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  • endoderm
  • We show that Gata6 mRNA is expressed predominantly in the developing pulmonary endoderm and epithelium, but at E15.5 also in the pulmonary mesenchyme. (eur.nl)
  • Chimeras generated in a ROSA26 background show that endodermal cells in these abnormally branched areas are derived from Gata6 mutant ES cells, implicating that the defect is intrinsic to the endoderm. (eur.nl)
  • GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells. (nih.gov)
  • Endoderm grafting experiments and ectopic basement membrane (BM) assembly suggest that both BM and non-BM factors contribute to cell survival. (sigmaaldrich.com)
  • mRNA
  • Transcription of mRNA coded by the zygotic genome begins during the first few cleavage divisions, and this transition from maternal to zygotic transcripts is known as zygotic genome activation (ZGA). (jci.org)
  • self-renewal
  • Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. (nih.gov)
  • congenital
  • GATA6 loss-of-function mutation contributes to congenital bicuspid aortic valve. (nih.gov)
  • Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV. (nih.gov)
  • mice
  • Three new studies found that giving old mice blood from young mice-or a factor found in young blood-improved the function of the aging animals' muscles and brains. (sciencemag.org)
  • SOX2
  • Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. (nih.gov)
  • Murine lacrimal gland stem cells expressed markers of pluripotency such as Nanog , Sox2 , Kruppel-like factor 4 ( Klf4 ), as well as early-lineage markers of all three germ layers. (arvojournals.org)
  • pluripotency
  • In contrast, stable partially reprogrammed cell lines show reactivation of a distinctive subset of stem-cell-related genes, incomplete repression of lineage-specifying transcription factors, and DNA hypermethylation at pluripotency-related loci. (nih.gov)
  • These observations suggest that some cells may become trapped in partially reprogrammed states owing to incomplete repression of transcription factors, and that DNA de-methylation is an inefficient step in the transition to pluripotency. (nih.gov)
  • role
  • Arman E, Haffner-Krausz R, Chen Y, Heath JK, Lonai P (1998) Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. (springer.com)
  • cells
  • Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes. (nih.gov)
  • b , The transcription factor Zeb2 is marked by H3K4me3 and expressed in MEFs, but gains H3K27me3 and is silenced in partially and fully reprogrammed cells. (nih.gov)
  • d , The endodermal transcription factor Gata6 inappropriately lost H3K27me3 and is activated in MCV6 cells. (nih.gov)
  • e , The autocrine growth factor Fgf4 loses H3K27me3, gains H3K4me3 and becomes highly expressed in both partially and fully reprogrammed cells. (nih.gov)
  • Interestingly, these lineage-specific transcription factors are initially co-expressed in early ICM cells, suggesting an initial multi-lineage priming state. (springer.com)
  • Human
  • Human gastrointestinal mucosa regenerates vigorously throughout life, but the factors controlling cell fate in mature mucosa are poorly understood. (uta.fi)
  • Title: Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA. (nih.gov)
  • heart
  • Targeted sequencing identifies novel GATA6 variants in a large cohort of patients with conotruncal heart defects. (nih.gov)
  • In the case of Gata6 mutants, the heart appears to be unaffected. (biologists.org)
  • cell
  • Through bioinformatics and cell-based experiments, we identified the AKT-repressed signal as glycogen synthase kinase 3 (GSK3)-catalyzed phosphorylation of Ser(37) on the long form of the transcription factor GATA6. (sigmaaldrich.com)