Gemcitabine and cisplatin biliary tract diseases. Medical search. Frequent questions

We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). (nih.gov)
The US Food and Drug Administration (FDA) approved durvalumab for certain types of bladder, lung, and biliary tract cancer: Adults with locally advanced or metastatic urothelial carcinoma who either have disease progression during or following platinum-containing chemotherapy or have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. (wikipedia.org)
Adults with unresectable, Stage III non-small cell lung cancer whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy. (wikipedia.org)
In combination with etoposide and either carboplatin or cisplatin, as first-line treatment for adults with extensive-stage small cell lung cancer. (wikipedia.org)
In combination with gemcitabine and cisplatin for adults with locally advanced or metastatic biliary tract cancer (BTC). (wikipedia.org)
709 patients with stage III NSCLC who did not have disease progression after two or more cycles of a platinum-based chemotherapy were randomly assigned to receive durvalumab or a placebo as consolidation therapy for their lung cancer. (wikipedia.org)
Current consensus guidelines from the Americas Hepato-Pancreato-Biliary Association recommend re-resection for patients with T1b, T2 or T3 gallbladder cancer that is incidentally identified in a cholecystectomy specimen, unless this surgery is contraindicated because of advanced disease or poor performance status. (medscape.com)
Following R0 resection of T2-4 disease in N1 gallbladder cancer, patients should be considered for adjuvant systemic chemotherapy and/or chemoradiotherapy. (medscape.com)
Neoadjuvant chemoradiotherapy is not currently a standard option for patients with biliary tract cancer. (medscape.com)
Advanced biliary tract cancer (ABC) has a poor prognosis. (nature.com)
Novel therapeutic options, based on an improved understanding of underlying biology and response to therapy, are urgently needed for patients presenting with advanced biliary tract cancer (ABC). (nature.com)
Whilst uncommon in the developed world, biliary tract cancer (BTC including cholangiocarcinoma [CCA], gallbladder and ampullary carcinoma) represent a significant global problem due to areas of high incidence, for instance of liver fluke-associated cholangiocarcinoma in Northern Thailand 1 and of gallbladder cancer in Chile and India. (nature.com)
As per records of NIH, the organization has spent USD 591 million dollars on Autoimmune Disease research compared to the USD 6.1 billion spent on cancer. (delveinsight.com)
On October 31, 2023, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) to be used with gemcitabine and cisplatin for locally advanced unresectable or metastatic biliary tract cancer (BTC). (fda.gov)
In patients with biliary tract cancer, a combination of two targeted drugs can shrink tumors with a specific genetic mutation. (cancer.gov)
The combination, dabrafenib (Tafinlar) plus trametinib (Mekinist) , shrank tumors in patients with advanced biliary tract cancer and adenocarcinoma of the small intestine. (cancer.gov)
There are few effective treatments for either type of cancer, and long-term survival is poor, particularly for patients with biliary tract cancer. (cancer.gov)
Given that patients diagnosed with biliary tract cancer have "very poor prognoses" and limited therapeutic options, Dr. Wainberg said, "the results are very compelling. (cancer.gov)
Currently, the first-line therapy for biliary tract cancer is a combination of the chemotherapy drugs cisplatin and gemcitabine. (cancer.gov)
At the symposium, he reported that 13 of the 32 evaluable patients with biliary tract cancer and 2 of the 3 patients with adenocarcinoma of the small intestine had experienced enough reduction in the size of their tumors to be classified as a tumor response. (cancer.gov)
Patients with advanced or metastatic biliary tract cancer like those enrolled in the trial would normally be expected to survive a few more months. (cancer.gov)
He noted that other genetic features found in some cases of biliary tract cancer-mutations in the IDH1 and IDH2 genes and FGFR fusion gene -are also under investigation as potential molecular targets for treatment, with ongoing clinical trials at various stages. (cancer.gov)
The clinical implications of tumor-infiltrating T cell subsets and their spatial distribution in biliary tract cancer (BTC) patients treated with gemcitabine plus cisplatin were investigated. (e-crt.org)
Biliary tract cancer (BTC) is an aggressive set of diseases including extrahepatic cholangiocarcinoma (EHCCA), intrahepatic cholangiocarcinoma (IHCCA), and gallbladder cancer (GBCA). (e-crt.org)
Ivosidenib efficacy was consistent across all subgroups," he said, citing line of therapy, extent of disease at screening, cancer type at initial diagnosis, region of treatment, and other factors. (ascopost.com)
Laboratory scientists are investigating the connections between autoimmune diseases and the mechanisms that help cancer grow and spread without being detected by the immune system. (benaroyaresearch.org)
Cancer is an umbrella term for a variety of diseases in which abnormal cells divide uncontrollably. (benaroyaresearch.org)
The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders. (benaroyaresearch.org)
Pancreatic cancer (PC) and biliary tract cancer (BTC) are both aggressive and highly fatal malignancies. (bvsalud.org)
Nilofer Azad, MD , Professor of Oncology at Johns Hopkins University School of Medicine and Co-Director of Cancer Genetics and Epigenetics at the Sidney Kimmel Comprehensive Cancer Center, Baltimore, was invited to discuss the results of the phase III TOPAZ-1 study, which found an overall survival benefit for durvalumab plus gemcitabine/cisplatin vs gemcitabine/cisplatin alone as first-line treatment of advanced biliary tract cancer. (ascopost.com)
1. Valle J, Wasan H, Palmer DH, et al: Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. (ascopost.com)
2. Piha-Paul SA, Oh DY, Ueno M, et al: Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: Results from the KEYNOTE-158 and KEYNOTE-028 studies. (ascopost.com)
For the first time , a phase III study has shown an overall survival benefit for upfront treatment using immunotherapy plus chemotherapy in advanced biliary tract cancer. (ascopost.com)
The regulatory agency has set a Prescription Drug User Fee Act date of February 7, 2024 for pembrolizumab plus chemotherapy as a treatment for patients with advanced or metastatic biliary tract cancer. (cancernetwork.com)
Supporting data for the sBLA came from the phase 3 KEYNOTE-966 trial (NCT04003636), in which investigators assessed the efficacy and safety of pembrolizumab plus chemotherapy vs chemotherapy alone in the treatment of patients with advanced unresectable or metastatic biliary tract cancer. (cancernetwork.com)
The FDA has accepted a supplemental biologics license application (sBLA) for pembrolizumab (Keytruda) plus gemcitabine and cisplatin for the treatment of those with locally advanced unresectable or metastatic biliary tract cancer, according to a press release from Merck. (cancernetwork.com)
