Gastric cancer. Medical search. Frequent questions

The most common form of stomach cancer associated with CDH1 mutations is diffuse-type adenocarcinoma. (wikipedia.org)
Surgical removal of the stomach (gastrectomy) is typically recommended for people after 20 years of age, and before 40 years of age in order to prevent development of diffuse gastric adenocarcinoma. (wikipedia.org)
SAN FRANCISCO ― An experimental monoclonal antibody combined with chemotherapy could offer a new standard of care for patients with claudin-18.2+ (CLDN18.2+) / HER2− advanced gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma, say researchers in reporting a phase 3 trial. (medscape.com)
In advanced adenocarcinoma of GC, gastroesophageal junction cancer (GEJC) and esophageal cancer (EC), the combination of nivolumab and chemotherapy in first-line therapy improves overall survival (OS) in PD-L1 (programmed cell death protein 1)-positive patients with approval in Europe (PD-L1 CPS (combined positivity score) ≥ 5), USA and Taiwan (CHECKMATE-649) and pembrolizumab plus chemotherapy for GEJC and EC in Europe (CPS ≥ 10) and the USA (KEYNOTE-590). (mdpi.com)
Gastric adenocarcinoma is one of the most lethal cancers worldwide due to inherent treatment resistance, but the cellular and molecular mechanisms involved in the progression from early pre-cancer to tumor formation and metastasis are not well understood. (news-medical.net)
Gastric adenocarcinoma exhibits a high degree of heterogeneity with respect to both its phenotypes and molecular characteristics, but research around it has lagged behind other cancer types. (news-medical.net)
This study represents the largest single-cell RNA sequencing cohort of gastric adenocarcinoma to date and brings important new insights into how these cell populations impact disease progression. (news-medical.net)
While stromal components within the tumor microenvironment play crucial roles in tumor initiation, progression and metastases, cancer treatment strategies have thus far rarely focused on modulating stromal components, especially in patients with gastric adenocarcinoma. (news-medical.net)
There are unmet needs for patients with gastric adenocarcinoma every step of the way in their clinical journey,' Ajani said. (news-medical.net)
The approval encompasses gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma and follows FDA priority review designation for the nivolumab-chemotherapy combination earlier this year. (medpagetoday.com)
Nivolumab is the first PD-1 inhibitor to demonstrate superior overall survival and [progression-free survival] in combination with chemotherapy in previously untreated patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma," said principal investigator Markus Moehler, MD, of Johannes-Gutenberg University Clinic in Mainz, Germany, during the virtual meeting of the European Society for Medical Oncology. (medpagetoday.com)
KEYTRUDA is indicated under accelerated approval in combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-positive gastric or GEJ adenocarcinoma. (merck.com)
Highly aggressive gastric adenocarcinoma with multiple skin. (lww.com)
Although gastric adenocarcinoma is common in middle- and old-aged population, it is rare in young people. (lww.com)
We report the case of a 19-year young man with gastric adenocarcinoma who had multiple skin nodules over the trunk during presentation. (lww.com)
Fine-needle aspiration cytology of the nodule revealed it to be metastasis from gastric adenocarcinoma. (lww.com)
Gastric adenocarcinoma is one of the common causes of cancer death in the world. (lww.com)
This case is reported due to the rarity of cutaneous metastasis at multiple sites from a highly aggressive adenocarcinoma in a young patient, to emphasize the importance of cutaneous metastasis as a poor prognostic sign in patients with a history of cancer. (lww.com)
Treatment of Opdivo and Stivarga plus chemotherapy improves survival in patients with advanced esophageal adenocarcinoma and certain esophageal and stomach cancers. (curetoday.com)
Opdivo (nivolumab) combined with Stivarga (regorafenib) and chemotherapy as first-line treatment has been shown to improve the time a patient lives before death or disease worsening in patients with advanced esophageal adenocarcinoma, a type of esophagus cancer, according to recent research published in The Lancet Oncology . (curetoday.com)
According to Memorial Sloan Kettering Cancer Center (MSKCC) in New York City, where the study was performed, esophageal adenocarcinoma is considered the most common type of esophageal cancer in the United States, constituting more than half of all new cases. (curetoday.com)
In the study, there was a total of 35 patients with advanced esophageal, gastric or gastroesophageal junction adenocarcinoma, who had not been previously treated, with a median follow-up of 18.1 months. (curetoday.com)
Gastric cancer is the most chemosensitive adenocarcinoma among digestive neoplasms. (cancernetwork.com)
AstraZeneca and Daiichi Sankyo announced on Oct. 28, 2020 that their supplemental biologics license application (sBLA) for Enhertu (trastuzumab deruxtecan), an antibody drug conjugate (ADC) for treating HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma, was accepted by FDA and granted priority review. (pharmtech.com)
On November 7, the U.S. Food and Drug Administration (FDA) revised the existing indication of pembrolizumab (Keytruda) in combination with trastuzumab, fluoropyrimidine, and platinum-containing chemotherapy for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma. (ascopost.com)
The FDA also approved the Agilent PD-L1 IHC 22C3 pharmDx as a companion diagnostic device to select patients with gastric or GEJ adenocarcinoma whose tumors express PD-L1 (CPS ≥ 1). (ascopost.com)
The efficacy of pembrolizumab in this setting was evaluated in KEYNOTE-811 (ClinicalTrials.gov identifier NCT03615326 ), a multicenter, randomized, double-blind, placebo-controlled trial in patients with HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma who have not previously received systemic therapy for metastatic disease. (ascopost.com)
Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. (springermedizin.at)
Untreated metastatic diffuse gastric adenocarcinoma (DGAC): Randomized phase III study of S-1 and cisplatin vs. 5-FU and cisplatin (the DIGEST trial). (springermedizin.at)
The most commonly used clinical classifications of gastric cancer are Lauren classification (intestinal, diffuse, mixed) and World Health Organization(WHO) classification (papillary adenocarcinoma, tubular adenocarcinoma, mucinous glands cancer and low-adhesion cancer). (centerwatch.com)
Hepatoid adenocarcinoma of the stomach (HAS) is a special and rare type of gastric cancer. (centerwatch.com)
The main treatment is based on gastric adenocarcinoma. (centerwatch.com)
We employed over 400 stomach adenocarcinoma (STAD) samples from The Cancer Genome Atlas (TCGA), as well as a single cell dataset, for the construction of a web suite of tools exploring multimodal data for GCs, and the exploration of changes in the TME of EBVaGCs and cellular phenotypes overrepresented in EBVaGCs. (uwo.ca)
Gastric adenocarcinoma is the second leading cause of cancer death worldwide, following lung cancer. (medscape.com)
Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)

