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  • TOXICITY
  • Mycophenolate mofetil (MMF): When coadministered with ganciclovir, the risk of hematological and renal toxicity may be increased. (nih.gov)
  • Monitor for ganciclovir and MMF toxicity. (nih.gov)
  • Other drugs associated with myelosuppression or nephrotoxicity: Due to potential for increased toxicity, such drugs should be considered for concomitant use with ganciclovir only if the potential benefits are judged to outweigh the risks. (nih.gov)
  • route
  • In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route [ 1-3 ]. (uptodate.com)
  • kinases
  • Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells. (uptodate.com)
  • Drugs
  • Search Drugs@FDA to access more information on ganciclovir, including additional drug labels and any generic equivalents. (nih.gov)
  • herpes simplex
  • Ganciclovir is phosphorylated to a substrate, which competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase resulting in inhibition of DNA replication by herpes simplex viruses. (drugs.com)
  • medication
  • If you are injecting ganciclovir at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. (cigna.com)
  • Ganciclovir may also be used for purposes other than those listed in this medication guide. (cigna.com)