have been identified in vertebrates. (origene.com)

With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
All the sgRNAs are available through the Bacillus Genetic Stock Center , which would allow for knockdown of native-sequence essential genes. (freegenes.org)
To be more precise, genetic drift occurs as a result of 'sampling error' in picking alleles for the future generation from the present generation's gene pool. (ignouhelpcenter.com)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)

SCID results from mutations in any of more than 15 known genes. (medscape.com)

Hier sind Adenylate Kinase 5 Antikörper für eine Vielzahl von Species wie anti-Human Adenylate Kinase 5, anti-Mouse Adenylate Kinase 5, anti-Rat Adenylate Kinase 5 zu finden. (antikoerper-online.de)
A DNA sequence encoding the Homo sapiens (Human) AK1 / Adenylate kinase 1, was expressed in the hosts and tags indicated. (enquirebio.com)
The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. (rhea-db.org)
ALFRED is a resource of gene frequency data on human populations supported by the Yale Center for Medical Informatics. (yale.edu)

2023. The gene regulatory network of Staphylococcus aureus ST239-SCCmecIII strain Bmb9393 and assessment of genes associated with the biofilm in diverse backgrounds. (openwetware.org)

At low inorganic carbon (C(i)) concentrations, the pyr genes encoding the enzymes of the pyrimidine biosynthetic pathway were overexpressed, in agreement with a previous study showing that these genes are regulated at the transcription level in response to C(i) via a PyrR(2)-mediated mechanism. (cnrs.fr)

The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. (embl.de)
We report the identification of the PPS1 gene of Saccharomyces cerevisiae. (embl.de)

In addition, kinase Rim15 may be involved in this regulatory pathway. (biomedcentral.com)
To better understand L. plantarum's adaptation to C(i) availability, additional C(i)-responsive genes were sought in the arginine biosynthetic pathway (arg and car genes) using slot-blot hybridization and a proteomic differential 2D gel electrophoresis (DIGE) global approach. (cnrs.fr)

This member is related to the UMP/CMP kinase of several species. (antikoerper-online.de)
Orthologs are sequences of genes that evolved from a common ancestor and can be traced evolutionarily through different species. (pharmaceuticalintelligence.com)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)

This suggests that MGCs utilize TCA cycle anaplerosis and cataplerosis to generate GTP and ~P transferring kinases to produce ATP that supports MGC energy requirements. (molvis.org)

The reaction for adenylate kinase is shown in figure 7. (igem.org)

Our goal was to examine gene transcription by B. burgdorferi following doxycycline treatment in an effort to identify both persister-associated genes and possible targets for antimicrobial intervention. (frontiersin.org)
In contrast, few changes in host gene transcription were found in uninfected cells. (microbiologyresearch.org)
However, the results of many researches proved that excessive transcription levels of target genes actually reduced the yield of the target product. (biomedcentral.com)
Furthermore, the results proved that the Hsf1, an upstream transcription factor of Hsps, had a positive effect on alleviating the unfolded protein response and that overexpression of Hsf1 reprogramed the pattern of ATF1 gene transcript levels. (biomedcentral.com)
The fine-tuning and precise control of key gene transcription levels are the important basis for the successful implementation of these strategies. (biomedcentral.com)

Whole-genome sequencing from semen and RNA sequencing of testis tissue revealed a critical mutation in adenylate kinase 9 (AK9) that impaired splicing, leading to a premature termination codon and a severely truncated protein. (ul.ie)
From here the genes are already present in the E. coli genome, they were not yet present in the metabolic network for E. coli in CellNetAnalyzer however. (igem.org)

261 essential genes from Bacillus subtilis , codon optimized for Escherichia coli in MoClo-compatible high-copy ampicillin resistance backbones. (freegenes.org)

A screen for suppressors of this growth arrest identified the RAS2 gene as a multicopy suppressor of the PPS1p overexpression arrest. (embl.de)
RNA-sequencing analysis showed that the overexpression of differential gene HSP30 increased the transcriptional abundance of ATF1 gene and production of ethyl acetate. (biomedcentral.com)

Discovery of genes essential for life is the first step in creating a truly synthetic organism. (freegenes.org)

As a broad host range pathogen, M. phaseolina possesses a large number of pathogen-host interaction genes including those for adhesion, signal transduction, cell wall breakdown, purine biosynthesis, and potent mycotoxin patulin. (biomedcentral.com)

For the mRNA analysis, RNA (1 mg) was reverse-transcribed by using the PrimeScript RT reagent Kit with gDNA Eraser (Tiangen), the mRNA level of the AK4 gene was quantified using duplex-qRT-PCR analysis where the Taqman probes with different fluorescence for β-actin were used in the FTC-3000P. (biomedcentral.com)

These mechanisms were developed using structurally conserved amino acid residues within hydrogen-bonding distance of a nucleotide in the active sites of crystallised kinases of a particular mechanistic class. (biomedcentral.com)

Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)

Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. (wikipedia.org)
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. (antikoerper-online.de)

However, the impacts of AK4 on metabolic genes and its translational value for drug repositioning remain unclear. (ellynaturals.pl)

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. (mousephenotype.org)

Gene regulatory network inference and gene module regulating virulence in Fusarium oxysporum. (openwetware.org)
VKRs consist of an extracellular Venus Flytrap Module (VFTM) linked via a transmembrane helix to a kinase domain. (bvsalud.org)

Three transcript variants encoding the same protein have been identified for this gene. (origene.com)

Our data revealed that both miR-199a-3p and its target gene AK4 are reversely correlated with the OS drug resistance. (biomedcentral.com)

Anatomy6

Organisms3

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes18

Information Science3

Mitochondrial2

Nucleoside diphos2

Creatine kinase1

Encodes4

Synthase1

Adenine nucleotide1

Regulation7

Nucleotides1

Proteins3

Chromosome2

Receptor2

Regulate4

Modulates1

Enzyme9

Deficiency1

Expression16

Molecular2

Symbol1

Subunit1

Bacterial1

20163

Isozymes1

Genetic4

Mutations1

Human4

20231

Enzymes1

Saccharomyces2

Pathway2

Species2

Sequences3

Suggests1

Reaction1

Transcription5

Genome2

Codon1

Overexpression2

Organism1

Adhesion1

MRNA1

Amino1

Cellular1

Isoforms2

Impacts1

Knockout1

Module2

Transcript1

Target gene1