Gata3 transcription factor. Medical search. Frequent questions

GATA3 belongs to the GATA family of transcription factors. (wikipedia.org)
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. (semanticscholar.org)
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. (bmj.com)
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
Group 2 ILCs (ILC2s), are characterized by the transcription factor GATA-3 and the IL-33 specific receptor ST-2. (elifesciences.org)
Haploinsufficiency for the trans-acting T-cell-specific transcription factor GATA-3 (encoded by the GATA3 gene, and mapped to the 10p14-pter region) is responsible for this phenotype. (orpha.net)
Activation of Th2-type responses is featured by the activation of Il-4Ra/STAT6 and the up-regulation of GATA-3, which serves as a transcription factor and mediates the transactivation of Th2 target genes, in CD4+cess. (cdc.gov)
We further identify Gata-3, a zinc-finger transcription factor in the dysfunctional module, as a regulator of dysfunction, and use CRISPR/Cas9 genome editing to show that it drives a dysfunctional phenotype in CD8+ TILs. (nih.gov)
ILC2 secrete 'T H 2-like' cytokines under the control of the transcription factors GATA-3 and RORa. (pasteur.fr)
We first assembled existing knowledge about transcription factors known to be important for T-cell specification to form a minimal core module consisting of TCF-1, GATA-3, BCL11B, and PU.1 aiming at dynamical modeling. (lu.se)
Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. (diagenode.com)

Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and Foxp3-counteracting interleukin-6 (IL-6), lower numbers of phospho-STAT3-containing lymphocytes, and higher Foxp3 + T-cell counts in the colon. (nature.com)
The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
TBX21 (Th1) , GATA3 (Th2) , RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4 + T cell subsets and can regulate T cell differentiation. (oncotarget.com)
An earlier study found that the ratio of Th1/Th17 cells was decreased in BD patients with uveitis [ 5 ], and another study reported an increase in the ratios of RORC / FOXP3 and TBX21 / GATA3 in neuro-Behçet's disease, suggesting a dysregulation of Th1, Th2, Th17 and Tregs in this disease [ 6 ]. (oncotarget.com)
The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. (diagenode.com)
We identify two transforming growth factor-β1 (TGF-β1)-dependent mechanisms that were vital for activation of Foxp3 transcription and were defective in Id3(-/-) CD4(+) T cells. (diagenode.com)
Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription. (diagenode.com)
Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells. (diagenode.com)
These cells express the master regulator transcription factor (TFs) Foxp3. (encyclopedia.pub)

Genome-wide gene expression analyses indicated that GATA3 regulated a similar set of cytokines and receptors in Th2 cells and ILC2s, but not in ILC3s. (nih.gov)
Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Intracellular markers include transcription factors that control CD4 + T cell differentiation as well as signature cytokines as they traffic through secretory organelles. (rndsystems.com)
Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
ILC3 includes several phenotypically distinct cells that express and require the transcription factor RORgt in order to produce notably the cytokines IL-17 and IL-22. (pasteur.fr)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)
Signature transcription factors and cytokines designated to different cell types are shown. (encyclopedia.pub)

GATA3 variant 1 is a linear protein consisting of 444 amino acids. (wikipedia.org)
GATA3 variant 2 protein is an identically structured isoform of, but 1 amino acid shorter than, GATA3 variant 1. (wikipedia.org)
The other zinc finger, ZNF1, is at the protein's N-terminus and interacts with various nuclear factors, including Zinc finger protein 1 (i.e. (wikipedia.org)
Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
A heterozygous mutation defect of the growth factor bone morphogenetic protein 4 (bmp 4) leads to renal hypoplasia or dysplasia, ureterovesicular junction obstruction, hydronephrosis, or the bifid/duplex kidney. (medscape.com)

GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. (bmj.com)
We used the AliBaba2.1 software to determine if the nucleotide changes of the associated SNPs changed the prediction of the presence of transcription-binding site sequences and we also analyzed the gene expression of the genes selected based on binding predictions. (medipol.edu.tr)

GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome. (wikipedia.org)
Knockout of both GATA3 genes in mice is fatal: these animals die at embryonic days 11 and 12 due to internal bleeding. (wikipedia.org)
The GATA3 transcription factor regulates the expression of genes involved in the development of various tissues as well as genes involved in physiological as well as pathological humoral inflammatory and allergic responses. (wikipedia.org)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
The comprehensive transcriptome analysis from KPNA3 knockdown cells indicated that KPNA3 is involved in the regulation of numerous EMT-related genes, including the downregulation of GATA3 and E-cadherin and the up-regulation of HAS2. (bmbreports.org)
Regarding the prediction of the transcription-binding site, the base change of the SNP rs17074565 was found to change the predicted-binding of genes that could be involved in the pathogenesis of caries. (medipol.edu.tr)
During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ureteric bud and the metanephric mesenchyme. (medscape.com)

