Gemcitabine maintenance chemotherapy. Medical search. Frequent questions

[ 6 ] Chemotherapy combinations, such as gemcitabine plus docetaxel and epirubicin plus interferon, have demonstrated possible efficacy. (medscape.com)
Patients with recurrent/multifocal low-grade Ta lesions who require intravesical therapy should receive intravesical chemotherapy such as mitomycin, gemcitabine, epirubicin, or docetaxel instead of BCG. (auanet.org)
The randomised TAXOGEM study compared gemcitabine versus gem- citabine plus docetaxel after the failure of doxorubicin- based therapy in metastatic or unresectable LMS (with uterine and soft-tissue subgroups) [3]. (dehydrogenasesignals.com)
In the uterine subgroups, the objective response rates were 19% with gemcitabine alone and 24% with gemcitabine plus docetaxel. (dehydrogenasesignals.com)
In the non-uterine groups, the response rates were 14% with gemcitabine alone and 5% with gemci- tabine plus docetaxel. (dehydrogenasesignals.com)
Gemcitabine with or without docetaxel had similar median progression-free survival (PFS). (dehydrogenasesignals.com)
Biweekly docetaxel as second-line chemotherapy of patients with advanced non-small cell lung cancer: a phase II study of the Galician Lung Cancer Group (GGCP 006-00). (grupogallegocancerdepulmon.org)
Alternative instillation techniques of sequential intravesical gemcitabine and docetaxel for non-muscle-invasive bladder cancer. (amedeo.com)
For platinum-resistant or platinum-sensitive ovarian cancer patients, non-platinum drugs such as doxorubicin, paclitaxel, gemcitabine, docetaxel and etoposide are recommended ( 5 ). (frontiersin.org)
Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer. (asitri.com)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

4 Patients typically receive between 3 and 6 cycles of carboplatin and paclitaxel (or another platinum-based regimen), followed by completion surgery and postoperative chemotherapy. (ahdbonline.com)
Paclitaxel, carboplatin, and gemcitabine (PCG) versus gemcitabine and vinorelbine (GV) in chemotherapy naïve patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase III trial of the Minnie Pearl Cancer Research Network (MPCRN). (asbestos.com)
This trial was designed such that patients with a response or stable disease after gemcitabine plus cisplatin or gemcitabine plus carboplatin were randomized to avelumab [Bavencio], a PD-L1 inhibitor plus best supportive care vs best supportive care alone. (onclive.com)
This randomized phase III trial studies carboplatin, paclitaxel and gemcitabine hydrochloride when given together with or without bevacizumab after surgery to see how well it works in treating patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer that has come back. (ucsf.edu)
Drugs used in chemotherapy, such as carboplatin, paclitaxel and gemcitabine hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsf.edu)
A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. (ucsf.edu)
To determine if the addition of bevacizumab to the second-line and maintenance phases of treatment increases the duration of overall survival relative to second-line paclitaxel and carboplatin alone in patients with recurrent platinum sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer. (ucsf.edu)
To identify molecular determinants that predict sensitivity or resistance to carboplatin and paclitaxel with or without bevacizumab followed with or without maintenance bevacizumab therapy. (ucsf.edu)
The most recent standard was systemic chemotherapy with either a cisplatin- or carboplatin-based regimen, followed by maintenance avelumab, which had been shown to extend patient lives. (guoncologynow.com)
There are some newer data saying maybe Gem Carbo [gemcitabine and carboplatin] does OK, but I would stick with gemcitabine and cisplatin if I can. (cancernetwork.com)
Chemotherapy was relatively evenly split between taxanes and the gemcitabine/carboplatin combination. (sense-studios.com)

Several systemic therapies, such as oxaliplatin + irinotecan/fluorouracil/leucovorin (FOLFIRINOX) and gemcitabine + nab-paclitaxel, have shown activity in the adjuvant and neoadjuvant settings. (jnccn.org)
To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases the duration of overall survival in patients with recurrent platinum sensitive epithelial ovarian cancer , peritoneal primary or fallopian tube cancer. (ucsf.edu)
To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases quality of life (QOL) in patients with recurrent platinum-sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer, as measured by the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) trial outcome index and Rand Short Form (SF)-36 physical functioning scale. (ucsf.edu)
Despite maximal cytoreduction at the time of primary surgery and platinum-based adjuvant chemotherapy, 70-80% of patients with advanced ovarian cancer will relapse ( 4 ). (frontiersin.org)
In fact, most patients with stage I disease are treated with adjuvant chemotherapy because of the luminal structure of the organ and the risk of shedding cells out of the tubes and into the abdominal cavity. (medscape.com)
Neo-adjuvant chemotherapy followed by chemoradiation and surgery with and without cetuximab in patients with resectable esophageal cancer: a randomized, open-label, phase III trial (SAKK 75/08). (canceropole-est.org)
Treatment protocols for bladder cancer are provided below, including those for chemotherapy, immunotherapy, and systemic neoadjuvant and adjuvant therapy. (medscape.com)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)