Early gastric cancer in the gastric body. (medscape.com)
however, some patients with incidental complaints are diagnosed with early gastric cancer. (medscape.com)
Is lymphadenectomy necessary for early gastric cancer? (nih.gov)
Although early gastric cancer (T1, NX) in Japan has been reported to have an excellent prognosis, the experience with this cancer in the United States is limited. (nih.gov)
Early gastric carcinoma in North America has an excellent prognosis, similar to that in Japan. (nih.gov)
Reduced pain, early ambulation, and better cosmetics are some of the benefits of minimally invasive surgery for early gastric cancer. (sages.org)
Gastric cancer remains difficult to cure , primarily because early gastric cancer has no associated symptoms and by the time most patients present with symptoms, it is with advanced disease . (medscape.com)
The final diagnosis was juvenile polyposis of the stomach with multiple early gastric cancers. (spandidos-publications.com)
The present study reported a case of juvenile polyposis of the stomach with multiple early gastric cancers treated by laparoscopy-assisted total gastrectomy. (spandidos-publications.com)
We conducted this study to compare the short-term outcomes of LADG with TLDG to provide the basis for standardization of laparoscopic gastrectomy in early gastric cancer. (sages.org)
METHODS AND PROCEDURES In this prospective study, 35 patients with early gastric cancer were randomized to either TLDG or LADG with Billroth II anastomosis from February to August 2001. (sages.org)
CONCLUSION(S) This study suggests that TLDG with Billroth II anastomosis was safe and feasible as LADG in early gastric cancer. (sages.org)
Participants were also matched against the National Registry of Diseases Office for missed diagnoses of early gastric neoplasia (EGN). (bmj.com)
Endoscopic Resection of Undifferentiated Early Gastric Cancer. (bvsalud.org)
Endoscopic resection (ER) is widely performed for early gastric cancer (EGC) with a negligible risk of lymph node metastasis (LNM) in Eastern Asian countries. (bvsalud.org)
Detection of early gastric cancer. (cdc.gov)

Forty-six patients with locally advanced or metastatic gastric cancer received a median of 3 courses each. (cancernetwork.com)

