• Scabiheal Lotion is a medication containing the active ingredients Gamma Benzene Hexachloride and Cetnimide. (medsbase.com)
  • Gamma Benzene Hexachloride functions as a pediculicide and a scabicide. (medsbase.com)
  • Lindane (1%) lotion and shampoo are available by prescription for single-use application to treat human scabies and head lice. (cdc.gov)
  • WASHINGTON - The US Food and Drug Administration (FDA) has rejected a citizen petition from the Natural Resources Defense Council to ban lindane-containing lice and scabies treatments from the US market. (medscape.com)
  • Lindane (gamma-hexachlorocyclohexane) has been used as both an agricultural pesticide and a pharmaceutical to treat head lice (1% shampoo) and scabies (1% lotion). (medscape.com)
  • It advised that lindane only be used in patients who cannot tolerate or have failed other first-line treatments for lice and scabies and that it only be used a single time. (medscape.com)
  • With other alternatives that are more effective, non-toxic, and less expensive, the continued approval of lindane as a treatment for head lice and scabies is unnecessarily dangerous. (medscape.com)
  • A German woman with a 2-month-old breastfed infant was treated with lindane 0.3% lotion (the product available in the United States contains 1%) for scabies. (nih.gov)
  • To our knowledge there are to date no published reports on the concentration of lindane in mother's milk after local scabies therapy. (nih.gov)
  • In a mother treated with lindane for scabies we found elevated levels of lindane in the mother's milk. (nih.gov)
  • The treatment of scabies with permethrin in comparison with lindane and benzyl benzoate]. (nih.gov)
  • Comparative effect of topical application of lindane and permethrin on oxidative stress parameters in adult scabies patients. (nih.gov)
  • Most medicines such as permethrin, benzyl benzoate, and gamma benzene hex chloride or ivermectin, that are generally used for classical scabies do not show satisfactory results as they fail to penetrate the thick and adjoined scales and crusts due to crusted scabies. (diseasefix.com)
  • Lindane in humans is used in lotions, creams, and shampoos to treat scabies and lice. (diseasefix.com)
  • The gamma isomer, commonly known as lindane, can be used as an insecticide and has been used to kill soil-dwelling and plant-eating insects. (cdc.gov)
  • gamma-Hexachlorocyclohexane) is a fat-soluble insecticide that is a persistent environmental contaminant. (nih.gov)
  • One of these forms, gamma-HCH (or γ-HCH, commonly called lindane) is produced and used as an insecticide on fruit, vegetables, and forest crops. (cdc.gov)
  • Lindane has not been produced in the United States since 1976, but is imported for insecticide use. (cdc.gov)
  • Technical-grade HCH was used as an insecticide in the United States and typically contained 10-15% gamma-HCH as well as the alpha (α), beta (β), delta (δ), and epsilon (ε) forms of HCH. (cdc.gov)
  • Lindane also known as gamma-hexachlorocyclohexane is used as an insecticide. (diseasefix.com)
  • An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. (nih.gov)
  • For example, there are two landfill sites that contain thousands of tonnes of soil contaminated with large amounts of the insecticide lindane (gamma-hexachlorocyclohexane) and its isomers (collectively referred to as HCH). (chemistryworld.com)
  • Ginsburg 3 found a mean peak blood level of 28 ng/mL 6 hours after total body application of Lindane Lotion to scabietic infants and children. (nih.gov)
  • We measured para, para' (p,p')-DDE, p,p'-DDT, ortho, para' (o,p')-DDT, HCB, beta (beta)-HCH (the most persistent isomer of technical-grade HCH) and gamma-HCH in serum from 426 low-income pregnant Latina women living in an agricultur al community in California. (cdc.gov)
  • 10.4194/1303-2712-v16_4_19 Viewed : 3987 - Downloaded : 2818 In this study, histopathological changes induced by lindane a gamma isomer of hexachlorocyclohexane and its intoxication associated with reproductive system and hormone levels were investigated in zebrafish. (trjfas.org)
  • In the study, the gamma-HCH-isomer was applied at rates of 5/10/20/40/80/160 μg/L/day as doses of immersion to each group for 21 days. (trjfas.org)
