Gaps drug resistance. Medical search. Frequent questions

If colistin resistance spreads to bacteria that are already resistant to all other antibiotics, those bacteria could cause truly untreatable infections. (cdc.gov)
This is why it is more important than ever to slow spread of resistance by following infection control measures for every patient, every time and to keep antibiotics working by improving how we use them. (cdc.gov)
Antimicrobial resistance (AMR) is a global health problem, with resistance to common antibiotics found in all regions of the world. (sanger.ac.uk)
One possible way of countering microbial drug resistance could rely on "natural antibiotics" - proteins naturally produced by bacteria in order to kill other microorganisms. (weizmann.ac.il)
They set out a common set of principles for global action that focus on reducing the development of antimicrobial resistance, invest in R&D to meet public health needs and improve access to antibiotics, vaccines and diagnostics. (ifpma.org)
With the World Health Organization calling antimicrobial resistance "one of the top ten global public health threats facing humanity" , developing new antibiotics is more urgent than ever. (innovationtoronto.com)
Conn said Priscilicidin was based on a natural antibiotic peptide, which made it less likely to cause antimicrobial resistance compared to existing conventional antibiotics. (innovationtoronto.com)
But that may also be an area where unnecessary use of antibiotics could be reduced in order to reduce drug resistance. (naturalnews.com)
But at the same time as the old antibiotics are losing their effectiveness, the supply of new drugs is drying up, with only two new classes of antibacterials having been developed during the past 30 years. (chemistryworld.com)
Over the years, it has developed increasing resistance to antibiotics. (medscape.com)
Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance to multiple antibiotics and potential to cause health care-associated infections with high mortality. (cdc.gov)
Concern about antibiotic resistance has been magnified by the paucity of new antibiotics to fill the ever-widening gap between pathogen treatments and available drugs. (medscape.com)
In contrast to many other drug categories, antibiotics are given for relatively short courses and are relatively inexpensive. (medscape.com)

WWARN will further plug knowledge gaps by expanding the molecular marker surveyors into a regional multi-marker resistance prevalence map. (wwarn.org)
Through collaboration with multiple organizations, including pharmaceutical and diagnostic industries, academic institutions, non-government organizations and global government bodies, CPTR delivered actionable solutions to bridge these critical knowledge gaps and provided the foundation for an efficient and effective TB drug development process. (c-path.org)
CPTR partnered with the Translational Genomics Research Institute's (TGen's) Pathogen Genomics Division to sequence isolates with critical patient-outcome data to help bridge knowledge gaps in identifying TB drug-resistance patterns across the globe. (c-path.org)
Knowledge gaps in vector distribution, insecticide resistance status and drug usage were also identified. (biomedcentral.com)

UCT's Professor Karen I Barnes, who coordinates the MARC SE-Africa consortium, explains the importance of the project: "This consortium will provide technical support to facilitate the implementation of the World Health Organisation Strategy to respond to antimalarial drug resistance in Africa in our region. (wwarn.org)
The occurrence of single nucleotide polymorphisms (SNPs) is found to correlate with antimalarial drug resistance. (bvsalud.org)

These conditions favor the risk of emergence of drug resistance (MoPH, 2017). (who.int)
Berlin, 18 May 2017 - Speaking at the B20 Health Conference in Berlin, IFPMA Director-General Thomas Cueni announced the launch of the AMR Industry Alliance, which will help give impetus to the life-sciences industry efforts to curb antimicrobial resistance. (ifpma.org)
However, in other cases, such deleterious side effects of resistance mutations are undetectable, and resistance can even confer benefits in specific, antibiotic-free environmental settings ( Maharjan and Ferenci, 2017 ). (elifesciences.org)
From 2017 until 2019 he worked as a Postdoc at FloV and the Centre of Antibiotic Resistance Research (CARe) at the University of Gothenburg (Sweden) on a project on antibiotic resistance. (uni-augsburg.de)

Scale up WGS of foodborne pathogens to better understand foodborne resistance patterns and outbreaks, and find new ways to prevent foodborne infections in humans. (cdc.gov)
UNICEF and the WHO have warned of the heightened risk for measles outbreaks, given widening immunisation gaps. (gavi.org)
The Ebola crisis from 2014 to 2016, which killed more than 11,000 people, brought a new level of urgency to the issue of global health threats - infectious disease outbreaks and drug resistance with the potential to spread across borders. (independent.gov.uk)

