SialicSeparationVitroExtracellularGT1bLipid CompositionDominantTissuesInteractionsMolecularTumorServeExpressionDevelopAnalysisStrategiesTypesHumanPresentContentSizeGrowthTotalPropertiesPeritumoral tissueCeramide structuresGlycolipidsKnockout miceLipidSynthesisBiosynthesisSialic acidTissueTumorsStructuralModulateMobilityExogenousMembranesPathologicalIonizationEffectsBrainIndividualMassBaseHumanCellLife
Sialic4
- Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets. (dsm.com)
- Gangliosides, complex glycosphingolipids on the plasma membrane containing one or more sialic acid residues, are key components of microdomains. (jneurosci.org)
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
- Gangliosides, sialic acid-containing glycosphingolipids exist in mammalian cell membranes particularly neuronal membranes. (biomedcentral.com)
Separation2
- Besides the availability of preparative tools for separation, combining multiple orthogonal and complementary characterization tools is crucial for defining the EV product of interest. (biaseparations.com)
- Creative Proteomics has a set of integrated separation, characterization, identification and quantification systems with excellent robustness and reproducibility, high sensitivity and hypersensitivity, providing reliable and cost-effective plant lipidomics analysis services through LC-MS and shotgun methods. (creative-proteomics.com)
Vitro1
- In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vivo . (jneurosci.org)
Extracellular1
- Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer. (gu.se)
GT1b3
- We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 gangliosideM1 is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons in adult rat. (jneurosci.org)
- The adult mammalian nervous system has four dominant types of gangliosides: GM1, GD1a, GD1b, and GT1b. (jneurosci.org)
- The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in the brain. (biomedcentral.com)
Lipid Composition1
- Effects of Feeding Sialyllactose and Galactosylated N-Acetylneuraminic Acid on Swimming Learning Ability and Brain Lipid Composition in Adult Rats. (dsm.com)
Dominant1
- The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). (bvsalud.org)
Tissues3
- We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. (bvsalud.org)
- Finally, we apply our method on mucin-type O-glycans, gangliosides, and site-specific compositional glycosylation data to reveal tissues and disease-specific glycan presentations. (omicsdi.org)
- Ferritins from various tissues were separated according to their subunit composition by anion exchange chromatography and according to their iron content by density-gradient centrifugation. (shengsci.com)
Interactions2
Molecular1
- Compositions such as liquid biopsies, molecular diagnostics, and imaging techniques have shown great promise in detecting cancer at its earliest stages, enabling timely intervention and treatment. (patentpc.com)
Tumor2
- Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. (bvsalud.org)
- Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
Serve1
- These findings support the possibility that under pathological conditions, gangliosides serve as cytotoxic factors in the central nervous system (CNS). (biomedcentral.com)
Expression1
- Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors. (bvsalud.org)
Develop1
- These companies are constantly striving to develop innovative compositions that can address the unmet needs of cancer patients. (patentpc.com)
Analysis1
- 2005). Preparation, Physical Characterization and Biological Analysis of Liposomal Formulations of Vincristine. (ubc.ca)
Strategies1
- In this context, major effort has been put in developing synthetic strategies towards gangliosides and the interested reader is referred to an excellent review of Hunter et al. (springer.com)
Types1
- Pharmaceutical and biotechnology companies are investing heavily in developing innovative compositions that can effectively target and treat various types of cancer. (patentpc.com)
Human2
- In examining the evidence concerning the influence of maternal nutrition on human milk composition, the subcommittee considered the broad spectrum of constituents of milk, the normal variation in their concentrations, and factors in addition to maternal nutrition that influence those variations. (nationalacademies.org)