Another frequently used regimen, nab-paclitaxel + gemcitabine, was evaluated in the global phase III MPACT trial. (jnccn.org)
Patients with an ECOG performance status of 2 were randomly assigned to receive gemcitabine alone or in combination with nab-paclitaxel. (jnccn.org)
This is the trial that put gemcitabine and nab-paclitaxel into [the NCCN Guidelines]. (jnccn.org)
According to Dr. Tempero, compared with FOLFIRNOX, gemcitabine + nab-paclitaxel demonstrates an improved toxicity profile. (jnccn.org)
Initiation of a Phase 2 study of VCN-01 in combination with standard-of-care chemotherapy (gemcitabine/nab-paclitaxel) as a first line therapy in newly diagnosed metastatic PDAC patients (H2 2022). (therivabio.com)

Results from a clinical trial of olaparib in 137 patients with BRCA mutation-positive ovarian cancer who had received ≥3 chemotherapy regimens demonstrated an investigator-assessed overall response rate of 34% and a median duration of response of 7.9 months. (ahdbonline.com)
The efficacy of rucaparib was established in Study 10 and in the ARIEL2 study, 2 open-label, single-arm, multicenter clinical trials of 106 patients with advanced BRCA mutation-positive ovarian cancer who received at least 2 previous chemotherapy regimens. (ahdbonline.com)
Currently, doxorubicin-based and gemcitabine- based regimens are the mainstay for early lines of treatment for metastatic LMS. (dehydrogenasesignals.com)
Hence, there is a need to explore new chemotherapy-free regimens for treating chemotherapy intolerant patients. (frontiersin.org)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

Abstract Background: Options in second-line therapy after doxorubicin-based chemo- therapy for metastatic/advanced leiomyosarcoma include gemcitabine (G), trabectedin and pazopanib (P) monotherapy. (dehydrogenasesignals.com)
Patients and methods: Patients (pts), ECOG 2, with metastatic leiomyosarcomas (LMS) after first-line doxorubicin chemotherapy failure were eligible. (dehydrogenasesignals.com)

In the phase II/III PRODIGE 4/ACCORD 11 trial, patients with metastatic pancreatic cancer were randomly assigned to receive gemcitabine or a combination chemotherapy regimen consisting of oxaliplatin/irinotecan/fluorouracil/leucovorin (FOLFIRINOX). (jnccn.org)
Omitting bolus fluorouracil, reducing doses, eliminating drugs that cause excessive toxicity, and using chemotherapy holidays have been found to increase the tolerability of this regimen. (jnccn.org)
Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
It is indicated for maintenance treatment of adults with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
There is a need to explore long-term treatments of chemotherapy-free regimen of chronic kidney disease in recurrent ovarian cancer. (frontiersin.org)
The patient accepted Niraparib-based treatment regimen after multi-line chemotherapy-induced stage 4 chronic kidney disease. (frontiersin.org)
Niraparib-based treatment regimen may be a good choice for patients with well-differentiated serous adenocarcinoma of the ovary who are intolerant to chemotherapy. (frontiersin.org)
With enfortumab vedotin plus pembrolizumab, we are seeing in a cohort of patients who are cisplatin-ineligible (not the typical candidates for frontline cisplatin-based chemotherapy) objective response rates that are over 70% and a regimen that appears to be more tolerated than most systemic chemotherapy options. (guoncologynow.com)
DESIGN, SETTING, AND PARTICIPANTS We developed a Markov model using data from multiple sources, including the SQUIRE trial, which compared standard chemotherapy with and without necitumumab as first-line treatment of mSqCLC, to evaluate the costs and patient life expectancies associated with each regimen. (psu.edu)
Centering discussion on a clinical scenario of metastatic urothelial carcinoma, panelists determine which first-line regimen they would utilize prior to maintenance therapy. (cancernetwork.com)
For those with aggressive or high-risk disease (positive margins) or multiple positive lymph nodes, consider switching to a gemcitabine-based regimen (see Systemic therapy , below). (medscape.com)

