• The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. (wikipedia.org)
  • GCK is regulated by GCKR (glucokinase regulatory protein). (ihcworld.com)
  • To find out what regulates blood follistatin levels, the researchers performed genome-wide association study (GWAS) on 5,124 people from Sweden, the UK and Italy, and revealed that follistatin levels are genetically regulated by glucokinase regulatory protein (GCKR), which impact on several metabolic traits. (omniaeducation.com)
  • In genome-wide association studies, performed mostly in nondiabetic individuals, genetic variability of glucokinase regulatory protein (GCKR) affects type 2 diabetes-relatedphenotypes, kidney function, and risk of chronic kidney disease (CKD). (univr.it)
  • The cytosolic glucokinase (GCK1):glucokinase regulatory protein (GKRP) complex dissociates.However, while GCK1:GKRP complex formation is reversible (Brocklehurst et al. (reactome.org)
  • Glucokinase regulator is a protein that in humans is encoded by the GCKR gene. (wikipedia.org)
  • glucokinase regulator [Source:HG. (gsea-msigdb.org)
  • This gene encodes a protein belonging to the GCKR subfamily of the SIS (sugar isomerase) family of proteins. (wikipedia.org)
  • GCKR is a 68 kDa protein which is expressed in pancreatic beta cells and in the liver. (ihcworld.com)
  • A lack of glucokinase activity leads to reduced insulin secretion and hyperglycemia and has been implicated as a cause for maturity onset diabetes of the youth (MODY). (ihcworld.com)
  • Variants of GCKR affect both beta cell and kidney function in patients with newly diagnosed type 2 diabetes. (univr.it)
  • We genotyped four tSNPs (rs4425043, rs780094, rs814295, and rs8179206) of the GCKR gene using the Taqman assay in 2,851 female subjects and investigated their associations with overweight and obesity. (nih.gov)
  • A genetic variant GCKR rs780094 has been previously associated with fasting lactate levels associated with glucose metabolism. (uef.fi)
  • The researchers investigated the association of GCKR rs780094 with lactate levels in a frequently sampled oral glucose tolerance test in the participants of the Finnish population-based METSIM study to evaluate the effects of increasing GCKR expression on lactate production in liver cells. (uef.fi)
  • The C allele of GCKR rs780094 was associated with lower lactate levels in fasting but increased lactate level during hyperglycemia, independently of insulin levels. (uef.fi)
  • The results suggest that the association of rs780094 with lactate levels may involve differential GCKR expression between the carriers of the C and T alleles. (uef.fi)
  • In another study, a metabolomics approach was applied to measure metabolites in the participants of the METSIM study to investigate the associations of rs780094 of GCKR with metabolites. (uef.fi)
  • The researchers found novel negative associations of the T allele of GCKR rs780094 with serine and threonine, and positive associations with two metabolites of tryptophan, indolelactate and N-acetyltryptophan. (uef.fi)
  • The study adds new information about the pleiotropy of GCKR , and shows the associations of the T allele of GCKR rs780094 with lipids. (uef.fi)
  • The aim of this study was to investigate the effects of GCKR polymorphism on the prevalence of overweight and obesity in Chinese female subjects using a gene-wide tagging- single nucleotide polymorphism (tSNP) strategy. (nih.gov)
  • In conclusion, a novel polymorphism (rs4425043) in the GCKR gene increases the risk of overweight and obesity in Chinese women. (nih.gov)
  • This gene encodes a protein belonging to the GCKR subfamily of the SIS (sugar isomerase) family of proteins. (wikipedia.org)
  • The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. (wikipedia.org)
  • They used these organoids to examine genetic contributors to NAFLD/NASH, finding that a variant of the glucokinase regulatory protein (GCKR) gene was associated with fat accumulation. (nih.gov)
  • The PhD work focused on the glucokinase regulatory protein gene ( GCKR ), a risk gene for T2D, and several genetic variants associated with the risk of NAFLD. (uef.fi)
  • Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. (cdc.gov)
  • In comparisons with 1,405 healthy controls from the Myocardial Genetics Consortium (MIGen), we observe significant associations with histologic NAFLD at variants in or near NCAN, GCKR, LYPLAL1, and PNPLA3, but not PPP1R3B. (nih.gov)
  • Other studies have implicated GCKR in NAFLD/NASH, although its role has been unclear. (nih.gov)
  • To study the connection between NAFLD and diabetes further, they treated the NAFLD/NASH liver organoids with metformin-the first-line drug for people with type 2 diabetes-and found that metformin may exacerbate liver disease in the presence of the GCKR variant. (nih.gov)
  • They were surprised to discover that the presence of the GCKR variant had differing effects on liver health. (nih.gov)
  • These observations suggest that HbA1c levels may be used to help predict the severity of liver disease progression in people with the GCKR variant-toward developing more personalized medicine approaches. (nih.gov)
  • 15. Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk. (nih.gov)
  • Multiple statistically significant associations of genetic variants were identified in seven genes ( PNPLA3 , TM6SF2 , GCKR , MBOAT7 , SAMM50 , PPP1R3B, HDS17B13 ) with metabolites reflecting different metabolic pathways regulating the liver fat content. (uef.fi)
  • 9. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. (nih.gov)
  • 17. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase. (nih.gov)
  • Ford BE, Chachra SS, Alshawi A, Brennan A, Harnor S, Cano C, Baker DJ, Smith DM, Fairclough RJ, Agius L. Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge . (ncl.ac.uk)
  • The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. (nih.gov)
  • Kimura M, Iguchi T, Iwasawa K,…Takebe T. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH . (nih.gov)
  • 2. The physiological role of glucokinase binding and translocation in hepatocytes. (nih.gov)