In addition, SDC2 expression was consistently elevated in stromal cells across various other cancer types, including pancreatic cancer, colorectal cancer, bladder cancer, breast cancer and clear cell renal cell carcinoma. (news-medical.net)
Therefore, we hope that nivolumab and chemotherapy will present a new potential standard treatment for patients with advanced gastric, gastroesophageal juncture, and esophageal carcinoma," he added. (medpagetoday.com)
Since its initial approval in 2014 for metastatic melanoma, Opdivo has added numerous indications across a variety of settings for patients with lung cancer, renal cell carcinoma, Hodgkin lymphoma and continued indications in combination with Yervoy (ipilimumab) for melanoma. (curetoday.com)
D2 gastrectomy for gastric carcinoma is a well-established procedure in patients undergoing surgery for gastric cancer and is the standard of care in our institution. (sages.org)
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. (spandidos-publications.com)
In 1990, Burke et al ( 3 ), first reported the association between EBV and gastric carcinoma with characteristic lymphoepithelioma-like histology based on polymerase chain reaction (PCR) techniques. (spandidos-publications.com)
In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
In addition to accumulating more case series of EBV-associated gastric carcinoma (EBVaGC), the development of comprehensive molecular analyses has provided evidence that EBVaGC is a distinct subset both in terms of its clinicopathological and molecular features. (spandidos-publications.com)
5] With this background, FLEP appeared to be an attractive schema for the treatment of gastric carcinoma, and it was decided to assess the efficacy and toxicity of FLEP in a phase II trial. (cancernetwork.com)
Compared with ordinary gastric cancer, HAS has unique clinicopathological characteristics, prone to liver metastasis and lymph node metastasis, has a highly aggressive and malignant biological behavior, a worse prognosis than alpha fetoprotein(AFP) normal gastric cancer, and is easily confused with hepatocellular carcinoma(HCC). (centerwatch.com)
Several classes of drug have been approved for the treatment of melanoma, renal cell carcinoma, non-small cell lung cancer, bladder cancer, and head and neck squamous cell carcinoma, among others. (medscape.com)
Epstein-Barr virus (EBV)-positive gastric carcinoma represents one of the four subtypes of gastric carcinoma recently defined by The Cancer Genome Atlas. (medscape.com)

Clinical evidence suggests that infection with H. pylori cagA + strains dramatically increases the risk of developing gastric cancer. (medicalxpress.com)

Zolbetuximab plus mFOLFOX6 is a new potential standard treatment for these patients," said lead study author Kohei Shitara, MD, Department of Gastrointestinal Oncology, National Cancer Center Hospital East Kashiwa City, Chiba, Japan. (medscape.com)
The findings were presented here at the Gastrointestinal Cancers Symposium (GICS) 2023, organized by the American Society of Clinical Oncology. (medscape.com)
In Moffitt Cancer Center's Gastrointestinal Oncology Program, a multispecialty stomach cancer team creates a highly individualized treatment plan for every patient. (moffitt.org)
This phase 3 study demonstrated the efficacy and safety of nivolumab as third or later line of treatment in patients with advanced gastric cancer,' said lead study investigator Yoon-Koo Kang, M.D., Ph.D., Department of Oncology at the University of Ulsan College of Medicine, Asan Medical Center in Seoul, Korea. (curetoday.com)
ONO-4538-12 is the first randomized, phase 3 Immuno-Oncology trial to demonstrate improved survival for patients with previously treated advanced or recurrent gastric cancer,' Ian M. Waxman, M.D., development lead, Gastrointestinal Oncology, Bristol-Myers Squibb, said in a statement. (curetoday.com)
Once patients with HER2-positive metastatic gastric cancer progress following initial treatment with an anti-HER2 regimen, there are no approved HER2-directed medicines," said José Baselga, executive vice-president, Oncology R&D, AstraZeneca, in the press release. (pharmtech.com)
D. Alderson, "Scottish Intercollegiate Guidelines Network (SIGN) 87-The Management of Oesophageal and Gastric Cancer," Clinical Oncology (Royal College of Radiologists), Vol. 20, No. 7, 2008, pp. 530-531. (scirp.org)
Recently, Peritoneal Surface Oncology Group International (PSOGI) developed a novel comprehensive treatment consisting of cytoreductive surgery (CRS) and perioperative chemotherapy (POC) for the treatment of peritoneal metastases (PM) from gastric cancer with curative intent. (lu.se)

In 2023, it is estimated that 26,500 Americans will be diagnosed with gastric cancer and 11,130 will die of it. (oncolink.org)
In July 2023 , we reviewed the evidence and made new recommendations on palliative management of luminal obstruction with no curative intent for adults with oesophageal or oesophago-gastric junctional cancer . (nice.org.uk)
Salnikov, Mikhail, "Exploration of the Immune Landscape of EBV-associated Gastric Cancers" (2023). (uwo.ca)
J Gastric Cancer;23(1): 146-158, 2023 Jan. (bvsalud.org)

