• Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
  • Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). (medscape.com)
  • The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. (biomedcentral.com)
  • Prophylactic Pancreatectomy for Intraductal Papillary Mucinous Neoplasm Does Not Negatively Impact Quality of Life: A Preliminary Study. (columbiasurgery.org)
  • Intraductal papillary mucinous neoplasm (IPMN) is a non-invasive mucin-producing neoplasm of the pancreas arising from the main pancreatic duct or side-branches. (utoronto.ca)
  • Histologically, IPMNs are lined by flat or papillary mucinous epithelium of gastric, intestinal, pancreatobiliary, or oncocytic type, exhibiting varying degrees of dysplasia, and surrounded by dense fibrotic stroma. (utoronto.ca)
  • Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles. (uchicago.edu)
  • Signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma that produces mucin. (wikipedia.org)
  • The pattern of metastasis is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. (wikipedia.org)
  • In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Histopathologically, the cyst was mucinous cystadenoma, and the surrounding pancreatic ducts and ductules showed epithelial dysplasia of moderate-to- severe degree having foci of unequivocal in situ carcinoma. (elsevierpure.com)
  • The diagnostic clue of in situ carcinoma of the pancreas in these two cases was a cystic lesion of the pancreas detected by check-up US and CT of known carcinoma of the stomach and liver. (elsevierpure.com)
  • In situ carcinoma of the pancreas was found to be independent of the cysts because of the different locations and divergent histopathologic natures of the two lesions. (elsevierpure.com)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
  • The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
  • E-cadherin, Gastric Carcinoma. (booksdo.com)
  • Mucinous Carcinoma, Upper Gastro-Intestinal Tract. (booksdo.com)
  • One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered. (wikipedia.org)
  • Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. (hindawi.com)
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
  • Background/Aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • Mesonephric adenocarcinoma (MA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • The term mesonephric-like adenocarcinoma (MLA) has been suggested for a malignant tumor arising in the uterine corpus and the adnexa. (iiarjournals.org)
  • Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
  • Gastric adenomyoma is a rare benign tumor, known to occur in the antrum or pylorus of the stomach. (biomedcentral.com)
  • According to the World Health Organization's histopathologic classification, gastric adenomyoma is a benign tumor of the stomach characterized by a smooth muscle stroma in the glandular structures of the cuboidal epithelium or columnar epithelium [ 1 ]. (biomedcentral.com)
  • Within this mass, focal lesions with anechoic foci that appeared to comprise the cystic portion were observed, along with an inhomogeneous pattern (Figures 3 A and 3 B). On the basis of these combined examination results, the possibility that the lesion was a tumor of mesenchymal origin with malignant potential was explained to the patient and a decision for surgical treatment was made. (biomedcentral.com)
  • Gastrointestinal stromal tumors formerly classified as either leiomyomas or leiomyosarcomas account for 2% of gastric neoplasms (see Gastric Stromal Tumors ). (medscape.com)
  • Any subject with a known pancreatic cancer histologic subtype other than adenocarcinoma (e.g., subjects with pancreatic neuroendocrine tumors are excluded). (cedars-sinai.edu)
  • PJS is autosomal-dominant condition caused by mutations of STK11, characterized by gastrointestinal polyposis, mucocutaneous pigmentation, and predisposition to a range of epithelial cancers: including colorectal, gastric, pancreatic, breast, ovarian cancers and sex cord tumors with annular tubules). (cancerindex.org)
  • A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
  • The World Health Organization (WHO) classification is more detailed and, in addition to the adenocarcinoma, describes other gastric tumors of lower frequency, taking into consideration histological characteristics as well as and molecular phenotype. (medconsonline.com)
  • Lesions of endocrine origin have been termed carcinoid tumors. (medscape.com)
  • In contrast, mucinous cystic neoplasms of the pancreas occur almost exclusively in women, arise in the body/tail, do not communicate with a pancreatic duct, and exhibit dense ovarian-type stroma. (utoronto.ca)
  • Whereas serous cystic neoplasms are benign, IPMNs as well as mucinous cystic neoplasms can progress to invasive adenocarcinoma and require surgical resection. (utoronto.ca)
