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  • Genes
  • In silico analyses demonstrated that genes altered during recovery from infection were transcriptionally regulated by conserved transcription factors, including GATA/ELT-2, FOXO/DAF-16, and Nrf/SKN-1. (duke.edu)
  • promoter
  • Loss of GATA-4 and GATA-5 , caused by their promoter hypermethylation has been reported in human gastric and colon cancer. (aacrjournals.org)
  • Like other proteins of the family, GATA-4 is approximately 50 kDa in size and contains two zinc finger domains of the form C-X-N-C-(X17)-C-N-X-C. Cotransfection assays in heterologous cells demonstrate that GATA-4 trans activates reporter constructs containing GATA promoter elements. (asm.org)
  • The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. (wikipedia.org)
  • The released E2F is then free to act as a transcription factor and it subsequently binds to DNA promoter regions and activates the expression of proteins required in the next stages of the cell cycle and in DNA replication. (wikipedia.org)
  • It possesses histone deacetylase activity and represses transcription when tethered to a promoter. (wikipedia.org)
  • The frq gene can be activated from two distinct cis-acting sequences in its promoter, a distal site, the clock-box, used in the context of circadian regulation, and a site close to the principal transcription start site that is used for light-induced expression (the proximal light-regulatory element or PLRE). (wikipedia.org)
  • epithelium
  • In contrast, GATA-6 was expressed throughout the gastrointestinal epithelium, and in the distal gut its expression was most intense at the bottom of the crypts, i.e. cells with proliferative capacity. (uta.fi)
  • This branching deficit, which will cause bilateral pulmonary hypoplasia after birth, has been locally associated with areas lacking differentiated alveolar epithelium, implicating this phenotype as inherent to endodermal function, and thus may be indirectly linked to improper GATA-6 expression. (wikipedia.org)
  • mRNA
  • T-bet mRNA level was reduced whereas GATA-3 mRNA level was increased and T-bet/GATA-3 ratio was significantly reduced in PBMC, indicating that Th1/Th2 ratio was of imbalance at TF levels in PBMC of HCC, displaying Th2 thrift phenomena. (medsci.org)
  • Tumors
  • Transcription Factor GATA-4 Is Expressed in Pediatric Yolk Sac Tumors. (thefreedictionary.com)
  • GATA-3 was shown to be required for the luminal A type of breast cancer, intertwined in pathways with ERĪ± but also androgen receptor signaling in ER-/AR+ tumors. (wikipedia.org)
  • Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. (wikipedia.org)
  • epithelial
  • GATA-4 was abundant in the differentiated epithelial cells of the proximal parts of the gastrointestinal tract but was absent from the distal parts. (uta.fi)
  • cofactor
  • Our data lead us to propose a model in which a nuclear cofactor(s) interacting with the N-finger facilitates transcriptional action by GATA-1 in erythroid cells. (asm.org)
  • The primary function of the N-finger, named for being near the N-terminal is binding to a cofactor named FOG1 (friend of GATA), although it has also been implicated in binding to naked DNA (DNA studied in the test tube that is not assembled into chromatin). (wikipedia.org)
  • interactions
  • Although cellculture based studies have revealed significant insights into factors contributing to virulence and host defense, the interactions between this pathogen and its intact host remain to be elucidated. (omicsonline.org)
  • Such multifunctional interactions may account for the observed synergy between transcription factors that use CBP and p300 as cofactors. (asm.org)
  • murine
  • GATA-4 and GATA-6 are considered crucial for the formation of murine gastrointestinal mucosa, but their role in human gastrointestinal tract remains unexplored. (uta.fi)
  • mucosa
  • Human gastrointestinal mucosa regenerates vigorously throughout life, but the factors controlling cell fate in mature mucosa are poorly understood. (uta.fi)
  • We studied in detail the expression patterns of these two GATA factors and a GATA-6 down-stream target, Indian hedgehog (Ihh), in normal human gastrointestinal mucosa. (uta.fi)
  • The results suggest differential but overlapping functions for GATA-4 and GATA-6 in the normal gastrointestinal mucosa. (uta.fi)
  • Mice
  • Mice deficient for GATA-1 succumb to fatal anemia due to an inability of erythroid precursor cells to survive and mature ( 14 , 43 , 44 ). (asm.org)
  • proliferate
  • Such data, though sometimes circumstantial, argue that there is limited capacity to proliferate specifically in response to Epo (and not other factors). (wikipedia.org)
  • vitro
  • Using [ 3 H]acetate labelling experiments and anti-acetyl lysine immunoprecipitations, we show that GATA-1 is acetylated in vivo at the same sites acetylated by CBP in vitro. (asm.org)
  • CBP associates with GATA-1 in vitro and in vivo and markedly stimulates its activity. (asm.org)