We look forward to working with the FDA to bring a new option to patients with advanced or unresectable biliary tract cancer that may help them live longer. (cancernetwork.com)
Biliary tract cancer is rising in incidence worldwide, and unfortunately most patients are diagnosed with this devastating type of cancer at an advanced stage, when the 5-year survival rate is less than 5%," Robin Kate Kelley, MD, professor of Clinical Medicine in the Division of Hematology/Oncology at the University of California, San Francisco, said at the time of the data readout. (cancernetwork.com)
Patients 18 years and older with a histologically confirmed diagnosis of advanced or unresectable biliary tract cancer and measurable disease based on RECIST v1.1 criteria were eligible to enroll on the trial. (cancernetwork.com)
[ 1 ] In contrast, bile duct tumors located outside of the liver had been classified with gallbladder cancer as extrahepatic biliary tract tumors. (tri-kobe.org)
2/3L biliary tract cancer (BTC), including intra-and extra-hepatic biliary duct cancer and cancer of the gallbladder. (uci.edu)
Phase 1 data from an early clinical trial (NCT02699515) in 30 pretreated biliary tract cancer patients showed an objective response rate of 20% (6/30), with median progression-free and overall survival of 2.5 and 12.7 months, respectively. (medicaltrend.org)
Challenge: A Phase III Study Of The Impact Of A Physical Activity Program On Disease-Free Survival In Patients With High Risk Stage II Or Stage III Colon Cancer: A Randomised Controlled Trial CHALLENGE aims to determine whether a supervised physical activity (PA) programme in patients with high risk Stage II or Stage III colon cancer will improve 3- year disease-free survival (DFS) in comparison to standard care. (cardiff.ac.uk)
The treatment of cancer patients involves efforts to cure the disease, prolong survival, and improve their quality of life. (financialnewsmedia.com)
3. The following BTC histologic subtypes are excluded: small cell cancer, neuroendocrine tumors, lymphoma, sarcoma, mixed tumor histology, and mucinous cystic neoplasms detected in the biliary tract region. (who.int)
Liver and biliary tract cancer among chemical workers. (setalo.hu)
Cancer 82, Cheng J. Cisplatin,epirubicin and fluorouracil for advanced biliary tract carcinoma. (setalo.hu)
Proc Am Soc Clin Oncol a Donohue J. Stewart, M. Cancer, Ekbom A. Lancet ,42Eschelman D. Radiology Fong Y. Cancer Francanzani AL, Conte D, Fraquelli M, et al: Increased cancer risk in a cohort of patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. (setalo.hu)
Hepatology Gall F. World J. Surg Hejna M. Eur J of Cancer ,4:, Biliary stent occlusion. (setalo.hu)
Ulusakarya et al [ 11 ] had reported that the median OS of patients with advanced biliary tract cancer treated with first-line FOLFIRINOX was as long as 15 months. (biomedcentral.com)
Stevens-Johnson syndrome patient received combination chemotherapy gemcitabine, cisplatin, and 5-FU for biliary tract cancer. (zju.edu.cn)
Gallbladder cancer is a rare disease that often arises in the setting of chronic inflammation. (medscape.com)
The American Cancer Society estimates that approximately 10,000 new cases of gallbladder cancer and other biliary cancers will be diagnosed in 2013. (medscape.com)
A schematic drawing of the extent of lymphadenectomy for gallbladder cancer, especially when the extrahepatic biliary tree is resected. (medscape.com)
Cancers of the biliary tract include cholangiocarcinoma (cancers arising from the bile duct epithelium), ampulla of Vater cancer , and gallbladder cancer. (medscape.com)
For each cancer discussed in the first part of our overview, as well as in Part II, which will deal with more common cancers, we briefly cover the tumor biology, how targeting was achieved, the introduction of immune modulation or immune-conjugates, and the impact these therapies are having in the disease. (cancernetwork.com)
Dr. Von Hoff sent Nicole information to share with her mom's doctors about a clinical trial specifically for advanced cancers of the biliary tract (liver, gall bladder or bile ducts) being conducted by an oncologist in Tucson, Arizona, Rachna T. Shroff, M.D. Dr. Shroff is chief of the Section of GI Medical Oncology at the University of Arizona Cancer Center. (seenamagowitzfoundation.org)
Typically, only gemcitabine and cisplatin are administered to patients with advanced biliary tract cancer, but outcomes with that regimen are not always encouraging. (seenamagowitzfoundation.org)
CT2 for advanced biliary tract cancer seems to be associated with longer survival only in selected patients. (cancertherapyadvisor.com)
Second-line chemotherapy (CT2) for advanced biliary tract cancer (ABTC) seems to be associated with longer survival only in selected patients, a recent study published online this week in the journal Cancer has shown. (cancertherapyadvisor.com)
Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: a large multicenter study by the Association des Gastro-Enterologues Oncologues. (cancertherapyadvisor.com)
The FDA approved AstraZeneca plc's AZN Imfinzi (durvalumab) for locally advanced or metastatic biliary tract cancer (BTC) in combination with chemotherapy (gemcitabine plus cisplatin). (wealthtrends.net)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Gallbladder cancer (GBC), a highly aggressive and the most widespread neoplasm of the biliary tract, is clinically characterized by late diagnosis and high recurrence after surgery [ 1 , 2 ]. (oncotarget.com)
At the beginning of May, NCNA announced that it had restarted enrollment for its Phase 3 NuTide:121 trial, which is examining Acelarin and cisplatin in front-line biliary tract cancer (BTC) patients. (invesbrain.com)
$RFL -5.6% Rafael Pharmaceuticals Announces Ongoing Successful Enrollment and Opening of Additional Sites for Phase 2 Clinical Trial of CPI-613® (Devimistat) in Combination with Gemcitabine and Cisplatin in Patients with Biliary Tract Cancer. (bpiq.com)
Wee1 inhibition by MK1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer. (riken.jp)
The data here demonstrates a deep reduction in variant allele frequency (VAF) among responders to immune checkpoint inhibitor therapy in biliary tract cancer. (predicine.com)
1 Phase II study assessing tolerability, efficacy, and biomarkers for durvalumab (D) ± tremelimumab (T) and gemcitabine/cisplatin (GemCis) in chemo-naïve advanced biliary tract cancer (aBTC). (predicine.com)
Cancer of the Biliary Tree. (medscape.com)
Ampullary cancer is a rare biliary tract cancer that accounts for 0.2% of digestive tract cancers in the USA [ 1 ]. (biomedcentral.com)
Because of the rarity of the disease, clinicopathological data and pathological specimens from ampullary cancer patients were collected through a multi-institutional collaboration. (biomedcentral.com)
Gallbladder cancer, although relatively rare, is the most common type of biliary tract cancer. (healthtrip.com)
Gallbladder cancer, while relatively rare, has several identifiable risk factors that can increase an individual's likelihood of developing the disease. (healthtrip.com)

