Gastric and duodenal mucosal bicarbonate secretion. Medical search. Frequent questions

Peptic ulcers occur because of an imbalance between aggressive factors (gastric acid and pepsin) and defensive factors (gastric mucus, bicarbonate, Prostaglandins). (susrutaayurveda.com)
Prostaglandin mediated mucus and bicarbonate secretion, epithelial hydrophobicity, blood flow, and cellular proliferation are all decreased. (nih.gov)
After ethanol administration, the gastric wall mucus was examined. (scialert.net)
Administration of SSE did not affect the gastric mucus production. (scialert.net)
1994). The pathophysiology of these ulcers involves an imbalance between offensive (acid, pepsin and Helicobacter pylori ) and defensive factors (mucus, prostaglandin, bicarbonate, nitric oxide and growth factors). (scialert.net)
Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. (bmj.com)
Mucosal production of mucus and HCO3 creates a pH gradient from the gastric lumen (low pH) to the mucosa (neutral pH). (msdmanuals.com)
By inhibiting prostaglandin production via blockage of the enzyme cyclooxygenase (COX), NSAIDs reduce gastric blood flow, reduce mucus and HCO3 secretion, and decrease cell repair and replication. (msdmanuals.com)
Also, because NSAIDs are weak acids and are nonionized at gastric pH, they diffuse freely across the mucus barrier into gastric epithelial cells, where H+ ions are liberated, leading to cellular damage. (msdmanuals.com)
The glandular region covers the remaining two-thirds of the stomach and contains glands that secrete hydrochloric acid, pepsin, bicarbonate, and mucus. (endurance.net)

The bicarbonate buffer system is an acid-base homeostatic mechanism involving the balance of carbonic acid (H2CO3), bicarbonate ion (HCO− 3), and carbon dioxide (CO2) in order to maintain pH in the blood and duodenum, among other tissues, to support proper metabolic function. (wikipedia.org)
In the human stomach and duodenum, the bicarbonate buffer system serves to both neutralize gastric acid and stabilize the intracellular pH of epithelial cells via the secretion of bicarbonate ion into the gastric mucosa. (wikipedia.org)
A peptic ulcer is defined as a disruption of the mucosal integrity of the stomach and/or duodenum leading to a local defect or excavation due to active inflammation. (susrutaayurveda.com)
Secretin helps regulate the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate from the ductal cells of the pancreas. (supplemented.co.uk)
This is significant because a single dose of any antacid taken in an empty stomach acts for 30-60 minutes, as the gastric content passes into the duodenum. (pharmacampus.in)
Peptic Ulcer Disease A peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates. (msdmanuals.com)
An ulcer found in the stomach is called a gastric ulcer and an ulcer found in the duodenum is called a duodenal ulcer. (missionnursing.in)
The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. (lookformedical.com)

A peptic ulcer in the stomach is called a gastric ulcer. (susrutaayurveda.com)
Both PGE and PGF induce the secretion of polysaccharide material in the stomach known as mucin, which acts as a protective agent against potential stomach ulceration induced by HCl and pepsin. (susrutaayurveda.com)
Epigastric discomfort- Classic pain of duodenal ulcer occurs in empty stomach whereas gastric ulcer (GU) causes more severe pain occurring soon after meals. (gastrotraining.com)
Secretin is also given by IV for pervasive developmental disorder (PDD), pancreatitis and other pancreas problems, overactive parathyroid gland, duodenal ulcers, bleeding in the stomach and intestines, and heart failure. (supplemented.co.uk)
Proton pump inhibitors (PPIs) prevent the final step of gastric acid secretion by blocking the hydrogen/potassium adenosine triphosphatase (H + /K + ATPase) enzyme, i.e. the "proton pump", in the parietal cells in the stomach. (bpac.org.nz)
Acid secretion is initiated by food: the thought, smell, or taste of food effects vagal stimulation of the gastrin-secreting G cells located in the distal one third (antrum) of the stomach. (msdmanuals.com)
Gastric ulcers have been identified in the non-glandular stratified squamous mucosa, margo plicatus, glandular mucosa, and pyloric regions of the equine stomach. (endurance.net)
The drugs are more potent inhibitors of acid secretion in the stomach. (missionnursing.in)
Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. (lookformedical.com)
The stomach is involved in the gastric phase of digestion , following chewing . (atozwiki.com)
The stomach secretes digestive enzymes and gastric acid to aid in food digestion. (atozwiki.com)
The stomach is surrounded by parasympathetic (stimulant) and sympathetic (inhibitor) plexuses (networks of blood vessels and nerves in the anterior gastric, posterior , superior and inferior , celiac and myenteric), which regulate both the secretory activity of the stomach and the motor (motion) activity of its muscles. (atozwiki.com)
The lesser curvature of the human stomach is supplied by the right gastric artery inferiorly and the left gastric artery superiorly, which also supplies the cardiac region. (atozwiki.com)