In this form, known as diffuse gastric cancer, there is no solid tumor. (medlineplus.gov)
A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
The surgical approach in gastric cancer depends on the location, size, and locally invasive characteristics of the tumor. (medscape.com)
Zolbetuximab is a monoclonal antibody that targets the cell surface molecule CLDN18.2, which is expressed in normal gastric mucosa cells and is retained in mG/GEJ tumor cells. (medscape.com)
Surgery - A surgical oncologist may be able to remove the tumor, depending on the stage of the stomach cancer. (moffitt.org)
For example, Moffitt's stomach cancer team may suggest radiation therapy before surgery to help shrink the size of the tumor, or radiation therapy might be needed after surgery to prevent recurrence and eliminate any cells that could have been left behind. (moffitt.org)
For a more comprehensive and unbiased proteomic characterization, the Clinical Proteomic Tumor Analysis Consortium performed mass spectrometry-based proteomic and/or phosphoproteomic analyses of tumor tissues from patients with colon, breast, and ovarian cancers, which demonstrated that proteomic signatures can provide information that can further stratify patients. (genomeweb.com)
A new study led by researchers at The University of Texas MD Anderson Cancer Center provides a deeper understanding of the evolution of the tumor microenvironment during gastric cancer progression. (news-medical.net)
Most studies have concentrated on tumor cells and largely overlooked the immune and stromal cells within the tumor microenvironment, which are very dynamic and play critical roles in cancer progression. (news-medical.net)
The Tumor Immune Estimation Resource (TIMER) platform has been used to assess the tumor-infiltrating immune cells of 32 cancer types in a comprehensive way. (hindawi.com)
Globally, gastric cancer remains a serious threat to human health given its high morbidity and mortality [ 1 - 3 ], and tumor treatment continues to be an important issue in modern medicine. (hindawi.com)
With increasing globalization and advancements in modern medicine, novel therapeutic approaches such as targeted molecular therapy [ 4 ], immunotherapy [ 5 ], and latent/residual tumor cell ablation have been used to improve clinical outcomes for cancer patients, but the prognosis for patients with gastric cancer remains poor. (hindawi.com)
The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)
my mom is scheduled for gastric sleeve surgery to lose about 50lbs before she can have surgery to remove her metastatic tumor in the vaginal wall recurrence of anal cancer. (cancer.org)
Gastric cancer is a highly heterogeneous tumor. (centerwatch.com)
In addition to gastric cancer, we are also evaluating BDC-1001 in 3 other tumor types with significant unmet medical need: HER2-positive breast, colorectal, and endometrial cancers," Perez stated in the press release. (onclive.com)

Moreover, in Western societies, there has been a gradual decrease in the incidence of the distal, intestinal type of gastric cancer, and an increase in the proximal, diffuse type ( 4 ). (frontiersin.org)
This type of gastric cancer has a relatively high degree of malignancy, rapid progress of the disease, and easy recurrence after surgery. (centerwatch.com)

Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study. (medscape.com)

A retrospective review of our prospective data base from July 1985 to March 1998 revealed 165 patients undergoing surgical resection for T1 gastric tumors. (nih.gov)
In 2014 the Cancer Genome Atlas Research Network identified and published four molecular subtypes of gastric cancer: Epstein-Barr virus positive, microsatellite unstable tumors, genomically stable, and chromosomally unstable tumors ( 5 ). (frontiersin.org)
A 4-part, first-in-human phase 1/2 trial (NCT04278144) is investigating the agent as monotherapy and in combination with nivolumab (Opdivo) in patients with advanced HER2-expressing solid tumors, including colorectal, endometrial, and gastroesophageal cancers. (onclive.com)
EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)

Download these slides from a live webinar reviewing current and emerging therapies for previously treated advanced HER2-negative gastric/GEJ cancers. (clinicaloptions.com)

Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. (medscape.com)

The reason for this is that Helicobacter Pylori ( H. pylori ), discovered in 1983 by Marshall and Warren, and classified as a definite carcinogen by World Health Organization in 1994, has been regarded as the major factor in almost all gastric carcinomas worldwide ( 7 - 9 ). (spandidos-publications.com)
The occurrence of birth-cohort phenomena in gastric cancer and peptic ulcer suggests that additional secular trends besides changes in the infection with Helicobacter pylori must have contributed to the peculiar long-term behaviour of these diagnoses. (bmj.com)