Over its nearly 10-year history, CPTR achieved a significant number of accomplishments by maintaining its focus on critical gaps in tools and knowledge that previously impeded the acceleration of drug development strategies in this complex arena. (c-path.org)
Health representatives from national governments and agencies, civil society, the private sector and global philanthropies will be invited to come together at the Call to Action to focus on how to address the most critical gaps in tackling the development and spread of drug-resistant infections. (unfoundation.org)

CDC through the AR Lab Network plans to expand testing as new or novel antimicrobial treatment options become available for serious infections caused by multi-drug resistant organisms. (clsi.org)
A new gene known as mcr -1-which can make bacteria resistant to colistin, a last-resort drug for some multidrug-resistant infections-was first reported in China in November 2015 and in the United States in May 2016. (cdc.gov)
In November 2015, mcr -1-a gene that can make bacteria resistant to colistin, an old antibiotic that is the last-resort drug for some multidrug-resistant infections-was reported in China. (cdc.gov)
The threat of antimicrobial resistance causing drug-resistant infections is now more urgent than ever. (ifpma.org)
We have also identified a potential link between these infections and antibiotic resistance. (naturalnews.com)
Resistance to currently available antibacterial drugs is causing growing concern among doctors who find themselves unable to treat common infections such as Staphylococcus aureus . (chemistryworld.com)
For the first time (they have) validated FtsZ as a target for antibacterial drug design effective for Staphylococcal infections. (chemistryworld.com)
While this is promising news, there are still a startling 2.8 million cases of drug-resistant infections predicted this year, which will result in an estimated 35,000 deaths. (hitconsultant.net)

The four-year MARC SE-Africa project is designed to promote the translation of evidence of artemisinin and other drug resistance of public health significance to inform better malaria policy and practice before drug resistance increases the number of malaria cases and deaths. (wwarn.org)
Working together we have the best chance of preventing a repetition of the devastating increase in malaria cases and deaths seen previously with chloroquine resistance. (wwarn.org)

Scientists in recent years have hypothesized that cell-cell differences, also known as cell heterogeneity, aides the emergence of drug resistance. (mlo-online.com)
In the case of drug resistance, it is also important to consider the possibility that the apparent burden of MDR/RR-TB among previously treated individuals (who are predominantly adults) may reflect either primary transmission of resistant strains or the emergence of acquired resistance during inadequate treatment. (ersjournals.com)
Emerging evidence suggests that they provide a cellular mechanism for induction and emergence of drug resistance and contribute to increased invasive and metastatic potential. (frontiersin.org)
The artemisinin drug resistance surveillance strategy involves continuous monitoring of Kelch 13-propeller biomarker to detect emergence of mutations which could herald drug resistance in the region. (bvsalud.org)

Com- microbial drug-resistance trends on a national or regional bined antimicrobial drug-susceptibility data were analyzed level are present in Australia ( 4 ) and Europe ( 5 ). (cdc.gov)

Better analytical laboratories and healthcare systems are essential, particularly in low- and middle-income countries, to fill the significant data gaps on the characteristics and distribution of drug-resistant pathogens, according to the WHO's first antimicrobial resistance (AMR) report, published last week (30 April). (nextbillion.net)
If compensatory mutations are indeed widespread, pathogens can reach both high level of resistance and high fitness. (elifesciences.org)
In its latest report on antibiotic resistance, the CDC revealed that infection rates for many threat pathogens are stagnant or in a nominal decline. (hitconsultant.net)

Antimicrobial drug resistance was generally gap. (cdc.gov)
had high rates of antimicrobial drug resistance, whereas the A laboratory-based surveillance program was estab- pediatric and women's hospital had much lower rates. (cdc.gov)
Faced with this growing healthcare issue, renewed interest from both industry and academia has led to a resurgence in antimicrobial drug discovery. (co-add.org)
Bringing together leading exponents in the field, the meeting will appeal to anyone with an interest in antimicrobial resistance and antimicrobial drug discovery. (co-add.org)
Antibiotic Awareness Week 2016 for talks by leading exponents in the field of antimicrobial resistance and antimicrobial drug discovery. (co-add.org)

