Gangliosides as tumor. Medical search. Frequent questions

Cholesterol, glycerophospholipids and sphingolipids are major constituents of the cell membrane and in certain cases function as second messengers in cell proliferation, apoptosis and cell adhesion in inflammation and tumor metastasis. (wikipedia.org)
Staging of the melanoma adheres to the traditional tumor-node-metastasis (TNM) classification system. (medscape.com)
Overall, Dr. Battula's lab is interested in understanding the mechanisms contributing chemo-resistance, tumor initiation and metastasis of cancer stem cells. (mdanderson.org)
We analyzed the ganglioside profiles of primary uveal melanoma in 14 cases and of cutaneous melanoma metastasis in 19 cases. (duke.edu)
These immune cells interact with tumor cells to influence the initiation, growth, and metastasis of tumors. (biomedcentral.com)
Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)

We aim to elucidate factors in the solid tumor microenvironment that can inhibit CAR T cells and develop decoys/traps or signaling switch receptors to rescue/enhance their activity. (unil.ch)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
One of the main reasons for this failure is the presence of ligands and immunosuppressive cells in the tumor microenvironment. (fapesp.br)
In addition to providing complementary co-stimulatory signals for effector CAR-T cells, secreted GITRL can suppress the action of regulatory T cells in the tumor microenvironment, thus possibly reducing local immunosuppression. (fapesp.br)
Non-resolving inflammation in a tumor microenvironment is a hallmark of cancer. (biomedcentral.com)
Leukocytes, fibroblasts, and vascular endothelial cells together form a tumor microenvironment, with immune cells representing its major component. (biomedcentral.com)

Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
So far, the most successful passive immunotherapy directed to VEGF is Bevacizumab, a monoclonal antibody that neutralizes the binding of VEGF to its receptors [5], which has been approved, in combination with chemotherapy, for the treatment of different tumors [6-12]. (researchsquare.com)
Targeting O-Acetyl-GD2 ganglioside for cancer immunotherapy[J]. J Immunol Res, 2017, 2017: 5604891. (magtechjournal.com)
Xeno-autoantigens such as Neu5Gc-gangliosides provide potential targets for immunotherapy. (unibe.ch)

Gangliosides, complex glycosphingolipids on the plasma membrane containing one or more sialic acid residues, are key components of microdomains. (jneurosci.org)
Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. (matreya.com)
Gangliosides are acidic glycosphingolipids that contribute a substantial presence to the outer leaflet of the cell plasma membrane. (matreya.com)
It is phosphorylated by ceramide kinase (CK) to form ceramide-1-phosphate or it can be glycosylated by glucosylceramide synthase to form glycosphingolipids (cerebrosides, globosides, gangliosides). (frontiersin.org)
With this assessment, we attempt zinc bioavailability to describe the particular sophisticated regulation overall performance from the Hippo signaling circle within most cancers advancement, such as it's position in signal transduction, metabolic rules, along with tumor development, as well as growth SR-4370 price remedies targeting the Hippo pathway.Aberrant phrase involving glycosphingolipids is a characteristic of cancer cellular material and is linked to their malignant components. (wee1-receptor.com)

Furthermore, the low metastatic capacity of uveal melanoma, in contrast to the high metastatic rate of cutaneous melanoma, may be a result of its differentiated ganglioside expression, which is strikingly similar to that of normal melanocytes. (duke.edu)
The expression of globe-series gangliosides was evaluated in fresh-frozen sections of 55 primary renal tumors and 8 metastatic deposits using monoclonal antibodies RM1 and RM2, which define mono-sialosyl and disialosyl galactosylgloboside, respectively. (elsevierpure.com)
The RM1/RM2 positive rate of the metastatic deposits was higher than that of the primary tumors. (elsevierpure.com)
Furthermore, a metastatic deposit obtained from one of the cases whose primary tumors were equivocal for RM1/ RM2 was extensively stained by RM1 and RM2. (elsevierpure.com)
These results indicate that globe-series gangliosides may be one of the biochemical indicators related to the metastatic potential of human RCC. (elsevierpure.com)
A heteroplasmic mutation in the 16srRNA gene was detected in a spontaneous metastatic VM brain tumor. (biomedcentral.com)
The 5-12 months event-free survival (EFS) for high-risk neuroblastoma is usually less than 50%, including patients with metastatic neuroblastoma greater than 18 months of age, and patients with locoregional or metastatic neuroblastoma with tumor gene amplification(2). (eagulf.net)

