Brain tumorsGlycosphingolipidsMetastasisAutoimmune responseTissuesCeramideAntigensReactive oxygenSphingoidResiduesProliferationInvasivenessImmunoreactivityTargetsProgressionSialicNovoCellsGlycoproteinsGenusMiceGenesTransportersMechanismInteractionsCancerAmountsResponseCellHighGeneAdditionMouseTypesContentNormalRepresentAnalysis
Brain tumors5
- Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors. (bvsalud.org)
- Somatic mutations in the mitochondrial genome occur in numerous tumor types including brain tumors. (biomedcentral.com)
- In this study we examined the entire mitochondrial genome in a series of chemically induced brain tumors in the C57BL/6J strain and spontaneous brain tumors in the VM mouse strain. (biomedcentral.com)
- None of the mutations were considered pathogenic, indicating that mtDNA somatic mutations do not likely contribute to the initiation or progression of these diverse mouse brain tumors. (biomedcentral.com)
- Other studies of the mitochondrial genome focused on mtDNA copy number in brain tumors [ 34 ]. (biomedcentral.com)
Glycosphingolipids2
- Gangliosides 1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. (matreya.com)
- It is phosphorylated by ceramide kinase (CK) to form ceramide-1-phosphate or it can be glycosylated by glucosylceramide synthase to form glycosphingolipids (cerebrosides, globosides, gangliosides). (frontiersin.org)
Metastasis1
- Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
Autoimmune response1
- An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. (matreya.com)
Tissues4
- We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. (bvsalud.org)
- PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa. (vectorlabs.com)
- Proteotranscriptomic Discrimination of Tumor and Normal Tissues in Renal Cell Carcinoma. (bioinformatics.hu)
- Finally, we apply our method on mucin-type O-glycans, gangliosides, and site-specific compositional glycosylation data to reveal tissues and disease-specific glycan presentations. (omicsdi.org)
Ceramide1
- Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16-C24) in ceramide portions. (bvsalud.org)
Antigens2
- Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
- The early region usually codes for two proteins, the small and large tumor antigens, produced by alternative splicing. (wikipedia.org)
Reactive oxygen2
- OH radicals and protects against brain mtDNA damage, seizures, and lipid peroxidation induced by reactive oxygen species producers. (matreya.com)
- This higher mutation rate may be due in part to a lack of protective histones, reduced fidelity of polymerase γ, or to the localization of the mitochondrial genome to the inner mitochondrial membrane near damaging reactive oxygen species [ 5 - 9 ]. (biomedcentral.com)
Sphingoid1
- The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). (bvsalud.org)
Residues1
- Cellular receptors for polyomaviruses are sialic acid residues of glycans, commonly gangliosides. (wikipedia.org)
Proliferation2
- Angiogenesis is the formation of new blood vessels from the existing vasculature, and it is significantly increased during tumor development with the aim to supply nutrients and oxygen that support the high rate proliferation of tumor cells. (researchsquare.com)
- Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Invasiveness1
- Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. (bvsalud.org)
Immunoreactivity3
- Our immunocytochemical analysis revealed a strong reduction of GABAARα1 immunoreactivity in the tumor compared to the PTME. (bvsalud.org)
- In contrast, the extent of NMDAR1 immunoreactivity in the tumor appeared comparable to the PTME. (bvsalud.org)
- Levels of tumor necrosis factor and alpha immunoreactivity in astrocytes and macrophages at the outermost edge of the demyelinating lesion are increased, suggesting a cytokine-mediated mechanism. (medscape.com)
Targets1
- Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates. (bioinformatics.hu)
Progression1
- It is not yet clear if mtDNA mutations contribute to brain tumor progression. (biomedcentral.com)
Sialic1
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
Novo1
- The memory response originated with previously dysfunctional tumor-specific T cells and did not involve de novo priming. (acir.org)
Cells9
- Interestingly, tumor cells maintained the potential to express both receptors. (bvsalud.org)
- Direct sequencing revealed a few homoplasmic base pair insertions, deletions, and substitutions in the tumor cells mainly in regions of mononucleotide repeats. (biomedcentral.com)
- MDSCs and M2 macrophages) and increased the population of CD8 + T cells and monocytes within the tumor microenvironment (TME). (acir.org)
- Combination of Adar1 loss and anti-PD-1 synergized to eliminate tumors and prolong survival in mice, and Adar1 deletion resensitized treatment-resistant tumors to immunotherapy, even in the case when tumor cells could not be recognized by CD8 + T cells due to B2m loss. (acir.org)