Countries worldwide have joined GLASS, establishing national surveillance systems that can monitor antibiotic-resistant bacteria to help understand resistance trends and inform treatment guidelines. (sanger.ac.uk)

A clearer picture would allow decision-makers to identify resistance hotspots and tailor treatment programmes, making them more effective for patients and minimising the risk of spreading resistance, it says. (nextbillion.net)
CPTR created the Relational Sequencing TB Data Platform (ReSeqTB) to integrate and standardize global TB patient data dispersed among multiple private and public databases, providing a tool to help identify correlations between Mycobacterium tuberculosis (M.tb) mutations and clinically relevant resistance. (c-path.org)
The Alliance will develop a reporting mechanism to track progress, identify gaps and set targets for the future. (ifpma.org)
One of the initial key objectives of the Alliance will be to develop a reporting mechanism to track progress, identify gaps and set targets for the future. (ifpma.org)
Respectively, these describe the first in an entirely new category of potential antibiotic agents, and identify a biological pathway that could provide a target for drugs active against a specific group of pathogenic bacteria. (chemistryworld.com)
The SPH Portal provides a comprehensive one-stop platform for partners and donors to identify gaps in a country's health security capacities, assess opportunities to target their financial and technical resources for the maximum public health benefit, and explore mechanisms for collaboration with countries. (who.int)

It can take years before these drugs are available on commercial antimicrobial susceptibility testing systems used in clinical laboratories. (clsi.org)
Upon confirmation of MTBC, phenotypic drug susceptibility testing (DST) was performed by diluting the primary isolate and then inoculating it into drug containing and drug free MGIT media. (who.int)
This aided the development of new rapid drug susceptibility tests, facilitated international research and collaboration, and ultimately, directly enabled interpretation of sequencing data for personalized patient care. (c-path.org)
In partnership with Critical Path Institute and CDISC, CPTR finalized version 2.0 of the CDISC TB Therapeutic Area User guide, which includes all necessary terminology required to support Rapid Drug Susceptibility testing and pediatric information. (c-path.org)

Low coverage of existing malaria tools, population dynamics and security issues, climate change, financial issues and biological challenges such as drug and insecticide resistance and invasive vectors are just some of the constraints. (aidspan.org)
Identified drug or insecticide resistance need for better, more expensive commodities. (aidspan.org)
Thirdly, operational research, particularly on vector distribution and insecticide resistance status must be conducted as a matter of urgency, and finally, the surveillance systems must be refined to ensure the information required to inform an elimination agenda are routinely collected. (biomedcentral.com)

As the range of targets for compensation is much broader, compensatory mutations are more likely than the reversion of resistance mutations. (elifesciences.org)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
The proteomes recorded in the study contain key information about potential new drug targets, providing hope for future treatment options. (charite.de)

Recent findings show that five killer microbes, and counting, are resistant to all available drug treatments. (cdc.gov)
Through CDC's Antibiotic Resistance Solutions Initiative, the agency is transforming the nation's capacity to further detect, respond, and prevent antibiotic resistant threats across healthcare settings and in communities to protect Americans and save lives. (cdc.gov)
The WHO major goal of ending the TB epidemics by 2030 is threatened by the increasing numbers of multi drug resistant (MDR) estimated at nearly 490,000 in 2016 (WHO, 2017a). (who.int)
CDC's Antibiotic Resistance Threats in the United States, 2019 [PDF - 150 pages] (2019 AR Threats Report) includes the latest national death and infection estimates for 18 antimicrobial-resistant bacteria and fungi. (cdc.gov)
Gains achieved in reducing the burden of malaria and advancing its elimination are now threatened by malaria parasites becoming resistant to the main group of drugs used to treat malaria, the artemisinins. (wwarn.org)
This consortium, led by University of Cape Town, will provide technical support to the eighteen countries of Southern and East Africa, the area historically first affected by drug resistant malaria. (wwarn.org)
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. (elifesciences.org)
Such strategies implicitly presume that resistance leads to reduced bacterial fitness in an antibiotic-free environment, and therefore these resistant populations should be rapidly outcompeted by antibiotic-sensitive variants. (elifesciences.org)
In theory, the extent of fitness costs determines the long-term stability of resistance, and consequently, the rate by which the frequency of resistant bacteria decreases in an antibiotic-free environment. (elifesciences.org)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
For the purpose of this review, we understand global health threats to include infectious disease epidemics that risk spreading across borders and emerging diseases with epidemic potential, as well as the threat posed by drug-resistant microbes. (independent.gov.uk)
The international, prospective, and multicenter cohort study also pointed out that people who had surgery in these countries have an increased chance of developing an infection linked to drug-resistant bacteria . (naturalnews.com)
During 2016, extensively drug-resistant typhoid (XDR) were documented in Pakistan. (medscape.com)
Other drugs- tigecycline , colistin , polymyxin, and aminoglycoside-are available to treat many resistant GNB, although previous use has been limited by toxicity. (medscape.com)
Resistant - drug therapy. (bvsalud.org)
Though current antiseizure medications (ASMs) can control seizures in two thirds of patients, drug-resistant epilepsy remains a major challenge for the remaining one third, as does the lack of disease-modifying therapies. (medscape.com)
the data included testing presumptive TB cases, TB notifications, drug-resistant cases, treatment outcomes and notifications in prisoners. (who.int)

