Gamma receptor. Medical search. Frequent questions

in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor gamma agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. (nih.gov)
These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor gamma agonists. (nih.gov)
The peroxisome proliferator activated receptor gamma co-activator 1 alpha (PGC1α) is an inducible transcriptional co-activator with direct function in the induction of mitochondrial biogenesis. (uniroma5.it)
Structure-activity relationships of FXR-active compounds revealed by this screening were then compared against the androgen receptor, estrogen receptor α, peroxisome proliferator-activated receptors δ and γ and the vitamin D receptor. (nature.com)
Introduction: The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis (SSc). (northwestern.edu)

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene. (wikipedia.org)
This gene encodes the gamma 2 subunit of GABA(A) receptor. (wikipedia.org)
Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. (aspetjournals.org)
A cDNA encoding the human gamma-aminobutyric acid (GABA)A receptor beta 2 subunit has been cloned and sequenced. (aspetjournals.org)
By expressing recombinant human GABAA receptors containing different beta subunits (beta 1, beta 2 or beta 3) in both transfected cells and Xenopus oocytes, we have been able to determine the influence of the beta subunit on the pharmacology of the receptor. (aspetjournals.org)
For a number of benzodiazepine binding site compounds, a barbiturate, and several neurosteroids, neither the affinity nor the efficacy of the compounds is influenced by the type of beta subunit present in the receptor molecule. (aspetjournals.org)
These data suggest that the beta subunit does not significantly influence the benzodiazepine, barbiturate, or steriod site pharmacologies of human GABAA receptor subtypes. (aspetjournals.org)
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. (drugbank.com)
A cDNA encoding the human gamma-aminobutyric acidA (GABAA) receptor alpha 6 subunit has been cloned and sequenced. (drugbank.com)
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. (wikidata.org)
This report covers detailed insights on Gamma-Aminobutyric Acid Receptor Subunit Alpha 5 Drugs under development, targeted therapeutics, assessment by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (datavagyanik.com)
The research report titled "Gamma-Aminobutyric Acid Receptor Subunit Alpha 5 Drugs Market, Business and Opportunity Analysis" published by Datavagyanik presents a detailed analysis of the Gamma-Aminobutyric Acid Receptor Subunit Alpha 5 Drugs Market with country-wise market statistics, drugs under development, qualitative insights, and market player analysis. (datavagyanik.com)
One of the prime objectives of the report is to provide an assessment of the market potential, market revenue, growth, and business opportunities for the Gamma-Aminobutyric Acid Receptor Subunit Alpha 5 Drugs Market in each country. (datavagyanik.com)
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Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)
Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia. (jci.org)
We determined the configuration of the genes for the beta (T beta) and gamma (T gamma) chains of the T cell receptor in DNA from 100 consecutive cases of B cell lymphoma and B cell chronic lymphocytic leukemia (B-CLL), and compared the findings with those in 18 T cell neoplasms. (jci.org)
Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-γ receptor 1 chain. (eur.nl)
Configuration of immunoglobulin and T cell receptor beta and gamma genes in acute myeloid leukaemia: pitfalls in the analysis of 40 cases. (bmj.com)
The heterodimeric T-cell surface receptors, either alpha/beta (90% -95% of T cells) or gamma/delta (5% - 10% of T cells) are produced following somatic rearrangement of the T-cell receptor (TCR) genes (alpha, beta, delta, and gamma). (ohsu.edu)
PCR-based detection of rearranged T-cell receptor genes can be used to help establish a diagnosis of T-cell lymphoma, monitor for treatment response, and/or measure minimal residual disease (MRD). (ohsu.edu)

The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. (wikipedia.org)

The ligand-induced assembly of the complete receptor complex contains two IFNGR1 and two IFNGR2 subunits, which bring into close juxtaposition the intracellular domains of these proteins together with the inactive Jak1 and Jak2 kinases that they associate with. (wikipedia.org)
The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. (wikipedia.org)
Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. (bvsalud.org)

Recombinant human alpha 6 beta gamma 2S GABAA receptors have been expressed in both stably transfected cells and Xenopus oocytes, and the pharmacology of the benzodiazepine binding site has been determined. (drugbank.com)

We also have observed that Fcγ receptors (FcγR), proteins present on the surface of microglia that bind immunoglobulin G (IgG) and other ligands, are key modulators of α-SYN-induced neurodegeneration. (biomedcentral.com)
Secreted autoantibodies specific to receptors or receptor ligands can activate or inhibit receptor functions. (hindawi.com)

