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  • protein
  • We report that doxorubicin treatment in cardiomyocytes resulted in inhibition of CARP transcription, depletion of CARP protein levels, inhibition of myofilament gene transcription, and marked sarcomere disarray. (nih.gov)
  • Protein/DNA arrays identify nitric oxide-regulated cis-element and trans-factor activities some of which govern neuroblastoma cell viability. (nih.gov)
  • CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. (nih.gov)
  • nuclear
  • 7 Calcium-activated phosphatase, calcineurin, dephosphorylates the serine residues of the calcineurin-regulated nuclear factors of activated T lymphocytes (NFATc) and unmasks its nuclear localization sequences. (ahajournals.org)
  • study
  • The aim of this retrospective study was to investigate the associations between GATA4 and GATA6 polymorphisms and bleeding complication risk at a therapeutic international normalized ratio (INR) in patients with mechanical heart valves. (dovepress.com)
  • This study showed that GATA4 and GATA6 gene polymorphisms could affect bleeding complications during warfarin treatment in patients with mechanical heart valves. (dovepress.com)
  • cells
  • We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP. (nih.gov)
  • The basic helix-loop-helix transcription factor Hand2 , together with Ascl1, Phox2a, Phox2b and Gata2/Gata3 , is induced by bone morphogenetic proteins in neural crest-derived precursor cells during sympathetic neuron generation. (biologists.org)
  • human
  • Synthetic peptide, corresponding to a region within amino acids 392-442 of Human GATA4 (NP_002043.2). (abcam.com)
  • data
  • The data further suggests that concurrent depletion of GATA4 and CARP in cardiomyocytes by doxorubicin contributes in large part to myofibrillar disarray and the overall pathophysiology of anthracycline cardiomyopathy. (nih.gov)
  • Site
  • Gata4-binding-site profiles and DNA methylation analyses suggested that DNA methylation modulates the Gata4 response through diverse mechanisms. (prolekare.cz)
  • region
  • GATA4 is most highly expressed within the precardiogenic splanchnic mesoderm at the posterior lip of the anterior intestinal portal, corresponding to the region of the embryo that undergoes ventral fusion. (nih.gov)