Using bacterial samples from human, retail meat, and food animal sources, the CDC, U.S. Food and Drug Administration (FDA), and U.S. Department of Agriculture (USDA) retrospectively screened nearly 55,000 bacterial isolates through the National Antimicrobial Resistance Monitoring System (NARMS) and collections of healthcare-associated bacteria. (cdc.gov)
In the case of yeast and bacterial cells, there is a lack of the fundamental knowledge required to develop the new antimicrobials that are urgently needed in the face of rising drug tolerance and resistance. (charite.de)
In November 2016, solithromycin narrowly won FDA advisory panel approval, but in December, the FDA rejected Cempra, Inc.'s new drug applications for oral and intravenous solithromycin for bacterial CAP in adults. (medscape.com)

Before the samples are transferred to LMSE, the reference center ensures a significant proportion of TB laboratory services including microscopic examination and a molecular test for Mycobacterium tuberculosis ( M. tuberculosis) identification and detection of common mutations in rpoB gene, associated to rifampicin resistance (GeneXpert). (who.int)
However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of resistance may proceed too slowly to be of practical importance. (elifesciences.org)
We present our study on the efficacy and phenotypic impact of compensatory evolution in Escherichia coli strains carrying multiple resistance mutations. (elifesciences.org)
The extent of resistance loss was found to be generally antibiotic-specific, driven by mutations that reduce both resistance level and fitness costs of antibiotic-resistance mutations. (elifesciences.org)
We conclude that phenotypic reversion to the antibiotic-sensitive state can be mediated by the acquisition of additional mutations, while maintaining the original resistance mutations. (elifesciences.org)
It is frequently assumed that such compensatory mutations mitigate the fitness costs of resistance mutations without affecting the level of resistance. (elifesciences.org)
The goal is to obtain critical information to interpret the ramifications of genetic mutations and help to close diagnostic gaps. (charite.de)

In the area of basic research, we launched the Global Health Drug Discovery Institute (GHDDI) in 2016, in partnership with the Beijing municipal government and Tsinghua University. (gatesfoundation.org)
The Alliance will show how - from Davos 2016 to Davos 2018 - industry has been delivering on its commitments and demonstrating this through concrete actions, by adopting a more practical approach and leading by example to curb antimicrobial resistance. (ifpma.org)

A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail. (mlo-online.com)
Their findings suggest that by combining current chemotherapy treatments with future methods that alter tumor heterogeneity, or by targeting persister cells, clinicians may be able to improve therapeutic efficiency by minimizing drug resistance. (mlo-online.com)
The fact we can control the viscosity of Priscilicidin means we can contemplate many applications as different products, diversifying the types of treatments to stop antimicrobial resistance," she said. (innovationtoronto.com)
Finding a method of blocking this new pathway should potentially allow more specific treatments as the drug would have no effect on bacteria using the men gene pathway. (chemistryworld.com)
At a time when emerging antimicrobial resistance is decreasing the efficacy of existing treatments, it is more important than ever that we refresh the drug pipeline with new antimicrobials displaying novel modes of action. (co-add.org)