Mutations leading to haploinsufficiency of the dual zinc finger transcription factor GATA3 result in the hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome which is an autosomal dominant disorder. (endocrine-abstracts.org)

Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. (nih.gov)
Gene-deletion studies in mice indicate that Gata3 (mouse gene equivalent to GATA3) is critical for the embryonic development and/or function of various cell types (e.g. fat cells, neural crest cells, lymphocytes) and tissues (e.g. kidney, liver, brain, spinal cord, mammary gland). (wikipedia.org)
All three of these interleukins serve to promote allergic responses, 4) GATA3 induces the maturation of precursor cells into breast epithelial cells and maintains these cells in their mature state in mice and possibly humans. (wikipedia.org)
5) In mice, GATA3 is responsible for the normal development of various tissues including the skin, fat cells, the thymus, and the nervous system. (wikipedia.org)

In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3. (biolegend.com)

After the ILCs had fully developed, GATA3 remained important for the maintenance and functions of ILC2s. (nih.gov)
Thus, GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL-7Rα(+) ILCs. (nih.gov)
2) In humans, GATA3 is required for the development and/or function of innate lymphoid cells (ILCs), particularly Group 2 ILCs as well as for the development of T helper cells,(Th cells), particularly Th2 cells. (wikipedia.org)
Group 2 ILCs and Th2 cells, and thereby GATA3, are critical for the development of allergic and humoral immune responses in humans. (wikipedia.org)

For example, the Lim1 and Pax2 transcription factors are essential for the formation of the mesonephric duct, from which the ureteric bud develops. (medscape.com)

We investigated 21 HDR probands and 14 patients with isolated hypoparathyroidism for GATA3 abnormalities. (endocrine-abstracts.org)

Comparable studies in animals implicate GATA3 in the development of lymphocytes that mediate allergic and humoral immunity as well as allergic and humoral immune responses. (wikipedia.org)
3) GATA3 promotes the secretion of IL-4, IL-5, and IL-13 from Th2 cells in humans and has similar actions on comparable mouse lymphocytes. (wikipedia.org)
Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
ILC1 consists of NK cells and other interferon-g producing innate lymphocytes characterized by expression of the transcription factors T-bet and/Eomes. (pasteur.fr)

Kim H, Lee E, Lim T, Jung J and Lyu Y: Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes. (spandidos-publications.com)

The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. (wikipedia.org)
Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma. (wikipedia.org)
Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)

We found that the promoter methylation level of GATA3, IL-4 and TGF-β was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. (oncotarget.com)
Regulation of the human interleukin-5 promoter by Ets transcription factors. (bvsalud.org)

However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear. (wikipedia.org)
In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and administration of GH has been shown to increase bone turnover and bone mineral density (BMD), but the mechanisms remain unclear. (endocrine-abstracts.org)

Mutations in GATA3 are linked to breast and bladder cancer. (bmj.com)

Although the pathogenesis of BD is still not clear, numerous studies have suggested that environmental factors, infection triggers, abnormal autoimmune regulation and genetic susceptibility are closely associated with BD [ 3 ]. (oncotarget.com)
Historically, genetic factors identified by conventional karyotyping have been used to diagnose ALL and to risk-stratify children with the disease. (haematologica.org)
Conclusions: Genetic factors contributing to caries experience may exist in 13q31.1. (medipol.edu.tr)

Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
During development, GATA3 plays a key role in cell differentiation. (bmj.com)
Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
Broadly speaking, Gata3 is a transcription factor involved in neurosensory specification and hair cell differentiation. (wmich.edu)
2005). At the T cell level, Th2 differentiation starts with induction of a TCR driven activation of GATA3 transcription factor, and induction of STAT5 phosphorylation, triggered by IL-2, or TSLP (Zhang et al. (icem2012.org)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)
This binding initiates a cascade of events that culminates in differentiation into Th1 cells, by increasing the transcription factor T-bet 12 . (bvsalud.org)
Th2 cells have a differentiation process which is dependent on IL-4, which causes the activation of the transcription factor STAT 6 . (bvsalud.org)

Expression of GATA3 may be regulated in part or at times by the antisense RNA, GATA3-AS1, whose gene is located close to the GATA3 gene on the short arm of chromosome 10 at position p14. (wikipedia.org)
To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. (bmj.com)
The mRNA expression of GATA3 and TGF-β was markedly down-regulated in active BD patients compared to healthy individuals. (oncotarget.com)
Our results suggest that an aberrant DNA methylation of GATA3 and TGF-β is associated with their mRNA expression and participates in the pathogenesis of BD. (oncotarget.com)
When Gata3 was conditionally knocked out and reduced in its expression, fewer neurons appear to have formed compared to the mutant and the neurons that do form lack normal projection patterns. (wmich.edu)
De Fanis U, Mori F, Kurnat RJ, Lee WK, Bova M, Adkinson NF, Casolaro V: GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. (exbio.cz)
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. (exbio.cz)