- Rather, this chapter provides a framework for understanding how maternal nutrition can have an impact on the composition of human milk, as well as when and in what context nutritional factors are likely to be operational. (nationalacademies.org)
Present1
- The present invention discloses a pharmaceutical composition containing antibodies or antigen-binding fragments of antibodies that bind to SSEA3, SSEA4, and globo H. It also describes methods for using the composition. (patentpc.com)
Content2
- Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. (bvsalud.org)
- An attempt was made to relate the iron and phosphate content of ferritin to its subunit composition. (shengsci.com)
Size1
- This technique visualizes sample composition by size, UV, light scattering and fluorescent properties. (biaseparations.com)
Growth2
- The market for compositions for the treatment and detection of cancer has witnessed significant growth in recent years. (patentpc.com)
- In conclusion, the market for compositions for the treatment and detection of cancer is witnessing significant growth due to the rising incidence of cancer, advancements in technology, increased research and development activities, and the growing importance of early cancer detection. (patentpc.com)
Total1
- EndoBI-1-released N-glycans were quantified by a phenol-sulphuric total carbohydrate assay and the resultant N-glycan structures monitored by nano-LC-Chip-Q-TOF MS. The kinetic parameters and structural characterization of glycans released suggest EndoBI-1 can facilitate large-scale release of complex, bioactive glycans from a variety of glycoprotein substrates. (omicsdi.org)
Properties1
- 2007) Characterization of the Drug Retention Properties and Pharmacokinetic Properties of Liposomal Nanoparticles Containing Dihydrosphingomyelin. (ubc.ca)
Peritumoral tissue2
- 10. Aberrant ganglioside composition in glioblastoma multiforme and peritumoral tissue: A mass spectrometry characterization. (nih.gov)
- The peritumoral tissue ganglioside composition was estimated as normal. (bvsalud.org)
Ceramide structures2
- Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors. (bvsalud.org)
- A commercially-available mono-sialo (GM1) ganglioside standard consists of three major components with different ceramide structures: C18:0 fatty acid/C18-sphingosine, C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)
Glycolipids3
- Sialic acid-containing glycolipids, known as gangliosides, play important structural and functional roles. (frontiersin.org)
- We are mapping and imaging the brain's and other organs lipidome (glycolipids, cerebrosides, sphingomyelin, gangliosides and cardiolipins) and proteome in health and in pathological conditions such as blast induced traumatic brain injury, as well as mapping and imaging the anatomical distribution and localization of drugs of abuse in the addicted brain. (nih.gov)
- The complex composition of the cell membrane comprises phospholipids, glycolipids, and cholesterol, as well as intrinsic and extrinsic proteins, and its functions are influenced by cytoplasmic components which include Ca.sup. (justia.com)
Knockout mice1
- In B4galnt1 knockout mice, mice with ganglioside GM1 deficiency show the characteristic symptoms of PD, such as reduced dopamine levels in the striatum, loss of dopaminergic neurons in the SNpc, aggregation of α-synuclein, and motor dysfunction. (researchsquare.com)
Lipid3
- Our results suggest that ganglioside GM1 deficiency could compromise the neurotrophic effects and signals downstream of GDNF by altering the assembly of lipid raft membrane microdomains. (researchsquare.com)
- Compositions disclosed for use of these cationic lipid include formulations for in vitro transfection and pharmaceutical formulations for parenteral and topical administration of therapeutic agents. (justia.com)
- The membrane barrier can be overcome in the first instance by associating these substances in complexes with lipid formulations closely resembling the lipid composition of natural cell membranes. (justia.com)
Synthesis1
- The expression of the ganglioside synthesis-related genes B3galt4 and St3gal2 is conspicuously absent in PD patients, and the GM1 level is decreased in the substantia nigra, prefrontal cortex and various peripheral tissues [ 5 , 6 ] . (researchsquare.com)
Biosynthesis1
- Is key in the biosynthesis of glycosphingolipids and gangliosides. (hmdb.ca)
Sialic acid1