Currently, first-line treatment for locally advanced or metastatic cholangiocarcinoma consists of chemotherapy with gemcitabine and cisplatin. (ascopost.com)
intrahepatic cholangiocarcinoma had a somewhat greater benefit, as did patients with nonmetastatic disease at diagnosis. (ascopost.com)
However, many sufferers identified as having cholangiocarcinoma possess disease that can't be treated with medical procedures or has pass on to other areas of your body, significantly limiting treatment plans hence. (giknet.org)
Gemcitabine plus platinum as the first-line chemotherapy for cholangiocarcinoma (CCA) has limited efficacy. (biomedcentral.com)
Cholangiocarcinoma is a tumor that arises as a result of differentiation of the cholangiocytes and can develop from anywhere in the biliary tree. (mdpi.com)
Subtypes of cholangiocarcinoma are differentiated based on their location in the biliary tree. (mdpi.com)
If diagnosed early these can be resected, but most cases of intrahepatic cholangiocarcinoma present late in the disease course where surgical resection is not an option. (mdpi.com)
At the CCA Summit during the 2021 Annual Meeting of the American Society of Clinical Oncology (ASCO), Mitesh J. Borad, MD, Associate Professor of Medicine, Mayo Clinic, Phoenix, AZ, reviewed some of the key topics presented at ASCO 2021 related to cholangiocarcinoma (CCA) and other biliary tract cancers. (ccanewsonline.com)
Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation. (riken.jp)