Basal bicarbonate secretion from gastric mucosa. (susrutaayurveda.com)
Administration of SSE significantly inhibited gastric mucosa damage induced by ethanol, water immersion restraint-stress and acetic acid in a dose-dependent manner. (scialert.net)
The results obtained in the present study indicate that the SSE has gastroprotective and antisecretory effects on gastric mucosa in rats. (scialert.net)
The most likely explanation for this is that gastric pH fluctuates widely throughout the dosing interval with short acting acid inhibitors leaving the mucosa vulnerable for significant periods of time. (quickcompany.in)
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. (lookformedical.com)

44), while investigating gastric ulcer, noted increased rates of recurrence for those discharged unhealed, for those with larger ulcers, and for smokers. (nih.gov)

The increased gastric acid secretion is mediated through the stimulation of the H2-receptor by histamine released after mast cell degranulation and due to the increase of the functional parietal cell volume or secretory capacity in smokers. (susrutaayurveda.com)
Although there have been many recent clinical trials concerning the treatment of both gastric and duodenal ulcers using the new histamine He receptor antagonist, cimetidine, none of these has carefully addressed the question of the influence of smoking on healing rates (67). (nih.gov)
Modern approach to this includes proton pump inhibitors, histamine receptor blockers, drugs affecting the mucosal barrier and prostaglandin analog (Manonmani et al . (scialert.net)
Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients. (bmj.com)
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). (lookformedical.com)
Histamine blockers reduce gastric acid by blocking the H2 receptors. (ulcertalk.com)

Physiological regulation of gastric acid secretion via feedback inhibition. (susrutaayurveda.com)
Secretin has 3 main functions: regulation of gastric acid, regulation of pancreatic bicarbonate, and osmoregulation. (supplemented.co.uk)

In canine duodenal mucosal explants, somatostatin did not alter the basal secretion of secretin but inhibited secretin secretion stimulated by pH 4.5 [5]. (supplemented.co.uk)

Misoprostol should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of complications from gastric ulcers associated with use of the NSAID, or is at high risk of developing gastric ulceration. (nih.gov)

Peptic ulcer disease (encompassing gastric ulcer and duodenal ulcer) affect a large portion of the world population and are induced by several factors, including stress, smoking, nutritional deficiencies and ingestion of non-steroidal anti-inflammatory drugs (Nash et al . (scialert.net)
Helicobacter pylori Infection Helicobacter pylori is a common gastric pathogen that causes gastritis, peptic ulcer disease, gastric adenocarcinoma, and low-grade gastric lymphoma. (msdmanuals.com)
A peptic ulcer, also known as ulcus pepticum, PUD or peptic ulcer disease, is an ulcer (defined as mucosal erosions equal to or greater than 0.5 cm) of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. (ijpsr.com)

42) recently showed for the first time the efficacy of antacids over placebo in the healing of duodenal ulcer (Table 2). (nih.gov)
antacids appeared to make the most difference in treating the duodenal ulcers of smokers. (nih.gov)
Antacids - Antacids is a chemical substance which is react with gastric acid and inhibit the gastric contents activities. (missionnursing.in)
Antacids neutralize gastric acid. (ulcertalk.com)

In patients with duodenal ulcers, Helicobacter pylori eradication can restore mucosal bicarbonate secretion and reduce the risk of ulcer recurrence. (wikipedia.org)
Simultaneous determinations of gastric and duodenal bicarbonate secretion and luminal release of PGE2 were performed in 16 healthy volunteers (5 Helicobacter pylori-positive) and 8 inactive DU patients (all H. pylori-positive). (nih.gov)

Secretion of intrinsic factor and hydrochloric acid after 12 weeks' treatment with cimetidine. (bmj.com)
Hydrochloric acid present in GASTRIC JUICE. (lookformedical.com)

These leukotrienes can contribute to gastrointestinal ulceration, through two mechanisms, firstly, by a reduction in prostaglandin level and secondly, through the release of oxygen radicals mediated mucosal injury produced in this pathway. (susrutaayurveda.com)
Chronic gastric ulceration was produced by injection of acetic acid in rat gastric subserosa. (scialert.net)

Gastric acid, bile salts, and luminal nutrients stimulate secretin, and somatostatin inhibits its release. (supplemented.co.uk)
Secretin also stimulates the gastric secretion of pepsinogen and inhibits lower esophageal sphincter tone, postprandial gastric emptying, gastrin release, and gastric acid secretion. (supplemented.co.uk)
The drug block the gastric M1 receptors and inhibits the gastric secretion. (missionnursing.in)
It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output. (lookformedical.com)