WT-1, a zinc-finger transcription factor expressed in the metanephric mesenchyme, is essential for ureteric bud outgrowth. (medscape.com)

GATA3 plays central role in allergy and immunity against worm infections. (wikipedia.org)

Here, we report that GATA3 was indispensable for the development of all IL-7Rα(+) ILC subsets and T cells but was not required for the development of classical natural killer cells. (nih.gov)
These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)
The transcription factor Gata3 is required for the generation of group 3 innate lymphoid cells (ILC3) that protect mucosal surfaces. (rupress.org)
Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)
this suggests that the novel independent signaling pathways KPNA3-TGF-β-GATA3-HAS2/E-cadherin and KPNA3-AKT-HAS2/E-cadherin are involved in the EMT-mediated progress of TNBC MDA-MB-231 cells. (bmbreports.org)
The Activated Caspase3 labelling follows the general pathway of the neurons, leading to the belief that neurons were the cells that were dying when Gata3 was conditionally knocked out. (wmich.edu)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, te Velde AA, Fokkens WJ, van Drunen CM, Spits H: The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. (exbio.cz)

The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)

In many of these cases, a single exon is involved, and its transcription yields a variant mRNA [ 5 ]. (ecancer.org)

Transcription factors such as EMX-2, BF-2, fibroblast growth factor 7 (FGF 7), epithelial growth factor receptor (EGF-R), GDNF, retinoic acid receptor alpha, and beta 2 are involved in the branching of the ureteric bud. (medscape.com)

Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
Consequently, it is critical that we understand the cellular and molecular immune factors that regulate the uterine environment. (elifesciences.org)
Several transcription factors regulate this process. (encyclopedia.pub)

TCF1 is a transcription factor, involved in the canonical Wingless/Integration 1 (Wnt) signaling pathway. (biolegend.com)

Using ChIP-seq analysis, we demonstrate that RIP140 shares more than 80% of its binding sites with ERα, colocalizing with its interaction partners FOXA1, GATA3, p300, CBP, and p160 family members at H3K4me1-demarcated enhancer regions. (aacrjournals.org)

Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)

Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation. (geresdengle.com)

This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker. (bmj.com)

They also discussed the diagnostic value of transcription factors T-bet/GATA3 ratio in predicting AMR, which may be of value in diagnosis of C4d-negative AMR. (hindawi.com)

To better understand the role of Gata3 in spiral ganglion neurons of the inner ear, a Neurod1-cre model was used to conditionally knock out Gata3 at E9-E9.5, the timepoint when neuroblasts first begin to delaminate from the otic placode. (wmich.edu)

The location of GATA3 borders that of other critical sites on chromosome 10, particularly a site located at 10p14-p13. (wikipedia.org)

GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. (wikipedia.org)
Studies in humans implicate GATA3 in the following: 1) GATA3 is required for the development of the parathyroid gland, sensory components of the auditory system, and the kidney in animals and humans. (wikipedia.org)

Large-scale deletions in GATA3 may span into the DiGeorge syndrome 2 area and thereby cause a complex syndrome with features of the Barakat syndrome combined with some of those of the DiGeorge syndrome 2. (wikipedia.org)

Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)

Introduction: Secondary hyperparathyroidism (SHPT) is a major risk factor for the development of postoperative hypocalcaemia. (endocrine-abstracts.org)

However, there are other benefits that are provided by lactation, such as the provision of immune factors that are secreted into the milk, which provide protection from infection, and also the close contact that occurs between mother and infant during nursing, which might have developmental benefits (Peaker et al. (biologists.com)

Model architecture was based on published experimental measurements of the effects on each factor when each of the others is perturbed. (lu.se)

GATA3 specific primers were used for PCR amplif. (endocrine-abstracts.org)
TCF1 is the first identified member of the T-cell-specific transcription factor family. (biolegend.com)
An immunohistochemical investigation of the gingival tissue was performed to detect the presence of the Th2 specific transcription factor (GATA3). (bvsalud.org)

Previous studies have shown that Gata3 null mutants do not develop neurons, so Gata3 appears to be necessary for neuronal survival. (wmich.edu)

Anatomy16

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Analytical, Diagnostic and Therapeutic Techniques and Equipment23

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GATA12

FOXP39

Cytokines8

Protein5

Gene expression2

Genes8

Haploinsufficiency1

Mice4

Transcriptional1

ILCs4

PAX21

Hypoparathyroidism1

Lymphocytes4

Secretion1

Inflammatory4

Promoter2

Unclear2

Mutations1

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Expression8

Zinc1

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