The mutation is found in about 15% of biliary tract cancers and adenocarcinomas of the small intestine, said one of the trial's lead investigators, Zev Wainberg, M.D., of the gastrointestinal oncology program at UCLA. (cancer.gov)
This study adds to our knowledge and reinforces that patients with biliary tract cancers should have their tumors sequenced or analyzed for molecular changes," Dr. Greten said. (cancer.gov)
Surgery is the only potentially curative therapy in both cancers, but disease recurrence is frequent. (bvsalud.org)
Most biliary tract cancers go undetected until an advanced stage, at which point many patients are ineligible for surgery and have few treatment options," Scot Ebbinghaus, MD, vice president of Global Clinical Development at Merck Research Laboratories, said in the press release. (cancernetwork.com)
Several studies are currently exploring the inhibitory effects of TGF-β and PD-1/PD-L1 in biliary tract cancers, with most involving Bintrafusp alfa. (medicaltrend.org)
Liver cancers including hepatocellular carcinoma (HCC) and biliary tract or bile duct cancers (BTC) are rare but deadly, with only 20% and 9% of the patients surviving at 5 years respectively. (survivornet.com)
aspect receptor pathway family in 6 sufferers with advanced sporadic biliary tract cancers. (giknet.org)
All subtypes of biliary tract cancers are rare and have an overall poor prognosis. (medscape.com)