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
54) and anti-tumor activity of 14G2a (55), a phase I trial of14G2a in combination with IL2 was conducted in 31neuroblastoma patients and 2 osteosarcoma, with1 complete response in osteosarcoma and 1 partial response in neuroblastoma patients (56). (eagulf.net)

Role of tumor-associated gangliosides in cancer progression. (matreya.com)
Gangliosides have been shown to be involved in development, differentiation, oncogenesis, and cancer progression. (elsevierpure.com)
LncRNA-UCA1 is enriched in hypoxic bladder cancer cell-derived TEXs, and hypoxic exosomal lncRNA-UCA1 can promote tumor growth and progression though accelerating EMT. (biomedcentral.com)
None of the mutations were considered pathogenic, indicating that mtDNA somatic mutations do not likely contribute to the initiation or progression of these diverse mouse brain tumors. (biomedcentral.com)
It is not yet clear if mtDNA mutations contribute to brain tumor progression. (biomedcentral.com)
The clinical behavior, which ranges from spontaneous maturation to inexorable progression despite multimodal intensive therapy, is attributable to molecular differences in the tumor. (eagulf.net)

As shown by immunohistochemical assays, 7c11.e8 antigen was expressed on all melanoma tumour tissues, and on a few samples of colon carcinoma, normal colon, skin, spinal cord, kidney and liver. (duke.edu)
The preferential binding of 7c11.e8 to melanoma tissues and the reactivity with two of the major melanoma gangliosides (GM3 and GD3) suggest that 7c11.e8 may provide a useful reagent for diagnosis and therapy of malignant melanoma. (duke.edu)
PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa. (vectorlabs.com)
The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. (biomedcentral.com)
One strategy for targeting TAMs is to block monocyte recruitment into tumor tissues. (biomedcentral.com)
Disialylated gangliosides GD2 and GD3 are viewed since guns regarding neuroectoderm beginning throughout cancers, whilst fucosyl-GM1 can be depicted within not many typical tissues however overexpressed in a variety of types of cancer, especially in small cell lungs carcinoma. (wee1-receptor.com)
Tay-Sachs Disease and Sandhoff Disease Tay-Sachs disease and Sandhoff disease are types of lysosomal storage disorder called sphingolipidoses and are caused by a buildup of gangliosides in the tissues in the brain. (msdmanuals.com)

All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
Matreya's monoclonal and polyclonal anti-ganglioside antibodies are directed against the carbohydrate chains of ganglioside and globoside glycolipids. (matreya.com)
Therapeutic treatments against tumors are being investigated using antibodies to target these ganglioside-rich cells. (matreya.com)
These elicited antibodies impaired the high affinity interaction between VEGF and monoclonal antibody Bevacizumab, an antiangiogenic drug approved in combination with chemotherapy for the treatment of different tumors. (researchsquare.com)
Treatment with systemic CD11b-neutralizing monoclonal antibodies has been shown to prevent the recruitment of myeloid cells to tumors. (biomedcentral.com)
It has been shown that the use of Mac-1 (CD11b/CD18) antibodies leads to an improved response to radiation therapy in squamous cell carcinoma xenografts of mice, which is accompanied by reduced infiltration of myeloid cells expressing matrix metallopeptidase-9 and S100A8 inside tumors [ 9 ]. (biomedcentral.com)
Although there are extensive laboratory studies and some early clinical trials investigating small molecule inhibitors and antibodies targeting relevant genetic pathways implicated in neuroblastoma proliferation, such as PI3kinase, mTOR, IGF1R and many others, the current review will put into perspective two of the most successful extremely tumor-specific brokers in current use which may further improve outcome, and evaluate a third more recent addition to the armamentarium. (eagulf.net)

