• They are essentially hardwired genomic regulatory codes, the role of which is to specify the sets of genes that must be expressed in specific spatial and temporal patterns. (pnas.org)
  • At least 16 mutations in the ALK gene have been identified in some people with neuroblastoma, a type of cancerous tumor composed of immature nerve cells (neuroblasts). (nih.gov)
  • Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes-those that control cell proliferation or differentiation-allows cells to grow and divide uncontrollably to form a tumor. (nih.gov)
  • Less commonly, gene mutations that increase the risk of developing cancer can be inherited from a parent. (nih.gov)
  • Somatic mutations in the ALK gene occur during the development of some cases of sporadic neuroblastoma, and inherited mutations in the ALK gene increase the risk of developing familial neuroblastoma. (nih.gov)
  • Mutations in the ALK gene change single protein building blocks (amino acids) in ALK receptor tyrosine kinase. (nih.gov)
  • More than 150 PSEN1 gene mutations have been identified in patients with early-onset Alzheimer disease, a degenerative brain condition that begins before age 65. (nih.gov)
  • Mutations in the PSEN1 gene are the most common cause of early-onset Alzheimer disease, accounting for up to 70 percent of cases. (nih.gov)
  • Almost all PSEN1 gene mutations change single building blocks of DNA (nucleotides) in a particular segment of the PSEN1 gene. (nih.gov)
  • Studies suggest that the PSEN1 gene mutation that causes hidradenitis suppurativa has a different effect on γ-secretase function than the mutations that cause early-onset Alzheimer disease. (nih.gov)
  • Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. (wikipedia.org)
  • Eugene (Gene) Okerlund ( Robbinsdale , 29 november 1942 - Sisseton , 2 januari 2019 ), beter bekend als "Mean" Gene Okerlund , was een Amerikaans sportjournalist (met als specialisme professioneel worstelen ) en presentator . (wikipedia.org)
  • Tissue-specific gene inactivation in Xenopus laevis: knockout of lhx1 in the kidney with CRISPR/Cas9. (mbl.edu)
  • Alternatively, in vivo gene transfer is applied locally or systemically to genetically modify the target cells in situ [ 9 ]. (bioscirep.org)
  • How are genetic conditions and genes named? (nih.gov)
  • Viral vectors are most commonly used for clinical gene therapy resulting in the marketing authorization approval for several products to treat genetic diseases and cancer [ 1 , 2 ]. (bioscirep.org)
  • They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation. (genenames.org)
  • This translocation fuses the ALK gene to the NPM gene and results in a fusion protein called NPM-ALK. (nih.gov)
  • This inversion fuses the ALK gene with another gene called EML4 and results in the EML4-ALK fusion protein. (nih.gov)
  • The PSEN1 gene provides instructions for making a protein called presenilin 1. (nih.gov)
  • Input entire protein-encoding gene or transcript repertoires from genomes of interest, and cluster homologs (orthologs and paralogs). (cyverse.org)
  • Each file should represent, as nearly as possible, a complete protein-encoding gene repertoire. (cyverse.org)
  • Each file represents a 'complete' protein-encoding gene repertoire for that species. (cyverse.org)
  • Largely incomplete protein-encoding gene repertoires, or the inclusion of distantly related species, must be considered when interpreting output. (cyverse.org)
  • Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. (wikipedia.org)
  • Functional linkages between these particular genes, and their associated regulatory modules, define the core networks underlying development. (pnas.org)
  • But gene regulatory network architecture can be authenticated only by experimental molecular biology in which the functional meaning of given regulatory sequences is directly determined. (pnas.org)
  • Sixteen years later, in 1905, Wilhelm Johannsen introduced the term 'gene' and William Bateson that of 'genetics' while Eduard Strasburger, amongst others, still used the term 'pangene' for the fundamental physical and functional unit of heredity. (wikipedia.org)
  • There can be other kinds of enzymes involved in gene-editing - Cas12 and Cpf1 for example - but all of them work in the same basic way. (wired.co.uk)
  • Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease. (nih.gov)
  • The Eugene Bell Center for Regenerative Biology and Tissue Engineering was established in 2010 through the extraordinary leadership gifts of Millicent Bell and John and Valerie Rowe. (mbl.edu)
