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  • biosynthesis
  • Charron M, Shaper JH, Shaper NL (1998) The increased level of β1,4-galactosyltransferase required for lactose biosynthesis is achieved in part by translational control. (springer.com)
  • Here, we report the role of galactosyltransferase β3GalT5, a key enzyme responsible for the biosynthesis of SSEA3 which is then converted to SSEA4 and Globo-H. We demonstrated that knockdown of β3GalT5 would destruct the complex formation of SSEA3/SSEA4/Globo-H with FAK/CAV1/AKT/RIP and cause the dissociation of RIP from the complex to interact with FADD, thus triggering cancer cell apoptosis and suppressing metastasis. (pnas.org)
  • protein
  • In this paper, we describe the capacitation phenotype of sperm lacking the long isoform of β1,4-galactosyltransferase I (GalT I), a sperm surface protein that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of the acrosome reaction following ZP3-dependent aggregation. (biologists.org)
  • murine
  • Charron M, Shaper NL, Rajput B, Shaper JH (1999) A novel 14-base-pair regulatory element is essential for in vivo expression of murine β4-galactosyltransferase-l in late pachytene spermatocytes and round spermatids. (springer.com)
  • Harduin-Lepers A, Shaper NL, Mahoney JA, Shaper JH (1992) Murine β1,4 galactosyltransferase: round spermatid transcripts are characterized by an extended 5′-untranslated region. (springer.com)