Individuals who inherit an inactive copy of the CDH1 gene are at significantly elevated risk for developing stomach cancer. (wikipedia.org)
Stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. (medlineplus.gov)
It is hard to diagnose stomach cancer in its early stages. (medlineplus.gov)
Doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy. (medlineplus.gov)
Because it is often found late, it can be hard to treat stomach cancer. (medlineplus.gov)
What Is Stomach Cancer? (medlineplus.gov)
What Causes Stomach Cancer? (medlineplus.gov)
What's New in Stomach Cancer Research and Treatment? (medlineplus.gov)
A variety of stomach cancer treatment options are available to patients today. (moffitt.org)
This form of stomach cancer treatment usually involves a prescribed number of sessions over a given span of time. (moffitt.org)
Molecularly targeted therapy - This form of therapy targets the cancer's specific genes, proteins or tissues to fight the spread and growth of the stomach cancer. (moffitt.org)
Oftentimes, these different forms of stomach cancer treatment will be paired with one another to create the most effective treatment plan. (moffitt.org)
Moffitt's stomach cancer program also offers clinical trials that allow patients to try some of the most promising breakthrough treatments that are not yet widely available. (moffitt.org)
We do not require referrals to meet with our multispecialty team of oncologists specializing in stomach cancer. (moffitt.org)
Contact Moffitt Cancer Center at 1-888-663-3488 , or schedule an appointment using our online form to learn more about our stomach cancer treatment options. (moffitt.org)
Opdivo was approved by the Food and Drug Administration (FDA) in April 2021 in combination with chemotherapy to treat patients with stomach cancer. (curetoday.com)
Stomach cancer can also cause slow chronic blood loss which may not be noticed in the stool, but may present with symptoms of anaemia such as palpitations, shortness of breath and chest discomfort. (singhealth.com.sg)
Epstein-Barr virus (EBV) is a virus that is responsible for 9% of gastric (stomach) cancer (GC) cases. (uwo.ca)
SEER Stat Fact Sheets: Stomach Cancer. (medscape.com)
What are the key statistics about stomach cancer? (medscape.com)
Available at http://www.cancer.org/cancer/stomachcancer/detailedguide/stomach-cancer-key-statistics . (medscape.com)

In this context first results for check point inhibitors active in esophageal and gastric cancer were presented. (springermedizin.at)

These results indicate that nivolumab could be a new treatment option for patients with heavily pretreated advanced gastric cancer, and also provide a strong rationale to explore nivolumab in earlier lines of treatment for gastric cancer. (curetoday.com)

There was a 37 percent reduced risk of death in patients with advanced gastric or gastroesophageal junction (GEJ) cancer who were treated with Opdivo (nivolumab) compared to placebo, following second or later-line chemotherapy, according to the findings from the phase 3 ONO-4538-12 trial presented at the 2017 Gastrointestinal Cancers Symposium. (curetoday.com)

Many of the recent treatment updates in the management of gastric cancer have a major influence on both surgical and oncological approaches. (frontiersin.org)

Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)

Economic development has contributed to the global reduction in the prevalence of H. pylori, a major factor for gastric cancer, as well as eradication therapy. (frontiersin.org)
A specialized protein delivered by H. pylori to the host, oncoprotein "CagA," has been shown to interact with multiple host proteins and promote gastric carcinogenesis (transformation of normal cells to cancer cells ). (medicalxpress.com)
Corresponding author Masanori Hatakeyama, Laboratory Head, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, says, "Perturbation of Wnt/PCP signaling by the H. pylori CagA-VANGL interaction induces hyperplastic changes, along with impaired cell differentiation in gastric pyloric glands. (medicalxpress.com)
In summary, the researchers conclude that through this study, they were able to elucidate the molecular mechanisms involved in gastric carcinogenesis induced by H. pylori, gain insights into the role of the Wnt/PCP pathway in carcinogenesis, and propose it as a potential target for clinical interventions against H. pylori cagA + infections. (medicalxpress.com)
Similarly to gastric cancer, gastric and duodenal ulcers are both linked to upper gastrointestinal infection with H pylori . (bmj.com)
8 At best, the earliest birth-cohort data of gastric cancer seemed to suggest an initial plateau that was consistent with the concept of an endemic H pylori infection of the general population before increasing standards of hygiene made the infection subside. (bmj.com)
H. pylori seropositivity lost its role in the presence of gastric cancer after multivariate analysis and the presence of p53 and Ki-67 were independent affecting factors for gastric cancer even in an endemic region for H. pylori such as Iran. (scialert.net)

The diagnosis of gastric cancer is frequently made at an advanced stage, resulting in a high mortality rate. (frontiersin.org)