A new consortium MARC SE-Africa (Mitigating Antimalarial Resistance Consortium in Southern and East Africa) launches today, responding to a growing crisis in malaria, one of the greatest infectious challenges facing Africa. (wwarn.org)
The potential impact of widespread ACT resistance in Africa has been estimated at 16 million more malaria cases and nearly 80 000 additional malaria deaths annually. (wwarn.org)
Reports in recent years of emerging resistance to artemisinin and its partner drugs initially in Asia, and now in Africa must be taken very seriously and as a matter of urgency. (wwarn.org)
COVID pandemic created immunisation gaps in Africa. (gavi.org)
In this narrative review paper, we examined existing literature to bridge the knowledge gap and accentuate the importance of routine surveillance for artemisinin resistance in sub-Saharan Africa. (bvsalud.org)

In the area of capacity building, we work with China's National Medical Products Administration (NMPA), universities, and research institutes to enhance the country's ability to navigate challenges with multidisciplinary drug review, including by providing expert and technical support for drug review and approval reform. (gatesfoundation.org)

The above uncertainties around the estimated incidence and notified cases reflect existing diagnostic gaps. (who.int)
In the medical realm, it has led to the creation of life-saving drugs, personalized medicines, gene therapies, and advanced diagnostic tools. (devx.com)
New Industry Alliance brings together research-based pharmaceutical companies, generics, biotech and diagnostic companies, to drive and measure industry progress to curb antimicrobial resistance. (ifpma.org)

In 2013, CDC published the first AR Threats Report, which sounded the alarm to the danger of antimicrobial resistance. (cdc.gov)
Antimicrobial resistance (AMR) is a growing global health crisis and is one of the major threats to public health. (innovationtoronto.com)
Antibiotic prescribing can lead to adverse drug events and antibiotic resistance, which pose ongoing urgent public health threats (1). (cdc.gov)

Preusser: "It is conceivable that greater therapeutic success could be achieved by using drugs to disrupt the formation or function of the membrane channels. (sciencedaily.com)
It is well established that the role of the tumor microenvironment (TME) in cancer progression and therapeutic resistance is crucial, but many of the underlying mechanisms are still being elucidated. (frontiersin.org)
Further studies are crucial to evaluate the therapeutic potential of Farnesol alone or in combination with other conventional drugs in animal models. (bvsalud.org)

Artemisinin drug resistance is one of the major reasons for malaria treatment failures in the sub-Saharan African countries where artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated malaria. (bvsalud.org)
The review provided pertinent information on artemisinin derivatives, artemisinin-based combination therapy, molecular action of artemisinin, definition of artemisinin resistance, genetic basis of artemisinin drug resistance and discovery of Kelch 13, and the importance of artemisinin resistance surveillance. (bvsalud.org)

This report underscores the continued threat of antimicrobial resistance in the U.S., the actions taken to combat this threat, and gaps slowing progress. (cdc.gov)

The 2019 report also emphasizes progress in combating antimicrobial resistance. (cdc.gov)
2019). "Epistemic architecture: steering the public perception of the messy problem of antibiotic resistance. (uni-augsburg.de)
Baseline HIV drug resistance testing: 12 U.S. jurisdictions, 2014-2019. (cdc.gov)

Puzzlingly, this process always leaves gaps in the genome. (weizmann.ac.il)

Children are more prone to developing drug resistance to first-line therapies, and yet the supply of the second-line medicines they need is constrained. (jnj.com)
It plays a crucial role in developing novel therapies and drugs, enhancing crop yield and resistance, and facilitating the production of biofuels and biodegradable materials. (devx.com)
Dairi told Chemistry World that the aim would be to produce anti-Helicobacter drugs that, unlike current therapies, do not destroy essential lactobacillus bugs and cause severe diarrhoea during treatment. (chemistryworld.com)

Thus, in our study, the generative-discriminative paradigm is key to bridging the gap between population genetic modeling and clinical decision making. (mpg.de)

