Ganglioside induced differentiation associated protein characterization gangliosides. Medical search. Frequent questions

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)

We found endosomal escape does not play a role for the enhancer effect of MIC while the effect of MIC on MAP30 is cholesterol dependent and that ganglioside GM1, a lipid raft marker, can competitively inhibit cytotoxicity of MAP30 enhanced by MIC. (bvsalud.org)
Pharmacological blocking of Neu3 sialidase, downregulation of Neu3 with siRNA, or depleting gangliosides all inhibit PNS regeneration. (jneurosci.org)

These animals are immunized with peripheral myelin or with the purified myelin proteins P0, P2 and/or PMP22. (biomedcentral.com)

Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. (neurotree.org)
however, DHCer induces autophagy and may be important in the regulation of this important cellular process. (sphingolipidclub.com)
MDR1 codes for P-glycoprotein (P-gp), a member of the ABC transporter superfamily of proteins that promote cellular efflux of chemotherapeutic agents. (sphingolipidclub.com)

These data further demonstrate that the ganglioside GM1 acts through its oligosaccharide also in preventing the α-synuclein pathogenic aggregation in Parkinson's disease, opening a perspective window for GM1-OS as drug candidate. (bvsalud.org)

We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 gangliosideM1 is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons in adult rat. (jneurosci.org)

specifically enhance the antiproliferative effect of recombinant MAP30 (a type I ribosome inactivating protein, RIP) in breast cancer cells. (bvsalud.org)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Examples include finding proteins indicating cardiac problems or looking for circulating tumour cells that can indicate the spread of cancer. (50webs.com)

Antibodies against neuronal receptors and synaptic proteins are associated with autoimmune encephalitides (AE) that produce movement and psychiatric disorders. (frontiersin.org)
Antibody-mediated central nervous system (CNS) autoimmunity, the hallmark of several autoimmune encephalitis (AE) syndromes that produce movement and psychiatric disorders, is initiated when antibodies recognize neuronal receptors or synaptic proteins as foreign proteins ( 1 - 3 ). (frontiersin.org)
Antibodies directed against neuronal antigens can arise in the periphery when target proteins are expressed ectopically on tumor cells. (frontiersin.org)

In people over 60, the total amount of gangliosides in the substantia nigra of the midbrain decreases, and this reduction is most pronounced in GM1 and GD1a [ 4 ] . (researchsquare.com)

The expression of the ganglioside synthesis-related genes B3galt4 and St3gal2 is conspicuously absent in PD patients, and the GM1 level is decreased in the substantia nigra, prefrontal cortex and various peripheral tissues [ 5 , 6 ] . (researchsquare.com)

In addition, after PDMP treatment, caveolin-1 and flotillin-1, the prototypical markers of lipid rafts, diffused from lipid rafts to non-lipid raft microdomains, and GDNF-induced RET translocation into lipid rafts was also reduced. (researchsquare.com)
Our results suggest that ganglioside GM1 deficiency could compromise the neurotrophic effects and signals downstream of GDNF by altering the assembly of lipid raft membrane microdomains. (researchsquare.com)

In B4galnt1 knockout mice, mice with ganglioside GM1 deficiency show the characteristic symptoms of PD, such as reduced dopamine levels in the striatum, loss of dopaminergic neurons in the SNpc, aggregation of α-synuclein, and motor dysfunction. (researchsquare.com)

The results suggest two mechanisms by which ts 1 survivors exhibit resistance to CVB3(m) induction of myocarditis, namely, the rapid production of high-titered anti-CVB3(m) neutralizing antibody in response to CVB3(m) inoculation and altered cell-mediated immune responses against CVB3(m) induced viral or novel cellular antigens. (nih.gov)

Sialic acid-containing glycolipids, known as gangliosides, play important structural and functional roles. (frontiersin.org)

PMID- 6299950 TI - Temperature-sensitive mutant of coxsackievirus B3 establishes resistance in neonatal mice that protects them during adolescence against coxsackievirus B3 induced myocarditis. (nih.gov)

Challenge of the ts 1 survivors with CVB3(m) did not induce myocarditis, as assessed by histological examination of heart tissues. (nih.gov)

CCK-8 assay, EdU cell proliferation assay and Western blot assay were used to evaluate the effect of GM1 deficiency on the proliferation and differentiation of SH-SY5Y cells induced by GDNF and on the GDNF-RET signaling pathway. (researchsquare.com)

All these results suggest that deficiency of endogenous ganglioside GM1 may be an initiator of the pathological process of PD and play an important role in it, but the specific mechanism is not clear. (researchsquare.com)