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  • Mucosa
  • BACKGROUND: Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. (biomedsearch.com)
  • However, changes in the distribution of acid-secreting mucosa after the eradication remain unknown. (biomedsearch.com)
  • Congo red chromoendoscopy is capable of visualizing the acid-secreting fundic mucosa. (biomedsearch.com)
  • OBJECTIVE: To evaluate the effect of H pylori eradication on the distribution of acid-secreting mucosa in the fundus by using Congo red chromoendoscopy. (biomedsearch.com)
  • DESIGN: An assessment of the distribution of acid-secreting mucosa by the visualized images of Congo red chromoendoscopy and a histologic evaluation of biopsy specimens were performed before and 1 and 7 months after the eradication. (biomedsearch.com)
  • The areas of the acid-secreting mucosa in the lesser and greater curvatures of the fundus were evaluated semiquantitatively. (biomedsearch.com)
  • RESULTS: The area of the acid-secreting mucosa increased in 27 cases (73%) by 1 month after eradication, and in 32 cases (86%) by 7 months. (biomedsearch.com)
  • This expansion of the acid-secreting mucosa coincided with the improvement of inflammatory changes rather than with that of the mucosal atrophy and was more prominent on the greater curvature than on the lesser curvature. (biomedsearch.com)
  • CONCLUSIONS: The acid-secreting mucosa in the fundus expanded in most cases with fundic atrophic gastritis after H pylori eradication, which could be responsible for the increase in acid secretion after the treatment. (biomedsearch.com)
  • In the acid-secreting parietal cells of the gastric mucosa, the use of various radioligands for adenosine receptors suggested the presence of the A 2 adenosine receptor subtype(s) on the cell surface. (physiology.org)
  • the parietal cell of the gastric mucosa is a highly specialized cell that is responsible for the production and secretion of concentrated hydrochloric acid (HCl) into the gastric lumen and, in humans, also of the Castle's intrinsic factor. (physiology.org)
  • Globally, a collection of neural stimuli, efferent and afferent, endocrine and paracrine agents, acting directly at apical and basolateral membrane receptors/transporters of the parietal cell or acting indirectly through the other cells of the gastric mucosa, as well as mechanical and chemical stimuli participate in acid secretion physiology (e.g., see recent reviews in Refs. (physiology.org)
  • This work advances the field by demonstrating that modest doses of a competitive CCK(2) receptor antagonist have significant and functionally important anti-trophic actions in the gastric mucosa. (biomedsearch.com)
  • 1. A phospholipase A2 (PLA2) was purified from rat gastric mucosa and its NH-2-terminal amino acid sequence, peptide maps obtained on lysylendopeptidase digestion, and immunochemical properties were identical to those of rat pancreatic PLA2. (nii.ac.jp)
  • 3. RNA blot analysis showed that group II PLA2 transcript existed in rat gastric mucosa. (nii.ac.jp)
  • 7. These results suggested that pancreatic PLA2 in gastric mucosa may play a role in digestion of phospholipids in foods and in the apical membrane turnover of parietal cells. (nii.ac.jp)
  • Publications] Sakata,T.: 'Presence of pancreatic type phospholipase A2 mRNA in rat gastric mucosa and lung' Biochim.Biophys.Acta. (nii.ac.jp)
  • suppressant
  • While noting that some variables were not considered in the study, such as the underlying reason why the gastric acid suppressant was needed, Khanna advised, "It may be reasonable to re-evaluate the need for these medications in patients with C-diff . (uspharmacist.com)
  • Therapeutic drug monitoring of pazopanib plasma concentrations may be helpful for patients on pazopanib and gastric acid suppressant therapy. (ascopost.com)
  • secretory
  • Upon stimulation by secretagogues in particular, the acid-secreting pump (H + -K + -ATPase) transits from the intracellular tubulovesicles, where it is stored, towards the apical surface of the cell, and remains there throughout the active acid secretory phase, allowing for the secretion of a proton in exchange for a potassium cation consuming the energy equivalent to one ATP molecule breakdown ( 53 ). (physiology.org)
  • suppressive therapy
  • Acid suppressive therapy use was associated with an increased risk of community-acquired Clostridium difficile -associated disease (CDAD), with PPIs appearing to be associated with a higher risk than H2 blockers. (ihi.org)
  • A study by Mir et al investigating whether gastric acid suppressive agents negatively impact the effectiveness of pazopanib in patients with soft-tissue sarcoma has found that the long-term use of gastric acid suppressive therapy with pazopanib was associated with significantly shortened progression-free survival and overall survival. (ascopost.com)
  • Coadministration of long-term gastric acid suppressive therapy with pazopanib was associated with significantly shortened [progression-free and overall survival]. (ascopost.com)
  • suppression
  • The team studied the effect of gastric acid suppression in the promotion of a series of chronic liver diseases - alcoholic liver disease , non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH) - using mouse models. (medicalnewstoday.com)
  • Rochester, MN- More questions about the safety of gastric acid suppression medications were raised in a recent study. (uspharmacist.com)
  • In our study, we found that use of gastric acid suppression medications are associated with a statistically significant increased risk of development of recurrent C-diff in patients with a prior episode of C. diff ," explained senior author Sahil Khanna, MBBS, a gastroenterologist at Mayo Clinic. (uspharmacist.com)