  • In univariate analyses, there is significant (8.0 months vs. 41.0 months, P = 0.000) difference in OS between patients with gastrointestinal cancer origin from breast origin, and between patients with gastric origin from colorectal origin (7.4 months vs. 8.8 months, P = 0.036). (biomedcentral.com)
  • Biopsy of any ulcerated lesion should include at least 6 specimens taken from around the lesion because of variable malignant transformation. (medscape.com)
  • For non-invasive IPMN, including low-grade and high-grade dysplasia, surveillance with a focus on the remnant pancreas is recommended because early detection of a malignant lesion and surgical resection may improve the prognosis. (biomedcentral.com)
  • Gastric epithelial dysplasia. (booksdo.com)
  • A biopsy revealed epithelial and smooth muscle proliferation, and a final diagnosis of gastric adenomyoma was made. (biomedcentral.com)
  • The Lauren system classifies gastric cancer pathology as either type I (intestinal) or type II (diffuse). (medscape.com)
  • Though incidence and mortality of gastric cancer has declined in many countries over the past 50 years, there has been an increase in occurrences of gastric SRCC-type cancers. (wikipedia.org)
  • The role of other risk factors in gastric cancer such as salt-preserved food, smoking, auto-immune gastritis are not well studied in SRCC. (wikipedia.org)
  • In the future, case studies indicate that bone marrow metastases will likely play a larger role in the diagnosis and management of signet ring cell gastric cancer. (wikipedia.org)
  • Ovarian mesonephric-like adenocarcinoma (MLA) is a rare cancer subtype. (bvsalud.org)
  • The presence of a cyst in subjects with pancreatic cancer is not an exclusion, including cancer arising from a mucinous cystic lesion. (cedars-sinai.edu)
  • Case 1: Ultrasonography (US) and computed tomography (CT) in a 54-yr-old Japanese man with a known gastric cancer revealed a pancreatic cyst. (elsevierpure.com)
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (tri-kobe.org)
  • As the biological behavior and clinical outcome of the ovarian metastatic lesions from extragenital cancer origins are rarely summarized, we presented in this study the characteristics and outcomes for all patients with surgically confirmed ovarian metastases from extragenital primary cancer in a single institution during an 8-year period. (biomedcentral.com)
  • Ectopic expression of CDX2 is associated with the development and progression of gastric cancer. (biomedcentral.com)
  • Previous studies showed that CDX2 may be an upstream regulator of Reg IV expression in gastric cancer, and our previous report showed that Reg IV upregulated SOX9 expression and enhanced cell migration and invasion in gastric cancer cells. (biomedcentral.com)
  • However, the regulatory roles of CDX2 have not been clarified in gastric cancer, and the correlation between CDX2 and Reg IV requires further study. (biomedcentral.com)
  • CDX2 and Reg IV were examined in gastric cancer specimens and paired adjacent tissues via real-time PCR and immunohistochemistry (IHC). (biomedcentral.com)
  • To verify their relationship, knockdown and exogenous expression of CDX2 or Reg IV were performed in AGS and MKN-45 gastric cancer cells, and their expression was subsequently analyzed via a real-time PCR and western blotting. (biomedcentral.com)
  • A positive correlation was observed between CDX2 and Reg IV expression at the mRNA and protein levels in gastric cancer tissues. (biomedcentral.com)
  • Our findings demonstrate that CDX2 expression was positively correlated with that of Reg IV in gastric cancer, and CDX2 promoted cell migration and invasion through upregulation of Reg IV expression in AGS and MKN-45 cells. (biomedcentral.com)
  • Gastric cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. (biomedcentral.com)
  • In addition, CDX2 overexpression promoted the development of MDR in SGC-7901/DDP (cisplatin-resistant) and BGC-823/5-FU (5-fluorouracil-resistant) human gastric cancer cells in vitro and in vivo [ 18 ]. (biomedcentral.com)
  • Taken together, these conflicting results show that the regulatory roles of CDX2 in gastric cancer remain unclear. (biomedcentral.com)
  • If the cancer originates from the stomach glandular tissue, the medical term for such a condition is gastric adenocarcinoma, or gastric cancer. (medconsonline.com)
  • Cancer in the body and tail may cause splenic vein obstruction, resulting in splenomegaly, gastric and esophageal varices, and gastrointestinal hemorrhage. (msdmanuals.com)
  • Resection of metastatic lesions may lead to greater survival benefit if the abdominal wall metastasis is the only manifestation of recurrent disease. (biomedcentral.com)
  • We report a case in which 18 F-fluorodeoxyglucose positron emission/computed tomography ( 18 F-FDG PET/CT) was very useful for early diagnosis and planning a theraupetic strategy for a case of mucinous adenocarcinoma metastasis at a laparoscopic port site. (biomedcentral.com)
  • Distal Pancreatectomy with En Bloc Celiac Axis Resection After Neoadjuvant Therapy for Locally Advanced Pancreatic Adenocarcinoma. (columbiasurgery.org)