Intravesical chemotherapy should be used as the first-line option for patients with intermediate-risk NMIBC. (auanet.org)
If BCG would be administered as second-line therapy for patients with intermediate-risk NMIBC, an alternative intravesical chemotherapy should be used rather than BCG in the setting of this BCG shortage. (auanet.org)
The optimal intravesical maintenance chemotherapy scheme for the intermediate-risk group non-muscle-invasive bladder cancer. (amedeo.com)

in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC) with no EGFR or ALK genomic tumor aberrations. (nih.gov)
The recommended dose of pemetrexed for injection administered with pembrolizumab and platinum chemotherapy in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes, administered after pembrolizumab and prior to platinum chemotherapy, on Day 1 of each 21-day cycle. (nih.gov)
Combining pembrolizumab with chemotherapy yielded a significant improvement in progression-free survival (PFS) compared with chemotherapy and placebo in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC) that was PD-L1-positive, according to a randomized, phase III trial presented during the ASCO20 Virtual Scientific Program [1]. (sense-studios.com)
The immunomodulatory properties of chemotherapy suggest that combining pembrolizumab with chemotherapy might enhance antitumor activity. (sense-studios.com)
events leading to discontinuation of any drug occurred in 18.1% of patients in the pembrolizumab group and in 11.0% in the chemotherapy-alone group. (sense-studios.com)
These findings suggest a role for the addition of pembrolizumab to standard chemotherapy for the first-line treatment of metastatic TNBC," Dr. Cortés concluded. (sense-studios.com)
So, in the setting of cisplatin shortages, at least in this country, we may be offering enfortumab vedotin plus pembrolizumab while we're still waiting for the head-to-head data of enfortumab vedotin/pembrolizumab vs platinum/gemcitabine from the phase 3 EV-302 study (NCT04223856). (urologytimes.com)

Gemcitabine, cisplatin and vinorelbine as induction chemotherapy followed by radical therapy in stage III non-small-cell lung cancer: a multicentre study of galician-lung-cancer-group. (grupogallegocancerdepulmon.org)

The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
Erlotinib has been approved by the FDA for use, in combination with gemcitabine, as a first-line treatment for locally advanced, unresectable, or metastatic pancreatic cancer. (medscape.com)
On the back of successful Phase III trials in pancreatic cancer, Tarceva secured approval for treatment of advanced pancreatic cancer in combination with gemcitabine in chemotherapy-naïve patients in both the US and Europe. (clinicaltrialsarena.com)
Treatment should continue until disease progression or unacceptable toxicity occurs.Pancreatic Cancer: The recommended daily dose of Erloren 150 mg for pancreatic cancer is 100 mg taken once daily in combination with gemcitabine. (medeasy.health)
The advent of effective combination chemotherapies has changed the treatment landscape for metastatic pancreatic cancer, extending median survival and leading to durable responses in a subset of patients. (ascopost.com)

The patient initially underwent 4 courses of systemic chemotherapy that consisted of cisplatin and gemcitabine, resulting in a partial response, but the disease subsequently progressed. (hindawi.com)
However, this approach did require patients to have stable disease or better following their frontline systemic chemotherapy. (guoncologynow.com)

and gemcitabine plus capecitabine (GemCap). (medscape.com)
This was combined with either 4 months of gemcitabine at 1,000 mg/m 2 weekly for 3 out of 4 weeks or capecitabine at 2,000 mg/m 2 for 14 days every 3 weeks for a total of 4 months. (iiarjournals.org)

Cisplatin-based chemotherapy has produced great results. (onclive.com)
I'm a strong proponent of gemcitabine and cisplatin based on the older data. (cancernetwork.com)
The harder part is with cisplatin because we know that there's a subset of patients-and it's mostly those with soft tissue metastasis-that gets cisplatin-based combinations and are cured, even without maintenance immunotherapy. (urologytimes.com)

