• Being a product derived from bone marrow and lymph gland cells, gamma globulin injections, along with blood transfusions and intravenous drug use, can pass hepatitis C to their recipients. (wikipedia.org)
  • Intravenous gamma globulin was FDA-approved in 2004 to reduce antibodies in a patient with kidney failure to allow that person to accept a kidney from a donor with a different blood type (ABO-incompatible), or who is an unacceptable tissue match. (wikipedia.org)
  • FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. (cornell.edu)
  • Intravenous immune globulin (IVIG) suppresses autoantibody-mediated inflammation by inducing and activating the inhibitory Fc receptor FcgammaRIIb and downstream negative signaling pathways. (cornell.edu)
  • Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with immune globulin intravenous (IGIV) products in predisposed patients. (drugs.com)
  • If fever disappears after intravenous gamma globulin therapy is started, fever may be of less than 5 days' duration, and the clinical case definition may still be met. (cdc.gov)
  • Gamma globulin infusions are also used to treat some immunological diseases, such as idiopathic thrombocytopenia purpura (ITP), a disease in which the platelets are being attacked by antibodies, leading to seriously low platelet counts. (wikipedia.org)
  • Item 13706 is payable for the transfusion of blood, or platelets or white blood cells or bone marrow or gamma globulins. (health.gov.au)
  • We investigated the effects of IVIG on cellular responses to interferon-gamma (IFN-gamma), a potent macrophage activator that exacerbates inflammation. (cornell.edu)
  • Our study showed that IVIG blocked IFN-gamma signaling and IFN-gamma-induced gene expression and suppressed IFN-gamma function in vivo during immune responses to Listeria monocytogenes and in an IFN-gamma-enhanced model of immune thrombocytopenic purpura. (cornell.edu)
  • These results reveal an unexpected inhibitory role for the activating FcgammaRIII in mediating suppression of IFN-gamma signaling and suggest that inhibition of macrophage responses to IFN-gamma contributes to the anti-inflammatory properties of IVIG. (cornell.edu)
  • Thrombosis may occur with immune globulin products, including PRIVIGEN. (drugs.com)
  • A disease of gamma globulins is called a "gammopathy" (for example, in monoclonal gammopathy of undetermined significance). (wikipedia.org)
  • In 1953, gamma globulin was shown to prevent paralytic polio. (wikipedia.org)
  • Injections are also used to boost immunity in patients unable to produce gamma globulins naturally because of an immune deficiency, such as X-linked agammaglobulinemia and hyper IgM syndrome. (wikipedia.org)
  • Efficacy of Gamma Globulins in Children with Kawasaki Disease and Factors Influencing Children's Short-Term Prognosis. (iasp-pain.org)
  • To explore and analyze the therapeutic effect of gamma globulins (GG) on Kawasaki disease (KD) in children and the influencing factors of short-term prognosis. (iasp-pain.org)
  • It appears that gamma globulin causes the spleen to ignore the antibody-tagged platelets, thus allowing them to survive and function. (wikipedia.org)
  • Gamma globulin injections are usually given in an attempt to temporarily boost a patient's immunity against disease. (wikipedia.org)
  • The major alpha-1 globulin is called alpha-1-antitrypsin, which is produced by the lungs and liver and increases with inflammatory diseases. (healthline.com)
  • Overloading the degradation mechanism causes the harmful gamma globulins to have a much shorter half of the life in sera. (wikipedia.org)
  • The mechanism of inhibition of IFN-gamma signaling was suppression of expression of the IFNGR2 subunit of the IFN-gamma receptor. (cornell.edu)
  • Evaluation of Red Cross gamma globulin as a prophylactic agent for poliomyelitis. (wikipedia.org)
  • Globulins play an important role in liver function, blood clotting, and fighting infection. (medlineplus.gov)
  • Low globulin levels may be a sign of liver or kidney disease, or malnutrition . (medlineplus.gov)
  • Antitoxin can be derived from either human (e.g., tetanus immune globulin) or animal (usually equine) sources (e.g., diphtheria and botulism antitoxin). (cdc.gov)
  • Another theory on how gamma globulin administration works in autoimmune disease is by overloading the mechanisms that degrade gamma globulins. (wikipedia.org)
  • Such injections are less common in modern medical practice than they were previously, and injections of gamma globulin previously recommended for travelers have largely been replaced by the use of hepatitis A vaccine. (wikipedia.org)
  • However, since hepatitis C is known to have been present since at least the 1940s, a gamma globulin shot received prior to the early 1990s put the recipient at risk of being infected. (wikipedia.org)