Based on fair evidence, screening with barium-meal photofluorography or serum pepsinogen would not result in a decrease in mortality from gastric cancer in areas with relatively low incidence of the disease, such as the United States. (oncolink.org)
Aim The aim of this epidemiological study was to follow the time trends of mortality from gastric cancer and compare them with those of gastric and duodenal ulcer. (bmj.com)
Conclusions The time trends of mortality from gastric cancer are shaped by an underlying birth-cohort pattern that resembles similar patterns of peptic ulcer mortality. (bmj.com)
Unexpectedly, the analysis revealed a rise in mortality from gastric cancer during the first half of the 19th century that preceded the rise in the occurrence of both ulcer types by 10-30 years. (bmj.com)

NEW YORK (GenomeWeb) - In a study published today in Cancer Cell , researchers from South Korea, the Netherlands, and the US National Institutes of Health reported their new proteogenomic analysis of diffuse gastric cancers (GCs) in young populations, identifying four subtypes of the disease. (genomeweb.com)

In the present review we highlight the latest findings on EBVaGC from clinicopathological and molecular perspectives to provide a better understanding of EBV involvement in gastric carcinogenesis. (spandidos-publications.com)
In spite of these findings, the importance of EBV in gastric carcinogenesis has long been underestimated. (spandidos-publications.com)
The disruption of Wnt/PCP signaling by the oncoprotein CagA seems to promote gastric carcinogenesis. (medicalxpress.com)
CagA interacts with multiple host proteins within the gastric epithelial cells, thereby inducing pathways associated with oncogenesis and promoting gastric carcinogenesis. (medicalxpress.com)

Additionally, the treatment continues to be assessed across multiple types of cancer, including gastrointestinal malignancies. (curetoday.com)
Although promising, no immunotherapy drugs have been approved by the FDA to treat gastrointestinal malignancies outside of the recent approval of pembrolizumab for the treatment of patients with colon cancer with microsatellite instability (MSI). (medscape.com)
Identifying potential biomarkers of response to immunotherapy in different malignancies including gastric cancer has been a daunting task. (medscape.com)

Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)

This guideline covers assessing and managing oesophago-gastric cancer in adults, including radical and palliative treatment and nutritional support. (nice.org.uk)
The National Oesophago-Gastric Cancer Audit (NOGCA) evaluates the quality of hospital care for patients with oesophago-gastric (OG) cancer in England and Wales. (hqip.org.uk)
This patient report is divided into two main parts: the first provides information about oesophago-gastric cancer, and the second is about high-grade dysplasia. (hqip.org.uk)
The 2018 Oesophago-Gastric Annual Report can be read alongside this patient report for further detail and findings. (hqip.org.uk)

Regardless of the scientific and technological advancement, the development of a multimodal treatment approach using resection (surgical or endoscopic) is still the foundation of curative management in gastric cancer ( 7 ). (frontiersin.org)

Hereditary diffuse gastric cancer (HDGC) is an inherited disorder that greatly increases the chance of developing a form of stomach(gastric) cancer. (medlineplus.gov)
Hereditary diffuse gastric cancer (HDGC) is an inherited genetic syndrome most often caused by an inactivating mutation in the E-cadherin gene (CDH1) located on chromosome 16. (wikipedia.org)
Hereditary diffuse gastric cancer is inherited as an autosomal dominant mutation of the E-cadherin gene (CDH1), which is located on chromosome 16q22.1. (wikipedia.org)
An estimated 1-3% of gastric cancers are associated with hereditary cancer syndromes. (wikipedia.org)
HDGC is the most common hereditary cancer syndrome of the stomach. (wikipedia.org)
Hereditary diffuse gastric cancer is a rare, autosomal dominant hereditary cancer syndrome associated with germline mutations in CDH 1 in which 60% - 80% of affected individuals develop advanced diffuse gastric cancer, many as young adults. (scirp.org)
J. Odegaard and I. Schrijver, "Molecular Pathology of Hereditary Diffuse Gastric Cancer," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 554-561. (scirp.org)
P. D. Pharoah, P. Guilford and C. Caldas, "Incidence of Gastric Cancer and Breast Cancer in CDH1 (E-Cadherin) Mutation Carriers from Hereditary Diffuse Gastric Cancer Families," Gastroenterology, Vol. 121, No. 6, 2001, pp. 1348-1353. (scirp.org)