The density of tumor margin-infiltrating FoxP3 − CD4 + helper T cells may be associated with clinical outcomes in BTC patients treated with gemcitabine plus cisplatin. (e-crt.org)

Patients were randomized (1:1) to receive either pembrolizumab on Day 1 plus gemcitabine and cisplatin on Day 1 and Day 8 every 3 weeks, or placebo on Day 1 plus gemcitabine and cisplatin on the above schedule. (fda.gov)
Pembrolizumab or placebo were continued until disease progression, unacceptable toxicity, or a maximum of 2 years. (fda.gov)
The recommended pembrolizumab dose is 200 mg every 3 weeks or 400 mg every 6 weeks until disease progression or unacceptable toxicity. (fda.gov)
In the randomized, double-blind phase 3 KEYNOTE-966 trial, 1069 patients were randomly assigned to receive 200 mg of pembrolizumab every 3 weeks for up to 2 years plus gemcitabine and cisplatin or matched placebo and the same chemotherapy backbone. (cancernetwork.com)
3. Received no more than 2 cycles of systemic therapy with gemcitabine and a platinum agent with or without a PD-1/L1 inhibitor (physician's choice of durvalumab or pembrolizumab, where approved under local regulations) for advanced unresectable or metastatic disease. (who.int)

Efficacy was evaluated in KEYNOTE-966 (NCT04003636), a multicenter, randomized, double-blind, placebo-controlled trial that enrolled 1069 patients with locally advanced unresectable or metastatic BTC who had not received prior systemic therapy for advanced disease. (fda.gov)
1 year in cases of unresectable disease. (e-crt.org)
Unfortunately, many patients present with unresectable disease. (medscape.com)
A Study of Docetaxel for Injection (Albumin-bound) and SG001 in Combination With Cisplatin and Simultaneous Radiotherapy for Locally Advanced Unresectable Esophageal Squamous Carcinoma. (ichgcp.net)
Unfortunately, many patients present with unresectable and/or metastatic disease at diagnosis surgically. (giknet.org)
One of the first-line chemotherapeutic agents, cisplatin (also known as DDP), has been universally found to benefit individuals with advanced, unresectable or metastatic GBC [ 5 , 6 ]. (oncotarget.com)

The aim of this study was to evaluate the effectiveness of modified FOLFIRINOX (mFOLFIRINOX) compared to that of gemcitabine plus oxaliplatin (Gemox) for patients with locally advanced or metastatic CCA. (biomedcentral.com)

Moreover, Dr. Oh and her team previously conducted a phase II study of durvalumab with or without the CTLA-4 inhibitor tremelimumab and gemcitabine/cisplatin, 3 in which response rates reached 50% to 73%, Dr. Azad noted. (ascopost.com)
This is the backdrop and the rationale for testing durvalumab in combination with gemcitabine/cisplatin. (ascopost.com)
in the experimental arm, patients received maintenance with durvalumab until disease progression, whereas the placebo arm received no further therapy. (ascopost.com)
In the TOPAZ-1 trial, the addition of the anti-PD-L1 agent durvalumab to gemcitabine plus cisplatin significantly improved. (ascopost.com)
The TOPAZ 1 study included patients with BTCs and combined durvalumab with the chemotherapy drugs, gemcitabine and cisplatin. (survivornet.com)