Imfinzi is indicated as maintenance therapy after definitive chemoradiation therapy (CRT) in locally-advanced (Stage III), unresectable non-small cell lung cancer (NSCLC). (pharmaceutical-technology.com)
A phase II trial of erlotinib as maintenance treatment after concurrent chemoradiotherapy in stage III non-small-cell lung cancer (NSCLC): a Galician Lung Cancer Group (GGCP) study. (grupogallegocancerdepulmon.org)
Third and successive-lines of chemotherapy in NSCLC patientes without therapeutic targets: Experience of the Grupo Gallego de Cáncer de Pulmón. (grupogallegocancerdepulmon.org)
European approval for treatment of NSCLC in patients failing prior chemotherapy followed in 2005. (clinicaltrialsarena.com)
Tarceva was approved by the FDA as a maintenance therapy for advanced NSCLC in April 2010. (clinicaltrialsarena.com)
Survival benefit was subsequently confirmed in the primary registration trial, a Phase III randomised, double-blind study in which Tarceva was compared with placebo in 731 patients with NSCLC who had failed prior chemotherapy. (clinicaltrialsarena.com)
Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. (biomedcentral.com)
This multicenter, randomized, phase 2 study compared continuation maintenance therapy with pemetrexed (500 mg/m 2 every 21 days) and best supportive care (BSC) versus BSC alone in patients with advanced, non-squamous NSCLC who had not progressed after 4 cycles of induction chemotherapy with pemetrexed (500 mg/m 2 ) and cisplatin (75 mg/m 2 ). (biomedcentral.com)
Continuation pemetrexed maintenance therapy resulted in promising PFS with an acceptable safety profile in a Middle Eastern population with advanced non-squamous NSCLC and is worthy of further investigation. (biomedcentral.com)
In patients with advanced non-small cell lung cancer (NSCLC), there is generally a brief period of disease control after response to first-line chemotherapy. (biomedcentral.com)
In advanced NSCLC, maintenance therapy is typically initiated after 4-6 cycles of induction chemotherapy with an active doublet and is continued until disease progresses or unacceptable toxicity is reached. (biomedcentral.com)
Pemetrexed received approval of the U.S. Food and Drug Administration (FDA) as initial therapy in combination with cisplatin, as monotherapy after prior chemotherapy, and as maintenance monotherapy in patients with locally advanced or metastatic non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy [ 3 ]. (biomedcentral.com)
as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. (nih.gov)
as a single agent for the treatment of patients with recurrent, metastatic non-squamous, NSCLC after prior chemotherapy. (nih.gov)

Women with these gene abnormalities who have tried at least two chemotherapy treatments for their ovarian cancer now have an additional treatment option," stated Richard Pazdur, MD, Director of the FDA's Office of Hematology and Oncology Products. (ahdbonline.com)

EGFR protects malignant tumour cells from the cytotoxic effects of chemotherapy and radiotherapy, making these treatments less effective. (clinicaltrialsarena.com)

For most people with advanced bladder cancer , starting immunotherapy shortly after initial treatment with chemotherapy is better than taking an extended break from cancer treatment, according to results from a new study. (cancer.gov)
In recent years, several studies have looked at different approaches, [such as] combinations of chemotherapy plus immunotherapy. (onclive.com)
At this time, there's really only one truly "prime-time" [level-1-evidence-supported] immunotherapy in the first-line setting and that is in a patient who has had first-line platinum-based chemotherapy and has had disease control, meaning a partial response or stable disease-we give those patients immunotherapy in the form of first-line avelumab maintenance. (urologytimes.com)

A frequently quoted trial showed a small, but statistically significant, improvement in overall survival with gemcitabine versus 5-FU (5.7 vs 4.4 mo). (medscape.com)
A cost-effectiveness analysis of avelumab plus best supportive care versus best supportive care alone as first-line maintenance treatment for patients with locally advanced or metastatic urothelial carcinoma in Taiwan. (amedeo.com)
Maintenance systemic therapy versus consolidative sterotactic body radiation therapy (SBRT) plus maintenance systemic therapy for limited metastatic non-small cell lung cancer: A randomized phases II/III trial. (mobapcancerresearch.org)
Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer. (canceropole-est.org)

4 Maintenance therapy (or postremission therapy) with pazopanib (Votrient) or bevacizumab (Avastin) can be considered in some clinical circumstances. (ahdbonline.com)
A Phase-2 Trial of Single Agent Axitinib as Maintenance Therapy Following First-Line Treatment With Modified FOLFOX/Bevacizumab in Patients With Metastatic Colorectal Cancer. (asbestos.com)
It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab after surgery in treating patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer. (ucsf.edu)
To define molecular and biochemical profiles associated with the duration of progression-free survival in platinum-sensitive recurrent ovarian, peritoneal primary or fallopian tube carcinoma treated with combination chemotherapy with or without bevacizumab followed with or without maintenance bevacizumab therapy in the presence or absence of secondary surgical cytoreduction. (ucsf.edu)
PFS did not differ in the BRCA1/2 mutational status among the patients who received bevacizumab maintenance (n=90, p=0.992). (e-crt.org)
In this real-world evidence study, BRCA1/2 mutational status itself was not associated with PFS and OS in PSR EOC, which was consistent with whether secondary CRS or not and with bevacizumab maintenance. (e-crt.org)