  • In 1946, Waugh and Clagett described a formal en-bloc resection of the gallbladder with the common bile duct (CBD), gastric antrum, duodenum, and pancreatic head performed as a one-stage procedure, which we recognize today as the classic pancreaticoduodenectomy. (medscape.com)
  • Although innumerable details of pancreaticoduodenectomy yield to continued innovation, a comprehensive discussion of intraoperative variants (ie, duct to mucosa vs invagination of the pancreaticojejunal anastomosis, diverse approaches to vein resection and reconstructions, nuances of each enteric anastomosis, and modifications of Roux-en-Y reconstructions, to name a few) is beyond the scope of this article. (medscape.com)
  • Histologic changes caused by injection of a novel submucosal lifting agent for endoscopic resection in GI lesions. (uchicago.edu)
  • With the patient under general anesthesia, a laparoscopic wedge resection of the gastric subepithelial lesion was performed. (biomedcentral.com)
  • Cases of gastric carcinomas metastasizing to the breast and forming signet-ring cells have also been reported. (wikipedia.org)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • Chest radiograph is done to evaluate for metastatic lesions. (medscape.com)
  • The differential diagnosis of an ovarian mass is complex as approximately 7% of ovarian masses encountered clinically are metastatic lesions, the most common sites of origin being the gastrointestinal tract and breast. (biomedcentral.com)
  • On physical examination, a 4 cm nodular yellowish lesion on the vestibule under the orifice of the urethra was seen and vulvar biopsy was taken. (hindawi.com)
  • The specimen of the vulvar biopsy was diagnosed vulvar adenocarcinoma. (hindawi.com)
  • Over the past decade, the role of the pathologist has changed as well, with the widespread availability of endoscopic ultrasound-guided fine-needle aspiration biopsy, a technique that has allowed for sampling of these lesions with relatively little morbidity and mortality. (coek.info)
  • Fifty-one-year-old male chronic smoker presented with symptoms of lower rectal mass, biopsy suggestive of mucinous adenocarcinoma and CT scan showed T 4 lesion with perirectal lymph node involvement. (jbclinpharm.org)
  • Seventy-three-year-old male chronic smoker presented with ulceroproliferative growth in the cecum and biopsy suggestive of adenocarcinoma. (jbclinpharm.org)
  • There are many cystic lesions of the pancreas, of which most are pseudocysts and only 5-15% are neoplastic. (utoronto.ca)
  • Further study is necessary to determine whether there is a rational relationship between mucinous cystadenoma of the pancreas and pancreatic adenocarcinoma. (elsevierpure.com)
  • Endoscopic retrograde cholangiopancreatography (ERCP) showed a cyst in the tail of the pancreas, and cytology of the pure pancreatic juice revealed adenocarcinoma. (elsevierpure.com)
  • Intraoperatively, the pancreas was cut along the portal vein, and cytology of the pancreatic juice from the pancreas distal to the cutting line showed adenocarcinoma. (elsevierpure.com)
  • Adenocarcinomas of the head of the pancreas cause obstructive jaundice (which can cause pruritus) in 80 to 90% of patients. (msdmanuals.com)
  • Gross section of an adenocarcinoma of the pancreas measuring 5 X 6 cm resected from the pancreatic body and tail. (medscape.com)
  • Of the histologically verified lesions, 68.4% (13/19) were purely of squamous origin. (tuni.fi)
  • Ivana Kholová Introduction: Although the cytological diagnostic criteria for cervical squamous and glandular lesions are established by the Bethesda System for Reporting Cervical Cytology , the reproducibility. (karger.com)
  • The lower anogenital squamous terminology (LAST), an acronym for LAST, incorporates the low- and high-grade squamous intraepithelial lesion (HSIL) terminology. (cytojournal.com)
  • No benefit of addition of other biomarkers like p63 or ki67 is found in problem-solving in differentiation of HSIL from mimics or low-grade squamous intraepithelial lesion. (cytojournal.com)
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • Histologically, most ductal adenocarcinomas are composed of glandlike structures embedded in an abundant desmoplastic stroma. (coek.info)
  • Histologically, papillary adenocarcinomas closely resemble adenocarcinomas of the colon. (medscape.com)
  • Transvaginal ultrasonography revealed an ovarian mass, and subsequent pelvic magnetic resonance imaging showed a 13 × 10â cm multicystic ovarian lesion with a solid part. (bvsalud.org)
  • No extra ovarian lesions were observed and a staging laparotomy was performed. (bvsalud.org)
  • The severity of mucosal damage is increased in patients who reflux both gastric and duodenal juice compared with patients who reflux gastric juice alone [ 6 ]. (jcancer.org)