Somatostatin and octreotide - Somatostatin or its long-acting analogue octreotide have a theoretical benefit in bleeding ulcer disease because they reduce splanchnic blood flow, inhibit gastric acid secretion, and may have gastric cytoprotective effects. (gastrotraining.com)
Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin. (bmj.com)

Duodenal ulcer (DU) patients have impaired proximal duodenal mucosal bicarbonate secretion at rest and in response to luminal acid with higher acid-stimulated mucosal release of prostaglandin (PG) E2 than healthy subjects. (nih.gov)

TDFME was found to exhibit its gastroprotective effect through antioxidant mechanism and by enhancing the production of gastric mucous. (hindawi.com)

In healthy volunteers the rates of gastroduodenal bicarbonate secretion and the release of PGE2 were not influenced by H. pylori status. (nih.gov)

Secretin stimulates pancreatic and biliary bicarbonate and water secretion, and it may regulate pancreatic enzyme secretion. (supplemented.co.uk)
Thus, we aimed to clarify whether significant differences in clinical characteristics, prevalence of pancreatic enzyme abnormalities, duodenal inflammation, and protease-activated receptor 2 (PAR2) expression levels related to hypersensitivity exist between functional dyspepsia (FD) alone and FD-irritable bowel syndrome (IBS) overlap group. (bvsalud.org)

Does secretin inhibit gastric emptying? (supplemented.co.uk)
Inhibit the gastric acid secretion. (missionnursing.in)
Mechanism of action - It neutralizes the gastric acid and inhibit the gastric acid secretion. (missionnursing.in)

T. divaricata flower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses-125, 250, and 500 mg/kg-orally using misoprostol as a standard. (hindawi.com)
In continuation to our research on pharmacological assessment of the gastroprotective potential of T. divaricata flowers, the present study was conducted to understand its mechanism of action in chemically induced gastric ulcers. (hindawi.com)

Diclofenac sodium and misoprostol delayed-release tablets are a combination product containing diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E 1 analog. (nih.gov)
[ 3 , 4 ] Prophylactic regimens that have been shown to dramatically reduce the risk of NSAID-induced gastric and duodenal ulcers include the use of a prostaglandin analog or a PPI. (medscape.com)
ARTHROTEC (diclofenac sodium/misoprostol) is a combination product containing diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E 1 analog. (nih.gov)
NSAID-induced ulcers account for approximately 26% of gastric ulcers, and they are believed to be secondary to a decrease in prostaglandin production resulting from the inhibition of cyclooxygenase.The topical effects of NSAIDs are superficial gastric erosions. (ijpsr.com)

This implies that NSAIDs cause gastric ulcers by inhibiting the secretion of this cytoprotective substance. (susrutaayurveda.com)

The major physiological actions of secretin are stimulation of pancreatic fluid and bicarbonate secretion. (supplemented.co.uk)

NSAIDs promote mucosal inflammation and ulcer formation (sometimes with gastrointestinal bleeding) both topically and systemically. (msdmanuals.com)
Because gastric prostaglandin production involves the COX-1 isoform, NSAIDs that are selective COX-2 inhibitors have fewer adverse gastric effects than other NSAIDs. (msdmanuals.com)

Smoking and nicotine stimulate pepsinogen secretion also by increasing the chief cell number or with an enhancement of their secretory capacity. (susrutaayurveda.com)

Effect of ioglycamide (Biligram) on bile flow and biliary lipid secretion in man. (bmj.com)

Mucous cell secretion of mucin and surface-active phospholipid. (susrutaayurveda.com)

However, below this plexus, the two vagal trunks again become separate and distinct before the anterior trunk branches to form the hepatic, pyloric, and anterior gastric (also termed the anterior nerve of Latarjet) branches. (medscape.com)

Gastric ulcers are also associated with considerable morbidity related to chronic epigastric pain, nausea, vomiting, and anemia 2 .Rarely, an ulcer can lead to a gastric or duodenal perforation. (ijpsr.com)

Peptic ulcers occur due to an imbalance between the secretion of acid, pepsin, bile and gastric mucosal defence. (missionnursing.in)

Pathophysiological responses to meals in the Zollinger-Ellison syndrome: I. Paradoxical postprandial inhibition of gastric secretion. (bmj.com)

Patients with gastric ulcers are also at risk of developing gastric malignancy. (medscape.com)
Duodenal ulcers - Patients with uncomplicated DU do not need further endoscopy unless symptoms persist or recur. (gastrotraining.com)
Herrmann and Piper (27) retrospectively looked at 101 patients with benign gastric ulcer, all radiologically diagnosed. (nih.gov)
Serum carbenoxolone in patients with gastric and duodenal ulcer: Absorption, efficacy and side-effects. (bmj.com)

