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  • mutation
  • There are no known environmental factors for development of the mutation, but the patients are susceptible to environmental infections, such as histoplasmosis, which has a finite geographic distribution. (clinicaladvisor.com)
  • fetal
  • We further determined that the etiology of anemia in conditional Gata2 mutant embryos involved HSC loss in the fetal liver, as demonstrated by in vitro colony-forming and immunophenotypic as well as in vivo long-term competitive repopulation experiments. (pubmedcentralcanada.ca)
  • erythropoiesis
  • This strategy allowed us to administer Tx, thereby activating Cre and inactivating the Gata2 fl allele, after the time when embryos would normally encounter the first lethal block in primitive erythropoiesis. (pubmedcentralcanada.ca)
  • sequence
  • A synthetic peptide corresponding to a sequence at the N-terminus of human GATA2(46-60aa DVFFNHLDSQGNPYY), identical to the related rat and mouse sequences. (bosterbio.com)
  • Definitive diagnosis depends on sequence of GATA2, and should include intronic regions as well as exons. (clinicaladvisor.com)
  • mRNA
  • Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in this process. (jci.org)
  • human
  • Recombinant fragment, corresponding to a region within amino acids 130-397 of Human GATA2. (abcam.com)
  • self-renewal
  • GATA2 overexpression at low level confers self-renewal capacity to myeloid progenitors and is relevant to myeloid leukemia development. (nih.gov)
  • Patients
  • GATA2 was differentially expressed between Fibromyalgia patients and healthy controls. (nih.gov)
  • Domain
  • To circumvent the normal E10.5 demise encountered in Gata2 -/- embryos, we utilized a version of Cre recombinase fused to a tamoxifen-sensitive (Tx-sensitive) ligand-binding domain of the estrogen receptor (CreERT 2 , ref. 15 ). (pubmedcentralcanada.ca)