- Haining concluded that Adar1 is a checkpoint, and its removal could potentially induce sufficient inflammation to restrict tumor growth while bypassing the need for recognition of tumor by CD8 + T cells. (acir.org)
- O'Donnell showed that this is due to a strong early expansion, subsequent contraction, and establishment of memory response of tumor-specific CD8 + T cells. (acir.org)
- After treatment, tumor-specific T cells from mice treated with neoadjuvant immunotherapy had an increased expression of granzyme B, TNFα, and IFNγ. (acir.org)
- In tumors, antigen-specific functional ICOS + CD4 + cells were increased, and both ICOS + CD4 + and CD8 + T cells were increased in the blood of patients. (acir.org)
- CXCL8) is produced by many solid tumors, where it attracts myeloid cells and potentiates the survival of tumor cells. (acir.org)
Glycoproteins1
- Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N -acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. (vectorlabs.com)
Genus3
- As of 2020, there are six recognized genera and 117 species, five of which are unassigned to a genus. (wikipedia.org)
- The genus of scutellaria includes approximately 300 species. (webmedcentral.com)
- A few species of swiflets (genus Aerodramus) build edible nests that are consumed by humans worldwide, as a delicacy known as the "Caviar of the East" or as a medicinal food. (researchgate.net)
Mice3
- For this purpose, glioneuronal tumors in mice were induced by intraventricular in utero electroporation (IUE) of piggyBac-based plasmids for BRAFV600E and activated Akt (AktT308D/S473D, further referred to as AktDD) and analyzed neurochemically by immunocytochemistry against specific marker proteins. (bvsalud.org)
- IUE of BRAFV600E/AktDD in mice resulted in tumors with the morphological features of human GGs. (bvsalud.org)
- This translated to reduced tumor growth and increased survival in mice. (acir.org)
Genes3
- The early genes - comprising at minimum the small tumor antigen (ST) and large tumor antigen (LT) - are expressed first, from a single alternatively spliced messenger RNA strand. (wikipedia.org)
- if the genes result from related place species, this technique is named cisgenesis (Schubert and Williams, 2006). (baxkyardgardener.com)
- Pre- and post-treatment tumor analysis after anti-CTLA-4 treatment demonstrated changes in a number of T cell genes, the most surprising of which was the ICOS pathway. (acir.org)
Transporters1
- Fittingly, the abundance of the presynaptic vesicular neurotransmitter transporters VGLUT1 and VGAT was also decreased in the tumor. (bvsalud.org)
Mechanism1
- The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. (nature.com)
Interactions1
- VEGF biological activity is mediated by its binding to VEGFR receptor 2 (VEGFR2) or VEGF receptor 1 (VEGFR1) [2], and both interactions have been implicated in tumor-induced angiogenesis and immunosuppression [3, 4]. (researchsquare.com)
Cancer1
- 4 Ehrlich tumor expresses the ganglioside GT 1b , and anti-GT1b has great therapeutic potential against this cancer. (matreya.com)
Amounts1
- Sulfoglucuronosyl paragloboside (SGPG) was the prominent species with lesser amounts of sulfoglucuronosyl lactosaminyl paragloboside (SGLPG) in these tumor cell lines as assessed by quantitative HPTLC immunostaining. (karger.com)
Response1
- This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
Cell6
- To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)
- Among the gangliosides surveyed, GD3 and 9-O-acetylated GD3 (OAc-GD3) were expressed in all tumor cell lines. (karger.com)
- A major cell surface receptor for PNA may be asialo GM 1 ganglioside. (vectorlabs.com)
- Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
- We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
- This bacterium injects a so-called tumor-inducing (Ti) plasmid in to the place cell, where it integrates in to the genome (Yadav et al. (baxkyardgardener.com)
High1
- All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
Gene2
- The timing of the genetic event and the specific gene involved during neurodevelopment will drive the nature and size of the lesion, whether it is a developmental malformation or a brain tumour. (bvsalud.org)
- A heteroplasmic mutation in the 16srRNA gene was detected in a spontaneous metastatic VM brain tumor. (biomedcentral.com)
Addition2
- In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
- In addition, Adar1-deficient tumors expressed more IFNβ and IFNγ, and experienced significant growth inhibition. (acir.org)
Mouse1
- The tumor mtDNA was compared to that of mtDNA in brain mitochondrial populations from the corresponding syngeneic mouse host strain. (biomedcentral.com)
Types1
- The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. (rndsystems.com)
Content1
- Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. (bvsalud.org)
Normal1
- The peritumoral tissue ganglioside composition was estimated as normal. (bvsalud.org)
Represent1
- Gangliogliomas (GGs), composed of dysmorphic neurons and neoplastic astroglia, represent the most frequent tumor entity associated with chronic recurrent epileptic seizures. (bvsalud.org)