Cediranib, in addition to cisplatin/gemcitabine [CisGem], improved the response rate, but did not improve the progression-free survival (PFS) in the ABC-03 study. (nature.com)
Changes in 15 circulating plasma angiogenesis or inflammatory-related proteins and cytokeratin-18 (CK18), measured at baseline and during therapy until disease progression, were correlated with overall survival (OS) using time-varying covariate Cox models (TVC). (nature.com)
4 Unfortunately, most patients are present with advanced (non-resectable or metastatic) disease and their survival is ≤3 months, with best supportive care alone. (nature.com)
Crossover from placebo to ivosidenib was permitted upon disease progression, and the crossover-adjusted overall survival was derived using rank-preserving structural failure time analysis. (ascopost.com)
The current first-line standard of care is gemcitabine plus cisplatin, which yielded a median overall survival of less than 12 months in the landmark trial. (ascopost.com)
The second endpoints were Overall survival (OS), Disease control rate (DCR) and incidence of severe toxicity (grade 3-4). (biomedcentral.com)
PIPAC is an emerging treatment that may convert the patient to resectable disease, and may increase survival without major morbidity, as indicated by many small studies. (stanford.edu)

Patients have derived a clinical benefit with tucatinib (Tukysa) plus trastuzumab (Herceptin) according to data from the phase 2 MOUNTAINEER trial (NCT03043313) and in January 2023, gained a second option with tucatinib tacking on another FDA approval for patients with RAS wild-type HER2-positive disease. (onclive.com)

Criteria for resectability include absence of all of the following: retropancreatic and paraceliac nodal metastases or distant liver metastases, invasion of the portal vein or main hepatic artery (although some centers can offer vascular reconstruction), extrahepatic adjacent organ invasion, and disseminated disease. (medscape.com)
The biliary system consists of a network of ducts that carry bile from the liver to the small bowel and is classified by its anatomic location (Figure 1 ). (tri-kobe.org)
He has dedicated his clinical practice to the surgical management of metastatic disease, particularly to the liver and peritoneum. (stanford.edu)
The program implements and develops novel treatment strategies for patients affected with peritoneal malignancies and oligometastatic disease to the liver. (stanford.edu)

Stents can be placed via endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) to relieve biliary obstruction. (medscape.com)
Klatskin G. Klempnauer J. Kondo S. Nimura Y. Kamiya J. Koronczay K. Metallic stents in malignant biliary obstruction: Prospective long-term clinical results. (setalo.hu)

This is an attractive option after gemcitabine + cisplatin, particularly in patients who may not tolerate oxaliplatin due to peripheral neuropathy. (fcshemoncreview.com)
Out of 603 patients who had already received first-line chemotherapy, 196 received CT2 as either 5-fluorouracil (5-FU) and irinotecan (n=64), 5-FU and oxaliplatin (n=21), 5-FU and cisplatin (n=38), 5-FU or capecitabine (n=40), sunitinib (n= 0), or other various regimens (n=23). (cancertherapyadvisor.com)
Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. (cancercentrum.se)

Treatment continued until unacceptable toxicity or disease progression. (fda.gov)
In the phase III ClarIDHy trial, the risk of disease progression or death was reduced by 63% with ivosidenib, an inhibitor of the isocitrate dehydrogenase 1 ( IDH1 ) mutation. (ascopost.com)
In contrast, all patients on the placebo arm had disease progression at data cutoff, Dr. Abou-Alfa reported. (ascopost.com)
The remaining 11 patients (78.6%) experienced disease progression. (medicaltrend.org)
Only one MSI-H, locally advanced PDAC patient showed a partial response lasting 10.5 months before disease progression. (medicaltrend.org)
For pembro + chemo, there was a 70% lower risk of disease progression in dMMR and a 46% lower risk in pMMR compared to placebo + chemo. (fcshemoncreview.com)