Regardless of mutation status, systemic treatment for advanced ovarian cancer most often includes platinum-based cytotoxic chemotherapy. (ahdbonline.com)
In December 2014, the US Food and Drug Administration (FDA) granted accelerated approval to olaparib (Lynparza), an inhibitor of poly ADP-ribose polymerase (PARP), for the treatment of women with advanced ovarian cancer who received ≥3 chemotherapies and who have deleterious or suspected deleterious germline BRCA mutation, as detected by the FDA-approved companion diagnostic test BRACAnalysis CDx. (ahdbonline.com)
Clovis Oncology) for the treatment of women who have received ≥2 chemotherapies and whose tumors are associated with deleterious BRCA mutation-associated (germline and/or somatic) advanced ovarian cancer, as detected by the FDA-approved companion diagnostic test FoundationFocus CDxBRCA. (ahdbonline.com)
For patients with advanced ovarian cancer who have received ≥2 chemotherapies and whose tumors have deleterious BRCA mutations, the recommended dosage of rucaparib is 600 mg, orally, twice daily with or without food. (ahdbonline.com)
Platinum-based combination chemotherapy is recommended first choice for relapsed ovarian cancer. (frontiersin.org)
Women with platinum-sensitive recurrent ovarian cancer (PSROC) can be treated with secondary cytoreductive surgery (SCS) and chemotherapy or chemotherapy alone. (frontiersin.org)
However, renal impairment is a common serious complication of chemotherapy in ovarian cancer ( 6 ). (frontiersin.org)
PARPi such as niraparib and olaparib, are approved by FDA as maintenance therapy for patients with PSROC and as posterior line therapy for patients with BRCA mutated recurrent ovarian cancer. (frontiersin.org)
As in ovarian cancer, the use of intraperitoneal (IP) chemotherapy must be considered the current standard treatment option in patients with stage II-IV disease. (medscape.com)
Approximately 90% of all ovarian cancer cases are histologically epithelial ovarian cancer (EOC), which tends to be diagnosed at an advanced stage and relapses despite primary treatment, consisting of extensive cytoreductive surgery (CRS) and platinum-based combination chemotherapy [ 3 ]. (e-crt.org)

It is indicated for metastatic adenocarcinoma of the pancreas as first-line treatment in combination with gemcitabine. (medscape.com)
Irinotecan liposomal is used in combination with fluorouracil and leucovorin for metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. (medscape.com)
The median PFS was 5.5 months in the uterine and 6.3 months in the non-uterine subgroups with gemcitabine alone, but shorter than 5 months in both groups with the gemcitabineedocetaxel combination. (dehydrogenasesignals.com)
Traditionally, retreatment of platinum-based combination chemotherapy has been recommended as a secondary treatment to patients with platinum-sensitive recurrence (PSR), defined as ≥ 6 months of platinum-free interval (PFI) [ 5 , 6 ]. (e-crt.org)
Dr. Kelly noted several remaining questions, including whether the specific chemotherapy partner matters, and whether those patients with PD-L1 CPS between 1 and 10 do derive benefit from the combination. (sense-studios.com)
On subsequent cycles, mg of obinutuzumab was administered on day 1 of In combination with chlorambucil chemotherapy for the treatment of people. (politcontakt.ru)
Duration of the Cycle Chemotherapy treatment may be a single drug or a combination of drugs. (politcontakt.ru)