Malignant melanoma is known to be a relatively chemoresistant tumor. (medscape.com)
Gangliosides may play an important role in the proliferation and spread of human malignant melanoma. (duke.edu)
The results in vivo indicated that tumors formed by GD2 + A549 cells grew faster ( P ＜0.001) and were more malignant ( P ＜0.01) as compared to GD2 - A549 cells. (magtechjournal.com)
Differential roles of gangliosides in malignant properties of melanomas[J]. PLoS One, 2018, 13: e0206881. (magtechjournal.com)
As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. (biomedcentral.com)
With the unraveling of the relationship between TAMs and malignant tumors, TAMs are now being recognized as potential therapeutic targets for cancer. (biomedcentral.com)

Scholars@Duke publication: Variations in the ganglioside profile of uveal melanoma correlate with cytologic heterogeneity. (duke.edu)
Because the frequency of metastases in uveal and cutaneous melanoma differs, it is possible that they may express different gangliosides. (duke.edu)
These results suggest that ganglioside expression of uveal melanoma is associated with host immune responses to the tumor. (duke.edu)
Scholars@Duke publication: Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides. (duke.edu)
In the presence of human serum the antibody initiated a strong lysis of melanoma tumour cells in complement-dependent cellular cytotoxicity (CDCC) assays. (duke.edu)

Dr. Battula is also interested in understanding the metabolic processes that regulate the expression of GD2 as well as the function of CSCs in primary tumors. (mdanderson.org)
The immunoreactivity of primary tumors to RM1 and/or RM2 was correlated with the clinicopathological data. (elsevierpure.com)

Gangliosides act as receptors for various toxins and bacteria, accumulate in different tumors, and aid in many neuronal functions. (matreya.com)

An increase in GD3 appears to be related to tumor polyclonality and infiltration of the tumor by lymphocytes and macrophages. (duke.edu)
With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. (biomedcentral.com)
Levels of tumor necrosis factor and alpha immunoreactivity in astrocytes and macrophages at the outermost edge of the demyelinating lesion are increased, suggesting a cytokine-mediated mechanism. (medscape.com)

Angiogenesis is the formation of new blood vessels from the existing vasculature, and it is significantly increased during tumor development with the aim to supply nutrients and oxygen that support the high rate proliferation of tumor cells. (researchsquare.com)
VEGF biological activity is mediated by its binding to VEGFR receptor 2 (VEGFR2) or VEGF receptor 1 (VEGFR1) [2], and both interactions have been implicated in tumor-induced angiogenesis and immunosuppression [3, 4]. (researchsquare.com)

Although glycan biosynthesis is not template bound, altered tumor glycosylation is not random, but associated with common glycosylation patterns. (unibe.ch)
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. (cdc.gov)

