The gasotransmitter hydrogen sulfide (H 2 S), recognized as the third gaseous signalling molecule along with nitric oxide (NO) and carbon monoxide (CO), is produced enzymatically in mammals under physiological conditions [ 1 ]. (hindawi.com)
Signalling molecule1
Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. (springeropen.com)
Endogenously2
Gaseous signaling molecules are gaseous molecules that are either synthesized internally (endogenously) in the organism, tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the case of oxygen) and that are used to transmit chemical signals which induce certain physiological or biochemical changes in the organism, tissue or cell. (wikipedia.org)
Hydrogen Sulfide, a pungent gas traditionally thought to be toxic to the human body, is now emerging as one of the most important endogenously synthesized gaseous transmitters. (esmed.org)
Physiological2
Nitric oxide, NO, is a key vertebrate biological messenger important in many physiological and pathological processes, acting, for instance, as a powerful vasodilator in humans (see Biological functions of nitric oxide). (wikipedia.org)
Now, there is a large body of literature that indicates H 2 S as a gasotransmitter with important physiological functions [ 20 - 25 ]. (hindawi.com)
Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H 2 S) have been reported previously. (hindawi.com)
Clinical2
In 1981, it was first suggested from clinical work with nitrous oxide (N2O) that a gas had a direct action at pharmacological receptors and thereby acted as a neurotransmitter. (wikipedia.org)
This review addresses the plausibility of hydrogen sulfide (H 2 S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. (springeropen.com)
Proteins4
Nitrous oxide does not bind as a ligand to the heme and does not react with thiol-containing proteins. (wikipedia.org)
Nevertheless, studies have shown that nitrous oxide can reversibly and non-covalently "insert" itself into the inner structures of some heme-containing proteins such as hemoglobin, myoglobin, cytochrome oxidase and alter their structure and function. (wikipedia.org)
The ability of nitrous oxide to alter the structure and function of these proteins was demonstrated by shifts in infrared spectra of cysteine thiols of hemoglobin and by partial and reversible inhibition of cytochrome oxidase. (wikipedia.org)
Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. (springeropen.com)
Therapy1
Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice. (esmed.org)
Work1
Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r. (springeropen.com)
Process1
This ongoing area of research has led to further investigations into the 1,5-hydrogen atom transfer process and in particular, studies into the effectiveness of deuterium as a protecting group for C-H bonds in radical and carbene chemistry. (exeter.ac.uk)
Studies1
In vitro studies have shown that endogenous nitrous oxide can be formed by the reaction between nitric oxide and thiol. (wikipedia.org)