The FDA approved nivolumab (Opdivo) plus chemotherapy as the first immunotherapy-containing regimen for previously untreated advanced/metastatic gastric or esophageal cancer . (medpagetoday.com)
Background: Immunotherapy has brought new hope to gastric cancer (GC) patients. (portlandpress.com)
For the last 10 years, immunotherapy has made a clinically significant impact on the treatment of several different types of cancer. (medscape.com)

Highlights of the study, published today in Cancer Cell , include a link between multicellular communities and clinical outcomes as well as a potential new therapeutic target. (news-medical.net)
Researchers found SDC2 overexpression in stromal cells, especially in cancer-associated fibroblasts, was correlated with aggressive disease and advanced stages, and strongly associated with unfavorable survival outcomes. (news-medical.net)
Two-year trends in psychological outcomes after gastric bypass in adolescents with severe obesity. (lu.se)

In other families, some affected members have diffuse gastric cancer and others have another associated form of cancer, such as lobular breast cancer. (medlineplus.gov)
These CDH1 gene mutations also lead to a 40 to 50 percent chance of lobular breast cancer in women, a slightly increased risk of prostate cancer in men, and a slightly increased risk of colorectal cancer. (medlineplus.gov)
Female patients are also estimated to have a 42% lifetime risk of developing lobular breast cancer. (wikipedia.org)
Frequent screening for breast cancer with both mammography and breast MRI is common and recommended for these individuals. (wikipedia.org)
1,3 Another phase 2 trial (NCT05954143) is evaluating the safety and efficacy of BDC-1001 with or without pertuzumab (Perjeta) in patients with HER2-positive breast cancer. (onclive.com)

In order to carry out their study, the researchers expressed oncoprotein CagA in three different models-embryos of Xenopus laevis (lab frog), adult mouse stomach, and cultured human gastric epithelial cells-and tried to understand its effect on the host cells and pathways. (medicalxpress.com)
Finally, the team expressed the CagA oncoprotein in cultured human gastric epithelial cells. (medicalxpress.com)

The incidence of gastric cancer has fallen dramatically in all Western countries. (bmj.com)
Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC. (bmj.com)
Song H, Ekheden IG, Zheng Z, Ericsson J, Nyrén O, Ye W. Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population. (medscape.com)

Overall, Wang believes that these results validate claudin 18 as a new predictive biomarker for advanced gastric cancer, although he noted that widespread implementation for this indication may be limited, as the assay to determine claudin 18 levels is not widely available. (medscape.com)
Hence, DOK5 might become a new gastric cancer biomarker and therapeutic target. (hindawi.com)
In this commentary, Gregory Botta, MD, PhD, evaluates claudin18.2 as a potential biomarker guiding patient care and placement of emerging claudin18.2-targeted agents within the therapeutic repertoire for advanced gastric and gastroesophageal cancers. (clinicaloptions.com)

One reason may be that claudin 18 positivity may be associated with a better prognosis for patients with diffuse gastric cancer, he explained. (medscape.com)

Generally, clinically staged T1N + M0 and T2-T4aN(any)M0 gastric cancer requires surgical resection with adequate lymphadenectomy, together with perioperative or adjuvant chemotherapy. (frontiersin.org)

Neugut AI, Hayek M, Howe G. Epidemiology of gastric cancer. (medscape.com)

A notable discovery is that two ecotypes (EC3 and EC6) correlated with different histological, genomic and clinical features of primary gastric adenocarcinomas. (news-medical.net)
Gastric adenocarcinomas can be further categorized into an intestinal type and a diffuse type. (oncolink.org)

Laparoscopic D2 gastrectomy for invasive gastric cancer is safe and feasible when carried out in high-volume centers by an experienced surgeon as part of a multidisciplinary team with careful case selection and appropriate high-quality postoperative support. (sages.org)

Methods: In the present study, the CIBERSORT algorithm was used to analyze the immune infiltration pattern in 373 samples in the Cancer Genome Atlas (TCGA) database. (portlandpress.com)

If the cancer metastasizes to other tissues, it may lead to an enlarged liver, yellowing of the eyes and skin (jaundice), an abnormal buildup of fluid in the abdominal cavity (ascites), firm lumps under the skin, or broken bones. (medlineplus.gov)
Subsequent development of in situ hybridization (ISH) techniques to detect EBV-encoded small RNAs (EBERs) facilitated the detection of EBV in cancer tissues ( 4 , 5 ). (spandidos-publications.com)

Evidence from case-control and cohort studies from East Asia are generally consistent with a substantial reduction in gastric cancer mortality associated with endoscopic screening. (oncolink.org)
No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. (oncolink.org)
In particular, endoscopic submucosal dissection (ESD) leads to a high en bloc resection rate, enabling accurate pathological evaluation. (bvsalud.org)