Previous studies have investigated maintenance therapy, but none has shown a great effect. (mesothelioma-line.com)
The approval is for the use of avelumab as maintenance therapy for advanced disease that has not spread ( locally advanced ) or disease that has spread beyond the bladder ( metastatic ). (cancer.gov)
Patients who received avelumab as maintenance therapy had "the longest overall survival ever documented" in a clinical trial for patients with metastatic bladder cancer, said Elizabeth Plimack, M.D., head of bladder cancer research at Fox Chase Cancer Center, who was not involved with the study, speaking at the ASCO meeting. (cancer.gov)
Several of these drugs were approved as initial therapies ( first-line therapy ) for some people with advanced bladder cancer who, for various health reasons, cannot receive platinum-based chemotherapy. (cancer.gov)
Other approvals were for bladder cancer that recurs after platinum-based chemotherapy ( second-line therapy ). (cancer.gov)
As a class, NSCLCs are relatively insensitive to chemotherapy and radiation therapy compared with SCLC. (medpagetoday.com)
Patients with metastatic disease were randomly assigned to receive 12 cycles of FOLFIRINOX (arm A), 8 cycles of FOLFIRINOX followed by maintenance therapy with fluorouracil + leucovorin (arm B), or a sequential treatment alternating gemcitabine and fluorouracil/leucovorin/irinotecan every 2 months (arm C). According to Dr. Tempero, the median durations of OS did not seem to differ between arms A and B (10.1 vs 11.2 months). (jnccn.org)
Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is used for maintenance therapy in pancreatic adenocarcinoma. (medscape.com)
If supply exists for maintenance therapy for patients with NMIBC, limit BCG dose to one year. (auanet.org)
There was a signal that maintenance therapy might be the way to go but [that trial] did not change practice because the OS was not prolonged. (onclive.com)
Conclusions: LMS03 failed to show that second-line therapy, with gemcitabine combined with pazopanib, followed by pazopanib alone, was beneficial for advanced LMS patients. (dehydrogenasesignals.com)
After receiving a 6 course first line chemotherapy and 8 course maintenance therapy, the patient suffered acute abdominal pain , so surgery was performed. (symptoma.com)
NOVA study is the first study to report effectiveness of niraparib as maintenance therapy in patients with PSROC regardless of BRCA mutation ( 9 ). (frontiersin.org)
The utility of continuation maintenance therapy requires further research. (biomedcentral.com)
A total of 106 patients commenced induction therapy, of whom 55 patients were randomized to maintenance pemetrexed/BSC (n = 28) or BSC (n = 27). (biomedcentral.com)
A key consideration for maintenance therapy is to utilize a well-tolerated agent with a relatively low risk of serious, cumulative toxicities. (biomedcentral.com)
This randomized phase II/III trial studies how well giving maintenance chemotherapy with or without stereotactic body radiation therapy works in treating patients with stage IV non-small cell lung cancer. (mobapcancerresearch.org)
Giving maintenance chemotherapy and stereotactic body radiation therapy together may work better than maintenance chemotherapy alone in treating patients with stage IV non-small cell lung cancer. (mobapcancerresearch.org)
After you get rid of the tumor, you may have to undergo maintenance therapy to prevent the tumor from coming back. (zenonco.io)
Both secondary cytoreductive surgery (CRS) and maintenance therapy were stratified considering real-world clinical practice. (e-crt.org)
The two groups had similar proportions of patients undergoing secondary CRS (26.4% vs. 32.7%, p=0.286) and maintenance therapy (54.9% vs. 46.2%, p=0.178). (e-crt.org)
However, recent landmark phase III randomized controlled trials (RCTs) proved survival benefit from maintenance therapy with poly(ADP-ribose) polymerase inhibitors (PARPis), both olaparib (OLA) and niraparib (NIRA), which significantly improved the progression-free survival (PFS) in PSR EOC, especially for BRCA mutated, high-grade serous or endometrioid carcinoma [ 7 - 9 ]. (e-crt.org)
We report the case of a 49-year-old Caucasian woman diagnosed with metastatic luminal A breast cancer with initial bone followed by liver and bone marrow metastases, treated with three lines of hormonal therapy, targeted therapy and six lines of chemotherapy. (biomedcentral.com)
Initiation of a Phase 2/3 pivotal trial of VCN-01 as either an adjunct to chemotherapy or a potential rescue therapy in pediatric patients with advanced retinoblastoma (early 2023). (therivabio.com)
In a single-institution study reported in JAMA Oncology, Reyngold et al found that definitive hypofractionated ablative radiation therapy following induction chemotherapy was associated with prolonged locoregional control and favorable survival in patients with inoperable locally advanced. (ascopost.com)
As maintenance therapy following ASCT, Revlimid is. (politcontakt.ru)
And that would be kind of first-line switch maintenance therapy. (urologytimes.com)
Sagar Lonial, MD, of Emory University School of Medicine, and Andrew D. Zelenetz, MD, PhD, of Memorial Sloan Kettering Cancer Center, discuss newly reported findings on rituximab maintenance therapy i. (ascopost.com)

Maintenance BCG should be prioritized for patients with high-risk non-muscle-invasive bladder cancer, including CIS, in the early maintenance period (eg, 3- and 6-months post-induction). (medscape.com)
On July 1, 2020, the Food and Drug Administration (FDA) approved avelumab (Bavencio) for people with advanced bladder cancer that has shrunk or stopped growing after chemotherapy using a platinum-based drug. (cancer.gov)
Although most bladder cancers stop growing, shrink, or even disappear in response to chemotherapy that uses a platinum-based drug (such as cisplatin), the cancer almost always returns rapidly, sometimes within just a few weeks or months, and grows aggressively. (cancer.gov)
EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells. (amedeo.com)
In this type of treatment, drugs like Mitomycin C and gemcitabine are administered directly into your bladder with the help of a thin tube called a catheter. (zenonco.io)

