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  • enzyme
  • It is now becoming increasingly apparent that hydrogen sulphide (H 2 S) formed from cysteine by the enzyme, cystathionine γ lyase (CSE), exerts complex effects on inflammation. (wiley.com)
  • Expression of CSE in the periphery [ 2 ] and CBS in the central nervous system [ 3 , 4 ] determines which enzyme is involved in hydrogen sulfide production at these sites. (hindawi.com)
  • Bile acids have been shown to cause inflammatory bowel disease in mice by stimulating the growth of the bacterium Bilophila, which is known to reduce sulphite to hydrogen sulphide via the sulphite reductase enzyme DsrA (Extended Data Fig. 10). (ketotic.org)
  • A growing body of research shows that isolated icariin-the extract of epimedium-inhibits the enzyme phosphodiesterase-5 (PDE-5) and significantly increases nitric oxide synthase, helping to improve erectile function," says Fisch. (menshealthworld.net)
  • inflammation
  • A. Hegde and M. Bhatia, "Hydrogen sulfide in inflammation: friend or foe? (hindawi.com)
  • It has been reported that hydrogen sulfide is produced by activity of CSE in macrophages and following this production hydrogen sulfide would induce further activation of macrophages [ 5 - 8 ] suggesting an important role for hydrogen sulfide in the signalling of inflammation. (hindawi.com)
  • Activated macrophages have been shown to amplify inflammation via release of proinflammatory mediators such as tumour necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and interleukin-1 β (IL1- β ). (hindawi.com)
  • Inhibition of hydrogen sulfide production with a CSE inhibitor, DL-propargylgycine (PAG) [ 15 ], and with a CSE gene silencer, small interfering RNA (siRNA) [ 5 ], has been shown to ameliorate inflammation suggesting of endogenous hydrogen sulfide has an important role in the pathophysiology of inflammation. (hindawi.com)
  • Inhibition
  • Warenycia MW, Smith KA, Blashko CS, Kombian SB, Reiffenstein RJ (1989) Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levels. (springer.com)
  • improves
  • 3',4'-dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. (edu.au)
  • pleiotropic
  • The primary mechanism of action of these drugs is through the mediation of NO. NO is one of the key molecules involved in ED. It is a short-lived, highly permeable, pleiotropic, gaseous molecule, secreted from the postganglionic cavernosal parasympathetic nerves, endothelium of the cavernosal blood vessels, platelets in the cavernosal sinuses and phagocytic cells (monocytes, macrophages and neutrophils). (menshealthworld.net)
  • biological
  • Since the recent discovery that H 2 S is a powerful gaseous signaling molecule, studies have begun to characterize the biological profile of this promiscuous gas. (pnas.org)
  • Gaseous substances constitute a unique class of indispensable biomaterials for maintaining the homeostasis of biological systems. (biomedcentral.com)
  • The present invention is directed to systems and methods for detecting biological and chemical species in liquid and gaseous phase. (freepatentsonline.com)