Our main research interest is the development of tumor-directed TCR- and CAR T cells that are programmed to logically respond to microenvironmental cues or/and small molecule administration for maximized function, fitness and safety. (unil.ch)
We have optimized retroviral, lentiviral and CRISPR-Cas9 based tools and methodologies, as well as T cell expansion conditions, allowing efficient evaluation of next-generation T cells in the context of both syngeneic and xenograft tumor models. (unil.ch)
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. (unil.ch)
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells. (unil.ch)
Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of Texas MD Anderson Cancer Center report online in Journal of Clinical Investigation . (weeksmd.com)
It's been difficult to identify cancer stem cells in solid tumors," Andreeff said. (weeksmd.com)
Research in several types of cancer has shown cancer stem cells are a small subpopulation of cancer cells that are capable of long-term self-renewal and generation of new tumors. (weeksmd.com)
Andreeff has shown these mobile mesenchymal stem cells home to wounds, including tumors, making them potential carriers of cancer therapy. (weeksmd.com)
Form twice as many mammospheres, a clumping of cells considered an indicator of tumor-forming capacity, as compared to GD2-negative cells. (weeksmd.com)
Form five times as many tumors when 10 cells of each type are transplanted into mice. (weeksmd.com)
An analysis of 12 human breast cancer tumors found an even higher correlation of 95.5 percent between GD2+ cells and CD44 high/CD24 low status. (weeksmd.com)
Several gangliosides are found to have elevated expressions in tumor cells. (matreya.com)
These transgenic T-cells are then infused back into the patient to specifically target tumor cells. (tufts.edu)
When activated, the T-cells mediate killing of tumor cells by two mechanisms: (1) secretion of granzymes and (2) activation of death receptor signaling in the tumor cell. (tufts.edu)
A technical limitation of CAR-T technology is that it is challenging for CAR T-cells to target solid tumors. (tufts.edu)
Immune-checkpoint proteins that are highly expressed in cancer cells play a crucial role in the inhibition of immune cells Dr. Battula is interested in identification and targeting of immune checkpoint proteins in solid tumors and hematologic malignancies. (mdanderson.org)
In most tumor types, MSCs support tumor growth and induce chemo-resistance in cancer cells. (mdanderson.org)
His current research is focused on understanding the role of tumor-stroma interactions in chemo-resistance of acute myeloid leukemia (AML) cells. (mdanderson.org)
Dr. Battula's research is also focused on targeting cancer stem cells (CSCs), a rare population of cells present in the primary tumor that are drug resistant and primary cause of disease relapse. (mdanderson.org)
However, the therapeutic efficacy of CAR-T cells is still low or non-existent against solid tumors, which make up the vast majority of neoplasms. (fapesp.br)
Histological examination of these 3 biopsy specimens showed at least 2 populations of tumor cells that were separable based on morphological grounds, and mononuclear inflammatory cells interspersed among the tumor cells. (duke.edu)
Objective To explore the feasibility of ganglioside GD2 as a marker for lung cancer stem cells (LCSCs). (magtechjournal.com)
Conclusions Ganglioside GD2 is a potential marker for LCSCs to identify cancer stem cells, providing a novel strategy of GD2-targeted lung cancer immunothearapy. (magtechjournal.com)
Ganglioside GD2 is a potential candidate marker for lung cancer stem cells[J]. Basic & Clinical Medicine, 2023, 43(5): 777-784. (magtechjournal.com)
Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis[J]. J Clin Invest, 2012, 122: 2066-2078. (magtechjournal.com)
Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2(+) breast cancer stem-like cells[J]. J Immunother Cancer, 2021, 9. (magtechjournal.com)
Direct sequencing revealed a few homoplasmic base pair insertions, deletions, and substitutions in the tumor cells mainly in regions of mononucleotide repeats. (biomedcentral.com)
Introduction Neuroblastoma, the most common extra- cranial solid tumor in children, is derived from primordial neural crest cells that ultimately inhabit the sympathetic ganglia and adrenal medulla. (eagulf.net)
The second is anti-GD2 antibody, targeting GD2 ganglioside, expressed on 98% of neuroblastoma and mediates immune destruction of the cells. (eagulf.net)

Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Anti-idiotypic antibody mimicking a T-antigen-specific lectin inhibits human epithelial tumor cell proliferation. (conicet.gov.ar)