  • Stomach cancers with both adenocarcinoma and some SRC (known as mixed-SRCC) exhibit more aggressive behavior than purely SRCC or non-SRCC histologies. (wikipedia.org)
  • Almost all primary papillary cancers are adenocarcinomas, although sarcomas, lymphomas, carcinoid, and islet-cell cancers also have been reported. (medscape.com)
  • Uptake patterns of incidentally identified focal hepatic lesions encountered on the hepatogram can inform the differential, but other modalities such as US, CT, and MRI are required for further workup. (radiologykey.com)
  • Among endocervical glandular lesions, screening with hrHPV test has previously shown to predict the outcome better than cytology, although around one-fifth of the EAC remain negative both in hrHPV testing and cytology. (tuni.fi)
  • Among hrHPV positive patients, three EAC, two adenocarcinomas in situ (AIS), one AIS + high-grade intraepithelial lesion (HSIL) and 13 HSIL were found. (tuni.fi)
  • Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
  • Study design: A total 100 patients with gastric lymphoma at the K hospital. (ungthuvn.org)
  • Somatic mutations of the APC gene have also been implicated in the development of gastric SRCCs. (wikipedia.org)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • Surveillance of these high-risk groups may lead to early detection of PDAC or detection of precursor lesions (PRLs), allowing curative surgical treatment. (medscape.com)
  • Gastric mucosal necrosis with vascular degeneration induced by doxycycline. (uchicago.edu)
  • The histological examination revealed a mucinous adenocarcinoma which invaded the cecal subserosa. (biomedcentral.com)
  • No high-grade histological lesions were found among the hrHPV negative patients with cytological glandular atypia. (tuni.fi)
  • Marked gastric foveolar hyperplasia associated with active cytomegalovirus infection. (uchicago.edu)
  • This procedure is also the primary method for obtaining a tissue diagnosis of suspected lesions. (medscape.com)
  • Histopathological examination of the resected nodule confirmed the diagnosis of metastatic mucinous adenocarcinoma. (biomedcentral.com)
  • Therefore, Patients with mucinous adenocarcinoma should be followed carefully after surgery, and receive rapid diagnosis and treatment if recurrence is suspected. (biomedcentral.com)
  • According to the Laurén classification, gastric adenocarcinomas are divided into the intestinal, diffuse and indeterminate (having an uncommon histology) type. (medconsonline.com)
  • The second most common gastric malignancies are lymphomas. (medscape.com)
  • Today colloid imaging remains useful for confirmation of splenosis and extramedullary hematopoiesis, but has otherwise been superseded by US, CT, and MRI for detection and evaluation of liver lesions. (radiologykey.com)
  • PATHOLOGY Ductal adenocarcinomas are firm to hard mass lesions that are often poorly defined grossly. (coek.info)
  • A 57-year-old man, who underwent laparoscopic surgery for advanced mucinous adenocarcinoma of the cecum 6 years prior, developed a nodule in the surgical wound at the lower right abdomen. (biomedcentral.com)
  • Although gastric adenomyoma occurs most frequently in the gallbladder, a few cases in the stomach have been reported. (biomedcentral.com)
  • To the best of our knowledge, this is the first case reported in the literature of a gastric adenomyoma in the stomach body, but not in the antrum. (biomedcentral.com)
  • We report the case of a 79-year-old Korean woman with a gastric subepithelial lesion in the stomach body. (biomedcentral.com)
  • The lesion was observed via endoscopy as a bulging mass in the stomach body with a cystic center. (biomedcentral.com)
  • Gastric adenomyoma can occur in the stomach body and can be treated completely with surgery. (biomedcentral.com)
  • In this report, we describe the case of a patient with a gastric subepithelial lesion in the stomach body that was discovered via endoscopic examination and diagnosed as a gastric adenomyoma. (biomedcentral.com)
  • A 79-year-old Korean woman was referred to our hospital for an incidentally detected subepithelial lesion in the stomach. (biomedcentral.com)
  • Purposes: to classify the gastric lymphoma by using the new WHO 2001 classification and to evaluate relationship of gastric lymphoma to HP infection. (ungthuvn.org)
  • However, it can be difficult to diagnose a lesion in the abdominal wall as recurrence of disease on the basis of clinical characteristics alone. (biomedcentral.com)
  • A 2-cm, firm, ill-defined, tender mass was palpable in the incision site, and was suspected to be a recurrence of the cecal mucinous adenocarcinoma. (biomedcentral.com)
  • Whereas surveillance for recurrence, including de novo lesions, is essential, optimal surveillance protocols have not been established. (biomedcentral.com)
  • Endoscopic ultrasonographic findings (A) and (B). The lesion seems to originate from the third layer with heterogeneous echogenicity and an approximately 18mm focally cystic center. (biomedcentral.com)