  • 2006) Removal of atrazine ,lindane and diazinone from water by organo-zeolites, water research, vol. 40, p. 1079-1085, DOI: 10.1016/j.watres.2006.01.001. (edu.pl)
  • Lindane Shampoo should only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of lice. (nih.gov)
  • Seizures and deaths have been reported following Lindane Shampoo use with repeat or prolonged application, but also in rare cases following a single application according to directions. (nih.gov)
  • Lindane Shampoo is contraindicated in premature infants and individuals with known uncontrolled seizure disorders. (nih.gov)
  • Instruct patients on proper use of Lindane Shampoo, the amount to apply, how long to leave it on, and avoiding retreatment. (nih.gov)
  • Inform patients that itching occurs after the successful killing of lice and is not necessarily an indication for retreatment with Lindane Shampoo. (nih.gov)
  • Lindane Shampoo USP, 1%, is an ectoparasiticide and ovicide effective against Pediculosis humanis capitis (head lice), Pthirus pubis (crab lice), and their ova. (nih.gov)
  • In addition to the active ingredient, lindane, it contains acetone, citric acid, polysorbate 60, purified water and triethanolamine lauryl sulfate to form a shampoo base. (nih.gov)
  • There are no clinical dose ranging studies for Lindane Shampoo. (nih.gov)
  • Sexual contacts should be prescribed Lindane Shampoo only if they either have failed to respond to adequate doses of other approved therapies or are intolerant of other approved therapies. (nih.gov)
  • Lindane Shampoo does not prevent infestation or reinfestation and should not be used to ward off a possible infestation. (nih.gov)
  • In 2007, the FDA sent a warning letter to lindane manufacturer Morton Grove Pharmaceuticals, citing the company for false safety and efficacy claims for its lindane shampoo and lotions, marketed under the brand name Kwell . (medscape.com)
  • The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on the insecticides dichlorodiphenyltrichloroethane (DDT) and gamma-hexachlorocyclohexane (lindane) and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is now available online. (who.int)
  • Current exposure to OC pesticides - dichlorodiphenyltrichloroethane (DDT), lindane (99% pure gamma-hexachlorocyclohexane (gamma-HCH)), hexachlorobenzene (HCB) - occurs on a limited basis. (cdc.gov)
  • A baseline lindane concentration in breastmilk was not obtained, but the average value of lindane in mothers' milk in Germany from pesticides in the food chain at the time of the study was 30 mcg/kg of milk fat. (nih.gov)
  • 1999). Integrated Risk Information System (IRIS) on gamma-Hexachlorocyclohexane. (edu.pl)
  • After another repeat application of lindane, lindane was found in aa concentration of 2000 mcg/kg on day 11. (nih.gov)
  • Lindane induced concentration-dependent decreases in contraction force (ED50 of 9.2 microM) and complete uterine quiescence at 30 microM. (nih.gov)
  • Lindane, DDT and its metabolites, Malathion and Chlorpyrifos were most commonly found in 36 soft drink Samples tested. (elaw.org)
  • The state of California banned the use of lindane in pharmaceutical products in 2002 because of concerns about the product contaminating the water supply. (medscape.com)
  • The number of dispensed prescriptions for lindane has dropped by 91% since 2002, and the agent currently accounts for only 2% of the prescription pediculicide and scabicide market in the United States, Dr. Woodcock noted. (medscape.com)
  • In 2003, the FDA required a black box warning on the lindane label emphasizing its potential for neurotoxicity, particularly in infants, children, the elderly, individuals with other skin conditions, and those weighing less than 110 pounds. (medscape.com)
  • Dale, et al 2 reported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a lindane-containing product. (nih.gov)
  • This has led to controversial discussions as to the indication for therapy with lindane in early infancy. (nih.gov)
  • Reactions induced by neurotoxic effects with lindane (gamma-hexachlorcyclohexane) after treatment of infants have been reported by different authors. (nih.gov)
  • Identified by the IARC and 14 sites for X-radiation and gamma-radiation. (cancer.org)