We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 gangliosideM1 is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons in adult rat. (jneurosci.org)
In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vivo . (jneurosci.org)
Externally applied sialidase converted GD1a ganglioside to GM1 and rescued axon regeneration in CNS axons and in PNS axons after Neu3 sialidase blockade. (jneurosci.org)
Ganglioside conversion by Neu3 sialidase further activates the ERK pathway. (jneurosci.org)
In this paper, we examine Neu3 sialidase action on axonal gangliosides and resultant axon regeneration, and we assess whether these mechanisms help to explain the different regeneration capacities of CNS and PNS axons. (jneurosci.org)
Pharmacological blocking of Neu3 sialidase, downregulation of Neu3 with siRNA, or depleting gangliosides all inhibit PNS regeneration. (jneurosci.org)

The defining characteristic of gangliosides is the sialic acid moiety of the oligosaccharide head group. (matreya.com)

These kind of gangliosides tend to be gone generally in most normal adult flesh, which makes them focuses on appealing within immuno-oncology. (wee1-receptor.com)

In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models. (fosterfoundation.com)

Vukelić, Željka (2021) Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence . (irb.hr)

To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)

Triptolide stymied cancer growth in cell line experiments and resulted in smaller tumors and prolonged survival in mouse experiments. (weeksmd.com)
2 Gangliosides have been implicated in numerous types of cancer where they are often over-expressed on the membrane surface. (matreya.com)
His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
Disialoganglioside GD2 expression in solid tumors and role as a target for cancer therapy[J]. Front Oncol, 2020, 10. (magtechjournal.com)
There are strong evidences of tumor promotion by TAMs in different cancer models, and an increased TAM prevalence correlates with low survival rates in many human cancers. (biomedcentral.com)
Because targeting monocytes, prior to being recruited to tumors, has been effective in various cancer models and partial clinical trials, TAMs can be directly targeted as well by other approaches once they invade tumors. (biomedcentral.com)
A better understanding of tumor 'glycan codes' as deciphered by lectins, such as siglecs, selectins, C-type lectins and galectins, may lead to novel treatment strategies, not only in cancer, but also in autoimmune disease or transplantation. (unibe.ch)

An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. (matreya.com)

3 A deficiency in the enzymes responsible for metabolizing gangliosides causes toxic levels of ganglioside accumulation which is indicative of several lysosomal storage diseases, including GM 1 gangliosidosis, GM 2 gangliosidosis, Tay-Sachs disease, and Sandhoff disease. (matreya.com)

The best outcome reported until recently for high-risk neuroblastoma was achieved with intensive combination induction chemotherapy and surgery, followed by myeloablative therapy with hematopoietic stem cell rescue, and then differentiation therapy with isotretinoin(3), the first tumor-targeted therapy with exhibited activity in neuroblastoma. (eagulf.net)
The first is 131I-metaiodobenzylguandine (MIBG), which targets the norepinephrine transporter (expressed in 90% of neuroblastoma tumors) for cell-specific uptake, then destroys the cell with the targeted radiation (4). (eagulf.net)

At the moment, the therapy is most effective against hematological (blood) cancers but not solid tumors. (tufts.edu)

A major cell surface receptor for PNA may be asialo GM 1 ganglioside. (vectorlabs.com)

Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)

Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N -acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. (vectorlabs.com)

Matreya now offers a number of high purity deuterated gangliosides which are ideal for mass spectrometry studies. (matreya.com)

The adult mammalian nervous system has four dominant types of gangliosides: GM1, GD1a, GD1b, and GT1b. (jneurosci.org)

There are 11 clinical trials for atypical teratoid/rhabdoid tumor, of which 10 are open and 1 is completed or closed. (mycancergenome.org)
SMARCB1, Ganglioside, and H3F3A are the most frequent gene inclusion criteria for atypical teratoid/rhabdoid tumor clinical trials [ 3 ]. (mycancergenome.org)
Etoposide, nivolumab, and cyclophosphamide are the most common interventions in atypical teratoid/rhabdoid tumor clinical trials. (mycancergenome.org)
APC is an inclusion eligibility criterion in 1 clinical trial for atypical teratoid/rhabdoid tumor, of which 1 is open and 0 are closed. (mycancergenome.org)
We investigated immunohistochemical expression of globe-series gangliosides in human renal cell carcinoma (RCC) and whether their expression is related to the clinical course. (elsevierpure.com)
The high-risk clinical prognostic factors of age greater than 18 months and advanced stage, are closely associated with unfavorable biologic risk factors, including unfavorable histopathology, tumor amplification of the oncogene, and loss of heterozygosity of 1p and 11q, or other partial chromosome deletions(1). (eagulf.net)