- The usual multiple reaction monitoring (MRM) liquid chromatography-tandem mass spectrometry (LC-MS/MS) of gangliosides, which monitors the dehydrated sialic acid fragment (m/z 290), cannot differentiate between the individual iso-molecular weight components C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)
Tissue2
- 14. Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. (nih.gov)
- Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. (bvsalud.org)
Tumors1
- [ 126 , 127 ] These small/moderate scale custom preparation could overcome at least some shelf life issues while providing a platform for personalized 'OMICS' characterization of individual tumors to enter mainstream treatment regimens. (medscape.com)
Structural2
- 1. Gangliosides of Human Glioblastoma Multiforme: A Comprehensive Mapping and Structural Analysis by Ion Mobility Tandem Mass Spectrometry. (nih.gov)
- 16. Human gliosarcoma-associated ganglioside composition is complex and distinctive as evidenced by high-performance mass spectrometric determination and structural characterization. (nih.gov)
Modulate1
- These results establish that NEU3 can modulate glycoconjugate composition and contribute to the regulation of integrin activity. (frontiersin.org)
Mobility3
- 4. Ion mobility mass spectrometry of human melanoma gangliosides. (nih.gov)
- 5. Cerebrospinal fluid: Profiling and fragmentation of gangliosides by ion mobility mass spectrometry. (nih.gov)
- 7. Electrospray Ionization Ion Mobility Mass Spectrometry of Human Brain Gangliosides. (nih.gov)
Exogenous1
- The enzyme is known to prefer glycolipid substrates, and we confirmed that exogenous enzyme altered the glycolipid composition of cells. (frontiersin.org)
Membranes1
- Although alpha-synuclein is a highly soluble, cytoplasmic protein, it binds to a variety of cellular membranes of different properties and compositions. (en-journal.org)
Pathological1
- All these results suggest that deficiency of endogenous ganglioside GM1 may be an initiator of the pathological process of PD and play an important role in it, but the specific mechanism is not clear. (researchsquare.com)
Ionization3
- 12. Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry. (nih.gov)
- Present characterization of ganglioside standards quantifies only the fatty acid content by gas chromatography-flame ionization detection (GC-FID) analysis of the ganglioside mixture and does not parse out the percentages of the individual mono-sialo ganglioside components. (omicsonline.org)
- 2,6-Dihydroxyacetophenone (DHA) matrix has been shown to provide efficient ionization of lipids, especially gangliosides. (nih.gov)
Effects1
- Title: The effects of bilayer composition, osmotic gradients and PNIPAM microgel adsorption on deformation in giant unilamellar vesicles. (lu.se)
Brain2
- 15. Assessment of ganglioside age-related and topographic specificity in human brain by Orbitrap mass spectrometry. (nih.gov)
- 19. 1H NMR ganglioside ceramide resonance region on the differential diagnosis of low and high malignancy of brain gliomas. (nih.gov)
Individual2
- Equations are derived which incorporate the combined data (Method 1) to calculate percentages of individual mono-sialo gangliosides in the standard. (omicsonline.org)
- Percentages for the individual mono-sialo gangliosides in the standard differed by at most 2% (absolute difference in the percentages) in comparing the results obtained by the two methods. (omicsonline.org)
Mass4
- 6. Profiling and sequence analysis of gangliosides in human astrocytoma by high-resolution mass spectrometry. (nih.gov)
- 8. Chip-nanoelectrospray quadrupole time-of-flight tandem mass spectrometry of meningioma gangliosides: a preliminary study. (nih.gov)
- 17. Profiling and sequencing of gangliosides from human caudate nucleus by chip-nanoelectrospray mass spectrometry. (nih.gov)
- AP-MALDI Mass Spectrometry Imaging of Gangliosides Using 2,6-Dihydroxyacetophenone. (nih.gov)
Base1
- The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). (bvsalud.org)
Human3
- 18. Human medulloblastoma gangliosides. (nih.gov)
- Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. (encyclopedia.pub)
- Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. (encyclopedia.pub)
Cell1
- Cell culture parameters and production platform selection might alter the number and composition of EVs. (biaseparations.com)
Life1
- In fact, some authors reported that HM microbiota contributes less than previously expected to gut microbiota composition during early life, and virtually nothing at 6 months of age [ 12 ] [ 13 ] . (encyclopedia.pub)