  • The pesticide used here is a chlorinated hydrocarbon called lindane found in the water (underground, land), beverages and foods. (edu.pl)
  • Biodegradation of lindane pesticide by non white-rots soil fungus Fusarium sp, World J. of Micro and Biotech, vol. 27, (8), p. 1747-1754. (edu.pl)
  • It is no longer produced or sold in the U.S. In 2006, the U.S. EPA cancelled agricultural uses of lindane (ATSDR, 2005). (cdc.gov)
  • Local authorities are yet to find a waste handler to deal with the lindane landfills, and until they are properly cleaned up, the potential consequences from lindane exposure could be severe, civic activists warn. (chemistryworld.com)
  • As a result, lindane was found to cause changes in the reproductive system, and consequently, to cause hormonal disorders and to have significant effects on ovulation and fertilization in the female zebrafish. (trjfas.org)
  • The petro-ether-chloroform was found to be the right solvent for the separation of lindane from wastewater because of high selectivity (25.36) and distribution coefficient (4). (edu.pl)
  • Milk from day 4 to 10 contained lindane in the range of 500 to 900 mcg/kg of milk fat. (nih.gov)
  • Compared to average levels of lindane in mother's milk (0.03 ppm, milk-fat) there was a 30-fold increase after three-day treatment and a 66-fold elevation after an additional one-day treatment with lindane. (nih.gov)
  • The fate of lindane in the conventional activated sludge treatment process, Chemosphere, vol. 55, p. 81-91, DOI: 10.1016/j.chemosphere.2003.11.020. (edu.pl)
  • In a telephone follow-up study, 9 mothers used lindane topically for head lice during breastfeeding. (nih.gov)
  • HCH isomers, particularly alpha and gamma have been detected widely in air, soil, water, and sediment as a result of historic production and use. (cdc.gov)
  • Removal of lindane and melathion from wastewater by activated carbon prepeared from apricot stone, Ass. (edu.pl)
  • Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. (nih.gov)
  • This vehicle was different from the approved product and the percutaneous penetration of lindane is dependent on the vehicle. (nih.gov)
  • Caregivers applying this product to patients should wear gloves less permeable to Lindane such as nitrile, latex with neoprene or sheer vinyl, and thoroughly clean hands after application. (nih.gov)
  • Lindane and other isomers of the same chemical, present in large quantities in OHIS, fall into the category of persistent organic pollutants, which means they persist in the environment and are transmitted through the food chain,' says Davor Pehcevski from Skopje-based citizens' association Eko-svest (Eco-sense). (chemistryworld.com)
  • Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. (nih.gov)
  • Lindane's inhibitory action may involve cAMP, arachidonic acid, or oxidative stress. (nih.gov)
  • Removal of lindane and mathion from wastewater using bagasse fly ash-a sugar industry waste, water research, vol. 36, (10), p. 2483-2490, PII: S0043-1354(01)00474-2. (edu.pl)
  • The NRDC's citizen petition cited those facts, among others, in support of its position that pharmaceutical products containing lindane be banned. (medscape.com)
  • The fact that the landfill with these chemicals is out in the open means that we have been exposed for a long time and the lindane is constantly accumulating into our bodies. (chemistryworld.com)
  • Technical grade HCH is a mixture of all four isomers, containing about 64% alpha and 10%-15% gamma isomers. (cdc.gov)
  • Additionally, the phospholipase A2 inhibitor and antioxidant quinacrine increased the ED50 for contraction force inhibition to 84.5 microM lindane. (nih.gov)
  • Feldmann and Maibach 1 reported approximately 10% absorption of a lindane acetone solution applied to the forearm of human subjects and left in place for 24 hours. (nih.gov)
  • X-radiation, gamma-radiation of human cancer. (cancer.org)
  • Lindane (gamma-HCH) inhibits uterine gap junctions but beta-HCH does not. (nih.gov)
  • Because gap junctions promote coordination of oscillatory uterine contractions, we hypothesized that lindane, but not beta-HCH, would inhibit uterine contractions. (nih.gov)
  • Lindane and beta-HCH have distinctly different actions in the uterus. (nih.gov)