The antiviral effect of propolis extracts and selected constituents, e.g. caffeic acid (1), p-coumaric acid (2), benzoic acid (3), galangin (4), pinocembrin (5) and chrysin (6) against herpes simplex virus type 1 (HSV-1) was analysed in cell culture. (nih.gov)
Our certified Propolis Capsules contain rich flavonoid content such as Chrysin, Pinocembrin, Galangin and Quercetin. (beehealthyfarms.com)
Our propolis is certified to contain active flavonoids, documented for having anti-fungal , antiviral and antitumor properties, thanks to such flavonoids as Pinocembrin , Galangin, Chrysin and Quercetin. (beehealthyfarms.com)
Chrysin1
Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. (nih.gov)
Propolis is thought to contain a natural antibiotic, called galangin, and is used in a variety of remedies to treat or prevent low-grade infections, especially in people who do not want to take antibiotics. (healthy.net)
Purified propolis (equivalent to 100mg raw propolis) in which, by means of proprietary technology, inactive substances such as wax are eliminated, and guarantees a minimum flavonoid content of 10% expressed as galangin . (marnys.com)
Flavonol2
Galangin is a flavonol, a type of flavonoid. (wikipedia.org)
Alpinia officinarum contains high concentrations of the flavonol galangin, which has been shown to slow the increase and growth of breast tumor cells. (findmeacure.com)
Include galangin1
Gallic acid is one of the antioxidant in manuka honey include galangin which promotes the growth of a healthy immune system. (maximizemarketresearch.com)
Alpinia3
Galangin is found in high concentrations in plants like Alpinia officinarum (lesser galangal) and Helichrysum aureonitens. (wikipedia.org)
The 6-week study involved female rats treated with galangin isolated from the Alpinia galanga rhizome. (indianpeopletimes.com)
Galangin, a flavonoid present in Alpinia officinarum is a PPARγ agonist proven to possess anti-asthmatic property. (scitechnol.com)
Kaempferol5
Galangin and kaempferol efficiently decreased MMP-9 secretion, whereas fisetin only weakly decreased its secretion. (molcells.org)
Galangin and kaempferol did not affect cell viability at concentrations up to 30 μM. (molcells.org)
Luciferase reporter assays showed that galangin and kaempferol decrease transcription of MMP-9 mRNA. (molcells.org)
Moreover, galangin and kaempferol strongly reduce IκBα phosphorylation and significantly decrease JNK phosphorylation. (molcells.org)
These results indicate that galangin and kaempferol suppress PMA-induced MMP-9 expression by blocking activation of NF-κB and AP-1. (molcells.org)
CYP1A15
Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity. (medchemexpress.com)
Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. (medchemexpress.com)
Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. (medchemexpress.com)
Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). (medchemexpress.com)
Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter [1] . (medchemexpress.com)
Antiviral1
Galangin has been shown to have in vitro antibacterial and antiviral activity. (wikipedia.org)
Potent1
Despite the potent therapeutic efficacy of galangin, poor aqueous solubility limits its pharmacological activity. (scitechnol.com)
Rats1
At the end of the experiment, macular adipose tissue, liver weight, and liver triglyceride levels in rats receiving galangin and sibutramine were between 33 and 42 per cent. (indianpeopletimes.com)
PPAR3
Objective: To investigate the role of the PPAR/DNMT3A pathway in the reversal of galangin-mediated inflammatory lung injury, promote the development of new anti-inflammatory drugs, reduce the side effects of chemical synthetic drugs on the body, and prove the effectiveness and safety of galangin in inhibiting inflammatory response and injury. (bvsalud.org)
In addition, galangin could significantly inhibit the LPS-induced expression of p65 and AP-1 in alveolar monocytes and their binding content in the promoter region of inflammatory genes by activating PPAR/DNMT3A pathway. (bvsalud.org)
Conclusion: Galangin can interfere with the binding of transcription factors to inflammatory gene promoters through the methylation modification induced by PPAR/DNMT3A pathway, so as to inhibit the synthesis of inflammatory molecules and reverse inflammatory lung injury. (bvsalud.org)
Inflammatory1
Results: Intraperitoneal injection of galangin could inhibit the synthesis of alveolar inflammatory factors (TFs) in the SD model of lung injury induced by LPS, reduce the degree of pathological injury of lung tissue, and improve the survival rate of the SD model. (bvsalud.org)
Inhibition3
Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. (medchemexpress.com)
The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level [2] . (medchemexpress.com)
Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils. (nih.gov)
Effect3
Effect of galangin on fluoride-dependent increases in phospho-MYPT1 levels. (biomolther.org)
GW9662 could completely reverse the inhibitory effect of galangin. (bvsalud.org)
Its medicinal effect is mainly due to the substance called galangin, which, among others slims, normalizes blood sugar and cholesterol. (indianpeopletimes.com)
Cells1
In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. (medchemexpress.com)
Levels1
Phospho-MYPT1 protein levels were decreased in rapidly-frozen galangin-treated muscles in the absence of endothelium compared to vehicle-treated muscles precontracted with fluoride. (biomolther.org)
Apigenin2
Propolis is an extract standardized in polyphenols (apigenin, chrysin, galangin), which have positive effects on antioxidant and soothing processes. (marnys.com)
Other flavonoids whose mechanisms of action have been investigated include robinetin, myricetin, apigenin, rutin, galangin, 2,4,2'-trihydroxy-5'-methylchalcone and lonchocarpol A. These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents. (propoleo.cl)
Antibacterial1
Galangin has been shown to have in vitro antibacterial and antiviral activity. (wikipedia.org)
Antibiotic1
This supplement has bioflavonoid, among which galangin is a natural antibiotic. (caninehilton.com)
Vivo1
18. Galangin ameliorates cisplatin induced nephrotoxicity in vivo by modulation of oxidative stress, apoptosis and inflammation through interplay of MAPK signaling cascade. (nih.gov)
Role1
1. Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways. (nih.gov)
Damage1
Galangin (1-100muM) exerted an antiproliferative effect that, with dose and exposure longevity, was progressively associated with an elevated hypodiploid DNA content and expression of the active form of caspase-3, principally prior to membrane damage. (propoleo.cl)
Drug2
Galangin/ß-Cyclodextrin Inclusion Complex as a Drug-Delivery System for Improved Solubility and Biocompatibility in Breast Cancer Treatment. (bvsalud.org)
The purpose of this study was to evaluate the potential of a newly modified cyclodextrin derivative, water -soluble ß- cyclodextrin - epichlorohydrin (ß-CD), as an effective drug carrier to enhance the poor solubility and bioavailability of galangin (GAL), a poorly water -soluble model drug . (bvsalud.org)