In a discussion of the paper, David H. Wang, MD, PhD, an associate professor in the Department of Internal Medicine at University of Texas Southwestern Medical Center, Dallas, pointed out that "zolbetuximab is the first molecularly targeted therapy, exclusive of immune checkpoint inhibitors, to demonstrate a statistically significant survival benefit in first-line treatment of advance gastric cancer since trastuzumab. (medscape.com)
Immune checkpoint inhibition is a new standard of targeted therapy in the treatment of advanced or metastatic gastric cancer (GC) and is represented in various combinations with and without chemotherapy in every therapy line within clinical trials. (mdpi.com)
Today's approval is the first treatment in more than a decade to show a survival benefit for patients with advanced or metastatic cancer who are being treated for the first time," said Richard Pazdur, MD, of the FDA Center for Drug Evaluation and Research, in a statement. (medpagetoday.com)
The FDA is committed to bringing new safe and effective treatment options like Opdivo to patients with advanced cancer. (medpagetoday.com)
These results provide an important theoretical basis for the clinical application of Nidus Vespae in gastric cancer treatment. (hindawi.com)
While there remains an unmet need for heavily pre-treated patients with advanced gastric cancer, we recognize that the treatment landscape has evolved and we respect the FDA's efforts to continually evaluate accelerated approvals," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
Our research with KEYTRUDA has contributed to recent advances in the treatment of gastric cancer, and we are continuing to advance studies to help more patients with this disease. (merck.com)
Merck's clinical program in gastric cancer includes the first-line Phase 3 studies KEYNOTE-811, KEYNOTE-859 and LEAP-015, as well as KEYNOTE-585 in the neoadjuvant and adjuvant treatment setting. (merck.com)
There are currently more than 1,500 trials studying KEYTRUDA across a wide variety of cancers and treatment settings. (merck.com)
The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers. (merck.com)
The study's primary endpoint (the main result that measures a treatment's efficacy) was progression-free survival (the period during and after treatment of cancer when the disease does not worsen) was met, researchers reported. (curetoday.com)
For this reason we did not recommend it for the treatment of advanced gastric cancer. (cancernetwork.com)
A Multidisciplinary Approach to the Treatment of Gastric Cancer: What Is the Role of the Surgeon? (scirp.org)
A. El-Sedfy, F. Frankul and N. Coburn, "A Multidisciplinary Approach to the Treatment of Gastric Cancer: What Is the Role of the Surgeon? (scirp.org)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.Lancet 376: 687-697, 2010. (springermedizin.at)
Taxanes alone or in combination with other agents have demonstrated efficacy in the treatment of hormone-refractory prostate cancer. (medscape.com)
The FDA has given an orphan drug designation to BDC-1001 for the treatment of patients with gastric cancers, including gastroesophageal junction cancer. (onclive.com)

It has been more than 140 years since Theodor Billroth's (1829-1894) first successful gastric resection for cancer in 1881. (frontiersin.org)

Pathological response to neoadjuvant 5-FU, oxaliplatin, and docetaxel (FLOT) versus epirubicin, cisplatin, and 5-FU (ECF) in patients with locally advanced, resectable gastric/esophagogastric junction (EGJ) cancer: Data from the phase II part of the FLOT4 phase III study of the AIO. (springermedizin.at)

Anatomy11

Organisms4

Diseases52

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups2

Health Care30

Geographicals6

Adenocarcinoma35

Early gastric16

Locally advanced or metastatic gastric1

Carcinoma14

Risk of developing gas1

Oncology8

20234

Tumor16

Type of gastric cancer2

Oesophageal1

Tumors4

HER2-Negative Gastric1

Molecular subtypes of gastric cancer1

Helicobacter2

Stomach cancer21

Esophageal and Gastric Cancer1

Pretreated advanced gastric cancer1

Advanced gastric or gastroesophageal1

Management of gastric cancer1

Associated gastric carcinogenesis1

Pylori7

Diagnosis of gastric cancer1

Mortality from gastric cancer4

Subtypes1

Carcinogenesis4

Malignancies3

Ovarian1

Oesophago-gastric4

Curative1

Hereditary8

Immunotherapy3

Outcomes3

Breast cancer5

Epithelial cells2

Incidence of gastric3

Biomarker3

Prognosis for pati1

Surgical resection1

Epidemiology1

Adenocarcinomas2

Safe and feasible1

Genome Atlas1

Tissues2

Endoscopic3

Treatment17

Resection1

Patients with locally advanced1