  • This phenomenon, known as gene amplification, results in overexpression of ALK receptor tyrosine kinase. (nih.gov)
  • By comparing the gene expression profiles of endothelial cells from regenerating liver to those derived from tumor-bearing livers, the researchers found 13 distinct genes that were selectively overexpressed (turned on to a greater degree than other genes) during disease-related angiogenesis. (nih.gov)
  • Gene regulatory networks explicitly represent the causality of developmental processes. (pnas.org)
  • Gene Woodbury is known for his work on Gifted (2017), The Bay (2012) and Full Moon High (1981). (imdb.com)
  • Occasionally, extra copies of the ALK gene are found in people with neuroblastoma. (nih.gov)
  • The Special Feature on gene regulatory networks in this issue of PNAS highlights an emerging field in the biosciences: gene regulatory networks that control animal development. (pnas.org)
  • Definitive regulatory functions emerge only from the architecture of intergenic linkages, and these functions are not visible at the level of any individual genes. (pnas.org)
  • It is most important to determine regulatory network architecture, and this can be done by experimental perturbation followed by measurement of the effects on function of many individual genes. (pnas.org)
  • Network substructure: Gene regulatory networks are inhomogeneous compositions of different kinds of subcircuits, each performing a specific kind of function. (pnas.org)
  • Reengineering genomic control systems: To redesign these most potent of all biological control systems, to both intellectual and practical ends, it is necessary to understand thoroughly the flow of causality in a genomically encoded gene regulatory network. (pnas.org)
  • For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. (wikipedia.org)
  • The ERG oncogene is activated in >50% of prostate cancer cases, generally through a gene fusion with the androgen‑responsive promoter of transmembrane protease serine 2. (spandidos-publications.com)
  • ETS-related gene ( ERG ), that is frequently found in aggressive prostate cancer. (spandidos-publications.com)
  • In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo retroviral transduction of surgically harvested cells. (aacrjournals.org)
  • Gene delivery can be achieved ex vivo , whereby donor-derived cells are cultured and genetically modified in vitro and subsequently reintroduced to autologous or allogeneic recipients [ 8 ]. (bioscirep.org)
  • The end result is the precise transcriptional control of the associated genes. (pnas.org)
  • Precise and inexpensive to produce, this small molecule can be programmed to edit the DNA of organisms right down to specific genes. (wired.co.uk)
  • This prompted numerous preclinical proof-of-concept studies in disease models that demonstrated the potential of DNA transposons for ex vivo and in vivo gene therapy. (bioscirep.org)
  • To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the most innovative papers to highlight the journal's impact on the field over the past 25 years. (nature.com)
  • To celebrate the 22nd ASGCT Annual Congress we are delighted to share with you a collection of Gene Therapy papers that reflect the themes of the conference. (nature.com)
  • Then, query clusters to assemble gene sets based on presence/absence and copy number. (cyverse.org)
  • How much of Gene Hackman's work have you seen? (imdb.com)
  • How much of Gene Woodbury's work have you seen? (imdb.com)
  • This disambiguation page lists articles associated with the title Gene . (wikipedia.org)
  • Although he did not use the term gene, he explained his results in terms of discrete inherited units that give rise to observable physical characteristics. (wikipedia.org)
  • In addition, the maximum cargo size of viral vectors is restricted, hampering gene transfer of larger therapeutic genes. (bioscirep.org)
  • A variety of non-viral gene delivery methods have been developed to improve the efficacy of gene transfer. (bioscirep.org)
  • How do geneticists indicate the location of a gene? (nih.gov)
  • The Transgenic and Gene Targeting Facility in London has generated four targeted gene replacements and more than a dozen transgenic lines through pronuclear injection in the last four years. (uwo.ca)
  • Usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to containing a different allele of the same, shared gene. (wikipedia.org)
  • The term gene was introduced by Danish botanist, plant physiologist and geneticist Wilhelm Johannsen in 1905. (wikipedia.org)