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  • Diabetes
  • Our data highlight plasma acylated ghrelin as a potential modifying factor in Roux-en-Y gastric bypass (RYGB)-induced diabetes remission," the authors wrote. (medpagetoday.com)
  • A two-year analysis of the trial , reported last June, showed that while both surgical techniques resulted in similar weight loss at 2 years, bypass patients had greater losses in android fat -- popularly known as belly fat -- and better rates of diabetes remission. (medpagetoday.com)
  • Roux
  • There are numerous slight modifications used, but the most common type in use today is the gastric bypass Roux-en-Y operation (Roux was the French surgeon who developed the technique). (everything2.com)
  • A Roux-en-Y operation requires severing the upper and lower portions of the stomach to create a bypass. (everything2.com)
  • Enhanced acylated ghrelin suppression persisted for up to 2 years after Roux-en-Y gastric bypass and was associated with decreased android obesity and improved insulin secretion. (medpagetoday.com)
  • Nicholas Stylopoulos, an obesity researcher at the Boston Children's Hospital in Massachusetts, and his colleagues decided to learn more about this mechanism by studying one of the most popular weight-loss procedures, the Roux-en-Y bypass. (scientificamerican.com)
  • Rats that had been given a Roux-en-Y bypass had higher levels of GLUT1 in the Roux limb than controls, and chemically inhibiting the protein halted the uptake of labeled glucose by the Roux limb. (scientificamerican.com)
  • In a randomized trial, significantly more patients who had Roux-en-Y gastric bypass plus a lifestyle and medication intervention achieved a composite of reduced metabolic endpoints compared with those who only had the lifestyle and medication intervention (odds ratio 4.8, 95% CI 1.9 to 11.7), Sayeed Ikramuddin, MD, of the University of Minnesota, and colleagues reported in the June 5 issue of the Journal of the American Medical Association . (medpagetoday.com)
  • metabolic
  • The researchers found that after 1 year, a significantly larger proportion of patients in the gastric bypass group achieved the primary composite endpoint (49% versus 19%), with a significantly greater likelihood of meeting the combined metabolic targets. (medpagetoday.com)
  • Treatment
  • They noted that among the composite endpoint components, the only significant treatment effect was for HbA1c, with 75% of those in the gastric bypass group achieving an HbA1c below 7% compared with 32% of those in the lifestyle-medical management group (OR 6.0, 95% CI 2.6 to 13.9). (medpagetoday.com)
  • lifestyle
  • Please do exhaust lifestyle measures before gastric bypass, which as the paster above said is not an easy or quick fix. (medhelp.org)
  • There were more serious adverse events in the gastric bypass group, and the gastric bypass group experienced more nutritional deficiency than the lifestyle-medical management group. (medpagetoday.com)
  • Those in the gastric bypass group required about three fewer medications (mean 1.7 versus 4.8) and lost more body weight (26.1% versus 7.9%) than those in the lifestyle-medication intervention group. (medpagetoday.com)
  • Ikramuddin and colleagues cautioned that there were 22 serious adverse events in the gastric bypass group and 15 in the lifestyle-medical management group. (medpagetoday.com)
  • The gastric bypass group experienced more nutritional deficiency than the lifestyle-medical management group. (medpagetoday.com)
  • morbid obesity
  • Gastric bypass is indicated for the surgical treatment of morbid obesity, a diagnosis which is made when the patient is seriously obese, has been unable to achieve satisfactory and sustained weight loss by dietary efforts, and suffers from comorbid conditions which are either life-threatening or a serious impairment to the quality of life. (wikipedia.org)