Surgical resection includes cholecystectomy, en bloc hepatic resection (typically of segments IVb and V), and lymphadenectomy with or without bile duct excision, depending on the location of the tumor. (medscape.com)
A biliary catheter (red tube) runs through the tumor volume and was used to deliver brachytherapy, which was given in addition to external-beam radiotherapy. (medscape.com)
Fast and sturdy disease regression was observed within this inactivated tumor when treated with erlotinib, an EGFR kinase inhibitor. (giknet.org)
Computed tomography (CT) scans also may be useful in patients with upper abdominal pain and can demonstrate tumor invasion outside of the gallbladder and identify metastatic disease elsewhere in the abdomen or pelvis. (medscape.com)
Using non-gene editing technology, the therapy has already shown anti-tumor activity in two out of twelve patients with a partial response and five patients with stable disease with a minimum of three months of duration. (invesbrain.com)

Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)

In these patients who are poor candidates for resection, a combination of chemotherapy, locoregional therapies like ablation, transarterial chemo and radioembolization, and in very advanced and metastatic disease, external radiation are the available options. (mdpi.com)

A large multicenter study conducted by the Association des Gastro-Entérologues Oncologues examined patients who failed the gemcitabine-platinum combination for ABTC at 17 French institutions. (cancertherapyadvisor.com)
PredicineATLAS™ assay is designed to help biopharmaceutical partners identify patients with the right molecular profile for their clinical program, assess response to investigational drugs or combination therapies, and detect presence of residual disease, recurrence, or relapse. (predicine.com)

Castro MP et al Efficacy of gemcitabine in the treatment of patients with gallbladder carcinoma: a case report. (setalo.hu)

Although complete surgical resection is the only therapy to afford a chance of cure, en bloc resections of the gallbladder and portal lymph nodes carry a high morbidity and mortality (similar to bile duct carcinoma). (medscape.com)

After development on pazopanib, the same individual acquired steady disease on ponatinib also, a pan-FGFR inhibitor (activation. (giknet.org)

Among 14 evaluable patients, 3 (21.4%) had stable disease, with only one patient achieving long-term clinical benefit. (medicaltrend.org)

Adequate biliary drainage can be achieved in a high percentage of cases. (medscape.com)
PDT is effective in restoring biliary drainage and improving quality of life in patients with nonresectable disseminated cholangiocarcinomas. (medscape.com)
Palliative measures such as resection, radiation therapy (e.g., brachytherapy or external-beam radiation therapy), or stenting procedures may maintain adequate biliary drainage and allow for improved quality of life. (tri-kobe.org)
Percutaneous transhepatic drainage of the biliary tract. (setalo.hu)

Launch Biliary tract malignancies (BTC) comprise malignant tumors from the intrahepatic and extrahepatic bile ducts. (giknet.org)
Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) have become accepted treatments for limited-volume peritoneal disease in appendiceal, ovarian, and colorectal malignancies, but there are limitations. (stanford.edu)

Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)
Results of a Japanese Society of Biliary Surgery Survey: a multicenter study. (cancercentrum.se)

A total of 52 BTC patients treated with palliative gemcitabine plus cisplatin were included. (e-crt.org)
Systemic therapy with cisplatin and gemcitabine continues to be set up as the typical of look after sufferers with advanced disease, but is palliative [20], emphasizing the imminent dependence on book therapies. (giknet.org)

No responses were observed with placebo, and 27.9% of this arm had stable disease. (ascopost.com)

those who have a clinical diagnosis and those who are at-risk of developing the disease. (cardiff.ac.uk)