The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. (wikipedia.org)
This protein is a high-affinity Fc-gamma receptor. (nih.gov)
Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
She carried a homozygous C71Y mutation in the extracellular part of the mature interferon-γ receptor 1 protein, resulting in the lack of detectable protein expression and absence of interferon-γ dependent signaling. (eur.nl)
A homozygous splice-site mutation in intron 3 was identified, resulting in the deletion of exon 3 at the mRNA level and consequently a truncated interferon-γ receptor 1 protein with absence of the transmembrane domain. (eur.nl)
Shen F, Wu M, Ross JF, Miller D, Ratnam M: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (t3db.ca)
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. (creative-biolabs.com)
While much is known about the structure and function of the T-cell receptor (TCR) alpha beta heterodimer, information has just begun to emerge about the gamma protein, the product of a third rearranging T-cell receptor gene. (johnshopkins.edu)
Exposure of MM6 cells, which do not express CD36 or other scavenger receptors, to such enzymatically modified LDL (enzLDL) resulted in upregulation of CD36 surface protein and mRNA expression. (edu.au)
Results: Increased concentrations of beta-synuclein, gamma-synuclein, neurogranin, phosphatidylethanolamine-binding protein 1, and 14-3-3 proteins were observed in AD patients compared to controls, while neuronal pentraxin-2 and. (lu.se)

We conclude that ordered rearrangement of the T cell receptor is a rare event in B cell lymphoma and B-CLL. (jci.org)

T cell receptor gene studies allow B and T cell lymphomas to be distinguished from each other and from common acute lymphoblastic leukemia antigen-positive non-T, non-B acute lymphoblastic leukemia. (jci.org)
Molecular cloning of the zeta chain of the T cell antigen receptor. (wikidata.org)
In addition, due to the great diversity of immune cell antigen receptor recombination breakpoints, only ~85% of all clonal T-cell populations will be identified with the primers utilized in this assay. (ohsu.edu)

Cytokines, including those that signal via receptors using the common cytokine receptor gamma-chain (gamma(c)), have been implicated at various stages of NK cell development. (pasteur.fr)
Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity. (pasteur.fr)
Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and cytokine receptors. (qub.ac.uk)
Dive into the research topics of 'Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and cytokine receptors. (qub.ac.uk)

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. (wikipedia.org)

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. (ohsu.edu)

Fc gamma receptors (FcγR) are proteins expressed on the surface of microglia as well as other cell types, including natural killer cells, neutrophils, and mast cells. (biomedcentral.com)
Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. (bvsalud.org)

The recombinant receptor has a diazepam-insensitive pharmacology, with negligible affinity for a number of classic benzodiazepines. (drugbank.com)

In our previous study, we demonstrated that an agonist of the perioxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipocyte differentiation, stimulates osteoblastic differentiation of cultured human periosteum-derived cells. (medsci.org)

In contrast to the conventional mechanism of nuclear receptor ligand activation, activation of ERRgamma by GSK4716 does not appear to involve a major rearrangement or significant stabilization of the C-terminal helix. (rcsb.org)
nuclear receptor. (duke.edu)

We here report two patients with unusual mycobacterial infections, both diagnosed with homozygous deleterious interferon-γ receptor 1 gene mutations. (eur.nl)

Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. (wikipedia.org)
In our previous studies in vivo , we have found that the Fc receptors appear to have a key role in α-SYN-induced inflammation: deficiency of FcγRs blocks α-SYN-induced NF-κB-driven pro-inflammatory signaling, and attenuates microglial activation and DA neurodegeneration [ 15 ]. (biomedcentral.com)

In this complex, Jak1 and Jak2 transactivate one another and then phosphorylate IFNGR1, thereby forming a paired set of Stat1 docking sites on the ligated receptor. (wikipedia.org)
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)

For T-cell receptor gamma targets, extracted genomic DNA from blood, lymph node, bone marrow, or other tissue types are PCR amplified and subjected to next generation sequencing (NGS) library preparation with a combination of heterogeneous TCR-gamma V(variable) region and J-(joining) region primers to generate TCR-gamma receptor VJ-rearranged templates, which are then subjected to next-generation sequencing on a MiSeq instrument. (ohsu.edu)
Analysis of T-cell receptor gamma chain expression in the thymus. (johnshopkins.edu)
We describe the use of antiserum to a carboxy-terminal peptide common to several of the murine gamma chain constant regions and a monoclonal antibody to the murine T3 complex to identify products of this T-cell receptor gene family in a subpopulation of Lyt2-, L3T4- thymocytes. (johnshopkins.edu)
The cells that bear this second T-cell receptor appear to represent a distinct lineage differentiating within the thymus. (johnshopkins.edu)
Dive into the research topics of 'Analysis of T-cell receptor gamma chain expression in the thymus. (johnshopkins.edu)
Whereas the majority of T cells use alpha and beta chains to form their T-cell receptor, a small minority of T cells, which do not express the CD4 or CD8 surface markers, use other chains termed gamma and delta to form their receptor. (ox.ac.uk)

Members of this family show sequence homology with estrogen receptors but are incapable of being bound by estrogen. (nature.com)
X-ray crystal structures of the ligand binding domain (LBD) of the estrogen-related receptor-gamma (ERRgamma) were determined that describe this receptor in three distinct states: unliganded, inverse agonist bound, and agonist bound. (rcsb.org)
Initially, interest was focused on estrogen because it had been found in one series that 30% of meningiomas have estrogen receptors. (medscape.com)

