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  • Ki67
  • The expression of geminin, p16, and Ki67 was examined in 95 samples, including CIN1 (n = 45), CIN2/3 (n = 40), and normal cervical tissues (n = 10) by immunohistochemistry. (ovid.com)
  • The positive predictive value (PPV) and accuracy of geminin were higher than p16 and Ki67. (ovid.com)
  • In addition to p16 and Ki67, geminin might be used as a new biomarker to distinguish between CIN1 and CIN2/3. (ovid.com)
  • human
  • The correlation between geminin or p16 expression and human papillomavirus (HPV) status was also evaluated. (ovid.com)
  • Here we investigate the consequences of ablating geminin in synchronised human U2OS cells. (dundee.ac.uk)
  • function
  • Model organisms have been used in the study of Geminin function. (wikipedia.org)
  • The findings argue that Geminin-family members form homodimers and heterodimers between them, and this ability is likely to be important for modulating their function in cycling and differentiating cells. (iucr.org)
  • cells
  • Following geminin loss, cells complete an apparently normal S phase, but a proportion arrest at the G2-M boundary. (dundee.ac.uk)
  • Checkpoint kinases thereby amplify re-replication into an all-or-nothing response by delaying geminin-depleted cells in G2. (dundee.ac.uk)
  • This link between the control of DNA replication during early development and germ cell neoplasia reveals Geminin as a potential chemotherapeutic target in the eradication of cancer progenitor cells. (mdpi.com)
  • activity
  • In G1, APC activity is adequate to suppress the accumulation of geminin, thereby indirectly promoting pre-RC assembly. (wikipedia.org)
  • high
  • These results suggested that geminin had a high degree of sensitivity and specificity in determining CIN2/3. (ovid.com)
  • expression
  • We aimed to evaluate the diagnostic value of geminin expression in cervical intraepithelial neoplasm (CIN). (ovid.com)
  • Geminin expression was negative in all normal tissues and expressed in 13.3% of CIN1 and 90.0% of CIN2/3. (ovid.com)
  • In addition, geminin expression showed a weak correlation with HPV status, but there was no association between p16 expression and HPV status. (ovid.com)
  • less
  • TIPT2 synergizes with geminin and TBP in the activation of TATA box-containing promoters, and with TBPL1 and geminin in the activation of the TATA-less NF1 promoter. (biomedcentral.com)