Using innovative technologies such as sequencing will help to fill some of these gaps and deliver much better data on drug resistance around the world. (sanger.ac.uk)
Having pioneered collaborative, global data sharing in resource-limited settings since 2009, WWARN, as part of the MARC-SE global consortium, will focus on engaging the research community and collating surveillance data by expanding the existing Clinical Trials Library and molecular marker surveyors in order to expedite the identification, collation, and mapping of regional antimalarial resistance data. (wwarn.org)
The University of Cape Town-led consortium includes (in alphabetical order): Infectious Diseases Research Collaboration, Karolinska Institutet, LINQ management GmbH, Liverpool School of Tropical Medicine and their Malawi-Liverpool-Wellcome Programme, Stichting Amsterdam Institute for Global Health and Development, Stiftelsen Magic Evidence Ecosystem, University of Melbourne, the University of Rwanda, and the WorldWide Antimalarial Resistance Network part of the Infectious Diseases Data Observatory. (wwarn.org)
Collaborations between the Critical Path Institute and the Special Programme for Research and Training in Tropical Diseases (hosted at the World Health Organization), enabled by CPTR, led to the implementation of the Platform for Aggregation of Clinical TB Studies (TB-PACTS) which integrated data from numerous Phase III TB drug trials. (c-path.org)
Still in use today, this platform is now funded by the ERA4TB program under the IMI's AMR Accelerator Initiative and provides a robust and comprehensive set of data which drug developers use for analysis and help evolve concepts such as biomarkers, predictability of earlier stage clinical data, and clinical trial design. (c-path.org)

The acetoxymethyl ester of calcein is also used to detect drug interactions with multidrug resistance proteins (ABC transporters ATP-binding cassette transporter genes) in intact cells as it is an excellent substrate of the multidrug resistance transporter 1 (MDR1) P-glycoprotein and the Multidrug Resistance-Associated Protein (MRP1). (wikipedia.org)

More specifically, the main objectives are to establish more solid diagnostics of TB cases and measure the actual incidence of drug resistance in the country by using phenotypic and molecular testing of samples collected nationwide. (who.int)
A new Technical Note from the World Health Organization (WHO) has been released to help countries worldwide improve their capacities to monitor antimicrobial resistance by using molecular tests. (sanger.ac.uk)
This information will enable health authorities to make informed choices on the most appropriate molecular tests in order to achieve a clearer picture of antimicrobial resistance globally. (sanger.ac.uk)
Even with better understanding of molecular oncology and identification of genomic drivers of these processes, there has been a relative lag in identifying and appreciating the cellular drivers of both invasion and resistance. (frontiersin.org)
CONCLUSIONS: While reported levels of baseline PR/RT (with or without IN) testing have remained sufficiently high for the purposes of molecular cluster detection, higher levels would strengthen jurisdictions' and the Centers for Disease Control and Prevention's ability to monitor trends in HIV drug resistance and detect and respond to HIV molecular clusters. (cdc.gov)
This is more so when drugs are in combination therapy, for instance, molecular surveillance can give a hint that one drug is failing despite the fact that in combination, it is still apparently clinically effective. (bvsalud.org)

Now a new study published online in Nature Communications has tested this theory and yielded findings that may provide a path to reduce chemotherapy resistance. (mlo-online.com)
Led by Gábor Balázsi, PhD, the Henry Laufer Associate Professor in Stony Brook University's Laufer Center and Department of Biomedical Engineering, the research team engineered mammalian cell lines to test how chemotherapy drug resistance evolves in the context of cell-cell differences. (mlo-online.com)
The current control strategy for leishmaniasis relies on chemotherapy drugs such as sodium antimony gluconate (SAG) and meglumine antimoniate (MA). (bvsalud.org)
However, all these chemotherapy compounds have poor efficacy, and they are associated with toxicity and other adverse effects, as well as drug resistance. (bvsalud.org)

Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)

Studies have shown that most children failing ART have evidence of drug resistance, highlighting the urgent need for follow-on (second- or third-line) treatment regimens towhich resistance has not developed. (jnj.com)
CPTR was a cross-sector initiative that was launched in 2010, in partnership with the Bill & Melinda Gates Foundation and TB Alliance, to expedite the development of safer and shorter duration anti-tuberculosis (TB) drug regimens. (c-path.org)

NET detected high levels of methicillin resistance among mented by VITEK 2 system (bioMérieux, Marcy l'Etoile, Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (cdc.gov)

OBJECTIVE: To understand recent patterns in reported baseline HIV drug resistance testing over time in the United States. (cdc.gov)

This drug demonstrates in vitro activity against metallo-β-lactamase (MBL) producing Enterobacteriaceae. (clsi.org)
and also to determine in vitro drug resistance of cells, including samples from patients. (wikipedia.org)