Her treatment was then switched to chemotherapy associating cyclophosphamide (600mg/m2) and epirubicin (75mg/m2, every three weeks), which induced a partial response after three and a half months (six cycles). (biomedcentral.com)

We investigated the addition of gemcitabine and oxaliplatin (GEMOX) to sorafenib in aHCC patients. (nature.com)

BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

Patients who have undergone optimal tumor debulking should be offered IP chemotherapy. (medscape.com)
In turn, this improves the anti-tumor effect of the oncolytic virus, as well as chemotherapies and immuno-oncology products. (therivabio.com)
Expression of mutations in tumor gene p53 may be associated with both progression and resistance to chemotherapy. (msdmanuals.com)

We aimed to assess the efficacy and safety of switch-maintenance gemcitabine in patients with malignant mesothelioma without disease progression after first-line chemotherapy. (mesothelioma-line.com)
We recruited patients aged older than 18 years with unresectable malignant mesothelioma with no evidence of disease progression after at least four cycles of first-line chemotherapy (with platinum and pemetrexed), who had a WHO performance status of 0-2, adequate organ function, and measurable or evaluable disease. (mesothelioma-line.com)
Interpretation: Switch-maintenance gemcitabine, after first-line chemotherapy, significantly prolonged progression-free survival compared with best supportive care alone, among patients with malignant mesothelioma. (mesothelioma-line.com)
In a single-institution phase II study reported in the Journal of Clinical Oncology, Kim A. Reiss, MD, and colleagues found that maintenance treatment with the poly (ADP-ribose) polymerase (PARP) inhibitor rucaparib produced responses and was associated with good progression-free survival in. (ascopost.com)
The major part of patient selection [for upfront avelumab maintenance] is that they have not had primary progression on platinum-based chemotherapy. (urologytimes.com)

National Comprehensive Cancer Network (NCCN) guidelines recommend that a one-half or one-third dose may be considered for BCG induction and should be used for BCG maintenance, if supply allows. (medscape.com)
Now, after platinum-based induction chemotherapy, those with a response or stable disease [receive] switch maintenance avelumab. (onclive.com)
Similar PFS results were observed for the overall study period (induction plus maintenance) and when the PFS analysis was adjusted for sex, baseline disease stage, and the ECOG PS prior to randomization. (biomedcentral.com)
In cancer, EMT plays various roles in the maintenance of cancer stemness and induction of metastasis, and is inducible by different growth factors, hormones, and intracellular molecules. (microrna21.com)

The patient had recurrence of platinum resistance after secondary cytoreductive surgery, and it was difficult to continue chemotherapy after multiple lines of chemotherapy due to myelosuppression, renal impairment and other factors. (frontiersin.org)

Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum chemotherapy. (aacrjournals.org)
If you compare them with the treatment standards that were in place when I began over 20 years ago, we had platinum-based chemotherapy as the standard with a median survival that was around 1 year for patients with metastatic surgically unresectable tumors. (guoncologynow.com)
The one-year survival probabilities were similar for both arms for the maintenance phase and the overall study period. (biomedcentral.com)
IMPORTANCE The SQUIRE trial demonstrated that adding necitumumab to chemotherapy for patients with metastatic squamous cell lung cancer (mSqCLC) increased median overall survival by 1.6 months (hazard ratio, 0.84). (psu.edu)
OLA maintenance even resulted in prolonged overall survival (OS) [ 10 ]. (e-crt.org)

The median OS for the maintenance phase was 12.2 months (95%CI: 5.6 to 20.6) for the pemetrexed/BSC arm and 11.8 months (95% CI: 6.3 to 25.6) for BSC arm. (biomedcentral.com)

Platinum-based chemotherapy can be grueling, he continued, and "these patients have had four to six cycles of treatment, and they're pretty beat up. (cancer.gov)
Consensus-based guidelines from the National Comprehensive Cancer Network (NCCN) suggest administering three to six cycles of chemotherapy for stage IA-IC disease and six to eight cycles for stage II-IV disease. (medscape.com)
In the analysis, patients were modeled to receive gemcitabine and cisplatin for 6 cycles or gemcitabine, cisplatin, and necitumumab for 6 cycles followed by maintenance necitumumab. (psu.edu)
The question I have is, maybe Tian you can help me, how many cycles of chemotherapy do you use? (cancernetwork.com)
I think on the trial, patients usually had at least 4 cycles of chemotherapy. (cancernetwork.com)
But most people, by the time they get through 4 cycles and they see on scans that their tumors are shrinking, they're very motivated to finish the 6 cycles of chemotherapy as well. (cancernetwork.com)
I would say a majority still go to 6 cycles, and then we do the maintenance avelumab. (cancernetwork.com)
Most chemotherapy treatments are given in repeating cycles. (politcontakt.ru)