Ulcers are also more common in blood group O subjects and in those who do not secrete blood group antibodies into gastric secretions. (susrutaayurveda.com)
The predominant effect of secretin on the pancreas is to stimulate duct cells to secrete water and bicarbonate. (supplemented.co.uk)

Bind to the proton pump, inhibitor, of gastric ulcers, trials, have shown that vitamin supplementation mirtazapine active substance of Mirtel on its own also does not reduce fracture. (hybridnutrition.co.za)

Salicylsalicylic acid (salsalate) is an effective antirheumatic drug that bypasses gastric absorption and also avoids cyclooxygenase inhibition. (nih.gov)
The formed chloride salt reacts with intestinal bicarbonate such that no HCO 3 - is spared for absorption. (pharmacampus.in)
Transport of digested end products from the lumen of the GI tract to the blood or lymph is absorption, and for absorption to happen, the digested foods must first enter the mucosal cells by active or passive transport processes. (nurseslabs.com)

It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. (lookformedical.com)

Mucosal proliferation is necessary for ulcer healing. (susrutaayurveda.com)

Epigastric pain is the most common symptom of both gastric and duodenal ulcers, characterized by a gnawing or burning sensation and that occurs after meals-classically, shortly after meals with gastric ulcers and 2-3 hours afterward with duodenal ulcers. (medscape.com)
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. (lookformedical.com)

Secretin release is mainly stimulated by gastric acid delivered into the duodenal lumen. (supplemented.co.uk)
Gastric acid stimulates secretin release, allowing movement into the duodenal lumen. (supplemented.co.uk)
Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion. (bmj.com)

Goblet cells dispersed among the intestinal epithelial cells are chiefly responsible for the synthesis and secretion of mucins within the gut and are heavily influenced by interactions with the immune system. (frontiersin.org)

A spiral bacterium active as a human gastric pathogen. (lookformedical.com)

It stimulates the release of bicarbonate and water from the pancreas to aid digestion. (supplemented.co.uk)

These effects are secondary to ethanol-induced slowing or cessation of gastric mucosal flow. (susrutaayurveda.com)

Gastric ulcer disease is common in foals and horses and the term Equine Gastric Ulcer Syndrome (EGUS) has been used to describe this disease because of its many causes and complicated nature. (endurance.net)

Bicarbonate concentration is also further regulated by renal compensation, the process by which the kidneys regulate the concentration of bicarbonate ions by secreting H+ ions into the urine while, at the same time, reabsorbing HCO− 3 ions into the blood plasma, or vice versa, depending on whether the plasma pH is falling or rising, respectively. (wikipedia.org)

The prevalence of GORD increases with age, which may be explained by age-related functional changes to the lower oesophageal sphincter, decreased salivary bicarbonate secretion or the use of medicines that affect sphincter tone, e.g. nitrates, calcium channel blockers, benzodiazepines, anticholinergics and antidepressants. (bpac.org.nz)

These medications decrease acid secretion and are a relatively safe treatment option. (ulcertalk.com)

Gastric ulcers - Repeat endoscopy to confirm GU healing is the standard practice to ensure that the lesions are benign. (gastrotraining.com)
Although non-steroidal anti-inflammatory drugs are widely accepted as effective agents for controlling pain, their administration can lead to the development of gastro duodenal lesions, e.g., ulcers and erosions, in susceptible individuals. (quickcompany.in)

A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. (lookformedical.com)

Anatomy5

Diseases1

Chemicals and Drugs11

Phenomena and Processes2

Mucus10

Duodenum8

Stomach13

Mucosa5

Investigating gastric ulcer1

Histamine6

Regulation of gastric acid2

Basal1

Ulcers associated1

Peptic ulcer d3

Antacids4

Helicobacter2

Hydrochloric acid2

Ulceration2

Inhibits4

Somatostatin2

Proximal1

Enhancing the production of gastric1

Gastroduodenal1

Pancreatic enzyme2

Inhibit3

Induced gastric ulcers2

NSAID4

Cytoprotective1

Physiological1

NSAIDs2

Pepsinogen1

Biliary1

Mucous1

Anterior gastric1

Perforation1

Bile1

Postprandial1

Patients4

Secrete2

Proton1

Absorption3

Intrinsic factor1

Proliferation1

Occurs2

Secretin3

Intestinal1

Pathogen1

Stimulates1

Ethanol1

Ulcer disease1

Regulate1

Blockers1

Decrease1

Lesions2

Gastrointestinal1