• Analyses of pooled data suggested a reduced risk of breast cancer associated with two intronic variants in GATA3 in linkage disequilibrium (rs3802604 in intron 3 and rs570613 in intron 4). (aacrjournals.org)
  • In summary, data from two independent study populations showed two intronic variants in GATA3 associated with overall decreases in breast cancer risk and suggested heterogeneity of these associations by ER status. (aacrjournals.org)
  • CD4 repression in DN and CD8 SP thymocytes is largely controlled by an intronic silencer ( 4 ) and Runx transcription factors ( 5 - 7 ). (rupress.org)
  • Compared with C4d deposition, T-bet-GATA3>1 had a slight lower 90% versus 100% specificity but a much higher 87.5% versus 68.8% sensitivity. (duhnnae.com)
  • We now demonstrate that Gata3 elimination in both differentiated embryonic and adult sympathetic neurons results in a virtually complete neuron loss by apoptotic cell death. (jneurosci.org)
  • In addition, through data mining analysis, we observed an extremely strong correlation between the expression levels of GATA3 and CtIP in paratumors, but the correlation turned insignificant in mammary tumors. (ovid.com)
  • The correlation of the diagnosis of AMR with the ratio of T-bet-GATA3 was examined. (duhnnae.com)
  • Transcriptional activator which probably serves as a general switch factor for cell-specific development. (uniprot.org)
  • The basis for the term "interleukin" was to streamline the growing number of biological properties attributed to soluble factors from macrophages and lymphocytes. (wikipedia.org)
  • The augmented levels of IL-21/IL-22 and GATA3/T-bet could be due to altered A2AR signaling. (sigmaaldrich.com)
  • These authors also confirmed that GATA3 levels are lower in tumors that are ER-negative and in those with high histologic grade. (aacrjournals.org)
  • Normal DN2 thymocytes also showed mast cell potential when interleukin 3 and stem cell factor were added in the absence of Notch signaling. (nih.gov)
  • Upon sensing unfolded proteins, IRE1 oligomerizes, is activated by autophosphorylation, and uses its endoribonuclease activity to excise an intron from the transcription factor Hac1p in yeast or its mammalian homologue, XBP-1, a cyclic-AMP response element binding protein/activating transcription factor family member first isolated in our laboratory ( 5 ). (rupress.org)
  • Other transcription factors have been implicated in CD4 and CD8 T cell development including GATA3, which is required for CD4 T cell development ( 9 , 10 ), and Tox, which can promote CD8 T cell development when ectopically expressed ( 11 ). (rupress.org)
  • Four tag single-nucleotide polymorphisms (SNP) in GATA3 and its 3′ flanking gene FLJ4598 were genotyped in two case control studies in Norway and Poland (2,726 cases and 3,420 controls). (aacrjournals.org)
  • Building upon previous reports, including metaanalysis of microarray studies of GATA3 transcripts ( 7 ), Mehra et al. (aacrjournals.org)
  • Nevertheless, T-bet-GATA3>1 is also correlated with C4d-negative ABMR and resistance to steroid treatment. (duhnnae.com)
  • The most conserved arm of the UPR involves IRE1α, an ER transmembrane kinase and endoribonuclease that activates the transcription factor XBP-1 to maintain ER homeostasis and prevent activation of cell death pathways caused by sustained ER stress. (rupress.org)
  • To address this hypothesis, we carried out a comprehensive evaluation of common variation in GATA3 and evaluated its relation with breast cancer risk in two independent study populations from Norway and Poland. (aacrjournals.org)