The funds will be used to support research into immune cell regulation and develop antibodies to treat autoimmune diseases by stimulating specific immune cell signals. (delveinsight.com)
It will help the company to expand its horizon in an approach it is working to treat autoimmune diseases, i.e., antibody modulators of immune cell receptors, an approach that has potential across a range of diseases, with an initial focus on auto-immune disease. (delveinsight.com)
At present, 50 million Americans are living with a type of Autoimmune Disease. (delveinsight.com)
In 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases(AⅡRD), it is recommended that patients with AⅡRD, in particular patients with SLE, should receive vaccinations against HPV in accordance with recommendations for the general population. (pumch.cn)
Systemic lupus erythematosus (SLE) is a common autoimmune disease characterized by chronic inflammation and multi-organ damage and mainly affects women of childbearing age. (pumch.cn)

A study by Kida et al found that covered biliary self-expandable metal stents could be safely removed when they become occluded and that patency rates were similar for reintervention and initial stent placement. (medscape.com)

The acquisition of Eximo Medical will increase the portfolio of AngioDynamics by adding Eximo's proprietary 355nm wavelength laser technology, which has received 510(k) clearance for use in the Peripheral Artery Disease (PAD) treatment. (delveinsight.com)
Currently, the drug is approved for the treatment of adolescents and adults living with moderate to severe plaque psoriasis (ages 12+), adults with active psoriatic arthritis, adults with moderate to severe Crohn's disease and adults with moderate to severe ulcerative colitis in the EU and other countries. (delveinsight.com)
Rexulti was found to be a well-tolerated treatment for the debilitating symptoms of agitation associated with dementia due to Alzheimer's disease. (appliedclinicaltrialsonline.com)
1 "The findings of this study provide evidence that brexpiprazole meets the needs of patients and their caregivers and is an efficacious, well-tolerated treatment for the often-debilitating symptoms of agitation associated with dementia due to Alzheimer's disease. (appliedclinicaltrialsonline.com)
Earlier this year, Rexulti was approved by the FDA as the first treatment indicated for agitation associated with dementia due to Alzheimer disease. (appliedclinicaltrialsonline.com)

Debate exists about whether preoperative stenting is warranted, but most surgeons believe that preoperative biliary decompression does not alter the outcome of surgery. (medscape.com)
Sue recovered from the surgery and recently completed another course of chemotherapy, this time with only gemcitabine and cisplatin given intravenously. (seenamagowitzfoundation.org)

The Ziegler laboratory is investigating the role of the epithelial cytokines TSLP and IL-33 in regulating protective responses at mucosal barrier surfaces such as the respiratory and gastrointestinal tracts. (benaroyaresearch.org)

Researchers will be encouraged to apply for access to the collected samples in order to try and establish the causal mechanisms for disease development, potential therapeutic targets and to relate clinical. (cardiff.ac.uk)

Brexpiprazole (Rexulti) produced statistically significant and clinically meaningful improvements among adults experiencing agitation associated with dementia due to Alzheimer disease, according to a recent study. (appliedclinicaltrialsonline.com)

Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Read Carefully before Using The Public Health Service Act (Section 308 (d)) provides that the data collected by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC), may be used only for the purpose of health statistical reporting and analysis. (cdc.gov)
The NAMCS is a national probability sample survey conducted by the Division of Health Care Statistics, National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). (cdc.gov)

Anatomy10

Organisms4

Diseases25

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes1

Health Care2

Cancer74

Cholangiocarcinoma9

Cancers8

Treated with gemcitabine plus cisplatin1

Pembrolizumab5

Unresectable6

Advanced or metastatic1

Durvalumab5

Survival7

20231

Liver4

Obstruction2

Oxaliplatin3

Progression6

Tumor5

Outcomes1

Metastatic disease1

Combination2

Efficacy1

Bile duct1

Inhibitor1

Evaluable patients1

Drainage4

Malignancies2

Multicenter study2

Palliative2

Placebo1

Diagnosis1

Autoimmune5

Stents1

Treatment5

Surgery2

Gastrointestinal1

Targets1

Clinically1

Centers for Diseas3