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  • amino
  • Lacking the first 83 amino acids and therefore one of the two activation domains of GATA1, GATA1-S has significantly less gene-regulating activity than GATA1. (wikipedia.org)
  • K-FPTGPMPPTTSTTVVAPLSS , with N-terminal added Lysine, conjugated to KLH by a Glutaraldehyde linker, corresponding to amino acids 394-413 of Human GATA1. (abcam.com)
  • mutation
  • The GATA1 mutation alone is insufficient for leukemogenesis because GATA1s causes transient proliferation of immature fetal megakaryocytic progenitors but no postnatal hematopoietic abnormalities ( 16 ) and individuals with germ-line GATA1s show no reported malignancies ( 17 ), strongly suggesting that trisomy 21 is essential for leukemic development. (aacrjournals.org)
  • How much a single mutation/alteration of a nucleotide affects the presence of a transcription fac. (biostars.org)
  • platelets
  • Studies in Gata1 - knockout mice , i.e. mice lacking the Gata1 gene, indicate that this gene is essential for the development and maintenance of blood-based and/or tissue-based hematological cells, particularly red blood cells and platelets but also eosinophils , basophils , mast cells , and dendritic cells . (wikipedia.org)
  • Genetic
  • However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. (biomedcentral.com)
  • Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed us to estimate the proportion of variation in gene expression that could be attributed to genetic and epigenetic variation, both crucial to understanding differences in drug response and the etiology of liver diseases. (biomedcentral.com)
  • interacts
  • Second, CBP interacts with numerous transcription factors via dedicated domains and could thus provide a scaffold for the assembly of a high-molecular-weight "enhanceosome" complex (for a review, see reference 38 ). (asm.org)
  • chemotherapy
  • A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. (springer.com)
  • homeostasis
  • First, I explored how changes in O-GlcNAc homeostasis affect the transcription of OGT and OGA. (ku.edu)
  • Together, these data suggest that OGA transcription was sensitive to changes in O-GlcNAc homeostasis and was potentially regulated by O-GlcNAc. (ku.edu)