The toxicity was lower with gemcitabine alone. (dehydrogenasesignals.com)

One patient (2%) in the gemcitabine group died, due to a treatment-related infection. (mesothelioma-line.com)
After first-line chemotherapy, only a minority of patients get second-line treatment. (cancer.gov)
Efforts to move beyond chemotherapy alone for patients with advanced urothelial cancer, shift effective treatments into the curative setting in renal cell carcinoma, and effectively escalate treatment for patients with high-risk and high-volume prostate cancer have been successfully met. (onclive.com)
Efforts to move beyond chemotherapy alone for patients with advanced urothelial cancer, shift effective treatments into the curative setting in renal cell carcinoma (RCC), and effectively escalate treatment for patients with high-risk and high-volume prostate cancer have been successfully met, explained Petros Grivas, MD, PhD, in an interview with OncLive ® during an Institutional Perspectives in Cancer webinar on genitourinary malignancies. (onclive.com)
Because of this peculiar way of administration, MC can be viewed as a form of long-term 'maintenance' treatment, and can be integrated with standard and conventional chemotherapy in a 'chemo-switching' strategy. (unica.it)
Cancer Genetic Testing · Cancer Treatment Center · Chemotherapy · Clinical Trials. (politcontakt.ru)
If you lost your hair, you should start to see it grow back 14 to 21 days after your last chemotherapy treatment. (politcontakt.ru)

How would you define attempts to improve upon outcomes with platinum-based chemotherapy for patients with newly diagnosed metastatic urothelial cancer? (onclive.com)
We did have 2 switch maintenance trials from chemotherapy to a checkpoint inhibitor in patients who had achieved a response or stable disease to platinum-based chemotherapy. (onclive.com)
These patients have been re-treated with platinum-based chemotherapy. (medscape.com)

This study confirms the activity of gemcitabine in treating malignant mesothelioma. (mesothelioma-line.com)

With the addition of immune checkpoint inhibitors, we started to see an expansion of life expectancy, patients living longer when we were able to sequence from chemotherapy to a checkpoint inhibitor and then use maintenance avelumab even in the frontline setting for patients with stable disease. (guoncologynow.com)

Tumour removal (resection), chemotherapy and chemoradiation may be indicated. (wikipedia.org)

If the patients are in really good shape and they're young, I think that MVAC is stronger than [gemcitabine and cisplatin]. (cancernetwork.com)

[ 1 , 2 ] Currently, both early-stage and advanced-stage fallopian tube cancers are treated in much the same way as ovarian cancers-that is, with surgery followed by chemotherapy. (medscape.com)
Accordingly, the chemotherapy used to treat primary fallopian tube cancers is based on the standard management of ovarian cancers. (medscape.com)

This chemotherapy usually follows the surgery. (zenonco.io)
After chemotherapy: When you are taking Herceptin after surgery and completion of chemotherapy, you may receive Herceptin either every 3 weeks OR once a week. (politcontakt.ru)

OBJECTIVE To evaluate the range of drug costs for which adding necitumumab to chemotherapy could be considered cost-effective. (psu.edu)

Study schema outlining a day cycle of chemotherapy and timing of acupuncture treatments. (politcontakt.ru)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)

Anatomy3

Organisms2

Diseases68

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Phenomena and Processes18

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science3

Health Care27

Docetaxel12

Carboplatin11

Adjuvant8

Paclitaxel5

Regimens5

Doxorubicin2

Regimen11

Intravesical3

Pembrolizumab7

Vinorelbine1

Pancreatic cancer5

Systemic chemotherapy2

Capecitabine2

Cisplatin-based3

NSCLC14

Tried at least two chemotherapy1

Radiotherapy1

Immunotherapy3

Versus4

Bevacizumab6

Ovarian cancer10

Combination7

Therapy28

Bladder5

Epirubicin1

Oxaliplatin1

Cytotoxic chemotherapy1

Tumor3

Progression5

Induction4

Lines of chemotherapy1

Survival5

Median1

Cycles8

Toxicity1

Treatment7

Platinum-based3

Malignant1

Inhibitor1

Chemoradiation1

MVAC1

Fallopian tube2

Surgery2

Necitumumab1

Treatments2