1998. Induction of mammary tumors in rats by single- dose gamma irradiation at different ages. (cdc.gov)

Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. (aspetjournals.org)
Regional differences in neuroactive steroid modulation of the gamma-aminobutyric acidA receptor-chloride ionophore complex (GBRC), as measured by t-butylbicyclophosphoro[35S]thionate ([35S] TBPS) binding and 36Cl- uptake, were demonstrated in rat spinal cord versus frontal cortex. (aspetjournals.org)

You need info about Human Retinoic acid receptor RXR-gamma (RXRG) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)

This observation demonstrates definitively that efficacy of benzodiazepine compounds cannot be generalized across receptor subtypes and may also help explain some of the behavioral effects that have been reported for these compounds. (drugbank.com)

abstract = "Previous [11C]flumazenil (FMZ) positron emission tomography (PET) investigations in patients with idiopathic generalized epilepsy (IGE) have demonstrated nonsignificant global cortical decreases in central benzodiazepine gamma-aminobutyric acid A (GABA[A]) receptor (cBZR) binding or focal decreases in the thalamus and increases in the cerebellar nuclei with no changes in cerebral cortex. (elsevierpure.com)

IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)

A number of compounds that bind to the benzodiazepine site potentiated the GABA response of alpha 6 beta 2 gamma 2 receptors. (drugbank.com)
Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. (nature.com)
Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. (cdc.gov)

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. (wikidata.org)

The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids and glucose. (nature.com)

T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate receptor, formed by variable gamma (γ) and delta (δ) chains, referred as γδ T cells. (creative-biolabs.com)

In this report, we have analyzed the roles for gamma(c)-dependent cytokines in the generation of bone marrow NKP and in their subsequent differentiation to mature NK cells in vivo. (pasteur.fr)
T cells expressing gamma delta chain receptors in rheumatoid arthritis. (ox.ac.uk)
Monoclonals which recognise the gamma and delta chains were used to compare the proportion of TCR gamma delta cells in these sites. (ox.ac.uk)
Approximately half the patients had more TCR gamma delta in the joints than in their blood and one newly diagnosed patient had high numbers of TCR gamma delta cells in both blood and joints. (ox.ac.uk)
In this preliminary study it is not possible to evaluate the role of these cells in the disease process, but it is of interest that in some RA patients there is an overabundance of both T cells that arise early in ontogeny (TCR gamma delta cells) and B cells that arise early in ontogeny, the CD5 B cell. (ox.ac.uk)
Upregulation of CD36 was inversely correlated to the state of cell differentiation, as showed by lower response to enzLDL of the scavenger receptor-expressing MM6-sr and THP1 cells. (edu.au)

Notch is a transmembrane receptor that controls a diverse array of cellular processes including cell proliferation, differentiation, survival, and migration. (ulaval.ca)

NKPs express the CD122 Ag (beta chain of the receptors for IL-2/IL-15), but lack other mature NK markers, including NK1.1, CD49b (DX5), or members of the Ly49 gene family. (pasteur.fr)

GABRG2 has been shown to interact with GABARAP and Dopamine receptor D5. (wikipedia.org)

Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development. (nih.gov)

Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase. (ulaval.ca)

GHB is manufactured readily from its precursor, gamma-butyrolactone (GBL). (medscape.com)

Two Stat1 molecules then associate with the paired docking sites, are brought into close proximity with receptor-associated-activated JAK kinases, and are activated by phosphorylation of the Stat1. (wikipedia.org)

The gamma chain has a molecular weight of 35kD, is disulfide bonded to a 45kD partner termed delta (delta) and is associated with the T3 complex. (johnshopkins.edu)

Tyrosine-phosphorylated Stat1 molecules dissociate from their receptor tether and form homodimeric complexes. (wikipedia.org)

The human interferon-gamma receptor. (wikidoc.org)

Anatomy21

Organisms7

Diseases2

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes42

Information Science3

Peroxisome6

Subunit17

Genes8

Interferon-gamma receptor c1

Subunits3

GABAA1

Ligands2

Protein10

Rearrangement of the T cell rec1

Antigen3

Cytokine4

GABA Receptors1

Immunoglobulin and T cell rec1

Proteins2

Pharmacology1

PPAR1

Nuclear2

Mutations1

Deficiency2

IFNGR12

Cell receptor6

Estrogen3

Rats1

AcidA2

Retinoic1

Subtypes1

Abstract1

Heterodimeric1

Compounds3

Membrane1

Regulates1

Minority of T cells1

Cells6

Transmembrane1

Gene family1

GABARAP1

Mediates1

Mitochondrial1

Precursor1

Phosphorylation1

Disulfide1

Complexes1

Human1