Sustained under-investment in antimicrobials has led to a severe shortage of new drugs for treating infection. (co-add.org)

It is estimated that, unless action is taken, the burden of deaths from antimicrobial resistance could be as high as 10 million lives each year by 2050 - more than cancer. (ifpma.org)

The researchers' objective was to investigate in detail how certain proteins are expressed and regulated, which should ultimately also help lay the groundwork for developing new drugs. (charite.de)

As part of a range of measures to address AMR, the WHO Global Antimicrobial Resistance Surveillance System (GLASS) was launched in 2015. (sanger.ac.uk)
Antimicrobial resistance threatens to make a wide range of drugs for common diseases such as pneumonia, diarrhoea, malaria and tuberculosis increasingly toothless, and poor surveillance networks are hindering response efforts, a UN report finds. (nextbillion.net)

Recognized gap in malaria funding, with the 2022 World Malaria Report reporting $3.8 billion for 2021 alone. (aidspan.org)
However, CDC's 2022 special report highlighting the impact of COVID-19 on antimicrobial resistance in the U.S. found that much of that progress was lost, in large part, due to the effects of the pandemic. (cdc.gov)

The researchers also discovered cells that are dormant, which neither grow nor die (called 'persister' cells) appear necessary for the evolution of drug resistance at high drug levels. (mlo-online.com)
As researchers we know that collaboration is a proven way to fast-track better outcomes for patients and by working together, we should do better than in the past," said Professor Philippe Guérin, Director of the WorldWide Antimalarial Resistance Network (WWARN). (wwarn.org)
One reason for this resistance could be their ability to form a communication network, say researchers. (sciencedaily.com)
Unfortunately, this gap impacts people in a manner that can adversely affect a person's health, according to researchers at the University of Birmingham , University of Edinburgh , and the University of Warwick . (naturalnews.com)

Globally, the odds of drug resistance among those with TB are the same for children as for adults. (ersjournals.com)

Ethics and Drug Resistance: Collective Responsibility for Global Public Health. (uni-augsburg.de)

49.6%), and third-generation France), following guidelines of the Clinical Laboratory cephalosporin resistance among Klebsiella pneumoniae Standards Institute (CSLI) ( 7 ). (cdc.gov)
This enabled Balázsi and colleagues to mimic the evolution of drug resistance in the laboratory. (mlo-online.com)

Fewer than 5% of oncology drugs that enter clinical trials in the US receive US FDA approval. (ddw-online.com)
CPTR's combination development model established the gold standard for TB drug development programs and clinical trials. (c-path.org)
Lloyd Czaplewski, Prolysis research director, said there is every prospect of the drug providing similar protection to human MRSA patients when it enters clinical trials sometime in the next two years. (chemistryworld.com)

BC Housing Minister, Rich Coleman (and also Minister for Gas and Natural Resources) callously responded last year that "we wouldn't build social housing to fill the gap-we would actually let the market do that. (socialist.ca)
But RNA-based therapeutics offer new hope and experts predict they could fill these gaps and revolutionize epilepsy treatment. (medscape.com)

Genetic engineering techniques, including the modification of plant genes, have resulted in crops with desirable characteristics such as resistance to pests, increased nutritional content, and higher crop yields. (devx.com)

Anatomy8

Organisms21

Diseases12

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes77

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Health Care6

Geographicals4

Antibiotics13

Knowledge gaps4

Antimalarial drug resistance2

20174

Outbreaks3

Critical gaps2

Infections8

Malaria cases and deaths2

Emergence4

Microbial drug-resistance1

Pathogens3

Antimicrobial drug5

Antibiotic-resistan1

Identify6

Susceptibility4

Insecticide resistance3

Targets3

Resistant17

Bacterial3

Mutations7

20162

Treatments5

Africa5

Country's1

Diagnostic3

Threats3

Therapeutic3

Artemisinin2

Threat1

20193

Genome1

Therapies3

Bridging1

Data5

Multidrug1

Molecular6

Chemotherapy4

Donors1

Regimens2

Acinetobacter1

Patterns1

Vitro2

Infection1

Deaths1

Proteins1

Surveillance2

20222

Researchers4

Globally1

Public health1

Laboratory2

Clinical trials3

Fill2

Characteristics1