The oncogenicity of different subpopulations in cell line A549 was compared with tumor xenograft model. (magtechjournal.com)

Dr. Battula discovered GD2 and GD3 Synthase as a unique marker to identify CSCs from primary breast tumors and cell lines. (mdanderson.org)
He discovered unique markers including ganglioside GD2 and GD3 synthase to identify/isolate CSCs from primary breast tumors (Battula et al. (mdanderson.org)

This is a neoplasm known to be aggressive, representing about 60% cases of brain tumors. (fapesp.br)
Glioblastoma Multiforme (GBM) is the most aggressive form and most common primary brain tumour in adults. (patentpc.com)
Somatic mutations in the mitochondrial genome occur in numerous tumor types including brain tumors. (biomedcentral.com)
In this study we examined the entire mitochondrial genome in a series of chemically induced brain tumors in the C57BL/6J strain and spontaneous brain tumors in the VM mouse strain. (biomedcentral.com)
The tumor mtDNA was compared to that of mtDNA in brain mitochondrial populations from the corresponding syngeneic mouse host strain. (biomedcentral.com)
Other studies of the mitochondrial genome focused on mtDNA copy number in brain tumors [ 34 ]. (biomedcentral.com)
2019. Paolo Mezzani, Detecting brain tumors with diffusion MRI: a computational study. (lu.se)

In addition, he is also interested in understanding the origin of CSCs in primary tumor. (mdanderson.org)

Instead, CAR-T recognizes antigens that are either proteins, carbohydrates, or gangliosides on the tumor cell surface. (tufts.edu)

To solve this problem, the biopharmaceutical Celyad is developing a CAR-T that expresses Natural Killer Receptors (NKR) that can bind ligands of solid tumors. (tufts.edu)

20192203). We are now using these tools to evaluate logic-based, next generation CAR designs for the treatment of syngeneic solid tumors in the context of a fully competent immune system. (unil.ch)
About 85 percent of all solid tumors start in the lining of an organ, called the epithelium. (weeksmd.com)

Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. (nature.com)
M112.357673) and of small molecule responsive T cell-signaling mediators for improved tumor control and safety. (unil.ch)
Sulfoglucuronosyl paragloboside (SGPG) was the prominent species with lesser amounts of sulfoglucuronosyl lactosaminyl paragloboside (SGLPG) in these tumor cell lines as assessed by quantitative HPTLC immunostaining. (karger.com)
Among the gangliosides surveyed, GD3 and 9-O-acetylated GD3 (OAc-GD3) were expressed in all tumor cell lines. (karger.com)
The marker is the cell surface protein ganglioside GD2. (weeksmd.com)
Heparanase drives exosome secretion, alters exosome composition, and facilitates production of exosomes that impact both tumor and host cell behavior. (biomedcentral.com)
This bacterium injects a so-called tumor-inducing (Ti) plasmid in to the place cell, where it integrates in to the genome (Yadav et al. (baxkyardgardener.com)

Modulation of neurotrophic factor receptor by ganglioside-Novel interaction of ganglioside GM1 and Trk receptor. (or.jp)
Targeting the chemokine (C-C motif) ligand 2 (CCL2) - chemokine (C-C motif) receptor (CCR2) axis is promising due to its important role in monocyte recruitment in tumors. (biomedcentral.com)

Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering. (conicet.gov.ar)

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