• It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool. (nih.gov)
  • In this follow-up to an earlier article by several British researchers, Finnerty and Freis confirmed that Hexamethonium acted longer and produced a greater degree of sympathetic blockade than tetraethylammonium, a ganglion-blocking agent that was found to be a poor treatment for chronic hypertension. (nih.gov)
  • A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system, often by acting as a nicotinic receptor antagonist. (wikipedia.org)
  • The nicotinic antagonist hexamethonium, for example, does this by blocking the transmission of outgoing signals across the autonomic ganglia at the postsynaptic nicotinic acetylcholine receptor. (wikipedia.org)
  • Nicotinic receptor antagonists: hexamethonium pentolinium mecamylamine trimetaphan tubocurarine pempidine benzohexonium chlorisondamine pentamine Nicotinic receptor agonists (acting through depolarization block): nicotine Blocking ACh release in autonomic ganglia (although these have many other actions elsewhere): botulinum toxin Ganglionic blockers are used less frequently now than they were in the past, because antihypertensives with fewer side effects are now available. (wikipedia.org)
  • A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. (nih.gov)
  • Because ganglionic blockers block both the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system. (wikipedia.org)
  • The first ganglion-blocker to be used clinically was tetraethylammonium, although it was soon superseded by better drugs. (wikipedia.org)