  • Results indicate that that the rate of recurrent CD in patients with gastric suppression was 22.1%, compared to 17.3% in patients without gastric acid suppression. (uspharmacist.com)
  • Another recent study looking at a large population found that intestinal infections with C difficile and Campylobacter bacteria increased for patients using commonly prescribed acid-suppression medications. (uspharmacist.com)
  • however, in modern-day humans the need for gastric acid can be questioned in light of the widespread use of safe and effective pharmacologic acid suppression. (uzh.ch)
  • We addressed each topic with the individual models available to answer our questions including animal versus human studies, pharmacologic, surgical as well as pathophysiologic states of acid suppression. (uzh.ch)
  • Furthermore, the oleic acid-induced suppression of gastic acid secretion was blocked significantly by intravenous injection of rabbit anti-secretin serum (0.1 ml), but not by intravenous infusion of a CCK-receptor antagonist, CR 1409 (5 mg/kg/hr). (springer.com)
  • digestion
  • Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. (genome.jp)
  • I have constant but not severe nausea and wonder if this is associated with the inhibiting of gastric acids - and is there anything I could do diet wise or otherwise to assist my digestion? (healthcaremagic.com)
  • endogenous
  • RESULTS: The histamine- or db-cAMP-induced acid secretion was attenuated by L-arginine, a known source of endogenous NO, and also by the NO-donors sodium nitroprusside (SNP) and S-nitroso-N-acetyl-penicillamine (SNAP). (biomedsearch.com)
  • stomach
  • They are different from antacids, which act on stomach acid after it has been produced and released into the stomach. (surgeryencyclopedia.com)
  • and Zollinger-Ellison syndrome, which is marked by atypical gastric ulcers and excessive amounts of stomach acid. (surgeryencyclopedia.com)
  • Histamine, in addition to its well-known effects in colds and allergies, also stimulates the stomach to produce more acid. (surgeryencyclopedia.com)
  • Blocking this enzyme stops the production of stomach acid. (surgeryencyclopedia.com)
  • These drugs are more effective in reducing stomach acid than the H 2 -receptor blockers. (surgeryencyclopedia.com)
  • For some conditions, particularly stomach ulcers, acid-inhibiting drugs may relieve the symptoms, but will not cure the underlying problems, which require both acid reduction and antibiotic therapy. (surgeryencyclopedia.com)
  • The spore coat protects the bacteria from the low pH of the stomach, but also swells in contact with the gastric juices such that by the time the bacteria reaches the intestine, it has shed its spore and germinates in the intestine. (pureprescriptions.com)
  • Pentagastrin
  • Moreover, an oral administration of tegoprazan at 1 and 3 mg/kg reversed the pentagastrin-induced acidified gastric pH to the neutral range. (aspetjournals.org)
  • Interestingly, 3 mg/kg tegoprazan immediately evoked a gastric phase III contraction of migrating motor complex (MMC) in pentagastrin-treated dogs and similar effects was observed with the other P-CAB, vonoprazan. (aspetjournals.org)
  • intestines
  • We found," he continues, "that the absence of gastric acid promotes growth of Enterococcus bacteria in the intestines and translocation [transfer] to the liver, where they exacerbate inflammation and worsen chronic liver disease. (medicalnewstoday.com)
  • The researchers commented that gastric acid is needed for the extraction of vitamin B12 from foods as well as for its absorption in the intestines. (thefreedictionary.com)
  • pancreatic
  • Shiratori K, Jo YH, Lee KY, Chang TM, Chey WY: Effect of pancreatic juice and trypsin on oleic acid-stimulated pancreatic secretion and plasma secretin in dogs. (springer.com)
  • The nucleotide sequence of gastric PLA2 cDNA was completely identical to that of pancreatic PLA2 cDNA. (nii.ac.jp)
  • Its NH2-terminal amino acid sequence and immunochemical propertries were identical to those of pancreatic type PLA2 in the supernatant fraction. (nii.ac.jp)
  • selective
  • In addition, both acid production and radioligand binding of adenosine analogs to isolated cell membranes were potently blocked by selective A2BR antagonists, whereas ligands for A 1 , A 2A , and A 3 adenosine receptors failed to abolish activation. (physiology.org)
  • acute
  • used in treatment of glaucoma and sometimes for epilepsy , familial periodic paralysis , acute mountain sickness , and kidney stones of uric acid. (thefreedictionary.com)
  • PPIs
  • They worked with a total 4,830 people, of whom 1,024 were taking PPIs, 745 had previously used gastric acid suppressors, and 3,061 had never taken PPIs. (medicalnewstoday.com)
  • E3710 is a novel PPI discovered by Eisai as a successor to Pariet, and compared to existing PPIs, potentially provides a stronger and a longer-lasting inhibitory effect on gastric acid secretion. (thefreedictionary.com)
  • Despite the OTC and generic availability of several PPIs and H2RAs and the association of these drugs with various safety concerns, gastric acid suppressants still represent a top-10 drug expense for third-party insurers. (uspharmacist.com)
  • mechanisms
  • Two other apical mechanisms are also needed to secrete HCl into the gastric lumen: secretion of Cl − , the other atomic component of HCl and K + recycling, which is necessary for maintaining constant luminal potassium concentrations for proper H + -K + -ATPase functioning ( 29 ). (physiology.org)
  • concentrations
  • Shaffalitzky de Muckadell OB, Olsen O, Canto P, Magid E: Concentrations of secretin and CCK in plasma and pancreaticobiliary secretion in response to intraduodenal acid and fat. (springer.com)