• In particular, plasma-type gelsolin (pGSN) can ameliorate deleterious inflammatory response by scavenging pro-inflammatory signals such as actin and lipopolysaccharide. (harvard.edu)
  • Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. (mdpi.com)
  • We have also found that monocyte derived macrophage (MDM) activated by HIV infection in vitro produce and secrete gelsolin (Ciborowski, P. (biomedcentral.com)
  • Macrophage induced gelsolin in response to Group B Streptococcus (GBS) infection. (semanticscholar.org)
  • (EN) Isolated, N-terminal gelsolin amino acid sequence fragments are provided. (wipo.int)
  • Gelsolin is positively correlated with serum albumin and negatively with tumor necrosis factor-alpha. (medsci.org)
  • As an important actin regulator, gelsolin plays a role in podosome formation (along with Arp3, cortactin, and Rho GTPases). (wikipedia.org)
  • These observations demonstrate the critical role of gelsolin in podosome assembly, rapid cell movements, and signal transduction through the α v β 3 integrin. (rupress.org)
  • Gelsolin, by regulating intracellular actin filaments, is important in cell morphology, migration and phagocytosis [ 18 ]. (medsci.org)
  • Here we show that gelsolin restructures cortical F-actin during HIV-1 Env-gp120-mediated signalling, without affecting cell-surface expression of receptors or viral co-receptor signalling. (sigmaaldrich.com)
  • Remarkably, efficient HIV-1 Env-mediated membrane fusion and infection of permissive lymphocytes were impaired when gelsolin was either overexpressed or silenced, which led to a loss or gain of cortical actin, respectively. (sigmaaldrich.com)
  • For the first time we provide evidence that through its severing of cortical actin, and by controlling the amount of actin available for reorganization during HIV-1 Env-mediated viral fusion, entry and infection, gelsolin can constitute a barrier that restricts HIV-1 infection of CD4+ lymphocytes in a pre-fusion step. (sigmaaldrich.com)
  • In several instances, multiple bands were identified (corresponding to different gelsolin forms) by one antibody, but not identified by another. (biomedcentral.com)
  • Additionally, some smaller forms of gelsolin were identified by mass spectrometry but not by any antibody. (biomedcentral.com)
  • An, Kim, Jang, Kim, Kang, Choi: Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. (antikoerper-online.de)
  • Gelsolin appears to function in the initiation of filopodial retraction and in its smooth progression. (rupress.org)
  • In this report, we aim to characterize progression in aortic arch calcification (AAC) and investigate its association with gelsolin. (medsci.org)
  • Compared to those with no AAC, patients with AAC progression had older age, lower gelsolin, higher waist circumference and prevalence of vascular disease. (medsci.org)
  • Regression analysis confirmed baseline gelsolin (odds ratio 0.845, 95% confidence interval [0.734-0. and waist circumference as the independent factors associated with AAC progression. (medsci.org)
  • Further investigation into the mechanistic roles of gelsolin in vascular calcification may provide new understanding of this key process. (medsci.org)
  • Such fragments have apoptotic activity and can be used in gene therapy for treatment of malignancy or hyperproliferative conditions and in diagnostic applications to identify gelsolin up regulation or down regulation. (wipo.int)
  • Thus, we propose that gelsolin is a new factor that can limit HIV-1 infection acting at a pre-fusion step, and accordingly, cell-signals that regulate gelsolin expression and/or its actin-severing activity may be crucial to combat HIV-1 infection. (sigmaaldrich.com)
  • Expression of the gelsolin cleavage product in multiple cell types caused the cells to round up, detach from the plate, and undergo nuclear fragmentation. (sciencemag.org)
  • Gelsolin was identified as a substrate for caspase-3 by screening the translation products of small complementary DNA pools for sensitivity to cleavage by caspase-3. (sciencemag.org)